NimbleMiner: An Open-Source Nursing-Sensitive Natural Language Processing System Based on Word EmbeddingThis study develops and evaluates an open-source software (called NimbleMiner) that allows clinicians to interact with word embedding models with a goal of creating lexicons of similar terms. As a case study, the system was used to identify similar terms for patient fall history from homecare visit notes (N = 1 149 586) extracted from a large US homecare agency. Several experiments with parameters...
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Patient-controlled Sedation During Flexible Bronchoscopy: A Randomized Controlled TrialBackground: Patient-controlled sedation (PCS) is a documented method for endoscopic procedures considered to facilitate early recovery. Limited data have been reported, however, on its use during flexible bronchoscopy (FB). Materials and Methods: This study hypothesized that PCS with propofol during FB would facilitate early recovery, with similar bronchoscopist and patient satisfaction compared with nurse-controlled...
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A Critical Evaluation of Current Methods for Exercise Prescription in Women and MenCommon methods to prescribe exercise intensity are based on fixed-percentages of maximum rate of oxygen uptake (V[Combining Dot Above]O2max), peak work rate (WRpeak), maximal heart rate (HRmax). However, it is unknown how these methods compare to the current models to partition the exercise intensity spectrum. Purpose Thus, the aim of this study was to compare contemporary gold-standard approaches for exercise prescription...
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Providing Care for Children in Immigrant Families,Julie M. Linton, Andrea Green and COUNCIL ON COMMUNITY PEDIATRICSIdentifying Child Abuse Fatalities During InfancyVincent J. Palusci, Council on Child Abuse and Neglect, Amanda J. Kay, Erich Batra, Section on Child Death Review and Prevention, Rachel Y. Moon, Task Force on Sudden Infant Death Syndrome, NATIONAL ASSOCIATION OF MEDICAL EXAMINERS, Tracey S. Corey, Thomas Andrew and Michael GrahamArticlesCannabis Concentrate Use in AdolescentsMadeline...
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Metastasiertes Nierenzellkarzinom: Neue Standards in der Erstlinie und mögliche Auswirkungen auf den klinischen Alltag und die FolgetherapienDie Therapie des metastasierten Nierenzellkarzinoms befindet sich derzeit in einem deutlichen Wandel, etwa durch die Zulassung der Immunkombination aus Nivolumab und Ipilimumab für Patienten mit einem mittleren oder hohen Risiko in der Erstlinie. Welche weiteren Therapien aktuell oder auch künftig für die Erstlinientherapie verfügbar sind bzw. sein werden und...
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PCSK9 Inhibitor Use in Heart Transplant Recipients: A Case Series and Review of the LiteratureNo abstract availableConstrictive Pericarditis after Lung TransplantationBackground: Constrictive pericarditis is a rare, but increasingly recognized long-term post-operative complication of lung transplantation. Heightened clinical suspicion, improved diagnostic imaging and effective surgical treatment of the disease have led to progressive awareness of the pathology. We present our institutional experience...
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Transfusion of Anaerobically or Conventionally Stored Blood After Hemorrhagic ShockBackground: Resuscitation from hemorrhagic shock (HS) by blood transfusion restores oxygen (O2) delivery and provides hemodynamic stability. Current regulations allow red blood cells (RBCs) to be stored and used for up to 42 days. During storage, RBCs undergo many structural and functional changes. These storage lesions have been associated with adverse events and increased mortality after transfusion, increasing the...
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Cardiopulmonary Exercise Testing Following Open Repair for a Proximal Thoracic Aortic Aneurysm or DissectionPurpose: There are limited data on cardiopulmonary exercise testing (CPX) and cardiorespiratory fitness (CRF), following open repair for a proximal thoracic aortic aneurysm or dissection. The aim was to evaluate serious adverse events, abnormal CPX event rate, CRF (peak oxygen uptake, Vo2peak), and blood pressure. Methods: Patients were retrospectively identified from cardiac rehabilitation...
