Publication date: Available online 13 March 2019Source: Allergology InternationalAuthor(s): Hiroyuki NagaseAbstractThe characteristic phenotype of severe asthma in Japan seems to be distilled into the following two features: low incidence of obesity and high prevalence of patients with type 2 inflammation. Only 5–7% of Japanese severe asthma patients had a body mass index (BMI) ≥30 kg/m2, and more than 80% of patients with severe asthma exhibited type 2 inflammation. Although the relationship between...
Publication date: Available online 11 March 2019Source: Allergology InternationalAuthor(s): Yoshihisa Nukui, Yasunari Miyazaki, Masahiro Masuo, Tsukasa Okamoto, Haruhiko Furusawa, Tomoya Tateishi, Mitsuhiro Kishino, Ukihide Tateishi, Junya Ono, Shoichiro Ohta, Kenji Izuhara, Naohiko InaseAbstractBackgroundPeriostin is an established biomarker of Th2 immune response and fibrogenesis. Recent research has indicated that periostin plays an important role in the pathogenesis of idiopathic interstitial...
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