Successful Treatment of Cosmetic Eyebrow Tattoos in Fitzpatrick III‐IV With Picosecond (1,064, 532‐nm) Neodymium‐Doped Yttrium Aluminum Garnet Laser With a Perfluorodecalin‐Infused Patch: A Pilot Study: Background and ObjectivesNanosecond Q‐switched lasers have been used for the removal of traditional and cosmetic tattoos. Picosecond lasers utilize pulse durations of 10−12 and provide more efficient clearance of tattoos. Safe and effective removal of tattoos is especially important in cosmetically...
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Residual Lesions After Pharmacological and Dye‐Laser Treatment of Infantile Hemangiomas: Critical Review of 432 Cases: Background and ObjectivesInfantile hemangiomas (IHs) are the most common benign tumors in infanthood. Although they are often self‐limiting, management of IHs is still controversial because residual lesions may persist in some cases. The aim of this study is to report our experience with patients affected with IH and investigate the frequency of residual lesions in treated versus...
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CO2 Laser Cordectomy Versus KTP Laser Tumor Ablation for Early Glottic Cancer: A Randomized Controlled Trial: Background and ObjectivesCO2 laser cordectomy has been the workhorse of laser surgery for early glottic squamous cell carcinoma (GSCC) since the early 1970s. During the last decades, potassium titanyl phosphate (KTP) laser surgery for early GSCC gained popularity, introducing the tumor ablation technique. Yet, there are no previous randomized controlled trials (RCT) that compare the oncologic...
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In Pursuit of the Parietal Cell – An Evolution of Scientific Methodology and Techniques: The stomach has unique embryologic and anatomic properties, making the study of the parietal cell technically challenging. Numerous individuals have devoted decades of research to unraveling the pathophysiological basis of this cell type. Here, we perform a scoping review of novel in vitro and in vivo methodology pertaining to the parietal cell. First, we evaluate early in vitro methods of parietal cell analysis....
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Potential Therapeutic Use of Neurosteroids for Hypertension: The sympathetic nervous system (SNS) contribution to long-term setting of blood pressure (BP) and hence hypertension has been a continuing controversy over many decades. However, the contribution of increased sympathetic vasomotor tone to the heart, kidney, and blood vessels has been suggested as a major influence on the development of high BP which affects 30–40% of the population. This is relevant to hypertension associated with chronic...
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Low-level laser-aided orthodontic treatment of periodontally compromised patients: a randomised controlled trial: AbstractLow-level laser irradiation (LLLI) shows effects in orthodontic pain relief and periodontal inflammation control. The aim of this article is to investigate the analgesic and inflammation-modulatory effects of low-level laser irradiation among orthodontic patients with compromised periodontium. A randomised controlled trial with split-mouth design was conducted in 27 adults with...
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Effect of Depth of Electroacupuncture on the IPSS of Patients with Benign Prostatic Hyperplasia: This study aimed to evaluate the efficacy of electroacupuncture (EA) on Ciliao (BL 32) and Zhongliao (BL 33) acupoints at different depths for the treatment of benign prostatic hyperplasia (BPH) through a single-blind randomized controlled trial. All 120 patients diagnosed with BPH were randomly allocated to an experimental group (deep insertion group, DI group, n = 60) and control group (shallow insertion...
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Risk of vasopressin use: a case of acute pulmonary oedema, post intramyometrial infiltration of vasopressin in laparoscopic myomectomy: A 34-year-old patient underwent a laparoscopic myomectomy, complicated by a profound episode of bradycardia and hypotension following intramyometrial infiltration of vasopressin (20 IU), promptly corrected with intravenous ephedrine (6 mg) and glycopyrrolate (200 µg). At extubation, pink frothy fluid was noted in the endotracheal tube; she was visibly distressed,...
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Natural recovery from long-lasting generalised dissociative amnesia and of cerebral blood flow: A 40-year-old man presented with generalised dissociative amnesia. At 2 weeks after onset, N-isopropyl-[123I] p-iodoamphetamine-single-photon emission CT imaging of the brain revealed hypoperfusion in the right medial temporal area. Organic brain damage was ruled out. His inability to recall information was attributed to psychological stress related to his employment. Consistent with this diagnosis, his...
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Opioid-induced hypoadrenalism resulting in fasting hypoglycaemia: An 18-year-old woman with a history of hollow visceral myopathy presented with a small-bowel obstruction. High-dose opioid analgesia was required subsequently during hospital admission. She suffered two episodes of documented fasting hypoglycaemia, despite adjustment of parenteral carbohydrate administration. Investigations for non-insulin-mediated hypoglycaemia revealed a low morning cortisol of 109 nmol/L and an inappropriately low...
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Facial disfigurement from Kaposi's sarcoma in a woman living with HIV/AIDS in the HAART era:
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Treatment-resistant eosinophilic oesophagitis successfully managed with tofacitinib: We present a case of a 34-year-old man with long-term diagnosis of eosinophilic oesophagitis (EoE) who did not achieve control of disease after multiple therapies including topical and systemic steroids, immune modulators and biologics. Initial endoscopic findings showed signs of active eosinophilic oesophagitis and biopsies were significant for up to 100 eosinophils per high power field during his various treatments....
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Association between anticholinergic drug burden and mortality in older people: a systematic review: AbstractPurposeThe purpose of the study is to conduct a systematic review of studies examining the association between anticholinergic burden and mortality in older individuals.MethodsA literature search was performed to identify relevant studies, using MEDLINE, EMBASE, PsycINFO and CENTRAL, from January 1990 to December 2018. We included studies of patients with a mean age of 65 years or older where...
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Personalising drug safety—results from the multi-centre prospective observational study on Adverse Drug Reactions in Emergency Departments (ADRED): AbstractPurposeAdverse drug reactions (ADR) account for 5 to 7% of emergency department (ED) consultations. We aimed to assess medication risk profiles for ADRs leading to ED visits.MethodsWe analysed medication intake and patient demographics in a prospective multi-centre observational study collecting ADR cases in four large EDs in Germany. Odds ratios...
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A Hurricane, Temporal Bone Paraganglioma, Cholesteatoma, Bezold's Abscess, and Necrotizing Fasciitis
A Hurricane, Temporal Bone Paraganglioma, Cholesteatoma, Bezold's Abscess, and Necrotizing Fasciitis:
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Functional Head Impulse Test With and Without Optokinetic Stimulation in Subjects With Persistent Postural Perceptual Dizziness (PPPD): Preliminary Report: Objective: Persistent postural perceptual dizziness (PPPD) is a clinical condition characterized by unsteadiness present on most days for a period of at least 3 months. The aim of our work was to assess vestibular function, the role of anxiety, and possible interactions between visual and vestibular systems in patients with PPPD.Study Design:...
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Clinical Characteristics of Acute Vestibular Neuritis According to Involvement Site:In Reply: Thanks for your comments. To answer the first issue, I agree that VEMP waveform could be poor in older people. But we excluded patients with bilateral no response of VEMP. Therefore, I think it could be divided into relatively accurate groups. As you told, vibration-induced nystagmus could be an option for differentiating the vestibular neuritis. However, although I don't have many experiences about vibration-induced...
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Understanding the Dizziness Handicap Inventory (DHI): A Cross Sectional Analysis of Symptom Factors That Contribute to DHI Variance: Objective: The Dizziness Handicap Inventory (DHI) is the most commonly used quality of life measure for vestibular disorders. However, there is wide variability in scores, and little is known about which variables contribute to dizziness-related quality of life. Our goal was to investigate the key demographic and symptom-related factors to that account for DHI variance.Study...
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Efficacy of Vestibular Rehabilitation Following Acute Vestibular Neuritis: A Randomized Controlled Trial: Objective: To investigate whether a vestibular rehabilitation program started early after diagnosis of vestibular neuritis combined with standard care reduces dizziness and improves functions of daily life more effectively than standard care alone in patients with acute vestibular neuritis.Study Design: Non-blinded, randomized controlled trial with 2 parallel groups.Setting: Specialist centers...
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Extraluminal Sigmoid Sinus Angioplasty: A Pertinent Reconstructive Surgical Method Targeting Dural Sinus Hemodynamics to Resolve Pulsatile Tinnitus: Objectives: 1) To provide information on the treatment of pulsatile tinnitus (PT) with transtemporal extraluminal sigmoid sinus angioplasty (ESSA); and 2) to discuss the current clinical management of PT.Study Design: This was a retrospective study.Settings: Multi-institutional tertiary university medical centers.Patients: Fifty-four PT patients with...
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Results From a Second-Generation Vestibular Implant in Human Subjects: Diagnosis May Impact Electrical Sensitivity of Vestibular Afferents: Objective: Auditory and vestibular outcomes after placement of a vestibular-cochlear implant in subjects with varying causes of vestibular loss.Study Design: Prospective case study.Setting: Tertiary referral center.Patients: Three human subjects received a vestibular-cochlear implant. Subject 1 had sudden hearing and vestibular loss 10 years before implantation....
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The Relation Between Tinnitus and a Neurovascular Conflict of the Cochleovestibular Nerve on Magnetic Resonance Imaging: Introduction: Magnetic resonance (MR) imaging is often used in diagnostic evaluation of tinnitus patients. Incidental findings like a neurovascular conflict (NVC) in the cerebellopontine angle are often found; however, the diagnostic value of this finding remains unclear. The aim of this study is to investigate whether the type or degree of compression of the vestibulocochlear...
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Long-Term Stability and Functional Outcome of an Active Middle Ear Implant Regarding Different Coupling Sites: Objectives: Indication and implantation of active middle ear implants (AMEI) are well established. Choice of the coupling site depends from the individual anatomical situation. Long-term stability of different coupling sites in terms of functional outcome and complications are rare and were investigated in this study.Design: Retrospective analysis of 41 consecutive patients (45 ears) with...