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Adult CranioplastyObjectives: After reading this article, the participant should be able to: Understand the etiology of cranial defects. Understand the anatomy of the cranium. Understand the importance of the preoperative workup in the cranial reconstruction decision-making process. Describe the options available for calvarial reconstruction including autologous and alloplastic materials. Describe the basic differences between available alloplastic materials. Understand the intraoperative and postoperative...
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Dermatology Early View Online Version of Record before inclusion in an issue Open Access Research...
DermatologyEarly ViewOnline Version of Record before inclusion in an issue Open AccessResearch LettersThe refined Hurley classification: the inter‐rater and intrarater reliability and face validityL.M. Prens, A. Rondags, R.J. Volkering, I.C. Janse, K. Politiek, Y.S. Zuidema, I. Turcan, J. van Hasselt, H.H. van der Zee, B. HorváthVersion of Record online: 29 August 2019Research LettersClinical characteristics of primary cutaneous lymphoma: analysis from two centres in ChinaH.‐Z. Shi, Y.‐X. Liu, Y.‐Q....
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In focus in HCB,Histochemistry and Cell BiologyZw10 is a spindle assembly checkpoint protein that regulates meiotic maturation in mouse oocytesAbstractFaithful chromosome segregation during the cell cycle is ensured by the spindle assembly checkpoint (SAC). Although SAC activity is highly conserved and most organisms share common SAC components, additional proteins that regulate SAC activity to ensure high fidelity chromosome segregation are present in higher eukaryotes. Zw10 is one of these additional...
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Introduction to the Special Issue: Out for Blood: Sacrifice, Tantra, and Normative HinduismĀyurveda and Mind-Body Healing: Legitimizing Strategies in the Autobiographical Writing of Deepak ChopraAbstractThis paper explores the early autobiographical work of the popular health and wellbeing guru, Deepak Chopra. The autobiography (entitled Return of the Rishi) is Chopra's account of his early forays into meditation and Āyurveda, the Indian health tradition. It is the story of his "spiritual transformation"...
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Association of Genetic Variants Related to Combined Exposure to Lower Low-Density Lipoproteins and Lower Systolic Blood Pressure With Lifetime Risk of Cardiovascular DiseaseBrian A. Ference, MD, MPhil, MSc; Deepak L. Bhatt, MD, MPH; Alberico L. Catapano, PhD; et al.Association of Metabolic Surgery With Major Adverse Cardiovascular Outcomes in Patients With Type 2 Diabetes and ObesityAli Aminian, MD; Alexander Zajichek, MS; David E. Arterburn, MD, MPH; et al.Editorial: The Role of Bariatric Surgery...
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What to choose in proximal hypospadias repair: onlay island flap or tubularized preputial flap?Response to letter to editor 'What to choose in proximal hypospadias repair: onlay Island flap or tabularized preputial flap?'Validation of risk prediction tools in elderly patients who initiate dialysis: methodological issuesHydrogen sulfide-induced relaxation of the bladder is attenuated in spontaneously hypertensive ratsAbstractPurposeTo compare hydrogen sulfide (H2S)-induced relaxation on the bladder...
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Screening for natural products that affect Wnt signaling activityThe article Screening for natural products that affect Wnt signaling activity, written by Masami Ishibashi, was originally published electronically on the publisher's internet portal (currently SpringerLink) on 30 May 2019 without open access.Correction to: Computationally-assisted discovery and structure elucidation of natural productsThe article Computationally-assisted discovery and structure elucidation of natural products, written...
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PRSS21/testisin inhibits ovarian tumor metastasis and antagonizes proangiogenic angiopoietins ANG2 and ANGPTL4The affiliation of Erik W. Martin is corrected in this paper.Rewiring of immune-metabolic crosstalk in the liver after viral infectionRelevance of VEGFA in rat livers subjected to partial hepatectomy under ischemia-reperfusionAbstractWe examined the effects of VEGFA on damage and regeneration in steatotic and non-steatotic livers of rats submitted to PH under I/R, and characterized the underlying...
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Indigenous land demarcation conflicts in Brazil: Has the Supreme Court's decision brought (in)stability?AbstractWe investigate judiciary decision-making patterns regarding property rights conflicts between native Brazilians and rural farmers in the Midwest region of Brazil. Our main contribution is the use of the qualitative comparative analysis (QCA) method for the evaluation of the issue. We use QCA to examine a unique database composed of cases heard by a regional federal court in Brazil between...
