Antibiotic Prophylaxis in Breast Reduction Surgery: A Systematic Review and Meta-analysis

Publication date: Available online 16 August 2017
Source:Journal of Plastic, Reconstructive & Aesthetic Surgery
Author(s): James Zapata-Copete, Santiago Aguilera-Mosquera, Herney Andrés García-Perdomo
ObjectiveTo determine the effectiveness and harm of using antibiotic prophylaxis versus placebo or no intervention in patients undergoing breast reduction surgery to prevent surgical site infection.Materials and MethodsA search strategy was conducted in the MEDLINE, CENTRAL, EMBASE and LILACS databases. Searches were also conducted in other databases and unpublished literature. Clinical trials were included without language restrictions. The risk of bias was evaluated with the Cochrane Collaboration's tool. An analysis of fixed effects was conducted. The primary outcome was surgical site infection. The secondary outcomes were delayed wound healing and adverse effects. The measure of the effect was the risk difference (RD) with a 95% confidence interval (CI). The planned interventions were antibiotic prophylaxis vs. placebo/no intervention.ResultsFive articles were included in the qualitative and quantitative analysis. A total of 584 patients were included from the five studies. A low risk of bias was shown for most of the study items. The overall risk difference (RD) for surgical site infection was -0.08 (95% CI -0.14 to -0.03) favouring antibiotic prophylaxis compared with placebo.ConclusionAntibiotic prophylaxis lowers the incidence of surgical site infection in breast reduction surgery compared with placebo or no intervention.



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