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Toll-like Receptor 4 Signaling and Downstream Neutrophilic Inflammation Mediate Endotoxemia-Enhanced Blood–Labyrinth Barrier Trafficking: Hypothesis: Both toll-like receptor 4 (TLR4) and downstream neutrophil activity are required for endotoxemia-enhanced blood–labyrinth barrier (BLB) trafficking.Background: Aminoglycoside and cisplatin are valuable clinical therapies; however, these drugs often cause life-long hearing loss. Endotoxemia enhances the ototoxicity of aminoglycosides and cisplatin in...
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Pregnancy Does Not Increase the Risk of Bell's Palsy: A National Cohort Study: Objectives: The objective of this study was to compare the incidence of Bell's palsy between women during pregnancy or postpartum periods and non-pregnant/non-postpartum women (controls).Methods: Using the national cohort from the Korean Health Insurance Review and Assessment Service, pregnant/postpartum participants (63,264) and control participants (126,528) were matched in a 1:2 ratio based on age, income, region of...
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The Endoscopic Relationship of the Stapedius Muscle to the Facial Nerve: Implications for Retrotympanic Surgery: Objectives: The stapedius muscle, tendon, and pyramidal eminence are structures within the retrotympanum. In cholesteatoma surgery, the retrotympanum is a common site of residual disease. The removal of the pyramidal eminence during surgery is sometimes necessary to obtain better visualization of the superior retrotympanum during surgery. Understanding the relational anatomy of structures...
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Usefulness of High Resolution T2-Weighted Images in the Evaluation and Surveillance of Vestibular Schwannomas? Is Gadolinium Needed?: Objectives: First aim of study was to compare the diagnostic accuracy of high resolution T2-WI (HRT2-WI) and gadolinium-enhanced T1-weighted image (Gd T1-WI) sequences in quantitative evaluation of vestibular schwannomas (VS). The second one was to determine through qualitative evaluation when Gd-injection should be recommended.Methods: Two observers in consensus retrospectively...
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Open Mastoid Cavity Obliteration With a High-Porosity Hydroxyapatite Ceramic Leads to High Rate of Revision Surgery and Insufficient Cavity Obliteration: Objective: To assess long-term results and present experience with a high-porosity hydroxyapatite ceramic for obliterating large open mastoid cavities.Study-Design: Cross-sectional cohort study.Setting: Tertiary academic referral center.Patients: All patients who underwent tympanomastoid surgery for chronic middle ear disease or revision surgery...
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Incidental Effect of Long-Term Tacrolimus Treatment on Sporadic Vestibular Schwannoma Volume Shrinkage and Clinical Improvement: Objective: We describe the effect of long-term tacrolimus delivery on sporadic vestibular schwannoma (VS).Patient: A 48-year-old woman who was diagnosed a right VS.Intervention: Long-term tacrolimus delivery following liver transplant.Main Outcome Measures: Clinical examination, audiometric test, and gadolinium-contrasted magnetic resonance imaging.Results: During the reported...
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Evaluation of Artificial Fixation of the Incus and Malleus With Minimally Invasive Intraoperative Laser Vibrometry (MIVIB) in a Temporal Bone Model: Background: A significant number of adults suffer from conductive hearing loss due to chronic otitis media, otosclerosis, or other pathologies. An objective measurement of ossicular mobility is needed to avoid unnecessarily invasive middle ear surgery and to improve hearing outcomes.Methods: Minimally invasive intraoperative laser vibrometry provides...
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Intraoperative Monitoring of Auditory Function During Lateral Skull Base Surgery: Objective: We present a unique case of a patient with a jugular foramen tumor with serviceable hearing. This study discusses the audiometric results and intraoperative electrocochleographic (ECochG) findings recorded during tumor removal to illustrate the potential utility of this technique in skull base surgery.Patients: A 22-year-old female patient presented with a jugular foramen schwannoma and associated symptoms...
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Characterizing Insertion Pressure Profiles During Cochlear Implantation: Simultaneous Fluoroscopy and Intracochlear Pressure Measurements: Background: Combined electrical-acoustical stimulation (EAS) has gained popularity as patients with residual hearing are increasingly undergoing cochlear implantation. Preservation of residual hearing correlates with hearing outcomes, but loss of hearing occurs in a subset of these patients. Several mechanisms have been proposed as causing this hearing loss; we...
09:40
Comparing the Suppression Head Impulse Paradigm and the Head Impulse Paradigm in Vestibular Neuritis
Comparing the Suppression Head Impulse Paradigm and the Head Impulse Paradigm in Vestibular Neuritis: Objective: To compare the results of suppression head impulse paradigm (SHIMP) and head impulse paradigm (HIMP) in acute vestibular neuritis (AVN).Study Design: Retrospective study.Setting: Tertiary otology clinic.Patients and Interventions: We tested 21 patients with AVN with the HIMP, SHIMP, and caloric tests, and we analyzed the relationships between the tests' results.Main Outcome Measures: For...
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Machine Learning and Cochlear Implantation—A Structured Review of Opportunities and Challenges: Objective: The use of machine learning technology to automate intellectual processes and boost clinical process efficiency in medicine has exploded in the past 5 years. Machine learning excels in automating pattern recognition and in adapting learned representations to new settings. Moreover, machine learning techniques have the advantage of incorporating complexity and are free from many of the limitations...
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Diffusion Tensor Magnetic Resonance Imaging: An Example of its Usefulness in an Unusual Cerebellopontine Angle Tumor:
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Predicting Speech Outcomes After Cochlear Implantation in Older Adults Using the Self-administered Gerocognitive Examination Test: Purpose: The purpose of this study is to determine if a cognitive test, Self-administered Gerocognitive Examination (SAGE), correlates with speech recognition outcomes 1 year after cochlear implantation in adults over 65 years of age.Methods: Retrospective study was conducted at a single institution. Surgery was performed by two surgeons on adult patients (>65 yrs)...
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Clioquinol for Otomycosis: A Lesser Understood Antimicrobial: To the Editor: Peled et al. (1) provide a detailed analysis of their experience with otitis externa. Treatment of this disease should be augmented with knowledge of the following antimicrobial which is less well understood in comparison to more traditional topical antibacterial and antimycotic agents. Clioquinol is a halogenated 8-hydroxyquinoline (also known as iodochlorohydroxyquin) and is primarily used for its antimicrobial activity...
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Evaluation of Cochlear Duct Length Measurements From a 3D Analytical Cochlear Model Using Synchrotron Radiation Phase-Contrast Imaging: Hypothesis: Evaluating the accuracy of cochlear duct length (CDL) measurements from a published three-dimensional (3D) analytical cochlear model using Synchrotron Radiation Phase–Contrast Imaging (SR-PCI) data will help determine its clinical applicability and allow for model adjustments to increase accuracy.Background: Accurate CDL determination can aid in cochlear...
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Horizontal Vestibulo-Ocular Reflex Gain Measures During Convergence Using a Monocular Video Technique: Hypothesis: Vestibulo-ocular reflex (VOR) response measures during convergence, which are clinically important to measure peripheral vestibular organ function during rotational and translational rapid head movements, can be implemented using existing clinically available monocular video-oculography (VOG) systems.Background: We have developed and validated a monocular VOG technique that allows for...
09:37
A Simple, Objective, and Mathematical Grading Scale for the Assessment of Facial Nerve Palsy: Objectives: It is imperative to acquire a simple, objective, and mathematical method for the assessment of facial nerve palsy which can be universally accepted and implemented. A grading scale which is convenient, continuous and economical was attempted for the first time for global and region-specific assessment of facial nerve palsy.Study Design: Hospital-based observational study.Setting: Medical college...
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Hearing Preservation Outcomes Using a Precurved Electrode Array Inserted With an External Sheath: Objectives: Describe audiologic outcomes in hearing preservation cochlear implantation (CI) using a precurved electrode array inserted using an external sheath and evaluate association of electrode positioning and preservation of residual hearing.Study Design: Retrospective review.Setting: Tertiary otologic center.Patients: Twenty-four adult patients who underwent hearing preservation CI with precurved...
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Factors Associated With Facial Nerve Paresis Following Gamma Knife for Vestibular Schwannoma: Objective: Evaluate the incidence of and potential contributory factors to facial nerve paresis and other cranial neuropathies (CN) following stereotactic radiosurgery with Gamma Knife (GK) for primary treatment of vestibular schwannoma (VS).Study Design: Retrospective chart review.Setting: Tertiary referral center.Patients: Charts were reviewed for all adult patients receiving primary GK treatment for unilateral...
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Mortality and Cause of Death in Hearing Loss Participants: A Longitudinal Follow-up Study Using a National Sample Cohort:Objective: The purpose of the present study was to estimate the risk of mortality in hearing loss subjects in accordance with the cause of death.Study Design: A longitudinal follow up study.Setting: Data from the Korean National Health Insurance Service-National Sample Cohort were collected from a period between 2002 and 2013.Patients and Intervention: The 4,606 severe and 1,007...
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Intratympanic Treatment in Menière's Disease, Efficacy of Aminoglycosides Versus Corticosteroids in Comparison Studies: A Systematic Review: Objective: To compare the functional outcomes and complications of intratympanic gentamicin (ITG) versus intratympanic corticosteroids (ITC) in Menière's disease.Data Sources: An electronic search was conducted in the Cochrane Library, PubMed, and Embase databases on February 3, 2019. Articles written in English, Dutch, German, French, or Turkish language were...
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The Role of Body Mass Index on Hearing Outcomes After Stapes Surgery: Background: Increased body mass index (BMI) has been associated with postoperative complications in multiple surgical specialties. In otologic surgery involving the stapes, where appropriate patient positioning and surgical dexterity are necessary for proper prosthesis placement, patients with higher BMI could make surgery more challenging. The purpose of this study is to evaluate the impact of BMI on outcomes after stapes surgery.Methods:...