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Maligner Kollisionstumor der HautErratum zu:Pathologe 2019https://doi.org/10.1007/s00292-019-0622-3In Abb. 1 des Beitrags wurde die Darstellung des Basalzellkarzinoms (Dreieck) und des Plattenepithelkarzinoms (Quadrat) vertauscht. Wir bitten Sie, die korrigierte Beschriftung zu beachten und den Fehler zu …Mitteilungen des Bundesverbandes Deutscher Pathologen e.V.Mitteilungen der Deutschen Gesellschaft für PathologieTumorverdächtiger Herdbefund am NierenhilusZusammenfassungOriginäre, z. B. narbig...
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Akshay Sarathi, Editor: Early Maritime Cultures in East Africa and the Western Indian Ocean: Papers from a Conference Held at the University of Wisconsin–Madison (African Studies Program) 23–24th October 2015, with Additional ContributionsCorrection to: Finite Element Analysis of Shell-First and Longitudinally Reinforced Frame-Based Wooden ShipsThe article "Finite Element Analysis of Shell-First and Longitudinally Reinforced Frame-Based Wooden Ships" written by Nathan Helfman, Boaz Nishri, and Deborah...
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Heuristics, Overconfidence, and Experience With Management of Neuromuscular Block: Self-Correction Is UnlikelyNo abstract availableIntraoperative Methadone Reduces Pain and Opioid Consumption in Acute Postoperative Pain: A Systematic Review and Meta-analysisBACKGROUND: Methadone is a potent opioid exerting an analgesic effect through N-methyl-D-aspartate receptor antagonism and the inhibition of serotonin and noradrenaline reuptake. It has also been used in several procedures to reduce postoperative...
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EditorialAutomatic Segmentation, Detection, and Diagnosis of Abdominal Aortic Aneurysm (AAA) Using Convolutional Neural Networks and Hough Circles AlgorithmAbstractPurposeAn abdominal aortic aneurysm (AAA) is known as a cardiovascular disease involving localized deformation (swelling or enlargement) of aorta occurring between the renal and iliac arteries. AAA would jeopardize patients' lives due to its rupturing risk, so prompt recognition and diagnosis of this disorder is vital. Although computed...
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Correction to: Fusulinoids from the Carboniferous–Permian transition beds from the Abadeh Region (Sanandaj–Sirjan Zone, Iran)The original version of this article unfortunately contained a mistake. Some labels are missing in the figure 3. The corrected figure is included in the next page.Biostratigraphy and lithostratigraphy of Tarbur Formation (Upper Cretaceous) in Hossein Abad section, Zagros basin (SW of Iran)AbstractThe Tarbur Formation is a Reef carbonate lithostratigraphic unit that outcrops...
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What to choose in proximal hypospadias repair: onlay island flap or tubularized preputial flap?Response to letter to editor 'What to choose in proximal hypospadias repair: onlay Island flap or tabularized preputial flap?'Validation of risk prediction tools in elderly patients who initiate dialysis: methodological issuesHydrogen sulfide-induced relaxation of the bladder is attenuated in spontaneously hypertensive ratsAbstractPurposeTo compare hydrogen sulfide (H2S)-induced relaxation on the bladder...
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Mitteilungen der DGGEFSteigerung der Lebensqualität durch HRTPerinatale Risiken für die nach assistierter Reproduktion konzipierten Kinder im Vergleich zu deren spontan konzipierten GeschwisterkindernMitteilungen der DMGHormonersatztherapie nach MammakarzinomZusammenfassungPatientinnen mit Brustkrebs leiden häufig während und nach der Therapie ihrer Erkrankung unter Symptomen, die auf niedrige Östrogenspiegel zurückzuführen sind. Dies kann zur relevanten Beeinträchtigung der Lebensqualität führen....
