Abstract Accurate genomic profiling for adult height is of high practical relevance in forensics genetics. Adult height is a classical reference trait in the field of human complex trait genetics characterized by highly polygenic nature and relatively high heritability. A meta-analysis of genome-wide association studies by the Genetic Investigation of Anthropocentric Traits (GIANT) consortium has identified 697 DNA variants associated with adult height in Europeans; however, whether...
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Abstract Several molecular modifications accumulate in the human organism with increasing age. Some of these "molecular clocks" in DNA and in proteins open up promising approaches for the development of methods for forensic age estimation. A natural limitation of these methods arises from the fact that the chronological age is determined only indirectly by analyzing defined molecular changes that occur during aging. These changes are not linked exclusively to the expired life span...
Thu Apr 11, 2019 03:00
Thu Apr 11, 2019 21:37
The crystal structures of two hydrated conglomerate forms of ivabradine hydrochloride are described. The stabilities of the two crystal forms are experimentally and theoretically investigated.Ivabradine hydrochloride (IVA‐HCl) (systematic name: {[3,4‐dimethoxybicyclo[4.2.0]octa‐1(6),2,4‐trien‐7‐yl]methyl}[3‐(7,8‐dimethoxy‐2‐oxo‐2,3,4,5‐tetrahydro‐1H‐3‐benzazepin‐3‐yl)propyl]methylazanium), is a novel medication used for the symptomatic management of stable angina pectoris. In many recent patents,...
Thu Apr 11, 2019 21:19
MacromoleculesDOI: 10.1021/acs.macromol.8b02061
Thu Apr 11, 2019 07:00
MacromoleculesDOI: 10.1021/acs.macromol.9b00396
Thu Apr 11, 2019 07:00
AbstractBackgroundPediatric emergency telemedicine consultations have been shown to provide support to community emergency departments treating critically ill pediatric patients. However, despite the recognized value of telemedicine, adoption has been slow. To determine why clinicians frequently do not use telemedicine when it is available for pediatric patients, as well as to learn how to improve telemedicine programs, we conducted a qualitative study using stakeholder interviews.MethodsWe...
Thu Apr 11, 2019 19:35
Abstract This paper presents a systemic investigation of ADA development and ADA impact of a human coagulation factor in nonclinical species during drug development and provides insights into potential implications in human if a similar ADA occurs. FXaI16L-induced ADA response was characterized in monkey, mouse, rat, and dog in different studies, and ADA effects on pharmacokinetic and/or pharmacodynamics of FXaI16L were further examined in ADA-negative and ADA-positive animals....
Thu Apr 11, 2019 03:00
Chemical Research in ToxicologyDOI: 10.1021/acs.chemrestox.8b00338
Thu Apr 11, 2019 07:00
ACS Synthetic BiologyDOI: 10.1021/acssynbio.9b00041
Thu Apr 11, 2019 07:00
MacromoleculesDOI: 10.1021/acs.macromol.8b02367
Thu Apr 11, 2019 07:00
The structures of three copper‐containing complexes are reported and tests for their activity in the oxidation of d‐galactose suggest that, unlike the enzyme galactose oxidase, due to the precipitation of Cu2O, this reaction is not catalytic as would have been expected.The structures of three copper‐containing complexes, namely (benzoato‐κ2O,O′)[(E)‐2‐({[2‐(diethylamino)ethyl]imino}methyl)phenolato‐κ3N,N′,O]copper(II) dihydrate, [Cu(C7H5O2)(C13H19N2O)]·2H2O, 1, [(E)‐2‐({[2‐(diethylamino)ethyl]imino}methyl)phenolato‐κ3N,N′,O](2‐phenylacetato‐κ2O,O′)copper(II),...
Wed Apr 10, 2019 22:00
Publication date: Available online 11 April 2019Source: Acta BiomaterialiaAuthor(s): Ce Xi, Ghassan S. Kassab, Lik Chuan LeeAbstractIsolating the role(s) of microstructural pathological features in affecting diastolic filling is important in developing targeted treatments for heart diseases. We developed a microstructure-based constitutive model of the myocardium and implemented it in an efficient open-source finite element modeling framework to simulate passive inflation of the left ventricle (LV)...
