Panax ginseng (PG) is a widely used functional food and herbal with immunoregulation activity. Currently, immunoregulation studies of PG mainly focused on the specific actions of individual constituents. However, the integral immunoregulation mechanisms of PG need further research. In this study, an integrated metabolomics and network pharmacology approach were used to investigate it. High-content screening was used to evaluate macrophage phagocytosis activity of PG. Untargeted metabolomics profiling...
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Abstract The elderly form a very heterogeneous group in relation to their general health state, degree of dependence, comorbidities, performance status, physical reserve and geriatric situation, so cancer treatment in the older patient remains a therapeutic challenge. The physiological changes associated with aging increase the risk of developing a serious toxicity induced by chemotherapy treatment, as well as other undesirable consequences as hospitalizations, dependence and non-compliance...
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Background. Myocardial inflammation following acute ischemic injury has been linked to poor cardiac remodeling and heart failure. Many studies have linked myeloperoxidase (MPO), a neutrophil and inflammatory marker, to cardiac inflammation in the setting of acute coronary syndrome (ACS). However, the prognostic role of MPO for adverse clinical outcomes in ACS patients has not been well established. Methods. MEDLINE and Cochrane databases were searched for studies from 1975 to March 2018 that investigated...
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Abstract Background An emerging subset of oropharyngeal squamous cell carcinomas (OPSCC) is caused by HPV. HPV-positive OPSCC has a better prognosis than HPV-negative OPSCC, but other prognostic markers for these two different diseases are scarce. Our aim was to evaluate serum levels and tumor expression of matrix metalloproteinase-8 (MMP-8) and tissue inhibitor of metalloproteinase-1 (TIMP-1) and to assess their prognostic role in HPV-positive...
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Chem. Commun., 2019, Accepted ManuscriptDOI: 10.1039/C9CC03571K, CommunicationYawei Du, Wei He, Wenya Zhou, Xinsong LiPhosphatidylcholine is the main component of liposomes and other phospholipid-based nanoassemblies used as nanocarriers in drug delivery. However, the functions and applications of these nanocarriers are extremely limited by the...The content of this RSS Feed (c) The Royal Society of Chemistry
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An algorithm dubbed “Netflix for exoplanets” identified more than 350 stars that, based on their chemistry, might have planets orbiting out of sight.
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Cancers, Vol. 11, Pages 886: Systematic Analysis of Gene Expression in Lung Adenocarcinoma and Squamous Cell Carcinoma with a Case Study of FAM83A and FAM83BCancers doi: 10.3390/cancers11060886Authors:Ling CaiDanni LuoBo YaoDonghan M. YangShinYi LinLuc GirardRalph J. DeBerardinisJohn D. MinnaYang XieGuanghua XiaoIntroduction: In our previous study, we constructed a Lung Cancer Explorer (LCE) database housing lung cancer-specific expression data and clinical data from over 6700 patients in 56 studies....
Cancers, Vol. 11, Pages 887: Utility of Circulating Cell-Free RNA Analysis for the Characterization of Global Transcriptome Profiles of Multiple Myeloma PatientsCancers doi: 10.3390/cancers11060887Authors:Maoshan ChenSridurga MithraprabhuMalarmathy RamachandranKawa ChoiTiffany KhongAndrew SpencerIn this study, we evaluated the utility of extracellular RNA (exRNA) derived from the plasma of multiple myeloma (MM) patients for whole transcriptome characterization. exRNA from 10 healthy controls (HC),...
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Abstract Purpose In heart failure with reduced ejection fraction (HFrEF), the effects of automatic positive airway pressure therapy (APAP) for obstructive sleep apnea (OSA) on sleep quality and sympatho-vagal balance (SVB) are unknown. Methods In this randomized controlled trial (6 months of APAP vs. nasal strips as control), sleep quality and SVB in patients...
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Publication date: Available online 25 June 2019Source: Auris Nasus LarynxAuthor(s): Shinsuke Suzuki, Satoshi Toyoma, Hiroki Tomizawa, Toshiki Yamada, Nobuko Iikawa, Kazuhiro Shiina, Hidekazu Saito, Koh Koizumi, Yohei Kawasaki, Takechiyo YamadaAbstractNivolumab, a programmed death-1 (PD-1) inhibitor, has shown promising results against squamous cell carcinoma of the head and neck (SCCHN) in cases of recurrence or in a metastatic setting after platinum-based therapy. However, treatment alternatives...
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Abstract Objective To evaluate the effect of the 2013–2014 ACA Medicaid Primary Care Rate Increase on Medicaid-insured women’s prenatal care utilization, overall and by race and ethnicity. Methods We employed a difference-in-differences design, using births data from the 2010–2014 National Vital Statistics System. Our study population included approximately...
