Related ArticlesStructure-based Design on Anticancer Drug Discovery. Curr Top Med Chem. 2020;20(10):813-814 Authors: Zhong HA PMID: 32463006 [PubMed - in process]
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Wheat cultivar Een1, 34 near isogenic lines (NILs), and two cultivars were used as plant materials to evaluate the resistance of Een1 to leaf rust disease. Infection type identification and gene postulation were carried out by inoculation of 12 Chinese Puccinia triticina (Pt) pathotypes. Based on the unique phenotype of Een1, we speculated that Een1 might carry Lr gene(s) different from the tested ones. The chromosomal locations for resistance gene to leaf rust disease was employed using SSR primers...
Pseudopimelodus is a Neotropical genus of bumblebee catfish, composed of four valid species occurring in both trans- and cis-Andean rivers of South America. The orogeny of the Andes has led to diversification in the genus Pseudopimelodus in Colombia. This study analyzed partial sequences of mitochondrial cox1 and nuclear rag2 genes to test the hypothesis that the species, nominally recognized as P. schultzi and P. bufonius in Colombia, correspond to more than two different evolutionary lineages....
Hydrothermal venting is rather prevalent in many marine areas around the world, and marine shallow vents are relatively abundant in the Mediterranean Sea, especially around Italy. However, investigations focusing on the characterization of meiofaunal organisms inhabiting shallow vent sediments are still scant compared to that on macrofauna. In the present study, we investigated the meiobenthic assemblages and nematode diversity inhabiting the Secca delle Fumose (SdF), a shallow water vent area located...
We investigated survival and cause-specific mortality for a mountain goat (Oreamnos americanus) population during a period when the puma (Puma concolor) population was growing in the Black Hills, South Dakota, 2006–2018. We obtained survival data from 47 adult goats (n = 33 females, n = 14 males). Annual survival varied from 0.538 (95% CI [0.285–0.773]) to 1.00 (95% CI [1.00–1.00]) and puma predation was the primary cause-specific mortality factor over a 12-year period. Cumulative hectares of mountain...
Bryozoans are small benthic colonial animals; their colonies consist of zooids which are composed of a cystid and polypide. According to morphological and molecular data, three classes of bryozoans are recognized: Phylactolaemata, Gymnolaemata and Stenolaemata. Bryozoans are active suspension feeders and their feeding apparatus, the lophophore, is fringed with a single row of ciliated tentacles. In gymnolaemates, the lophophore is bell-shaped and its tentacles may be equal in length (equitentacled...
The impacts of sea-level rise (SLR) are likely to be the greatest for ecosystems that exist at the land-sea interface, where small changes in sea-level could result in drastic changes in habitat availability. Rocky intertidal ecosystems possess a number of characteristics which make them highly vulnerable to changes in sea-level, yet our understanding of potential community-scale responses to future SLR scenarios is limited. Combining remote-sensing with in-situ large-area imaging, we quantified...
Ctenomys Blainville 1826 is one of the most diverse genera of South American caviomorph rodents. Currently, six species of this genus are reported from Patagonia, south of 42°S. In this contribution, we assessed the taxonomic status of several populations from eastern and central Chubut province, northern Patagonia. Based on phylogenetic analyses of DNA sequences, morphology assessment (qualitative and quantitative), and previously published karyological data, we describe three new species of this...
Background Poor executive functions are associated with dysregulated eating and greater caloric intake in healthy samples. In parallel, findings suggested that sleep deprivation impairs executive functions. Methods We investigated whether partial sleep deprivation impairs executive functions in individuals reporting binge eating (BE, N = 14) and healthy controls (C, N = 13). Switch cost and backward inhibition were measured...
Cervical cancer (CC) remains a major disease burden on the female population worldwide. Chemotherapy with cisplatin (cis-diamminedichloroplatinum (II); CDDP) and related drugs are the main treatment option for CC; however, their efficacy is limited by the development of drug resistance. Noncoding RNAs (ncRNAs) have been found to play critical roles in numerous physiological and pathological cellular processes, including drug resistance of cancer cells. In this review, we describe some of the ncRNAs,...
Atmospheric pollution has become a serious threat for human health and the environment. However, the deployment, operation and maintenance of monitoring networks can represent a high cost for local governments. In certain locations, the use of naturally occurring plants for monitoring pollution can be a useful supplement of existing monitoring networks, and even provide information when other types of monitoring are lacking. In this work, we (i) determined the tissue carbon content and the δ13C values...