Thu Apr 11, 2019 15:35
Publication date: Available online 11 April 2019Source: Acta BiomaterialiaAuthor(s): Mohamad Nageeb Hassan, Mohammed Ahmed Yassin, Salwa Suliman, Stein Atle Lie, Harald Gjengedal, Kamal MustafaAbstract3D-printed templates are being used for bone tissue regeneration (BTR) as temporary guides. In the current review, we analyze the factors considered in producing potentially bioresorbable/degradable 3D-printed templates and their influence on BTR in calvarial bone defect (CBD) animal models. In addition,...
Thu Apr 11, 2019 15:35
Publication date: Available online 10 April 2019Source: Acta BiomaterialiaAuthor(s): Yang Zhou, Jinyi Tan, Jianfeng Wu, Qi Zhang, John Andre, Chuanwu Xi, Zhan Chen, Mark E. MeyerhoffAbstractNitric oxide (NO) releasing polymers have been widely applied as biomaterials for a variety of biomedical implants and devices. However, the chemical leaching of NO donors and their byproduct species is almost always observed during the application of polymers doped with NO donors, unless the donor is covalently...
Thu Apr 11, 2019 15:35
Abstract Rice cultivation is practiced in various agro-climatic zones ranging from tropical to temperate. Anthesis is a critical stage for deciding productivity which is controlled by numerous biotic and abiotic stresses. Elevated temperature is one of the key abiotic stresses that adversely modulate the pollen formation and structure, i.e., infertility, results in productivity decline. The present study was conducted to investigate the effects of elevated temperature on morphological...
Thu Apr 11, 2019 03:00
Publication date: July 2019Source: Accident Analysis & Prevention, Volume 128Author(s): Daniel Albalate, Paula Bel-PiñanaAbstractPublic Private Partnerships (PPP) have become common in providing high-quality infrastructure in many countries worldwide. One of the main reasons for PPP agreements is to improve efficiency and quality in the delivery of public services, as well as to boost investments for expensive projects. Despite PPPs having been particularly widespread in the case of the construction...
Thu Apr 11, 2019 14:47
Publication date: Available online 10 April 2019Source: Accident Analysis & PreventionAuthor(s): Ben Beck, Derek Chong, Jake Olivier, Monica Perkins, Anthony Tsay, Adam Rushford, Lingxiao Li, Peter Cameron, Richard Fry, Marilyn JohnsonAbstractBackground: Understanding factors that influence the distance that drivers provide when passing cyclists is critical to reducing subjective risk and improving cycling participation. This study aimed to quantify passing distance and assess the impact of motor...
Thu Apr 11, 2019 14:47
Publication date: Available online 11 April 2019Source: Archives of Oral BiologyAuthor(s): Huifang Wang, Jie Yin, Pengfei Lu, Qing YuAbstractObjectivesClassify and obtain the representative shape of the maxillary central incisor by three -dimensional geometric morphological method.Materials and MethodsOne hundred three dental plaster models of Chinese juvenile were scanned by a 3D laser scanner, including 51 males and 52 females. The mean value model of all samples was obtained by using Procrustes...
Thu Apr 11, 2019 14:45
Related ArticlesDevelopment of a Biosensory Computer Application to Assess Physiological and Emotional Responses from Sensory Panelists. Sensors (Basel). 2018 Sep 05;18(9): Authors: Fuentes S, Gonzalez Viejo C, Torrico DD, Dunshea FR Abstract In sensory evaluation, there have been many attempts to obtain responses from the autonomic nervous system (ANS) by analyzing heart rate, body temperature, and facial expressions. However, the methods involved...
Thu Apr 11, 2019 14:23
Related ArticlesUltra-Wideband (UWB) Antenna Sensor Based Microwave Breast Imaging: A Review. Sensors (Basel). 2018 Sep 05;18(9): Authors: Mahmud MZ, Islam MT, Misran N, Almutairi AF, Cho M Abstract Globally, breast cancer is reported as a primary cause of death in women. More than 1.8 million new breast cancer cases are diagnosed every year. Because of the current limitations on clinical imaging, researchers are motivated to investigate complementary...