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Modern Pathology, Published online: 25 June 2019; doi:10.1038/s41379-019-0302-0A combination of the immunohistochemical markers CK7 and SATB2 is highly sensitive and specific for distinguishing primary ovarian mucinous tumors from colorectal and appendiceal metastases
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Related ArticlesSpatial Hearing processing: Electrophysiological documentation at subcortical and cortical levels. Int J Neurosci. 2019 Jun 24;:1-17 Authors: Rouhbakhsh N, Mahdi J, Hwo J, Nobel B, Mousave F Abstract Objective: Recognition of target signal improves when the target and distracted sources are spatially separated; an effect defined as 'spatial release from masking' (SRM). The neural mechanisms underpin SRM is complicated and still need to...
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Abstract Background Adverse drug reactions (ADRs) are undesirable effects to drugs at doses normally used in the clinical setting for diagnosis, treatment or prophylaxis of diseases. Spontaneous ADR reporting is currently considered as a critical part of ADRs detection. Objective The study aims to assess the knowledge, attitude, and practice of healthcare providers towards adverse drug reaction reporting in public and private settings within the Baghdad area. Method We follow a...
Abstract Background The survival rate of prostate cancer is relatively higher than other cancers, therefore, the health-related quality of life (HRQoL) becomes a critical issue for the patients. There are limited quality of life data evaluating the difference between androgen deprivation therapy and non-androgen deprivation therapy. Objective To evaluate the HRQoL among prostate cancer patients with androgen deprivation therapy and non-androgen deprivation therapy in an Asian population....
Abstract Background Internationally, antipsychotics are frequently initiated during hospital admission for older patients and use often continues post-discharge without indication. We located no Australian studies on this topic. Objective to identify the hospital admissions (excluding psychosis) associated with antipsychotic initiation and continuation in older Australians. Setting Australian Government Department of Veterans’ Affairs. Method Retrospective analysis of administrative...
Abstract Background Adverse drug reactions (ADRs) monitoring in cancer patients is important to ensure early detection, effective management and possible prevention subsequently. Objectives This study was conducted to detect and monitor ADRs to anti-cancer agents, and to assess impact of clinical pharmacists (CPs)’ interventions in minimizing ADRs to anti-cancer agents. Setting Private, specialty oncology care hospital in South India. Methods CPs prospectively followed cancer patients...
Abstract Background For the large number of systemic lupus erythematosus (SLE) patients in China, it is critical to carry out effective disease management to improve the treatment effect and reduce disease burden. A pharmacist-led multidisciplinary care model has not been reported in Chinese SLE patients before. Objective To assess the effect of patient-centered, pharmacist-led, multidisciplinary care on clinical outcomes and satisfaction with health care in Chinese SLE patients....
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Related ArticlesComputerized ultrasonic axiographic evaluation of condylar movement in patients with internal derangement of the temporomandibular joint. Angle Orthod. 2019 Jun 24;: Authors: Choi BT, Hwang DY, Lee GH, Moon DN, Lee KM Abstract OBJECTIVES: To evaluate condylar movement during lateral excursion in individuals with internal derangement of the temporomandibular joint (TMJ) using ultrasonic axiography. MATERIALS AND METHODS: A total...
Related ArticlesTreatment effects of the Carriere® Motion 3D™ appliance for the correction of Class II malocclusion in adolescents. Angle Orthod. 2019 Jun 24;: Authors: Kim-Berman H, McNamara JA, Lints JP, McMullen C, Franchi L Abstract OBJECTIVES: To determine the treatment effects produced in Class II patients by the Carriere® Motion 3D™ appliance (CMA) followed by full fixed appliances (FFA). MATERIALS AND METHODS: This retrospective study...
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Abstract Klebsiella sp. TN-10, isolated from tannery wastewater, exhibited excellent nitrification ability cultivated in media with NaCl contents ranging from 0 to 35 g/L. Analysis of antioxidative enzyme activities of TN-10 stressed by NaCl showed that the stain produced more superoxide dismutase (SOD) and catalase (CAT) to fight against salt stress conditions. Moreover, the auto-aggregation index of TN-10 decreased with the increment of NaCl contents, which is consistent with...
Abstract Recently, China is named among the most carbon dioxide (CO2)-emitting countries in the world after the United State of America (USA). A major part of Chinese carbon dioxide emissions is as a result of offshore industrial activities which come into the economy as foreign direct investment (FDI). Following this, the present study seeks to investigate the nexus between CO2 emissions, FDI, energy use, and tourism arrivals, and possibly to advise on who will bear the responsibility...
Abstract Trace metal element contamination in mining areas is always a huge environmental challenge for the global mining industry. In this study, an abandoned sphalerite mine near the Yanshan Mountains was selected as subject to evaluate the soil and water contamination caused by small-scale mining. The results show that (1) Pearson correlation matrix and principal component analysis (PCA) results reveal that Zn, Cu, Cd, and Pb were greatly affected by the operation of mines,...
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