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Long-term Outcomes for the Treatment of Paragangliomas in the Upfront, Adjuvant, and Salvage Settings With Stereotactic Radiosurgery and Intensity-modulated Radiotherapy: Objective: To analyze local control (LC) and toxicity rates between stereotactic radiosurgery (SRS) and intensity-modulated radiotherapy (IMRT) in relation to reported surgical rates in the treatment of paragangliomas (PG) in the upfront, adjuvant, and salvage settings, and to explore factors affecting tumor size reduction, toxicity...
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Neural Substrates of Tinnitus in an Auditory Brainstem Implant Patient: A Preliminary Molecular Imaging Study Using H2 15 O-PET Including a 5-year Follow-up of Auditory Performance and Tinnitus Perception: Introduction: It was previously demonstrated that tinnitus due to profound unilateral hearing loss can be treated by the use of electrical stimulation via a cochlear implant (CI) with long-lasting positive effects. In cases where patients are not suitable for cochlear implantation due to aplasia/hypoplasia,...
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Initial Immune Response in Escherichia coli , Staphylococcus aureus , and Candida albicans Bacteremia: AbstractSepsis remains a leading cause of mortality worldwide and is characterized by sustained inflammatory responses, reflected as changes in the expression profile of cytokines with time. The aim of the present study was to investigate the dynamic changes in complete blood count, serum chemistry, procalcitonin (PCT), tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6) in Escherichia...
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Phillyrin Relieves Lipopolysaccharide-Induced AKI by Protecting Against Glycocalyx Damage and Inhibiting Inflammatory Responses: Abstract Damage to the integrity of heparin sulfate (HS) in the endothelial glycocalyx is an important factor of glomerular filtration barrier dysfunction, which is the basic pathological feature of acute kidney injury (AKI). AKI is a common clinical critical illness with few drugs options offering effective treatment. Phillyrin (Phil), the main pharmacological component...
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Effects of physical exercise on the prevention of stem cells senescence: AbstractRegular physical activity is essential for maintaining wellbeing; physical inactivity, on the contrary, is considered by the World Health Organization (WHO) as one of the most important risk factors for global mortality. During physical exercise different growth factors, cytokines and hormones are released, which affect positively the functions of heart, bone, brain and skeletal muscle. It has been reported that physical...
09:34
CPI-17 Overexpression and Its Correlation With the NF2 Mutation Spectrum in Sporadic Vestibular Schwannomas: Hypothesis: We hypothesized that CPI-17 expression and NF2 mutations are correlated with merlin phosphorylation in the etiology of sporadic vestibular schwannoma (VS).Background: NF2 gene mutations have been identified in the majority of sporadic and NF2-associated schwannomas and NF2 gene mutations have been shown to result in merlin protein phosphorylation. CPI-17 can drive Ras activity...
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Effects of Age at Auditory Brainstem Implantation: Impact on Auditory Perception, Language Development, Speech Intelligibility: Objective: To study the effect of age at auditory brainstem implant (ABI) surgery on auditory perception, language, and speech intelligibility.Study Design: Retrospective single cohort design.Setting: Tertiary referral center.Patients: In this study, 30 pediatric ABI users with no significant developmental issues were included. Participants were divided into two groups,...
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Pulmonary Myoepithelial Tumors With Exuberant Reactive Pneumocytes: Proposed Reclassification of So-called Pneumocytic Adenomyoepithelioma:Pneumocytic adenomyoepithelioma (PAM) was first described in 2007 and was included in the 2015 World Health Organization Classification of lung tumors as a variant of epithelial-myoepithelial tumor. This rare pulmonary neoplasm was reported to show both myoepithelial and duct-like components, with the latter exhibiting pneumocytic differentiation with TTF-1 expression....
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Papillary Lesions of the Male Breast: A Study of 117 Cases and Brief Review of the Literature Demonstrate a Broad Clinicopathologic Spectrum: Papillary lesions of the male breast (PLMB) are uncommon. To date, PLMB have been reported as individual case reports and in relatively small series. We reviewed cases of PLMB diagnosed at our medical center over a 19-year (2000-2019) period. A total of 117 cases were identified, with an age range of 7 months to 88 years. These cases included 3 of papillary...
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Novel SRF-ICA1L Fusions in Cellular Myoid Neoplasms With Potential For Malignant Behavior: Pericytic tumors comprise a histologic continuum of neoplasms with perivascular myoid differentiation, which includes glomus tumors, myopericytoma, myofibroma, and angioleiomyoma. Despite their morphologic overlap, recent data suggest a dichotomy in their genetic signatures, including recurrent NOTCH gene fusions in glomus tumors and PDGFRB mutations in myofibromas and myopericytomas. Moreover, SRF-RELA fusions...
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Specific Histopathologic Features Aid in Distinguishing Diffuse-type Gastric Adenocarcinoma From Metastatic Lobular Breast Carcinoma: Metastatic invasive lobular carcinoma (mILC) may masquerade as primary diffuse gastric adenocarcinoma (PDGA) by demonstrating significant clinical and pathologic overlap. Accurate distinction is of therapeutic and prognostic significance. On the basis of anecdotal cases of mILC that lacked estrogen receptor and/or GATA3 expression, we analyzed the cytoarchitectural...
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Pathology of Echinococcosis: A Morphologic and Immunohistochemical Study on 138 Specimens With Focus on the Differential Diagnosis Between Cystic and Alveolar Echinococcosis: Infection of humans by the larval stage of the tapeworms Echinococcus granulosus sensu lato or Echinococcus multilocularis causes the life-threatening zoonoses cystic echinococcosis (CE) and alveolar echinococcosis (AE). Although cystic liver lesions are a hallmark of both diseases, course, prognosis, and patients' management...
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p16 Positive Histologically Bland Squamous Metaplasia of the Cervix: What does It Signify?: With increasing use of p16 immunohistochemistry (IHC) in diagnosis of premalignant lesions of cervix, we occasionally encounter p16 positivity in squamous metaplasia that lacks morphologic characteristics of "atypical squamous metaplasia" or of squamous intraepithelial lesion (SIL). Our study aims to investigate if transcriptionally active human papilloma virus (HPV) can be identified in such foci and if they...
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Comparative Study of Myxofibrosarcoma With Undifferentiated Pleomorphic Sarcoma: Histopathologic and Clinicopathologic Review: Myxofibrosarcoma (MFS) is a malignant fibroblastic/myofibroblastic neoplasm with the prominent myxoid area. It has the clinical features of frequent local recurrence and occasional distant metastasis. Morphologically, MFS is occasionally difficult to distinguish from undifferentiated pleomorphic sarcoma (UPS), especially in the case of high-grade MFS. Here, we reviewed clinical...
09:32
Compound Clear Cell Sarcoma of the Skin—A Potential Diagnostic Pitfall: Report of a Series of 4 New Cases and a Review of the Literature: The proliferation of cells with melanocytic lineage and a nested pattern has traditionally been regarded as a characteristic feature of a wide range of benign and malignant melanocytic proliferations. Herein, we report a series of 4 clear cell sarcomas, including 3 primary cutaneous and 1 metastatic to the skin, associated with a clear-cut intraepidermal proliferation...
09:31
Evidence-based Tumor Staging of Skeletal Chondrosarcoma: The eighth edition of the American Joint Committee on Cancer (AJCC) staging system has introduced major changes for the staging of skeletal sarcomas. However, it is unclear if these changes improve the predictive value for chondrosarcomas of the nonpelvic appendicular and nonspinal axial skeleton. Specifically, there is no clear evidence that supports the use of the proposed binary size cutoff of 8 cm for risk stratification, nor is a rationale...
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CD24 and PRAME Are Novel Grading and Prognostic Indicators for Pineal Parenchymal Tumors of Intermediate Differentiation: The pineal parenchymal tumors of intermediate differentiation (PPTIDs) are extremely rare tumor entities. They exhibit low-risk (grade II) and high-risk (grade III) malignancies, which may lead to different therapies and prognosis. However, the histological grading criteria remains elusive, and novel biomarkers may be helpful to differentiate the grade of PPTIDs. Immunohistochemical...
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Denosumab-treated Giant Cell Tumors of Bone: A Clinicopathologic Analysis of 35 Cases From the French Group of Bone Pathology: Denosumab, an antibody directed against receptor activator of nuclear factor-κB ligand (RANKL), has recently been introduced in the treatment strategy of giant cell tumor of bone. In this study, we assessed the tumor changes induced by denosumab in a national multicentric series of 35 cases (French Bone Pathology Group network—ResOs). Tissue specimens collected before and...
09:31
Sound Measurement in Patient-Specific 3D Printed Bench Models of Venous Pulsatile Tinnitus: Hypothesis: We hypothesize patient-specific flow models to be an adequate in vitro surrogate to allow for characterization of pulsatile tinnitus (PT) that affects three to five million Americans.Background: PT, rhythmic sounds without an extracorporeal source that patients appreciate, can be caused by aberrant blood flow in large cerebral veins near the cochlea. To investigate the sound production mechanism,...
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NF2-Related Intravestibular Schwannomas: Long-Term Outcomes of Cochlear Implantation: Objective: Intravestibular schwannomas (IVS) are uncommon tumors in Neurofibromatosis type 2 (NF2) and are mainly associated with multiple internal auditory meatus (IAM) and cerebellopontine angle (CPA) tumors. They usually induce profound hearing loss which can be rehabilitated by cochlear implantation (CI). The aim of this study was to analyze the long-term outcomes of CI during the unpredictable evolution of...
