A highly enantioselective synthesis of (S)-Flurbiprofen methyl ester in two steps from commercially available 4-bromo-2-fluoro-1,1'-biphenyl is shown. [PdCl2((S)-Xylyl-Phanephos)] catalyst is used to accomplish both Grignard cross-coupling and the highly enantioselective intermolecular methoxycarbonylation reaction.
from # All Medicine by Alexandros G. Sfakianakis via alkiviadis.1961 on Inoreader http://ift.tt/2eKQIZY
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