Introduction of Zika virus in Bangladesh: an impending public health threat

Publication date: Available online 13 September 2017
Source:Asian Pacific Journal of Tropical Medicine
Author(s): A.K.M. Muraduzzaman, Sharmin Sultana, Tahmina Shirin, Selina Khatun, MdTarikul Islam, Mahmudur Rahman
ObjectiveTo explore the presence of Zika virus (ZIKV) in Bangladesh and to understand the associated risk factors.MethodsA retrospective sero-surveillance was performed on stored serum samples of dengue surveillance conducted from 2013 to 2016. Real time RT-PCR was performed on randomly selected acute serum samples to detect the Zika virus nucleic acid.ResultsOf 200 samples screened, one was found positive for ZIKV by real time RT-PCR and further confirmed by genome sequencing. The case was a 65 years old male from a metropolitan city of Bangladesh who had no history of travel outside Bangladesh. Phylogenetic analysis of partial E gene sequences from Bangladeshi isolates demonstrated a close relationship with ZIKV from Brazil and current South American strains clustering within a monophyletic clade distinct from African lineage.ConclusionsPresence of ZIKV raises serious public health concerns in Bangladesh owing to its association with congenital anomalies/neurological-manifestations. We, therefore, recommend every suspected viral fever patient, particularly pregnant women be screened for ZIKV infection to rule out yet another emerging infection in Bangladesh.



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