Adding Polyamine Metabolism to the mTORC1 Toolkit in Cell Growth and Cancer

Publication date: 24 July 2017
Source:Developmental Cell, Volume 42, Issue 2
Author(s): Ana P. Gomes, Tanya Schild, John Blenis
The mammalian/mechanistic target of rapamycin complex 1 (mTORC1) is a major nutrient sensor and regulator of cellular metabolic flux. Reporting recently in Nature, Zabala-Letona et al. (2017) show that mTORC1 regulates an additional branch of metabolism in the cell—polyamine synthesis—that is important for prostate cancer tumorigenicity.

Teaser

The mammalian/mechanistic target of rapamycin complex 1 (mTORC1) is a major nutrient sensor and regulator of cellular metabolic flux. Reporting recently in Nature, Zabala-Letona et al. (2017) show that mTORC1 regulates an additional branch of metabolism in the cell—polyamine synthesis—that is important for prostate cancer tumorigenicity.


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