GSE74383 Targets of ROR2 overexpression in MCF-7 cells revealed a differentially regulated module of non-canonical WNT signaling pathway

Contributors : Michaela Bayerlová ; Kerstin Menk ; Tim Beissbarth ; Florian Klemm ; Annalen Bleckmann
Series Type : Expression profiling by high throughput sequencing
Organism : Homo sapiens

RNA-Seq profiling of estrogen-receptor-positive MCF-7 cell lines with different perturbations of non-canonical WNT signaling .
The MCF-7 cells were either transfected with an empty vector (pcDNA) or with a ROR2 overexpression construct, in parallel with or without stimulation with recombinant WNT5A. The objective was to find expression-responsive targets of these perturbations as potential drivers of increased cell invasiveness.

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