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Multiple Sklerose: selektive Wirkung von Teriflunomid auf T‑ZellenUnklare Bewusstlosigkeit bei 32-jährigem MountainbikerProgrediente Schlafstörungen, bulbäre Dysfunktion und Myoklonien bei einem 59-jährigem PatientenProgrediente Dysarthrie, Ataxie, schmerzhafte Dysästhesien der Beine und Gedächtnisstörung – was war die Ursache?Kontroversen beim Management erster Anfälle und deren aktuelle EvidenzAufsteigende LähmungZervikale Dystonie als NetzwerkerkrankungFehlende Justiziabilität medizinisch-wissenschaftlicher...
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Complete NMR chemical shift assignments of odorant binding protein 22 from the yellow fever mosquito, Aedes aegypti , bound to arachidonic acidThe article listed above was initially published with incorrect copyright information. Upon publication of this Correction, the copyright of the article is changed to "The Author(s)". The original article has been corrected.1 H N, 13 C, and 15 N resonance assignments of human calmodulin bound to a peptide derived from the STRA6 vitamin A transporter (CaMBP2)AbstractVitamin...
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The effect of alignment on knee osteoarthritis initiation and progression differs based on anterior cruciate ligament status: data from the Osteoarthritis InitiativeAbstractIntroduction/objectiveKnee alignment and anterior cruciate ligament (ACL) injury are risk factors for knee osteoarthritis (OA). The objective was to examine interactions between knee alignment and ACL status on cartilage volume loss in participants with or at risk of knee OA.MethodParticipants were from the Osteoarthritis Initiative,...
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The use of end-tidal argon to detect venous air embolism: foiled by "fake oxygen!"AbstractVenous air-embolism (VAE) potentially catastrophic complication surgery. Based on previous data using changes in end-tidal nitrogen as an indicator of VAE, we surmised that changes in end-tidal argon (EtAr) may be an indicator of VAE. We sought to determine if a commercial mass-spectrometer (PCT Proline Analyzer 61700-8 Class 85, Ametek, Pittsburgh, PA 15238) could be used to detect changes in EtAr in an invitro...
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Inhibitory effect of melatonin on Mst1 ameliorates myocarditis through attenuating ER stress and mitochondrial dysfunctionAbstractViral myocarditis has been found to be one of the leading causes of sudden death in young adults. However, no effective drugs have been developed to intervene the progression of myocarditis. Accordingly, the present study is carried out to explore the protective role played by melatonin in the setting of viral myocarditis with a focus on Mst1-Hippo pathway, mitochondrial...
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Effects of Gasotransmitters on Membrane Elasticity and Microrheology of ErythrocytesAbstractErythrocytes change their micromechanical properties associated with membrane viscoelasticity when they perform the transport function. There is some evidence that this is due to the influence of signaling molecules, including such gasotransmitters as nitrogen oxide (NO) and hydrogen sulfide (H2S). The aim of this study was to investigate the changes in microrheology of human erythrocytes under the influence...
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Intraosseous basivertebral nerve ablation for the treatment of chronic low back pain: a prospective randomized double-blind sham-controlled multi-center study" by Fischgrund JS, et al. [Eur Spine J; (2018) 27(5): 1146–1156]AnnouncementLetter to the editor concerning "Head to pelvis alignment of adolescent idiopathic scoliosis patients both in and out of brace" by Vergari C, Courtois I, Ebermeyer E, Pietton R, Bouloussa H, Vialle R, Skalli W (Eur Spine J; 2019: https://doi.org/10.1007/s00586-019-05981-8)Answer...
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Etiology and therapy indication for cochlear implantation in children with single-sided deafnessAbstractObjectiveThe characteristics of children with single-sided deafness (SSD) who become candidates for unilateral cochlear implantation (uCI) were identified.Study designIn all, 118 children with SSD presenting from 2013–2019 to a tertiary pediatric children's hospital were retrospectively assessed regarding candidacy for uCI.ResultsOf the 118 children, 103 had completed uCI candidacy assessment,...
