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[Analysis of gene expression pattern in peripheral blood leukocytes during experimental heat wave].
Biomed Khim. 2017 Mar;63(2):139-146
Authors: Feoktistova ES, Skamrov AV, Goryunova LE, Khaspekov GL, Osyaeva MK, Rodnenkov OV, Beabealashvilli RS
Abstract
The conditions of Moscow 2010 summer heat wave were simulated in an accommodation module. Six healthy men aged from 22 to 46 years stayed in the module for 30 days. Measurements of gene expression in peripheral blood leukocytes before, during and 3 day after simulated heat wave were performed using qRT-PCR. We observed a shift in the expression level of certain genes after heat exposure for a long time, and rapid return to the initial level, when volunteers leaved the accommodation module. Eight genes were chosen to form the "heat expression signature". EGR2, EGR3 were upregulated in all six volunteers, EGR1, SIRT1, CYP51A1, MAPK9, BAG5, MNDA were upregulated in 5 volunteers.
PMID: 28414285 [PubMed - indexed for MEDLINE]
from # All Medicine by Alexandros G. Sfakianakis via alkiviadis.1961 on Inoreader http://ift.tt/2joWz8X
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