Brain Metastases in Oncogene-Addicted Non-Small Cell Lung Cancer Patients: Incidence and Treatment

J. Remon, Benjamin Besse

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Classical NF-κB Metabolically Reprograms Sarcoma Cells Through Regulation of Hexokinase 2

Priya Londhe, Peter Y. Yu, Yuichi Ijiri, Katherine J. Ladner, Joelle M. Fenger, Cheryl London, Peter J. Houghton, Denis C. Guttridge

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Acuedan definiciones biológicas para investigar | Nuevo marco de investigación biológica para el Alzheimer

La Asociación de Alzheimer convoca un esfuerzo para actualizar la definición de la enfermedad

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Editorial Board

Publication date: May 2018
Source:Peptides, Volume 103





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Toxins, Vol. 10, Pages 152: Bovine Peripheral Blood Mononuclear Cells Are More Sensitive to Deoxynivalenol Than Those Derived from Poultry and Swine

Toxins, Vol. 10, Pages 152: Bovine Peripheral Blood Mononuclear Cells Are More Sensitive to Deoxynivalenol Than Those Derived from Poultry and Swine

Toxins doi: 10.3390/toxins10040152

Authors: Barbara Novak Eleni Vatzia Alexandra Springler Alix Pierron Wilhelm Gerner Nicole Reisinger Sabine Hessenberger Gerd Schatzmayr Elisabeth Mayer

Deoxynivalenol (DON) is one of the most prevalent mycotoxins, contaminating cereals and cereal-derived products. Its derivative deepoxy-deoxynivalenol (DOM-1) is produced by certain bacteria, which either occur naturally or are supplemented in feed additive. DON-induced impairments in protein synthesis are particularly problematic for highly proliferating immune cells. This study provides the first comparison of the effects of DON and DOM-1 on the concanavalin A-induced proliferation of porcine, chicken, and bovine peripheral blood mononuclear cells (PBMCs). Therefore, isolated PBMCs were treated with DON (0.01–3.37 µM) and DOM-1 (1.39–357 µM) separately, and proliferation was measured using a bromodeoxyuridine (BrdU) assay. Although pigs are considered highly sensitive to DON, the present study revealed a substantially higher sensitivity of bovine (IC50 = 0.314 µM) PBMCs compared to chicken (IC50 = 0.691 µM) and porcine (IC50 = 0.693 µM) PBMCs. Analyses on the proliferation of bovine T-cell subsets showed that all major subsets, namely, CD4+, CD8β+, and γδ T cells, were affected to a similar extent. In contrast, DOM-1 did not affect bovine PBMCs, but reduced the proliferation of chicken and porcine PBMCs at the highest tested concentration (357 µM). Results confirm the necessity of feed additives containing DON-to-DOM-1-transforming bacteria and highlights species-specific differences in the DON sensitivity of immune cells.

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Different Levels of Expression of the Clock Protein PER and the Glial Marker REPO in Ensheathing and Astrocyte-Like Glia of the Distal Medulla of Drosophila Optic Lobe

Wojciech Krzeptowski, Lucyna Walkowicz, Alicja Płonczyńska, Jolanta Górska-Andrzejak

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The Contribution of Different Components in QiShenYiQi Pills® to Its Potential to Modulate Energy Metabolism in Protection of Ischemic Myocardial Injury

Yuan-Chen Cui, Li Yan, Chun-Shui Pan, Bai-He Hu, Xin Chang, Jing-Yu Fan, Jing-Yan Han

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