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EPOVB Award Winners 2019The New White Flight?: The Effects of Political Appeals to Latinos on White DemocratsAbstractOne explanation for the post-1965 shift in the vote choice of White Americans posits that it was driven by a shift in the racial imagery of the two major parties. The growing role of Latinos in the Democratic Party has brought new changes in the racial groups associated with the parties. In this paper, I explore whether the increasing attention to Latinos in Democratic Party politics...
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Joint Contact Forces with Changes in Running Stride Length and Midsole StiffnessAbstractThe purpose of this study was to determine if lower extremity joint loading was influenced by stride length or shoe midsole cushioning. Ten subjects completed 10 trials of overground running at an average speed of 4.43 m/s in each of three conditions: normal running, running with a stride length (SL) reduced by 10% of normal, and running with a cushioned midsole stiffness (i.e., mechanical impact reduction of...
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Democratizing assessment practices through multimodal critique in the design classroomAbstractCritique is a primary method of assessment and feedback used in design education, yet is not well understood apart from traditional instructor-led activities in physical learning spaces. In this study, we analyze a series of group critiques in a human–computer interaction learning experience, focusing on an emergent instructional design for technologically-mediated critique created by experienced students...
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Move backward, forward signalsLabellum structure of Bulbophyllum echinolabium J.J. Sm. (section Lepidorhiza Schltr., Bulbophyllinae Schltr., Orchidaceae Juss.)AbstractThis micromorphological, chemical and ultrastructural study is a continuation of research conducted on the section Lepidorhiza. The Bulbophyllum echinolabium flowers comprised features that characterize a sapromyophilous syndrome, having large, glistening parts that emit an intense scent of rotten meat. The secretory activity was described...
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Irish Endocrine Society 43 rd Annual Meeting44th Sir Peter Freyer Memorial Lecture & Surgical Symposium 2019Patients referred for arteriovenous fistula construction: a retrospective outcome analysisAbstractObjectivesWith lower rates of sepsis and re-interventions, arteriovenous fistula (AVF) is the preferred vascular access modality. The aim of this study is to evaluate the outcomes of patients referred for AVF construction at a single center in Cork, Ireland.MethodsThe current study is a single-center...
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PediatricsSeptember 2019From the American Academy of PediatricsPolicy Statement Download PDFAbstractThis statement updates the recommendations of the American Academy of Pediatrics for the routine use of influenza vaccines and antiviral medications in the prevention and treatment of influenza in children during the 2019–2020 season. The American Academy of Pediatrics continues to recommend routine influenza immunization of all children without medical contraindications, starting at 6 months of age....
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In vitro propagation of Trichosanthes kirilowii Maxim. through nodal segment shoot proliferationAbstractTrichosanthes kirilowii Maxim. is a vital traditional herbal medicinal plant found in northeastern Asia. Its roots, fruits, and seeds are used as food and medicine. Roots harvested for medicinal use take over 3 yr to mature when the plant is grown in a traditional way through cultivation in the field. This coupled with uncertainty in identification of the plant when collected from the wild calls...
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Clinical and Experimental DermatologyEarly ViewOnline Version of Record before inclusion in an issueOriginal ArticlesExploring the perspectives of dermatology undergraduates with an escape room gameJ. Guckian, A. Sridhar, S. J. MeggittVersion of Record online: 31 August 2019Viewpoints in dermatologyCorrespondenceSmall papular pseudolymphoma induced by a patch test for goldT. Kiyohara, H. Tanimura, K. Makimura, S. Shimada, S. Ohnishi, M. Miyamoto, T. Shijimaya, N. Ma, H. OkamotoVersion of Record online:...
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Correlation study between A 3 adenosine receptor binding affinity and anti-renal interstitial fibrosis activity of truncated adenosine derivativesAbstractTruncated 4′-thionucleosides 1–4 and 4′-oxonucleosides 5–8 as potent and selective A3AR antagonists were synthesized from d-mannose and d-erythronic acid γ-lactone, respectively. These nucleosides were evaluated for their anti-fibrotic renoprotective activity in TGF-β1-treated murine proximal tubular (mProx) cells. Their antagonistic activities...
