GSE77651 Expression data from PU.1low URE-/- AML cell line after treatment with small molecule acting as PU.1 inhibitor

Contributors : Ileana Antony-Debre ; Ulrich Steidl
Series Type : Expression profiling by array
Organism : Mus musculus

Downregulation of the hematopoietic transcription factor PU.1 in PU.1 low acute myeloid leukemia cells (AML) by novel heterocyclic diamidines or PU.1 inhibitors leads to decrease cell proliferation and apoptosis, representing a new therapeutic strategy for AML treatment. These inhibitors induces decreased PU.1 binding on its target sites, as well as deregulation in PU.1 canonical target genes
We used microarray to identify the pathways deregulated after drug treatment.

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