Seasonal exacerbation of eosinophilic esophagitis histologic activity in adults and children implicates role of aeroallergens

Eosinophilic esophagitis (EoE) is a chronic immune/antigen-mediated disorder characterized histologically by eosinophilic-predominant esophageal inflammation and clinically by esophageal dysfunction. The condition is diagnosed when there are at least 15 eosinophils per high-power field (eos/hpf) on esophageal biopsies following the exclusion of alternative etiologies of esophageal eosinophilia.1–4 EoE contributes significantly to esophageal morbidity and represents the second-leading cause of esophagitis.

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