09:28
Temporomandibular Joint Herniation: Review of the Literature: Objective: To define clear clinical characteristics and management strategies of herniation of temporomandibular joint (TMJ) into the external auditory canal (EAC).Data Source: MEDLINE, PubMed, and EMBASE databases.Study Selection: A search was conducted using the keywords "temporomandibular joint" and "herniation" with all of their synonyms. Literature selection criteria included articles published in English, and articles dating back...
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Intratympanic Diltiazem-Chitosan Hydrogel as an Otoprotectant Against Cisplatin-Induced Ototoxicity in a Mouse Model: Hypothesis: Local administration of the calcium-channel blocker (CCB), diltiazem, via intratympanic (IT) chitosan-glycerophosphate (CGP) hydrogel will protect against cisplatin-induced ototoxicity.Background: Cisplatin induces calcium-mediated apoptosis of cochlear outer hair cells (OHCs). Previous work demonstrated otoprotection and reduced auditory brainstem response (ABR) threshold...
09:26
The von Willebrand Factor antigen to platelet ratio (VITRO) score predicts hepatic decompensation and mortality in cirrhosis: AbstractBackgroundThe ratio of von Willebrand Factor to platelets (VITRO) reflects the severity of fibrosis and portal hypertension and might thus hold prognostic value.MethodsPatients with compensated cirrhosis were recruited. VITRO, Child–Pugh score (CPS) and MELD were determined at study entry. Hepatic decompensation was defined as variceal bleeding, ascites or hepatic...
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Processing grapefruit juice with γ‐cyclodextrin attenuates its inhibitory effect on cytochrome P450 3A activity: AbstractObjectivesGrapefruit (Citrus paradisi) juice enhances the oral bioavailability of drugs that are metabolized by intestinal cytochrome P450 3A4 (CYP3A4). Patients are advised to avoid drinking grapefruit juice to prevent this drug–grapefruit juice interaction. The aim of this study was to investigate whether processing grapefruit juice with cyclodextrins (CDs) would result in preventing...
09:26
Jerky Movement with Ceftazidime: A Case of Ceftazidime-Induced Neurotoxicity with a Review of the Literature: Neurotoxicity manifested as confusion and seizures has been recognized as a side effect of multiple cephalosporins including ceftazidime. Renal impairment and inappropriate dosing are the most common contributors to the development of neurological abnormalities in patients receiving these antibiotics. The presence of baseline neurological abnormalities likely contributes to the frequency...
09:25
Dynamic proteome profiling of human pluripotent stem cell‐derived pancreatic progenitors: Proteome adaptations occur in waves during early stages of hPSC differentiation towards pancreatic progenitors. In this study, we utilized quantitative mass spectrometry‐based proteomics, an extremely useful tool, for the discovery of novel molecular signatures of intermediate stages during early pancreatic differentiation. Here, we uncovered a potential regulatory role of the Hippo signaling pathway during...
09:25
Extracellular Vesicles and Their Roles in Stem Cell Biology: Concise Review: Stem cells generate different classes of extracellular vesicles containing bio‐active cargo. These vesicles are transferred to other cells and promote phenotypic changes. Stem cell extracellular vesicles have been shown to play important roles in development and cellular reprogramming. They are also being pursued for clinical applications, including their potential use as a drug delivery system and for their regenerative...
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MicroRNA‐124a Inhibits Endoderm Lineage Commitment by Targeting Sox17 and Gata6 in Mouse Embryonic Stem Cells: microRNA‐124a was identified as a key repressor of endoderm lineage commitment in mouse embryonic stem cells. miR‐124a inhibits endoderm differentiation through targeting the 3' untranslated region (UTR) of Sox17 and Gata6, which are indispensable transcription factors for endoderm germ layer formation. AbstractThe role of microRNAs (miRNAs) during mouse early development, especially in...
09:25
Fall-related mortality trends in older Japanese adults aged >=65 years: a nationwide observational study: ObjectivesFall-related mortality among older adults is a major public health issue, especially for ageing societies. This study aimed to investigate current trends in fall-related mortality in Japan using nationwide population-based data covering 1997–2016.DesignWe analysed fall-related deaths among older persons aged ≥65 years using the data provided by the Japanese Ministry of Health, Labour...
09:24
Tracing the decision-making process for myelofibrosis: diagnosis, stratification, and management of ruxolitinib therapy in real-word practice: AbstractThe management of patients with myelofibrosis (MF) has dramatically changed since the introduction of ruxolitinib as a tailored treatment strategy. However, the perceptions about the use of this drug in clinical practice remain, at times, a matter of discussion. We conducted a survey about the diagnostic evaluation, prognostic assessment, and management...
09:23
An Atypical Cause of an Epiglottic Abscess: An epiglottic abscess is a rare complication of acute epiglottitis and is life threatening. We describe a case report of a diabetic adult male, who presented with an epiglottic abscess. Culture results showed Aeromonas hydrophila, an organism rarely reported as a cause of acute epiglottitis. Early recognition can be lifesaving.
09:23
Synergistic effect of Cordia curassavica Jacq. essential oils association against the phytopathogen X anthomonas campestris pv. campestris: AbstractThe increased use of pesticides applied to treat diseases caused by bacteria has caused serious environmental problems. There are few fungicides/bactericides for the treatment of plant diseases caused by Xanthomonas campestris pv. campestris (Xcc), and only two natural products with general bactericidal/fungicidal use are available on the market. Thus,...
09:23
Test-retest reliability of the twenty-five-hole peg test in patients who had a stroke: ObjectivesWeaknesses of the nine-hole peg test include high floor effects and a result that might be difficult to interpret. In the twenty-five-hole peg test (TFHPT), the larger number of available pegs allows for the straightforward counting of the number of pegs inserted as the result. The TFHPT provides a comprehensible result and low floor effects. The objective was to assess the test-retest reliability of...
09:22
Exposure to outdoor air pollution and its human-related health outcomes: an evidence gap map: ObjectivesOutdoor air pollution is a serious environmental problem worldwide. Current systematic reviews (SRs) and meta-analyses (MAs) mostly focused on some specific health outcomes or some specific air pollution.DesignThis evidence gap map (EGM) is to identify existing gaps from SRs and MAs and report them in broad topic areas.Data sourcesPubMed, Cochrane, Scopus and Web of Science were searched from their...
09:21
Quality evaluation of community pharmacy blood pressure (BP) screening services: an English cross-sectional survey with geospatial analysis: ObjectivesThe primary objective was to assess the accuracy (calibration and validation status) of digital blood pressure (BP) monitors used within community pharmacy in England and the secondary objectives were to assess the overall quality of the BP service by assessing service prevalence, service utilisation and other in-service considerations.DesignA cross-sectional...
09:21
Secondhand smoke exposure and support for smoke-free policies in cities and rural areas of China from 2009 to 2015: a population-based cohort study (the ITC China Survey): ObjectivesTo examine trends in smoking prevalence in key venues (workplaces, restaurants, bars) and in public support for comprehensive smoke-free laws, with comparisons between cities and rural areas in China.DesignData are from Waves 3–5 (2009–2015) of the International Tobacco Control (ITC) China Survey, a cohort survey of smokers...
09:20
Systematic review and meta-analysis of the prognosis and prognostic factors of interstitial pneumonia with autoimmune features: ObjectiveTo clarify the prognosis and prognostic factors of interstitial pneumonia with autoimmune features (IPAF) in comparison to idiopathic pulmonary fibrosis (IPF), the most common idiopathic interstitial pneumonia, and connective tissue disease-associated interstitial pneumonia (CTD-IP).DesignA systematic review and meta-analysis.Data sourcesElectronic databases such...
09:20
Current state of science in machine learning methods for automatic infant pain evaluation using facial expression information: study protocol of a systematic review and meta-analysis: IntroductionInfants can experience pain similar to adults, and improperly controlled pain stimuli could have a long-term adverse impact on their cognitive and neurological function development. The biggest challenge of achieving good infant pain control is obtaining objective pain assessment when direct communication...
09:19
Effects of photobiomodulation therapy in the integration of skin graft in rats: AbstractSkin graft is one of the most common techniques used in plastic surgery and repair. However, there are some complications that can lead to loss of the skin graft. Thus, several features have been studied with the aim of promoting the integration of skin grafts. Among these resources, the use of laser photobiomodulation (laser PBM) has been highlighted. The present study aimed to investigate the effects of laser...
09:19
Acceptability to patients of screening disposable transnasal endoscopy: qualitative interview analysis: ObjectivesScreening in selected high risk populations for Barrett's oesophagus (BO) and oesophageal varices (OVs) has been proposed, but there are obstacles with conventional oesophagogastroduodenoscopy (C-OGD), including patient acceptability. Portable and disposable office-based transnasal endoscopy (TNE) is a feasible and accurate alternative to C-OGD that may have use in primary and secondary...
09:18
Safety and efficacy of perioperative benzodiazepine administration: study protocol for a systematic review and meta-analysis: IntroductionPerioperative benzodiazepines are used because of their anxiolytic, sedative and amnestic effects. Evidence has demonstrated an association of benzodiazepines with adverse neuropsychiatric effects. Nonetheless, because of their potential benefits, perioperative benzodiazepines continue to be used routinely. We seek to evaluate the body of evidence of the risks...
09:18
Sleep duration and eating behaviours in youth: a scoping review protocol: IntroductionDevelopmental alterations to the circadian rhythm, in combination with lifestyle changes (eg, changes in school start time, part-time employment), contribute to insufficient sleep among youth. Insufficient sleep is associated with poor eating behaviours in other developmental stages (ie, childhood, adulthood); however, it is currently unknown if this finding generalises to youth. Consequently, identifying the characteristics...