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Performance Nutrition for the Adolescent Athlete: A Realistic ApproachNo abstract availableA Preliminary Study of the Effect of Early Aerobic Exercise Treatment for Sport-Related Concussion in MalesObjective: To study the effect of early prescribed aerobic exercise versus relative rest on rate of recovery in male adolescents acutely after sport-related concussion (SRC). Design: Quasi-experimental design. Setting: University sports medicine centers. Participants: Exercise group (EG, n = 24, 15.13...
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From "Sit Still and Listen" to "Get Up and Move," the Leap May Be One of Educational Paradigms but No Longer One of FaithNo abstract availableInfluence of Physical Activity on Elementary School Children: Challenges and PracticeNo abstract availableA Review of Acute Physical Activity Effects on Brain and Cognition in ChildrenThe prevalence of physical inactivity in children has become a global pandemic and has consequences for physical, as well as cognitive and brain, health. Single bouts of physical...
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Sequential neural information processing in nidopallium caudolaterale of pigeons during the acquisition process of operant conditioningThe avian nidopallium caudolaterale, a key region of information integration and processing, is considered to be playing an important role in operant conditioning acquisition and extinction. To reveal sequential neural information processing in the process, neural signals of different experimental periods (induction, acquisition, and extinction) from the nidopallium...
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Impact of housing market transformation in Germany on affordable housing: the case of North Rhine-WestphaliaIn the original publication of the article, the author corrections regarding figures 5, 6 and 7 were inadvertently missed. As all the necessary information is provided in the newly supplied figure 5, figure 6 was removed and Figure 7 has been replaced as figure 6.Rowland Atkinson and Keith Jacobs: House, home and societyMaarten van Ham, Darja Reuschke, Reinout Kleinhans, Colin Mason and Stephen...
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Biomarkers, measured during therapy, for response of melanoma patients to immune checkpoint inhibitors: a systematic reviewImmune checkpoint inhibitors (ICIs), which target CTLA-4 or PD-(L)1 molecules, have shown impressive therapeutic results. Durable responses, however, are only observed in a segment of the patient population and must be offset against severe off-target immune toxicity and high costs. This calls for biomarkers that predict response during ICI treatment. Although many candidate...
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Establishing Urinary Leukotriene E4 as a Diagnostic Biomarker for Chronic Rhinosinusitis with Comorbid Asthma and AtopyGriffin D. Santarelli, Kent K. Lam, Joseph K. HanOtolaryngology–Head and Neck SurgeryAug 27, 2019 | OnlineFirstAbstract Objective While urinary leukotriene E4 (uLTE4) is a validated biomarker for the cysteinyl leukotriene pathway, which is central to the pathophysiology of asthma, atopy, and chronic rhinosinusitis (CRS), the contributions of comorbid asthma and atopy to uLTE4 levels...
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The PI3K-Akt-HIF-1α Pathway Reducing Nasal Airway Inflammation and Remodeling in Nasal PolyposisFei He, Huaigang Liu, Wei LuoEar, Nose & Throat JournalAug 28, 2019 | OnlineFirstAbstract Objective: Previous studies suggested that hypoxia-inducible factor-1α (HIF-1α) plays an important role in the progression of inflammation and remodeling of chronic rhinosinusitis with nasal polyposis. However, the molecule mechanisms of HIF-1α activation and regulation of cytokine expressions, such as interleukin...
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Epiglottitis,N. Chapurin and A. Gelbard,N Engl J Med 381:e15, August 29, 2019,A previously healthy, fully immunized 48-year-old man presented to an urgent care clinic with a 3-day history of odynophagia, fever with temperatures of up to 40°C, and progressive shortness of breath. A lateral radiograph of the neck showed the "thumb sign" (Panel A, arrow), which was suggestive of an enlarged epiglottis. He was transferred to the emergency department, where a physical examination showed inspiratory stridor;...
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Combating EPA Rollbacks — Health Care's Response to a Retreat on ClimateG. McCarthy and A. BernsteinN Engl J Med 381:696, August 22, 2019Audio | CommentsORIGINAL ARTICLEAmbient Particulate Air Pollution and Daily Mortality in 652 CitiesC. Liu and OthersN Engl J Med 381:705, August 22, 2019CME Quick Take | Interactive/Multimedia | CommentsREVIEW ARTICLEAdrenal CrisisR.L. Rushworth and OthersN Engl J Med 381:852, August 29, 2019CMEEDITORIALDo We Really Need Another Time-Series Study of the PM2.5–Mortality...
