AUTOMATED MECHANICAL PERIPHERAL STIMULATION IMPROVES GAIT PARAMETERS IN SUBJECTS WITH PARKINSON’S DISEASE AND FREEZING OF GAIT: A RANDOMIZED CLINICAL TRIAL

AbstractObjectiveThis study aimed to assess spatiotemporal gait parameters and lower limbs range of motion (ROM) in subjects with Parkinson's Disease (PD) and freezing of gait (FOG), treated with Automated Mechanical Peripheral Stimulation (AMPS) or AMPS SHAM (placebo).DesignThis randomized clinical trial included thirty subjects allocated into two groups: AMPS (15 subjects with PD) and AMPS SHAM (15 subjects with PD). Fourteen age-matched healthy subjects were also included as a REFERENCE group. Both PD groups received the treatment twice a week during 4 weeks. AMPS was applied using a commercial medical device (Gondola™) and consisted of mechanical pressure in four areas of feet. For AMPS SHAM group, a subliminal stimulus was delivered. Gait analyses were measured at PRE, POST 1st, POST 4th, and POST 8th sessions.ResultsWe did not find significant differences between AMPS and AMPS SHAM groups either for spatiotemporal gait parameters or for lower limbs ROM. However, within-group analysis showed that AMPS group significantly improved spatiotemporal gait parameters and hip rotation ROM throughout the treatment period. AMPS SHAM group did not show any improvement.ConclusionsAMPS therapy induces improvements in spatiotemporal parameters and hip rotation ROM of subjects with PD and FOG. Objective This study aimed to assess spatiotemporal gait parameters and lower limbs range of motion (ROM) in subjects with Parkinson's Disease (PD) and freezing of gait (FOG), treated with Automated Mechanical Peripheral Stimulation (AMPS) or AMPS SHAM (placebo). Design This randomized clinical trial included thirty subjects allocated into two groups: AMPS (15 subjects with PD) and AMPS SHAM (15 subjects with PD). Fourteen age-matched healthy subjects were also included as a REFERENCE group. Both PD groups received the treatment twice a week during 4 weeks. AMPS was applied using a commercial medical device (Gondola™) and consisted of mechanical pressure in four areas of feet. For AMPS SHAM group, a subliminal stimulus was delivered. Gait analyses were measured at PRE, POST 1st, POST 4th, and POST 8th sessions. Results We did not find significant differences between AMPS and AMPS SHAM groups either for spatiotemporal gait parameters or for lower limbs ROM. However, within-group analysis showed that AMPS group significantly improved spatiotemporal gait parameters and hip rotation ROM throughout the treatment period. AMPS SHAM group did not show any improvement. Conclusions AMPS therapy induces improvements in spatiotemporal parameters and hip rotation ROM of subjects with PD and FOG. Funding: A Research contract is active since November 2015 between the society Gondola Medical technology and Politecnico de Milano. Disclosures: The authors report no disclosures. Conflict of interests: None. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

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