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Publication date: Available online 29 May 2020Source: Human PathologyAuthor(s): Francisco Vega, L. Jeffrey Medeiros
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Severe and recurrent infections of the respiratory tract in early childhood constitute major risk factors for the development of bronchial hyper-responsiveness and obstructive respiratory diseases in later lif...
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Related ArticlesFreedom of assembly: metabolic enzymes come together. Mol Biol Cell. 2020 Jun 01;31(12):1201-1205 Authors: Simonet JC, Burrell AL, Kollman JM, Peterson JR Abstract Many different enzymes in intermediate metabolism dynamically assemble filamentous polymers in cells, often in response to changes in physiological conditions. Most of the enzyme filaments known to date have only been observed in cells, but in a handful of cases structural...
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Related ArticlesFluorometric Na+ Evaluation in Single Cells Using Flow Cytometry: Comparison with Flame Emission Assay. Cell Physiol Biochem. 2020 May 29;54(4):556-566 Authors: Yurinskaya VE, Aksenov ND, Moshkov AV, Goryachaya TS, Vereninov AA Abstract BACKGROUND/AIMS: Sodium is a key player in the fundamental cell functions. Fluorescent probes are indispensable tools for monitoring intracellular sodium levels in single living cells. Since the fluorescence...
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Related ArticlesReadability of Printed Online Education Materials on Pituitary Tumors: Untangling a Web of Complexity. Am J Rhinol Allergy. 2020 May 27;:1945892420927288 Authors: Ye MJ, Alwani MM, Harper JL, Buren LMV, Bandali EH, Illing EA, Shipchandler TZ, Ting JY Abstract BACKGROUND: Patients are increasingly turning to the internet for health education. Due to the complex pathophysiology, clinic-diagnostic profile, and management spectrum of...
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The Journal of Antibiotics, Published online: 29 May 2020; doi:10.1038/s41429-020-0320-7Application of Mycobacterium smegmatis as a surrogate to evaluate drug leads against Mycobacterium tuberculosis
The Journal of Antibiotics, Published online: 29 May 2020; doi:10.1038/s41429-020-0328-zPhallac acids A and B, new sesquiterpenes from the fruiting bodies of Phallus luteus
The Journal of Antibiotics, Published online: 29 May 2020; doi:10.1038/s41429-020-0317-2Two novel milbemycin derivatives from the genetically engineered strain Streptomyces avermitilis AVE-H39
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New Findings What is the central question of this study? Do elevated levels of the stress‐response NDRG2 protein protect against fasting and chronic disease in mouse skeletal muscle? What is the main finding and its importance? NDRG2 levels increased in response to fasting and motor neurone disease effects in the tibialis anterior muscle. No alleviation of the stress‐related and proteasomal pathways, mitochondrial dysfunction or muscle mass loss was observed even with further...
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Abstract Influenza (flu) infection increases the risk for disability, falls, and broken bones in older adults. We have employed a preclinical model to examine the impact of flu on muscle function, which has a direct impact on fall risk. In mice, flu causes mobility and strength impairments with induction of inflammatory and muscle degradation genes that are increased and prolonged with aging. To determine if vaccination could reduce flu-induced muscle decrements, mice were vaccinated...
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Abstract Purpose of Review Syndromic gastrointestinal (GI) panels are molecular tests that evaluate stool specimens for multiple enteric pathogens simultaneously, including viruses, bacteria, and parasites. The Luminex xTAG GI panel includes 14 microbial targets and the Biofire FilmArray GI panel includes 22. The purpose of this scoping review was to describe clinical use of these two commercially available syndromic GI panels. ...
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Abstract Objectives To achieve in vitro remineralization of enamel white spot lesions (WSLs) via a mesoporous delivery system of amorphous calcium phosphate (ACP) precursors. Materials and methods Amine-functionalized expanded pore mesoporous silica (aMSN) was loaded with polyacrylic acid–stabilized amorphous calcium phosphate (PAA-ACP) to develop...
Abstract Objectives Periodontitis is a highly prevalent chronic inflammatory disease caused by periodontopathogens, such as Filifactor alocis. This study sought to examine the matrix metalloproteinase (MMP)-1 synthesis by monocytic and fibroblastic cells in response to F. alocis and to unravel the underlying cellular mechanisms. Material and methods ...
Abstract Objectives The present study investigated the clinical significance of the G8 screening tool in elderly oral squamous cell carcinoma (OSCC) patients using a multicenter analysis. Materials and methods The medical records of 438 primary OSCC patients aged 75 years and older were retrospectively reviewed. To examine the clinical significance...