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Clinical OtolaryngologyAccepted ArticlesAccepted, unedited articles published online and citable. The final edited and typeset Version of Record will appear in the future.Original ArticlesTreating nasal symptoms associated with rhinitis using the intranasal herbal ointment Biyeom‐go: A prospective observational studyMi Ju Son, Jeeyoun Jung, Young‐Eun Kim, Chang‐Sub Yeum, So Min Lee, So Young Jung, Ojin Kwon, Sungha Kim, Jeong‐In Kang, Dong‐Hyo LeeFirst Published: 29 August 2019Original ArticlesImpact...
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Losing Hahnemann — Real-Life Lessons in "Value-Based" MedicineL. RosenbaumN Engl J Med, August 28, 2019ORIGINAL ARTICLEComplete Revascularization with Multivessel PCI for Myocardial InfarctionS.R. Mehta and OthersN Engl J Med, September 1, 2019Myocardial Viability and Long-Term Outcomes in Ischemic CardiomyopathyJ.A. Panza and OthersN Engl J Med 381:739, August 22, 2019REVIEW ARTICLEPheochromocytoma and ParagangliomaH.P.H. Neumann and OthersN Engl J Med 381:552, August 8, 2019CME | VideoIMAGES IN...
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Dermatology,Volume 46, Issue 9Pages: 743-821, e308-e342September 2019Issue InformationIssue InformationPages: 743-744 | First Published: 01 September 2019Original Articles Open AccessTwenty‐four‐week interim analysis from a phase 3 open‐label trial of adalimumab in Japanese patients with moderate to severe hidradenitis suppurativaAkimichi Morita, Hidetoshi Takahashi, Kentaro Ozawa, Shinichi Imafuku, Takekuni Nakama, Kenzo Takahashi, Takashi Matsuyama, Yukari Okubo, Susumu Kitamura, Naoto Matsuda, Yiwei...
Mon Sep 02, 2019 11:35
Factors involved in relapse of multiple sclerosisFatemah Omar KamelJournal of Microscopy and Ultrastructure 2019 7(3):103-108Multiple sclerosis (MS), a chronic autoimmune disorder, affects the central nervous system (CNS). It affects the brain, spinal cord, and optic nerve, leading to problems with vision, balance, muscle control, and other basic bodily functions. MS relapse (MSR) involves an acute inflammatory demyelinating reaction within the CNS. This review focuses on the main factors involved...
Mon Sep 02, 2019 11:35
Dermatology and Venereology,Volume 33, Issue 9Pages: 1619-1807, e310-e347September 2019Issue InformationIssue InformationPages: 1619-1624 | First Published: 29 August 2019EDITOR'S PICKSEditor's PicksPages: 1625 | First Published: 29 August 2019EDITORIALJEADV on the road and in your pocket – recent developments in our JournalJ. RingPages: 1626 | First Published: 29 August 2019COMMENTARIESLivedoid vasculopathy: how to diagnose and how to treat?D. LipskerPages: 1627-1628 | First Published: 29 August...
Mon Sep 02, 2019 11:34
Regulation of HMGB1 release protects chemoradiotherapy-associated mucositisKeon-Il Im, Young-Sun Nam, Nayoun Kim, Yunejin Song, Eun-Sol Lee et al. Mucosal Immunology 2019 12 :1070 - 1081; January 15, 2019; 10.1038/s41385-019-0132-xAbstract | Full TextBLT1 mediates commensal bacteria-dependent innate immune signals to enhance antigen-specific intestinal IgA responsesTakahiro Nagatake, So-ichiro Hirata, Tomoaki Koga, Etsushi Kuroda, Shingo Kobari et al. Mucosal Immunology 2019 12 :1082 - 1091; May...