09:18
Furosemide versus mannitol in Japanese patients with thoracic malignancy who received cisplatin-based chemotherapy using short hydration: study protocol for a randomised controlled trial: IntroductionCisplatin (CDDP) is a key drug for various thoracic malignancies. To avoid renal toxicity of CDDP, mannitol is routinely used, but it sometimes causes phlebitis which damages patients' quality of life. Furosemide is another widely used option for diuresis administered more quickly. To date, previous...
09:17
Associations between expression levels of nine core nucleotide excision repair genes in lymphocytes and risk of head and neck squamous cell carcinomas in a Chinese population: AbstractBackgroundHead and neck squamous cell carcinomas (HNSCCs) are one of the most common cancers in the world, and nucleotide excision repair (NER) is involved in HNSCCs susceptibility. We investigated whether mRNA expression levels of nine core NER genes were associated with risk of HNSCCs in a Chinese population.MethodsIn...
09:17
Lack of association between interleukin-22 gene polymorphisms and cancer risk: a case–control study and a meta-analysis: AbstractBackgroundInterleukin-22 (IL22) has been implicated in inflammation and tumorigenesis. The association between IL22 gene polymorphisms and cancer risk has been widely explored. However, the limited sample sizes of previous studies may produce inadequate statistical power and conflicting results, which calls for further investigations. In this study, we recruited a total...
09:17
High‐resolution metabolomic profiling of Alzheimer's disease in plasma: AbstractBackgroundAlzheimer's disease (AD) is a complex neurological disorder with contributions from genetic and environmental factors. High‐resolution metabolomics (HRM) has the potential to identify novel endogenous and environmental factors involved in AD. Previous metabolomics studies have identified circulating metabolites linked to AD, but lack of replication and inconsistent diagnostic algorithms have hindered the generalizability...
09:16
Overall Survival with Ribociclib plus Fulvestrant in Advanced Breast Cancer: Cyclin-dependent kinases 4 and 6 (CDK4/6) have emerged as important targets in the treatment of breast cancer, given their role in cell-cycle progression and the successes that inhibitors of these kinases have had in improving outcomes in patients with advanced breast cancer. Ribociclib is one of…
09:16
Trastuzumab Deruxtecan in Previously Treated HER2-Positive Breast Cancer: Approximately 15 to 20% of metastatic breast cancers are characterized by overexpression or amplification of human epidermal growth factor receptor 2 (HER2). The recommended first-line therapy for HER2-positive metastatic breast cancer consists of the anti-HER2 monoclonal antibodies trastuzumab and…
09:16
Proteomic profile of saliva collected directly from ducts: a systematic review: AbstractObjectiveTo present a systematic review that provides updated information about proteins found in salivary fluid extracted strictly from ducts.MethodsThe systematic review probing strategy was based on electronic databases word search (PubMed, EMBASE, LILACS, Web of Science, and Scopus). Risk of bias was assessed based on Joanna Briggs Institute Critical Appraisal Checklist for Studies Reporting Prevalence Data.ResultsAfter...
09:15
Brainstem and Cerebellar Involvement in Ramsay Hunt Syndrome: We present a case of a 62-year-old Caucasian male with laryngeal cancer and Ramsay Hunt Syndrome otherwise known as herpes zoster oticus due to reactivation of the varicella zoster virus. Classic findings include the triad of ipsilateral facial paralysis, otic pain, and herpetic lesions in the sensory supply of the facial nerve. The common pathogenesis is associated with anterograde axonal reactivation of the varicella zoster virus in...
09:15
Social distance towards halitosis sufferers: Related ArticlesSocial distance towards halitosis sufferersSwiss Dent J. 2019 Dec 09;129(12):1026-1030Authors: Azodo CC, Ogbebor OGAbstract Halitosis is a frustrating condition that can lead to significant discomforts, negative social and psychological effects including social interaction suppression and self-confidence diminution. The purpose of the study was to assess the social distance attitude towards halitosis sufferers in Nigeria. A cross-sectional...
09:14
Bacteremia risk in preventive and restorative dentistry – prevalence of bacteremia and systemic antibiotics: a review focusing on preventive and restorative dentistry: Related ArticlesBacteremia risk in preventive and restorative dentistry – prevalence of bacteremia and systemic antibiotics: a review focusing on preventive and restorative dentistrySwiss Dent J. 2019 Dec 09;129(12):1047-1052Authors: Schmidlin PR, Attin T, Wegehaupt FJAbstract This review assessed defined specific areas of...
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Cold Agglutinins and Cardiac Surgey: a Case Report.: Related ArticlesCold Agglutinins and Cardiac Surgey: a Case Report.Rev Port Cir Cardiotorac Vasc. 2019 Jul-Sep;26(3):223-224Authors: Magro PL, Marques S, Calquinha J, Neves JPAbstract Cold agglutinins (CA) are autoantibodies whose clinical significance depends upon titer and thermal amplitude. Patients, which undergo cardio-pulmonary bypass and especially hypothermic cardioplegia myocardial protection, represent a challenge regarding operative...
09:13
Successful resuscitation from prolonged hypothermic cardiac arrest without extracorporeal life support: a case report.: Related ArticlesSuccessful resuscitation from prolonged hypothermic cardiac arrest without extracorporeal life support: a case report.J Med Case Rep. 2019 Dec 02;13(1):354Authors: Kuhnke M, Albrecht R, Schefold JC, Paal PAbstract BACKGROUND: We report a case of successful prolonged cardiopulmonary resuscitation (5 hours and 44 minutes) following severe accidental hypothermia...
09:13
Therapeutic Hypothermia: Comparing Surface vs Intravascular Cooling.: Related ArticlesTherapeutic Hypothermia: Comparing Surface vs Intravascular Cooling.Dimens Crit Care Nurs. 2020 Jan/Feb;39(1):12-22Authors: Alne TAbstract BACKGROUND: Therapeutic hypothermia (TH) has shown promise for increasing survival and neurological recovery for post-cardiac arrest patients who are not responding neurologically initially after return of spontaneous circulation. OBJECTIVE: The aim of this study...
09:13
The effect of continuous digital hypothermia on lamellar energy metabolism and perfusion during laminitis development in two experimental models.: Related ArticlesThe effect of continuous digital hypothermia on lamellar energy metabolism and perfusion during laminitis development in two experimental models.Equine Vet J. 2019 Dec 02;:Authors: Stokes SM, Bertin FR, Stefanovski D, Poulsen L, Belknap JK, Medina-Torres CE, Pollitt CC, van Eps AWAbstract BACKGROUND: Continuous digital hypothermia...
09:12
Low-temperature health hazards among workers of cold storage facilities in Lahore, Pakistan.: Related ArticlesLow-temperature health hazards among workers of cold storage facilities in Lahore, Pakistan.Med Pr. 2019 Nov 28;:Authors: Ghani N, Tariq F, Javed H, Nisar N, Tahir AAbstract BACKGROUND: Cold storage facilities are the most common workplaces that produce artificially cold work environments and are associated with different adverse effects on human health, work productivity and the...
09:12
Selective suppression of oral allergen-induced anaphylaxis by Allergin-1 on basophils in mice.: Related ArticlesSelective suppression of oral allergen-induced anaphylaxis by Allergin-1 on basophils in mice.Int Immunol. 2019 Dec 03;:Authors: Lin YH, Tahara-Hanaoka S, Nagai K, Yoshikawa S, Kubo M, Shibayama S, Karasuyama H, Shibuya AAbstract Mast cells (MCs) play a critical role in oral allergen-induced anaphylaxis. However, the contribution of basophils to the anaphylaxis remains unclear....
09:12
T cell epitope of arginine kinase with CpG co-encapsulated nanoparticles attenuates a shrimp allergen-induced Th2-bias food allergy.: Related ArticlesT cell epitope of arginine kinase with CpG co-encapsulated nanoparticles attenuates a shrimp allergen-induced Th2-bias food allergy.Biosci Biotechnol Biochem. 2019 Dec 04;:1-11Authors: Hong J, Gao Q, Xiao X, Cao H, Yuan R, Liu Z, Chen TAbstract T cell peptide-based immunotherapy (PIT) is an appealing therapeutic strategy for modulating allergic...
09:12
Temporal trends in the use of targeted temperature management after cardiac arrest and association with outcome: insights from the Paris Sudden Death Expertise Centre.: Related ArticlesTemporal trends in the use of targeted temperature management after cardiac arrest and association with outcome: insights from the Paris Sudden Death Expertise Centre.Crit Care. 2019 Dec 03;23(1):391Authors: Lascarrou JB, Dumas F, Bougouin W, Chocron R, Beganton F, Legriel S, Aissaoui N, Deye N, Lamhaut L, Jost D,...
09:11
Curcumin: Novel Treatment in Neonatal Hypoxic-Ischemic Brain Injury.: Related ArticlesCurcumin: Novel Treatment in Neonatal Hypoxic-Ischemic Brain Injury.Front Physiol. 2019;10:1351Authors: Rocha-Ferreira E, Sisa C, Bright S, Fautz T, Harris M, Contreras Riquelme I, Agwu C, Kurulday T, Mistry B, Hill D, Lange S, Hristova MAbstract Hypoxic-ischemic encephalopathy (HIE) is a major cause of mortality and morbidity in neonates, with an estimated global incidence of 3/1,000 live births. HIE brain...
09:11
Casein kinase-1γ1 and 3 stimulate tumor necrosis factor-induced necroptosis through RIPK3.: Related ArticlesCasein kinase-1γ1 and 3 stimulate tumor necrosis factor-induced necroptosis through RIPK3.Cell Death Dis. 2019 Dec 04;10(12):923Authors: Lee SY, Kim H, Li CM, Kang J, Najafov A, Jung M, Kang S, Wang S, Yuan J, Jung YKAbstract Upon necroptosis activation, receptor interacting serine/threonine kinase (RIPK)1 and RIPK3 form a necrosome complex with pseudokinase mixed lineage kinase-like...
