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Idiopathic low ovarian reserve is associated with more frequent positive thyroid peroxidase antibody.
Thyroid. 2017 Aug 16;:
Authors: Chen CW, Huang YL, Huang RL, Tzeng CR, Chen CH
Abstract
BACKGROUND: While screening on thyroid peroxidase antibody (TPO-Ab) has been recommended in women with primary ovarian insufficiency, the relationship between thyroid autoimmunity (TAI) and ovarian reserve remains undetermined. Because the TAI prevalence was reported to be different between races, we aimed to investigate the TAI prevalence in Chinese women with different ovarian reserve.
METHODS: This is a cross-sectional study conducted in a university infertility clinic between October 2013 and March 2016. Among patients at their first entry to the infertility clinic, a total of 1044 patients with available results of anti-Müllerian hormone (AMH), thyroid-stimulating hormone (TSH), TPO-Ab, and thyroglobulin antibody (TG-Ab) were enrolled. The TSH levels and the prevalence of positive TPO-Ab and positive TG-Ab were compared between patients with low, normal, and high ovarian reserve categorized with age-specific AMH levels.
RESULTS: For the whole study population, the TSH levels, TPO-Ab positivity and TG-Ab positivity were comparable between patients with different ovarian reserve. However, after patients with known causes compromising ovarian reserve (iatrogenic or genetic) were excluded, only TPO-Ab positivity became significantly different between patients with low (22.7%), normal (14.0%), and high ovarian reserve (10.3%), P=0.012. The TPO-Ab levels were not significantly correlated to AMH levels (Spearman's rho= -0.027, P=0.413). For the infertile subgroup, TPO-Ab positivity was significantly associated with idiopathic low ovarian reserve in unexplained infertility (low ovarian reserve: 28.6%, normal: 15.7%, and high: 9.5%, P=0.020).
CONCLUSIONS: Idiopathic low ovarian reserve was associated with more frequent positive TPO-Ab rather than thyroid function or TG-Ab positivity in Chinese women.
PMID: 28810821 [PubMed - as supplied by publisher]
from # All Medicine by Alexandros G. Sfakianakis via alkiviadis.1961 on Inoreader http://ift.tt/2wdKRnt
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