Abstract
A growing number of clinical studies demonstrate that extracorporeal shock wave therapy is a feasible noninvasive method for improving chronic wound healing. This systematic review and meta-analysis aimed to assess the effectiveness of extracorporeal shock wave therapy compared with that of the standard care treatment for the healing of chronic wounds, irrespective of etiology, in clinical practice. Randomized controlled trials that investigated the effect of extracorporeal shock wave therapy on chronic wounds with different etiologies from 2000 to 2017 were included in this review. The methodological quality of each selected article was rated using the Jadad scale. A fixed or random effects model was used to calculate the pooled effect sizes according to the heterogeneity of the studies. The cumulative effect of extracorporeal shock wave therapy on each outcome was illustrated using forest plots. Seven randomized controlled trials involving 301 subjects were included in this review. Meta-analyses revealed that the use of extracorporeal shock wave therapy as an adjunct to wound treatment could significantly accelerate the impaired healing process of chronic wounds. Compared with the control treatment, extracorporeal shock wave therapy markedly increased the wound healing rate by 1.86-fold (OR =2.86, 95% CI: 1.63-5.03, p=0.0003) and the percentage of the wound healing area by 30.46% (SMD=30.46; 95% CI: 23.80-37.12; p<0.00001). In addition, the wound healing time was reduced by 19 days (SMD=-19.11, 95% CI:-23.74-(-14.47), p<0.00001) in chronic wound patients. No serious complications or adverse effects were observed secondary to the application of extracorporeal shock wave therapy. The above data suggested that extracorporeal shock wave therapy as an adjunct to wound treatment, could more significantly improve the healing process of chronic wounds than the standard care treatment alone. More high-quality, well-controlled randomized trials are needed to evaluate the efficacy of extracorporeal shock wave therapy in clinical practice. This article is protected by copyright. All rights reserved.
from # All Medicine by Alexandros G. Sfakianakis via alkiviadis.1961 on Inoreader http://ift.tt/2vliCmo
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