09:11
A meta-analysis of the effects of therapeutic hypothermia in adult patients with traumatic brain injury.: Related ArticlesA meta-analysis of the effects of therapeutic hypothermia in adult patients with traumatic brain injury.Crit Care. 2019 Dec 05;23(1):396Authors: Chen H, Wu F, Yang P, Shao J, Chen Q, Zheng RAbstract PURPOSE: Therapeutic hypothermia management remains controversial in patients with traumatic brain injury. We conducted a meta-analysis to evaluate the risks and benefits of...
09:11
Safety and tolerability of cryocompression as a method of enhanced limb hypothermia to reduce taxane-induced peripheral neuropathy.: Related ArticlesSafety and tolerability of cryocompression as a method of enhanced limb hypothermia to reduce taxane-induced peripheral neuropathy.Support Care Cancer. 2019 Dec 06;:Authors: Bandla A, Tan S, Kumarakulasinghe NB, Huang Y, Ang S, Magarajah G, Hairom Z, Lim JSJ, Wong A, Chan G, Ngoi N, Ang E, Lee YM, Chan A, Lee SC, Thakor N, Wilder-Smith E, Sundar RAbstract...
09:10
Neuroprotection Strategies for Term Encephalopathy.: Related ArticlesNeuroprotection Strategies for Term Encephalopathy.Semin Pediatr Neurol. 2019 Dec;32:100773Authors: Gonzalez FFAbstract Brain injury in the full-term and near-term neonates is a significant cause of mortality and long-term morbidity, resulting in injury patterns distinct from that seen in premature infants and older patients. Therapeutic hypothermia improves long-term outcomes for many of these infants, but there is a continued...
09:10
Neonatal Neurocritical Care: Providing Brain-Focused Care for All at Risk Neonates.: Related ArticlesNeonatal Neurocritical Care: Providing Brain-Focused Care for All at Risk Neonates.Semin Pediatr Neurol. 2019 Dec;32:100774Authors: Bonifacio SL, Van Meurs KAbstract Neonatal neurocritical care is an evolving subsubspecialty whose goal is to implement neuroprotective care strategies, continuous bedside monitoring of neurologic function, and therapies in order to reduce the risk of neurologic...
09:10
COMMENCE trial (Comparing hypOtherMic teMperaturEs duriNg hemiarCh surgEry): a randomized controlled trial of mild vs moderate hypothermia on patient outcomes in aortic hemiarch surgery with anterograde cerebral perfusion.: Related ArticlesCOMMENCE trial (Comparing hypOtherMic teMperaturEs duriNg hemiarCh surgEry): a randomized controlled trial of mild vs moderate hypothermia on patient outcomes in aortic hemiarch surgery with anterograde cerebral perfusion.Trials. 2019 Dec 09;20(1):691Authors:...
09:10
Safety of withholding intubation in gamma-hydroxybutyrate and gamma-butyrolactone-intoxicated coma patients in the emergency department.: Related ArticlesSafety of withholding intubation in gamma-hydroxybutyrate and gamma-butyrolactone-intoxicated coma patients in the emergency department.Eur J Emerg Med. 2019 Dec 06;:Authors: van Helmond LPFM, Gresnigt FMJAbstract OBJECTIVE: The objective of this study was to determine if supportive care without endotracheal intubation in the emergency...
09:09
Relationship Between Duration of Targeted Temperature Management, Ischemic Interval, and Good Functional Outcome From Out-of-Hospital Cardiac Arrest.: Related ArticlesRelationship Between Duration of Targeted Temperature Management, Ischemic Interval, and Good Functional Outcome From Out-of-Hospital Cardiac Arrest.Crit Care Med. 2019 Dec 10;:Authors: Sawyer KN, Humbert A, Leroux BG, Nichol G, Kudenchuk PJ, Daya MR, Grunau B, Wang HE, Ornato JP, Rittenberger JC, Aufderheide TP, Wittwer L, Colella...
09:09
RBM3 and CIRP expressions in targeted temperature management treated cardiac arrest patients-A prospective single center study.: Related ArticlesRBM3 and CIRP expressions in targeted temperature management treated cardiac arrest patients-A prospective single center study.PLoS One. 2019;14(12):e0226005Authors: Rosenthal LM, Leithner C, Tong G, Streitberger KJ, Krech J, Storm C, Schmitt KRLAbstract BACKGROUND: Management of cardiac arrest patients includes active body temperature control and...
09:09
Regional hypothermia improves gastric microcirculatory oxygenation during hemorrhage in dogs.: Related ArticlesRegional hypothermia improves gastric microcirculatory oxygenation during hemorrhage in dogs.PLoS One. 2019;14(12):e0226146Authors: Truse R, Smyk M, Schulz J, Herminghaus A, Weber APM, Mettler-Altmann T, Bauer I, Picker O, Vollmer CAbstract Mild systemic hypothermia increases gastric mucosal oxygenation (μHbO2) during hemorrhagic shock in dogs. In the context of critical blood loss...
09:09
Nailfold Capillaroscopy in Systemic Lupus Erythematosus (SLE): a Point-of-Care Tool That Parallels Disease Activity and Predicts Future Complications: AbstractPurpose of ReviewSystemic lupus erythematosus (SLE) is an autoimmune disease characterized by vascular complications, endothelial cell injury with subsequent dysfunction. Nailfold video capillaroscopy (NVC) is a non-invasive and reliable point-of-care method that can be used to directly visualize microscopic digital capillaries and monitor...
09:08
SGLT2 inhibition slows tumor growth in mice by reversing hyperinsulinemia: AbstractBackgroundObesity confers an increased risk and accelerates the progression of multiple tumor types in rodents and humans, including both breast and colon cancer. Because sustained weight loss is rarely achieved, therapeutic approaches to slow or prevent obesity-associated cancer development have been limited, and mechanistic insights as to the obesity-cancer connection have been lacking.MethodsE0771 breast tumors...
09:08
Qigong and Musculoskeletal Pain: AbstractPurpose of ReviewMusculoskeletal pain is a widespread symptom that commonly produces considerable disability, particularly in later life. This brief review strove to summarize and critically review the recent research base concerning the use of Qigong as a possible strategy for alleviating longstanding or chronic musculoskeletal pain states.MethodsResearch reports and literature reviews specifically focusing on Qigong and its impact on various forms of musculoskeletal...
09:08
Chlamydia -Induced Reactive Arthritis: Disappearing Entity or Lack of Research?: AbstractPurpose of ReviewRecent studies regarding the frequency of Chlamydia-induced reactive arthritis (ReA) are reviewed, with a focus on the question of whether the entity is in fact disappearing or whether it is simply being underdiagnosed/underreported. Epidemiological reports indicate diversity in the frequency of Chlamydia-associated ReA in various parts of the world, with evidence of declining incidence in some...
09:08
Inflammation and the Central Nervous System in Inflammatory Rheumatic Disease: AbstractPurpose of ReviewTo review how peripheral inflammation in rheumatic disease influences the central nervous system. We consider recent studies of rheumatic disease that employ functional and structural neuroimaging in the context of inflammation, as well as recent studies considering how immunosuppressive therapy is associated with changes in brain function and structure.Recent FindingsThe most compelling evidence...
09:07
Adipokines: New Therapeutic Target for Osteoarthritis?: AbstractPurpose of the ReviewOsteoarthritis (OA) is an aging-associated and injury-induced joint disease characterized by cartilage degradation, bone sclerosis, and persistent low-grade inflammation in the joint. Aging and injury are triggers of joint pathological changes mediated by pro-inflammatory factors, some of which are secreted by white adipose tissue. Adipokines including adiponectin, leptin, resistin, chemerin, IL-6, and TNF-α are...
09:07
Epigenetic Control of Scleroderma: Current Knowledge and Future Perspectives: AbstractPurpose of ReviewEpigenetics has been implicated in the pathogenesis of systemic sclerosis (SSc). In this review, the involvement of the three epigenetic mechanisms in SSc development and progression—DNA methylation, histone modifications, and non-coding RNAs—will be discussed.Recent FindingsAlteration in epigenetics was observed in immune cells, dermal fibroblasts, and endothelial cells derived from SSc patients....
09:07
Juvenile Dermatomyositis—Clinical Phenotypes: AbstractPurpose of ReviewJuvenile dermatomyositis is a heterogeneous disease with variable clinical outcomes. Here, we describe the recognised subtypes of idiopathic inflammatory myositis which occur in children, with particular reference to disease-associated autoantibodies.Recent FindingsLarge cohort studies have demonstrated that myositis autoantibodies are common in juvenile dermatomyositis and can be found in the majority of patients. They identify...
09:07
Application of Non-invasive Imaging in Inflammatory Disease Conditions to Evaluate Subclinical Coronary Artery Disease: AbstractPurpose of ReviewTraditional risk models, such as the Framingham risk score, fail to capture the increased cardiovascular disease risk seen in patients with chronic inflammatory diseases. This review will cover imaging modalities and their emerging applications in assessing subclinical cardiovascular disease for both research and clinical care in patients with chronic inflammatory...
09:07
Using Registry Data to Understand Disease Evolution in Inflammatory Myositis and Other Rheumatic Diseases: AbstractPurpose of ReviewWhile rheumatic disease registries collect longitudinal patient information, longitudinal analytic methods are usually not applied to these data. This review will showcase advances in longitudinal designs/analyses, and ways to leverage digital technologies to recruit and retain more registry participants.Recent FindingsWe will show how the accelerated cohort and longitudinal...
09:06
Impact of a multiplex PCR assay (FilmArray®) on the management of patients with suspected central nervous system infections: AbstractMicrobiological diagnosis of central nervous system (CNS) infections is challenging due to limited access to CNS samples, overlap between meningitis and encephalitis, and the multiplicity of pathogens potentially involved. We aimed to estimate the impact of a commercial multiplex PCR assay (FilmArray® meningitis/encephalitis) on the management of patients with suspicion...