Thu Apr 11, 2019 14:23
Related ArticlesMembrane-Based Microwave-Mediated Electrochemical Immunoassay for the In Vitro, Highly Sensitive Detection of Osteoporosis-Related Biomarkers. Sensors (Basel). 2018 Sep 04;18(9): Authors: Kim HY, Sato S, Takenaka S, Lee MH Abstract Highly sensitive and multiplexed in vitro detection of osteoporosis-related biochemical markers were carried out based on the membrane-based microwave-mediated electrochemical immunoassay (MMeEIA), where we...
Thu Apr 11, 2019 14:23
Related ArticlesA Time-Distributed Spatiotemporal Feature Learning Method for Machine Health Monitoring with Multi-Sensor Time Series. Sensors (Basel). 2018 Sep 03;18(9): Authors: Qiao H, Wang T, Wang P, Qiao S, Zhang L Abstract Data-driven methods with multi-sensor time series data are the most promising approaches for monitoring machine health. Extracting fault-sensitive features from multi-sensor time series is a daunting task for both traditional...
Thu Apr 11, 2019 14:23
Related ArticlesThe Dynamic EEG Microstates in Mental Rotation. Sensors (Basel). 2018 Sep 03;18(9): Authors: Kong W, Wang L, Zhang J, Zhao Q, Sun J Abstract Mental rotation is generally analyzed based on event-related potential (ERP) in a time domain with several characteristic electrodes, but neglects the whole spatial-temporal brain pattern in the cognitive process which may reflect the underlying cognitive mechanism. In this paper, we mainly proposed...
Thu Apr 11, 2019 14:23
Related ArticlesA Review of Emotion Recognition Using Physiological Signals. Sensors (Basel). 2018 Jun 28;18(7): Authors: Shu L, Xie J, Yang M, Li Z, Li Z, Liao D, Xu X, Yang X Abstract Emotion recognition based on physiological signals has been a hot topic and applied in many areas such as safe driving, health care and social security. In this paper, we present a comprehensive review on physiological signal-based emotion recognition, including emotion...
Thu Apr 11, 2019 14:23
Related ArticlesThreshold-Based Noise Detection and Reduction for Automatic Speech Recognition System in Human-Robot Interactions. Sensors (Basel). 2018 Jun 28;18(7): Authors: Lee SC, Wang JF, Chen MH Abstract This work develops a speech recognition system that uses two procedures of proposed noise detection and combined noise reduction. The system can be used in applications that require interactive robots to recognize the contents of speech that includes...
Thu Apr 11, 2019 14:23
Related ArticlesFaceLooks: A Smart Headband for Signaling Face-to-Face Behavior. Sensors (Basel). 2018 Jun 28;18(7): Authors: Hachisu T, Pan Y, Matsuda S, Bourreau B, Suzuki K Abstract Eye-to-eye contact and facial expressions are key communicators, yet there has been little done to evaluate the basic properties of face-to-face; mutual head orientation behaviors. This may be because there is no practical device available to measure the behavior. This...
Thu Apr 11, 2019 14:23
Related ArticlesA Plug-and-Play Human-Centered Virtual TEDS Architecture for the Web of Things. Sensors (Basel). 2018 Jun 27;18(7): Authors: Hernández-Rojas DL, Fernández-Caramés TM, Fraga-Lamas P, Escudero CJ Abstract This article presents a Virtual Transducer Electronic Data Sheet (VTEDS)-based framework for the development of intelligent sensor nodes with plug-and-play capabilities in order to contribute to the evolution of the Internet of Things...
Thu Apr 11, 2019 14:23
Related ArticlesCoumarin Probe for Selective Detection of Fluoride Ions in Aqueous Solution and Its Bioimaging in Live Cells. Sensors (Basel). 2018 Jun 26;18(7): Authors: Chansaenpak K, Kamkaew A, Weeranantanapan O, Suttisintong K, Tumcharern G Abstract We have synthesized novel coumarin-based fluorescent chemosensors for detection of fluoride ions in aqueous solution. The detection mechanism relied on a fluoride-mediated desilylation triggering fluorogenic...
Thu Apr 11, 2019 14:23
Publication date: Available online 11 April 2019Source: Academic PediatricsAuthor(s): Emara Nabi-Burza, Susan Regan, Bethany Hipple Walters, Jeremy E. Drehmer, Nancy A. Rigotti, Deborah J. Ossip, Julie A. Gorzkowski, Douglas E. Levy, Jonathan P. WinickoffAbstractBackgroundE-cigarettes are growing in popularity. Dual use of e-cigarettes and cigarettes is an increasingly common practice, but little is known about patterns of dual use in parents.ObjectivesTo describe smoking-related behaviors among...