Abstract Objectives To describe the number of second primary malignancies in a series of 33 patients with proliferative verrucous leukoplakia (PVL), detailing the mean time between primary malignancies and their clinical characteristics. Materials and methods Two groups of patients were included in this study: group 1 comprised 33 PVL patients...
Abstract Objective To assess dental treatment under dental general anesthesia (DGA) among Chinese preschool children by investigating changes in their oral health-related quality of life (OHRQoL), the incidence of postoperative complications, and parental satisfaction. Method A single-center prospective cohort study was conducted. A total of...
Abstract Objectives To clinically evaluate the oro-facial manifestations in lepromatous leprosy patients undergoing multidrug therapy in Central India. Materials and methods Two hundred patients from 2 leprosy treatment centers in Central India who satisfied the diagnostic criteria set by the WHO (2006–2010) committee on leprosy were included...
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British Journal of Nursing, Volume 29, Issue 10, Page S15-S21, May 2020.
British Journal of Nursing, Volume 29, Issue 10, Page 547-552, May 2020.
British Journal of Nursing, Volume 29, Issue 10, Page 570-576, May 2020.
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: In the last decade, some institutions have begun combining the CFNG and masseteric nerve to provide dual innervation to the gracilis muscle for dynamic facial reanimation in facial paralysis patients . We reviewed the various ways that these two nerves have been coapted to provide dual innervation, and summarized the functional outcome for these methods.
Before the pandemic the idea of any dramatic change in our plastic surgery service would be unthinkable. In the National Health Service (NHS) it is rare to see services change overnight; if you want to set up a new service we go through departmental approval, ethical approval and often red tape from management. The process is almost not worth the Herculean effort. It is the truth of the world that it takes a great disruption in society for things to change dramatically out of necessity. Disruption...
The first reported cases of the novel Coronavirus SARS-CoV-2 (COVID-19) emerged from Wuhan, the capital of Hubei province (China) in December 2019 [1]. At the time of writing, there have been 201,101 laboratory confirmed cases in the United Kingdom (UK), with 30,076 associated deaths [2]. The UK response on the 23rd March 2020 was to impose a nationwide lockdown to prevent the transmission and spread of the virus. This involved the closure of all non-essential businesses, schools and nurseries, strict...
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Journal of Investigative Medicine High Impact Case Reports, Volume 8, Issue , January-December 2020. Dyspnea in a HIV patient often warrants an extensive workup. The most common etiology of this presentation is likely due to an infectious etiology. However, with the introduction of antiretroviral treatment, non–AIDS-defining illness including malignancies are increasingly being reported. We report the case of a 46-year-old African American female, nonsmoker who presented with dyspnea and found to...
Journal of Investigative Medicine High Impact Case Reports, Volume 8, Issue , January-December 2020. Idiopathic acute eosinophilic pneumonia (AEP) is a very rare disease with fewer than 200 cases reported. It has been hypothesized to be a hypersensitivity reaction to an unidentified antigen. The clinical presentation typically involves fever, nonproductive cough, shortness of breath, and bibasilar inspiratory crackles within the first week of antigen exposure. Chest imaging usually reveals bilateral...
Journal of Investigative Medicine High Impact Case Reports, Volume 8, Issue , January-December 2020. The distinction between persistent infection and immunologic reactions in leprosy is often difficult but critically important since their management is different. We present the case of a 51-year-old Vietnamese female who presented in 2015 with areas of erythema and skin infiltration on face and chest, as well as edema on her hands and feet. Skin biopsy was consistent with lepromatous leprosy. She...
Journal of Investigative Medicine High Impact Case Reports, Volume 8, Issue , January-December 2020. Platypnea orthodeoxia syndrome (POS) occurs when an upright position results in acute-onset hypoxemia and is relieved with recumbency. POS can be due to intracardiac shunting, intrapulmonary shunting, ventilation-perfusion mismatch, or a combination of these. We report a case of POS that developed 3 days post liver transplantation as a result of new-onset right to left shunting across a patent foramen...
Journal of Investigative Medicine High Impact Case Reports, Volume 8, Issue , January-December 2020. A 78-year-old male, originally from China, was brought to the hospital for weakness, urinary incontinence, confusion, and poor oral intake. He was started on empiric antibiotics, which were narrowed when blood cultures produced gram-negative bacteremia speciating to Klebsiella pneumoniae, sensitive to ceftriaxone. Computed tomography scan of the abdomen and pelvis demonstrated a large cystic region...