09:06
Elimination of Staphylococcus aureus nasal carriage in intensive care patients lowers infection rates: AbstractThis study surveys the clinical relevance of the nasal Staphylococcus aureus colonization status on intensive care unit (ICU)–acquired S. aureus infections and compares molecular characteristics of isolates from the nose and infectious sites. The 390 patients included comprised 278 non-carriers and 112 carriers. Among the carriers, 56 were decolonized with mupirocin. Decolonization was verified...
09:05
Elimination of Staphylococcus aureus nasal carriage in intensive care patients lowers infection rates: AbstractThis study surveys the clinical relevance of the nasal Staphylococcus aureus colonization status on intensive care unit (ICU)–acquired S. aureus infections and compares molecular characteristics of isolates from the nose and infectious sites. The 390 patients included comprised 278 non-carriers and 112 carriers. Among the carriers, 56 were decolonized with mupirocin. Decolonization was verified...
09:05
Evaluation of Bio-Rad® discs for antimicrobial susceptibility testing by disc diffusion and the ADAGIO™ system for the automatic reading and interpretation of results: AbstractThe disc diffusion test is used for antimicrobial susceptibility testing worldwide. In this study, the performance of both Bio-Rad® antibiotic discs (as compared with Oxoid® discs) and the ADAGIO™ automated system for the reading of disc diffusion test results was evaluated with American Type Culture Collection (ATCC) quality...
09:05
A multidrug-resistant microorganism infection risk prediction model: development and validation in an emergency medicine population: AbstractThe aim was to develop a predictive model of infection by multidrug-resistant microorganisms (MDRO). A national, retrospective cohort study was carried out including all patients attended for an infectious disease in 54 Spanish Emergency Departments (ED), in whom a microbiological isolation was available from a culture obtained during their attention in the...
09:05
Effect of conjugated bilirubin on clinical outcomes in infective endocarditis: AbstractLiver dysfunction is associated with adverse events in infective endocarditis (IE). However, few studies have explored the predictive value of conjugated bilirubin (CB) in IE. We aimed to investigate the nature of the link between CB and adverse prognosis in patients with IE. Consecutive patients with IE between January 2009 and July 2015 were enrolled. Multivariate analysis was performed to confirm whether CB...
09:05
Predicting factors for chronic colonization of Pseudomonas aeruginosa in bronchiectasis: AbstractAbout 25% of the patients with bronchiectasis are likely to develop a chronic colonization with Pseudomonas aeruginosa. A better understanding of predictors of acquiring Pseudomonas within the patient population may facilitate future focused research. The aim of this retrospective observational study was to investigate predicting factors for P. aeruginosa colonization in patients with bronchiectasis....
09:05
Evaluation of telavancin susceptibility in isolates of Staphylococcus aureus with reduced susceptibility to vancomycin: AbstractHistorically, vancomycin has been considered a primary therapeutic option for treating infections with Staphylococcus aureus, but isolates with reduced vancomycin susceptibility (SA-RVS) (MIC ≥ 4 μg/mL) have emerged. Telavancin, a semisynthetic lipoglycopeptide, is an alternative treatment option for S. aureus, but data examining telavancin activity against SA-RVS are limited....
09:03
Statins and outcomes of hospitalized patients with laboratory-confirmed 2017–2018 influenza: AbstractNo studies evaluating the association between statins and outcomes of patients with seasonal influenza have been performed since the 2007–2008 and the 2009 pandemic H1N1 influenza seasons. All consecutive hospitalized patients between October 2017 and April 2018, diagnosed with laboratory-confirmed influenza A and B virus, were included. Patients were divided into two groups: statin and non-statin...
09:03
Impact of thrombocytes, on bacterial growth and antimicrobial activity of selected antibiotics: AbstractIn vitro pharmacodynamic models are used to optimize in vivo dosing regimens in antimicrobial drug development. One limiting factor of such models is the lack of host factors such as corpuscular blood components as erythrocytes which have already been shown to impact activity of antibiotics and/or growth of the pathogen. However, the impact of thrombocytes has not previously been investigated....
09:03
Abundance of the nasopharyngeal microbiome effects pertussis diagnosis and explains the sensitivity difference between bacterial culture and real-time PCR: AbstractQuantitative real time PCR (qPCR)is used for pertussis diagnosis. The positive rate of qPCR is generally much higher than that of bacterial culture, which may cause confusion. The current study utilized the 16S ribosomal RNA (16S rRNA) sequencing to assess the correlation between conventional culture and qPCR and to explore the value of...
09:03
Factors affecting the discharge of patients from hospital with seasonal influenza—the role of the Rapid Influenza testing in hospital discharges: AbstractInfluenza is a major cause of presentations to the emergency departments. Introduction of the Rapid Influenza tests has assisted with diagnosis and facilitated patient discharges. We designed this study to identify factors affecting hospital discharge and to understand the role of Rapid Influenza testing. A retrospective observational study of patients...
09:03
Incidence of coagulase-negative staphylococcal bacteremia among ICU patients: decontamination studies as a natural experiment: AbstractThe epidemiology of coagulase-negative staphylococcal (CNS) bacteremia among adult ICU patients remains unclear. Decontamination studies among ICU patients provide a unique opportunity to study the impacts of different diagnostic criteria, exposure to various decontamination interventions, and various other factors, on its incidence over three decades. Decontamination...
09:03
Treatment and recurrence on re-treatment tuberculosis patients: a randomized clinical trial and 7-year perspective cohort study in China: AbstractPreviously treated TB patients still pose a serious threat to global control of TB, yet new re-treatment therapies were little studied. This study aimed to examine the therapeutic effects of new re-treatment regimens, and explore risk factors associated with recurrence after successful treatment. We conducted a cohort study in nine regions of China and...
09:03
Five-year Pan-European, longitudinal surveillance of Clostridium difficile ribotype prevalence and antimicrobial resistance: the extended Clos ER study: AbstractClostridium difficile infection (CDI) has been primarily treated with metronidazole or vancomycin. High recurrence rates, the emergence of epidemic PCR ribotypes (RTs) and the introduction of fidaxomicin in Europe in 2011 necessitate surveillance of antimicrobial resistance and CDI epidemiology. The ClosER study monitored antimicrobial susceptibility...
09:02
Application of metagenomic next-generation sequencing for bronchoalveolar lavage diagnostics in critically ill patients: AbstractThe purpose of this study was to assess the value of metagenomic next-generation sequencing (mNGS) of bronchoalveolar lavage fluid (BALF) for the diagnosis of severe respiratory diseases based on interpretation of sequencing results. BALF samples were harvested and used for mNGS as well as microbiological detection. Infectious bacteria or fungi were defined according to...
09:02
Determination of pentraxin 3 levels in cerebrospinal fluid during central nervous system infections: AbstractPentraxin 3 (PTX3) is an acute phase protein; its plasmatic levels significantly rise during severe infections. Data on PTX3 levels in cerebrospinal fluid (CSF) of patients with central nervous system (CNS) infections are lacking. We aimed (a) to assess the diagnostic potential of measuring CSF PTX3 levels in patients with CNS infections and (b) to establish CSF PTX3 cutoffs to distinguish...
09:02
Diagnostic accuracy and clinical impact of loop-mediated isothermal amplification for rapid detection of Staphylococcus aureus bacteremia: a retrospective observational study: AbstractThe aim of this study was to evaluate the diagnostic accuracy and the clinical impact of isothermal loop-mediated amplification (LAMP; eazyplex® MRSA kits) for rapid diagnosis of Staphylococcus aureus bacteremia (SAB) in comparison with conventional blood culture diagnostics. We performed a retrospective, single-center...
09:02
A novel id-iri score: development and internal validation of the multivariable community acquired sepsis clinical risk prediction model: AbstractWe aimed to develop a scoring system for predicting in-hospital mortality of community-acquired (CA) sepsis patients. This was a prospective, observational multicenter study performed to analyze CA sepsis among adult patients through ID-IRI (Infectious Diseases International Research Initiative) at 32 centers in 10 countries between December 1, 2015, and...
09:02
Evidence supporting recommendations from international guidelines on treatment, diagnosis, and prevention of HAP and VAP in adults: AbstractClinical practice guidelines (CPGs) are intended to support clinical decisions and should be based on high-quality evidence. The objective of the study was to evaluate the quality of evidence supporting the recommendations issued in CPGs for therapy, diagnosis, and prevention of hospital-acquired and ventilator-associated pneumonia (HAP/VAP). CPGs released by...
09:02
Pathogenic characteristics of Pseudomonas aeruginosa bacteraemia isolates in a high-endemicity setting for ST175 and ST235 high-risk clones: AbstractMultidrug-resistant (MDR) Pseudomonas aeruginosa represents a major clinical concern. The interplay between antimicrobial resistance and virulence of P. aeruginosa was investigated in in vitro and in vivo studies. Thirty-eight well-characterized (21 MDR and 17 non-MDR) P. aeruginosa strains from patients with bacteraemia were analysed. Resistance phenotype,...
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Non-alcoholic fatty liver diseases: from role of gut microbiota to microbial-based therapies: AbstractNon-alcoholic fatty liver disease (NAFLD) is the well-known disease of the liver in adults and children throughout the world. The main manifestations related to NAFLD are an unusual storage of lipid in hepatocytes (hepatic steatosis) and progression of inflammation for non-alcoholic steatohepatitis (NASH). NAFLD is described as a multifactorial complication due to the genetic predisposition, metabolic...
