Partial breast irradiation: The time is there!

Authors: Meattini I, Livi L, Pallotta S, Marrazzo L Abstract The conventionally fractionated partial breast irradiation (PBI) IMPORT LOW trial represents the perfect example of how an adequate selection of patients led to a minimal local relapse rate for patients. Coles and colleagues, demonstrated a 5-year non-inferiority local relapse rate for PBI compared to standard whole breast irradiation, together with a significant reduction in terms of breast toxicity using a conventional radiation technique implementable worldwide. Most of enrolled patients had early stage node negative, grade1-2, oestrogen receptor positive, human epidermal growth factor receptor 2 negative tumours. An exponential decrease in term of local relapse rate was observed from the first published PBI studies. T...

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