Ggnbp2 Null Mutation in Mice Leads to Male Infertility Due to a Defect at the Spermiogenesis Stage

Gametogenetin binding protein 2 (GGNBP2) is an evolutionarily conserved zinc finger protein. Although Ggnbp2 null embryos in the B6 background died due to a defective placenta, 6.8% of Ggnbp2 null mice in the B6/129 mixed background were viable and continued to adulthood. Adult Ggnbp2 null males were sterile with smaller testes and an azoospermic phenotype, while mutant females were fertile. Histopathological analysis of 2-month-old Ggnbp2 null testes revealed absence of mature spermatozoa in the seminiferous tubules and epididymides and reduction of the number of spermatids.

from # All Medicine by Alexandros G. Sfakianakis via alkiviadis.1961 on Inoreader http://ift.tt/2weDBYx