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Predictors of nasal bacterial culture rates in patients with chronic rhinosinusitis: AbstractAll nontechnical factors were analyzed to predict nasal bacterial culture results in patients with chronic rhinosinusitis (CRS). Four hundred and ninety-six CRS patients, who underwent functional endoscopic sinus surgery (FESS), were enrolled. Prior to FESS, the severity of each patient's CRS was evaluated using a questionnaire, endoscopic examination, acoustic rhinometry, smell test, saccharine transit test,...
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Emergence of multidrug resistance among Haemophilus parainfluenzae from respiratory and urogenital samples in Barcelona, Spain: AbstractHaemophilus parainfluenzae (HPAR) is a Gram-negative bacterium that can become an opportunistic urogenital pathogen. Recently, multidrug resistant (MDR) strains have emerged. We aim to analyse the epidemiology of HPAR at Hospital Universitari de Bellvitge between 2013 and 2017 to determine its putative role in sexually transmitted infections (STI). Strains were classified...
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Diagnostic and medical needs for therapeutic drug monitoring of antibiotics: AbstractTherapeutic drug monitoring (TDM) of antibiotics has been practiced for more than half a century, but it is still not widely applied for infected patients. It has a traditional focus on limiting toxicity of specific classes of antibiotics such as aminoglycosides and vancomycin. With more patients in critical care with higher levels of sickness severity and immunosuppression as well as an increasingly obese and ageing...
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Increased risk for tooth extraction in primary hyperparathyroidism and hypercalcemia: a population study: AbstractThe aim of this study was to analyze dental comorbidities in untreated primary hyperparathyroidism (pHPT). Patients with pHPT subjected to parathyroidectomy (PTX) at Karolinska University Hospital, Stockholm, during 2011–2016 (n = 982) were selected from the Scandinavian Quality Register of Thyroid, Parathyroid and Adrenal surgery and compared to a general population cohort (n = 2944),...
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A novel method for harvesting concentrated platelet-rich fibrin (C-PRF) with a 10-fold increase in platelet and leukocyte yields: AbstractBackground and objectivesLiquid platelet rich fibrin (PRF; often referred to as injectable PRF) has been utilized as an injectable formulation of PRF that is capable of stimulating tissue regeneration. Our research group recently found that following standard L-PRF protocols (2700 RPM for 12 min), a massive increase in platelets and leukocytes was observed directly...
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Expression of gingival crevicular fluid markers during early and late healing of intrabony defects after surgical treatment: a systematic review: AbstractBackgroundSurgical treatments such as guided tissue regeneration (GTR) and access flap surgery are widely employed for the treatment of intrabony defects. However, little is known regarding the postoperative expression of gingival crevicular fluid (GCF) markers.ObjectiveThe aim of this systematic review was to compare the expression of GCF markers...
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Impact of Hyperbaric Oxygen on the Healing of Teeth Extraction Sockets and Alveolar Ridge Preservation: AbstractObjectivesThe purpose of this study was to investigate the role of hyperbaric oxygen (HBO) in the healing of teeth extraction sockets and in alveolar ridge preservation. This may provide an experimental basis for the widespread application of HBO in oral implantation.MethodsA total of 32 beagle dogs were included in the study and randomly divided equally between an HBO group treated with...
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Effect of ammonium acryloyldimethyltaurate copolymer on the physical and chemical properties of bleached dental enamel: AbstractObjectiveTo analyze the effect of bioadhesive polymer, Aristoflex® AVC, on enamel physical and chemical properties.Materials and methodsBovine enamel blocks were divided into CP 10% with carbopol—Whiteness Perfect® (WP-FGM), CP 10% with Aristoflex (A + CP 10%), CP 10% with carbopol (C + CP 10%), Aristoflex (A), carbopol (C), carbamide peroxide 10% (CP 10%) and control (no...
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Outcomes of endodontically treated cracked teeth: a systematic review and meta-analysis: AbstractObjectiveSystematic review analyzing the treatment outcomes of cracked teeth that received endodontic treatment is unavailable. The purpose of this study was to examine the treatment outcome of cracked teeth that received root canal treatment and to determine factors that influenced outcome.Materials and methodsThe specific PIO questions were as follows: Population: patients who were healthy individuals...
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Metal ion quantification in the saliva of patients with lingual arch appliances using silver solder, laser, or TIG welding: AbstractObjectivesQuantify metal ion release in the saliva, considering that orthodontic appliances with soldered or welded parts may suffer corrosion and release metal ions into saliva, which can trigger adverse effects, such as hypersensitivity.MethodsSixty-four patients were distributed into four groups: G1 (control), G2 (silver-soldered lingual arch), G3 (laser-welded lingual...
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Comparison of mandibular cortical bone among obese, overweight, and normal weight adolescents using panoramic mandibular index and mental index: AbstractObjectiveThe objective of this study is to evaluate the mental index (MI) and panoramic mandibular index (PMI) of a group of adolescent patients in different body mass index (BMI) percentile.Material and methodsSubjects were divided into three different groups in accordance to their BMI percentile status: normal weight (35 subjects; mean age, 14.81...
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Adhesive luting of orthodontic devices to silica-based ceramic crowns—comparison of shear bond strength and surface properties: AbstractObjectivesThe aim of this study was to analyse the impact of different clinical conditioning approaches and an ammonium polyfluoride- and trimethoxysilylpropyl methacrylate-based experimental primer for intraoral luting of buccal tubes on silica-based ceramic surfaces.Materials and methodsA total of 60 leucite-reinforced glass ceramic molar crowns were conditioned...
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Adhesive luting of orthodontic devices to silica-based ceramic crowns—comparison of shear bond strength and surface properties: AbstractObjectivesThe aim of this study was to analyse the impact of different clinical conditioning approaches and an ammonium polyfluoride- and trimethoxysilylpropyl methacrylate-based experimental primer for intraoral luting of buccal tubes on silica-based ceramic surfaces.Materials and methodsA total of 60 leucite-reinforced glass ceramic molar crowns were conditioned...
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The effect of water spray on the release of composite nano-dust: AbstractObjectiveTo evaluate the collection efficiency of water spray on the release of airborne composite particles during grinding of composite materials.Materials and methodsComposite sticks (L:35 mm × W:5.4 mm × H:1.6 mm) of seven commercial dental composites were ground with a rough diamond bur (grain size 100 μm, speed 200,000 rpm). All experiments were performed in an enclosed 1-m3 chamber with low particulate background (<...
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Quick bonding using a universal adhesive: AbstractObjectivesThis study aimed to measure the microtensile bond strength (μTBS) of a new universal adhesive (UA) bonded to dentin following a quick bonding mode.Materials and methodsThe experimental UA 'SKB-100,' now commercialized as Clearfil Universal Bond Quick ('C-UBq'; Kuraray Noritake), was investigated, with Scotchbond Universal ('SBU'; 3M Oral Care) and the two-step self-etch (SE) adhesive Clearfil SE Bond 2 ('C-SE2'; Kuraray Noritake) serving...
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Evaluating the effects of orthodontic materials, field of view, and artifact reduction mode on accuracy of CBCT-based caries detection: AbstractObjectivesTo investigate the influence of orthodontic materials, field of view (FOV), and artifact reduction (AR) on the assessment of approximal caries using cone beam computed tomography.Materials and methodsForty non-cavitated and restoration-free human premolars and molars ranging from sound to various grades of lesions without cavitations were assigned...
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Craniofacial growth in infants with deformational plagiocephaly: does prematurity affect the duration of head orthosis therapy and the extent of the reduction in asymmetry during treatment?: AbstractObjectiveAlthough prematurity is a risk factor for developing deformational plagiocephaly (DP), to our knowledge, there are no studies that have analyzed the impact of a premature birth on the duration of head orthosis therapy and the extent of the reduction in asymmetry during treatment.Materials and...
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Longitudinal study of risk for facial nerve injury in mandibular condyle fracture surgery: marginal mandibular branch-traversing classification of percutaneous approaches: AbstractObjectiveThis study aimed to longitudinally assess the risk of facial nerve injury (FNI) in the surgical repair of mandibular condylar neck and subcondylar fractures (CN/SCFs) and to explore its predictors.Materials and methodsIn a retrospective cohort study, the outcome was defined as FNI at 1 week and 1, 3, and 6 months...
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Evaluation of magnetic resonance imaging for diagnostic purposes in operative dentistry—a systematic review: AbstractObjectivesMagnetic resonance imaging (MRI) is a well-established diagnostic tool in various areas of medicine. The technique provides radiographic images in the absence of ionizing radiation. The aim of the present analysis was to evaluate the best available current external evidence for application of MRI in operative dentistry.Material and methodsA systematic literature search was...
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Clustering effects of oral conditions based on clinical and radiographic examinations: AbstractObjectivesThe intra-class correlation coefficient (ICC) is a measure of intra-subject clustering effects. A priori estimates of the ICC and the associated design effect (DE) are required for sample size estimation in clustered studies, and should be considered during their analysis, too. We aimed to determine the clustering effects of carious lesions, apical lesions, periodontal bone loss, and periodontal...
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Osseous ingrowth in allogeneic bone blocks applied for vertical bone augmentation: a preclinical randomised controlled study: AbstractObjectivesThe aim of the present study was the qualitative and quantitative evaluation of osseous graft consolidation using allogeneic bone blocks for vertical bone augmentation in an animal model.Material and methodsStandardised allogeneic and autologous bone blocks were fixed on the frontal skull of 20 adult female pigs and covered with a resorbable collagen membrane....
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Proteomic profile of saliva collected directly from ducts: a systematic review: AbstractObjectiveTo present a systematic review that provides updated information about proteins found in salivary fluid extracted strictly from ducts.MethodsThe systematic review probing strategy was based on electronic databases word search (PubMed, EMBASE, LILACS, Web of Science, and Scopus). Risk of bias was assessed based on Joanna Briggs Institute Critical Appraisal Checklist for Studies Reporting Prevalence Data.ResultsAfter...
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