Thu Apr 11, 2019 14:18
Publication date: Available online 11 April 2019Source: Academic PediatricsAuthor(s): Charles T. Wood, Jane D. Brown, Callie L. Brown, Janna B. Howard, Michael J. Steiner, Andrew J. Perrin, Cary Levine, Eliana M. PerrinABSTRACTObjectiveLittle is known about the concordance of parent and child reports of children's media consumption, even though parents are often asked to report for their children in clinical care settings. We aimed to understand how parent and child reports of children's media consumption...
Thu Apr 11, 2019 14:18
Publication date: Available online 11 April 2019Source: Academic PediatricsAuthor(s): Jaspreet Loyal, Theresa R. Weiss, Jessica H. Cheng, Laura R. Kair, Eve ColsonAbstractBackground and ObjectiveDespite American Academy of Pediatrics recommendations, some parents refuse IM vitamin K as prophylaxis against vitamin K deficiency bleeding (VKDB) for their newborn. The purpose of our study was to describe attitudes and perceptions of parents who choose to defer IM vitamin K for their newborn.MethodsUsing...
Thu Apr 11, 2019 14:18
Related ArticlesConfronting Incivility in the Online Classroom. J Christ Nurs. 2019 Apr/Jun;36(2):104-111 Authors: Swartzwelder K, Clements P, Holt K, Childs G Abstract Confronting incivility in the online classroom can significantly benefit from spiritual approaches that address behaviors on a continuum of mild to aggressive. This may include the need to intervene when covert or overt threats occur. Electronic communications can lead to misperceptions...
Thu Apr 11, 2019 13:34
Related ArticlesPotential application of amino acids in analytical toxicology. Talanta. 2019 May 15;197:168-174 Authors: Riahi-Zanjani B, Balali-Mood M, Asoodeh A, Es'haghi Z, Ghorani-Azam A Abstract The ability of extraction and preconcentration of small quantities of substances from biological samples is important in analytical sciences, particularly forensic medicine. In the present study, we evaluated the binding potential of amino acids to produce...
Thu Apr 11, 2019 13:34
Related ArticlesNuclear factor erythroid 2-related factors 1 and 2 are able to define the worst prognosis group among high-risk diffuse large B cell lymphomas treated with R-CHOEP. J Clin Pathol. 2019 Apr;72(4):316-321 Authors: Kari E, Teppo HR, Haapasaari KM, Kuusisto MEL, Lemma A, Karihtala P, Pirinen R, Soini Y, Jantunen E, Turpeenniemi-Hujanen T, Kuittinen O Abstract AIMS: Oxidative stress markers and antioxidant enzymes have previously been shown...
Thu Apr 11, 2019 13:34
Related ArticlesNo effect of unacylated ghrelin administration on subcutaneous PC3 xenograft growth or metabolic parameters in a Rag1-/- mouse model of metabolic dysfunction. PLoS One. 2018;13(11):e0198495 Authors: Maugham ML, Seim I, Thomas PB, Crisp GJ, Shah ET, Herington AC, Brown KA, Gregory LS, Nelson CC, Jeffery PL, Chopin LK Abstract Ghrelin is a peptide hormone which, when acylated, regulates appetite, energy balance and a range of other biological...
Thu Apr 11, 2019 13:34
Related ArticlesPosttraumatic Stress Disorder Augments Plasma Triglycerides in TT Homozygotes of rs495225 at Growth Hormone Secretagogue Receptor Gene. Biochem Genet. 2019 Apr;57(2):273-288 Authors: Su M, Si YJ, Guo QW, Yang M, Chen X, Lin J, Fang DZ Abstract Posttraumatic stress disorder (PTSD) and growth hormone secretagogue receptor (GHSR) were reported to be associated with plasma lipid and glucose levels. However, interplays of PTSD with GHSR on...