Mon Sep 02, 2019 11:33
Regulation of HMGB1 release protects chemoradiotherapy-associated mucositisKeon-Il Im, Young-Sun Nam, Nayoun Kim, Yunejin Song, Eun-Sol Lee et al. Mucosal Immunology 2019 12 :1070 - 1081; January 15, 2019; 10.1038/s41385-019-0132-xAbstract | Full TextBLT1 mediates commensal bacteria-dependent innate immune signals to enhance antigen-specific intestinal IgA responsesTakahiro Nagatake, So-ichiro Hirata, Tomoaki Koga, Etsushi Kuroda, Shingo Kobari et al. Mucosal Immunology 2019 12 :1082 - 1091; May...
Mon Sep 02, 2019 11:22
Towards precise, safe genome editingSebastian Memczak, Yanjiao Shao & Juan Carlos Izpisua Belmonte Cell Research 2019 29 :687 - 689; June 14, 2019; 10.1038/s41422-019-0188-xAbstract | Full TextLnc(ing) interferon production and actionGanes C. Sen & Bryan R. G. Williams Cell Research 2019 29 :690 - 691; July 23, 2019; 10.1038/s41422-019-0207-yAbstract | Full TextInterferon-γ induces cancer cell ferroptosisLaurence Zitvogel & Guido Kroemer Cell Research 2019 29 :692 - 693; June 03, 2019;...
Mon Sep 02, 2019 11:21
A Critical Evaluation of Current Methods for Exercise Prescription in Women and MenCommon methods to prescribe exercise intensity are based on fixed-percentages of maximum rate of oxygen uptake (V[Combining Dot Above]O2max), peak work rate (WRpeak), maximal heart rate (HRmax). However, it is unknown how these methods compare to the current models to partition the exercise intensity spectrum. Purpose Thus, the aim of this study was to compare contemporary gold-standard approaches for exercise prescription...
Mon Sep 02, 2019 11:21
Guidelines in hernia surgery – friend or foeM Pawlak, B East, H Gok, AC de BeauxInternational Journal of Abdominal Wall and Hernia Surgery 2019 2(3):75-77Teaching and learning laparoendoscopic hernia in the Philippines problems and solutionsJose Macario FaylonaInternational Journal of Abdominal Wall and Hernia Surgery 2019 2(3):78-82Laparoendoscopic hernia surgery in the Philippines has been constantly growing in terms of training, education, and skills acquisition. Since hernia surgery is one of...
Mon Sep 02, 2019 11:21
Molecular Systems Biology,Volume 15, Issue 8,Articles Open AccessHigh‐fat diet in a mouse insulin‐resistant model induces widespread rewiring of the phosphotyrosine signaling networkAntje Dittmann, Norman J Kennedy, Nina L Soltero, Nader Morshed, Miyeko D Mana, Ömer H Yilmaz, Roger J Davis, Forest M Whitee8849 | First Published: 01 August 2019 A comprehensive proteomics analysis reveals the effects of high‐fat diet and free fatty acid overload on signaling pathways in murine livers and hepatocytes....
Mon Sep 02, 2019 11:20
A Critical Evaluation of Current Methods for Exercise Prescription in Women and MenCommon methods to prescribe exercise intensity are based on fixed-percentages of maximum rate of oxygen uptake (V[Combining Dot Above]O2max), peak work rate (WRpeak), maximal heart rate (HRmax). However, it is unknown how these methods compare to the current models to partition the exercise intensity spectrum. Purpose Thus, the aim of this study was to compare contemporary gold-standard approaches for exercise prescription...
Mon Sep 02, 2019 11:19
Leukaemic stem cells go under the radar Lucy Bird p533 | doi:10.1038/s41577-019-0204-x Leukaemia stem cells seem to evade immune surveillance by repressing the expression of stress-induced activating natural killer (NK) cell ligands. Overriding this repression with inhibitors renders them amenable to control by NK cells and prevents leukaemogenesis. PDF Stress response to innate immune signalosomes Kirsty Minton pp534 - 535 | doi:10.1038/s41577-019-0201-0 Cytosolic protein oligomers formed by certain...
Mon Sep 02, 2019 11:19
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