Publication date: Available online 17 December 2018
Source: Academic Radiology
Author(s): Guang-xian Wang, Chao Xia, Jian Liu, Chun Cui, Sheng Lei, Ming-fu Gong, Li Wen, Dong Zhang
Rationale and Objectives
To identify the relationship between enhancement ratio (ER) of aneurysm walls and degrees of inflammation.
Materials and Methods
Twenty-five white rabbits were used in this study; all underwent surgery to isolate the right common carotid artery (RCCA). Twenty rabbits underwent an aneurysm creation procedure, and 5 underwent a control procedure. In the aneurysm creation procedure, there was surgical exposure of the origin of RCCA and temporary occlusion with an aneurysm clip. The distal RCCA was ligated, and the trapped segment was infused with elastase for 20 minutes, after which the clip was removed. In the control procedure, the trapped segment was infused with saline. High-resolution magnetic resonance imaging was performed at weeks 2, 3, 4, and 5 after the procedure, and wall ER was calculated. After MRI, aneurysms were harvested and stained with hematoxylin-eosin. Pearson correlation analysis and scatter plots were used to evaluate the relationship between wall ER and the degree of inflammation. The relationships between the wall ER, the number of inflammatory cells and time were analyzed by linear graphs.
Results
Wall ER positively correlated with inflammatory cell count of the aneurysm wall (r = 0.877, p < 0.001). The relationships between wall ER, the number of inflammatory cells, and time increased and then decreased according linear graphs.
Conclusion
In this study, the aneurysm wall ER was confirmed to be associated with the degree of inflammation on the rabbit aneurysm model.
from Imaging via a.sfakia on Inoreader https://ift.tt/2PKYyPQ
No comments:
Post a Comment
Note: Only a member of this blog may post a comment.