Thu Apr 11, 2019 13:34
Related ArticlesAccuracy of the Demirjian and Willems methods of dental age estimation for children from central southern China. Int J Legal Med. 2019 Mar;133(2):593-601 Authors: Yang Z, Geng K, Liu Y, Sun S, Wen D, Xiao J, Zheng Y, Cai J, Zha L, Liu Y Abstract The aim of this study was to compare the accuracy of the Demirjian method and the Demirjian method as revised by Willems for age estimation based on orthopantomograms from central southern Chinese...
Thu Apr 11, 2019 13:34
Related Articles[Reuse of Clinical Records for Scientific Research: Legal Issues Related to the Authorization of the Holders and Anonymisation]. Acta Med Port. 2018 Jun 29;31(6):299-302 Authors: Guimarães R, Rodrigues P, Santos A, Dinis-Oliveira RJ PMID: 30020874 [PubMed - indexed for MEDLINE]
Thu Apr 11, 2019 13:34
Related ArticlesSex, gender and the carceral: Female staff experiences of working in forensic care with sexual offenders. Int J Law Psychiatry. 2018 Jul - Aug;59:38-43 Authors: Mercer D, Perkins E Abstract English high-secure hospitals have contained individuals deemed mentally disordered, and dangerous, since the mid-nineteenth century. With the development of gender sensitive services female patients have been moved out of these institutions into...
Thu Apr 11, 2019 13:34
Related ArticlesFactors that predict murder defendants' competence to stand trial. Int J Law Psychiatry. 2018 Jul - Aug;59:31-37 Authors: Tartaro C, Duntley J, Medvetz S, Hafner N Abstract One hundred sixty-three homicide case files from The Center for Forensic Psychiatry in Ypsilanti, Michigan were examined for evidence of factors associated with the outcomes of Competency to Stand Trial (CST) evaluations. Of the socio-demographic, legal, and clinical...
Thu Apr 11, 2019 13:34
Related ArticlesCIO inventory: A new tool for measuring personality traits common to psychopathy and narcissism and their interaction with gender. Int J Law Psychiatry. 2018 Jul - Aug;59:1-9 Authors: Carraro L, Spironelli C, Poli E, Bobbio A, Castelli L, Arcuri L, Angrilli A Abstract A lack of empathy, interpersonal dominance, aggression and the exploitation of others are the key features of both narcissism and psychopathic disorders. With the aim to...
Thu Apr 11, 2019 13:34
Related ArticlesMain and interaction effects of childhood trauma and the MAOA uVNTR polymorphism on psychopathy. Psychoneuroendocrinology. 2018 09;95:106-112 Authors: Hollerbach P, Johansson A, Ventus D, Jern P, Neumann CS, Westberg L, Santtila P, Habermeyer E, Mokros A Abstract Psychopathy is characterized by callous affect, interpersonal manipulation, a deviant lifestyle, and antisocial behavior. Previous research has linked psychopathic traits to...
Thu Apr 11, 2019 13:34
Related ArticlesEthical, legal and social implications of forensic molecular phenotyping in South Africa. Dev World Bioeth. 2018 06;18(2):171-181 Authors: Slabbert N, Heathfield LJ Abstract Conventional forensic DNA analysis involves a matching principle, which compares DNA profiles from evidential samples to those from reference samples of known origin. In casework, however, the accessibility to a reference sample is not guaranteed which limits the...
Thu Apr 11, 2019 13:34
Related ArticlesArtemisinin-Luminol Chemiluminescence for Forensic Bloodstain Detection Using a Smart Phone as a Detector. Anal Chem. 2017 06 06;89(11):6160-6165 Authors: Gao W, Wang C, Muzyka K, Kitte SA, Li J, Zhang W, Xu G Abstract Forensic luminol chemiluminescence test is one of the most sensitive and popular methods for the determination of latent bloodstains. It mainly uses hydrogen peroxide or sodium perborate as coreactants. The easy decomposition...
Thu Apr 11, 2019 13:34
Thu Apr 11, 2019 03:00
Abstract Objective To investigate an automated aortic calcium segmentation and scoring tool at abdominal CT in an adult screening cohort. Methods Using instance segmentation with convolutional neural networks (Mask R-CNN), a fully automated vascular calcification algorithm was applied to a data set of 9914 non-contrast CT scans from 9032 consecutive asymptomatic...
Thu Apr 11, 2019 03:00
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