Association between asthma, rhinitis and conjunctivitis multimorbidities with molecular IgE sensitization in adults

from Allergy and Immunology via a.sfakia on Inoreader https://ift.tt/2DJgZlI

Xray features Chronic Osteomyelitis :DAMS eQ Series

Sharing brief video about visual multiple choice question on chronic osteomyelitis in DAMS eQ series.

Famous Radiology Blog https://ift.tt/1MM2hKr TeleRad Providers at https://ift.tt/1NgppuI Mail us at sales@teleradproviders.com

from Imaging via a.sfakia on Inoreader https://ift.tt/2Sa6CeH

Influence of glass-ceramic coating on composite zirconia bonding and its characterization

Publication date: Available online 24 November 2018

Source: Dental Materials

Author(s): Putsadeeporn Thammajaruk, Supanee Buranadham, Ornnicha Thanatvarakorn, Marco Ferrari, Massimiliano Guazzato

Abstracts

Objective

The aims of this study were to compare micro-tensile bond strength and characterize the bond of ceramic-coated versus air-abraded and chemically treated zirconia specimens.

Methods

Eight zirconia blocks were fabricated and assigned to two groups as follows: AA-alumina air-abrasion; and CC-DCMhotbond coating followed by alumina air-abrasion and hydrofluoric acid etching. For each group, two identically pre-treated zirconia blocks were applied G-Multi Primer, cemented together with G-Cem Linkforce cement and cut into 30 stick-shaped specimens (1 × 1 × 9 mm³). A total of 120 specimens were stored in distilled water for 24 h and then assigned to three groups: (i) short-term test, (ii) thermocycling for 5000, and (iii) thermocycling for 10,000 cycles. The specimens were tested in tensile mode. The bond strength results were analyzed using two-way ANOVA, followed by one-way ANOVA and Dunnett T3 (α = 0.05). Failure mode and surfaces were analyzed with optical microscopy and SEM. The EDS, FTIR, XRD, and FIB-SEM were used for chemical, crystalline phase analyses.

Results

The AA groups recorded higher mean bond strength than the CC groups in all aging conditions. Thermocycling did not affect the bond strength of the AA groups, whereas the bond strength of the CC groups decreased significantly after aging. The MDP monomer and silane in G-Multi Primer chemically reacted with mechanically pre-treated AA and CC surfaces via the absorption of P–O and Si–O groups.

Significance

The bond strength of a conventional protocol involving alumina air-abrasion was greater than ceramic coating technique.

from OroFacial via a.sfakia on Inoreader https://ift.tt/2DItL3P

Anesthetic Management for Medialization Laryngoplasty Performed Under Concurrent Dexmedetomidine, Remifentanil, and Propofol Infusions

Publication date: Available online 25 November 2018

Source: Journal of Voice

Author(s): Megan C. Hamre, Dale C. Ekbom, Kathryn S. Handlogten, Toby N. Weingarten, Troy G. Seelhammer

Abstract

Introduction

Type I thyroplasty, or medialization larygoplasty (ML), is a procedure which improves the voice by medializing a vocal fold with a permanent implant. Anesthetic management of these cases is challenging because patients can require periods of deep sedation followed by fully awake moments for phonation to assess the implant size. We present our experience of ML with or without arytenoid adduction (AA) using a multimodal anesthetic regimen consisting of concurrent infusions of dexmedetomidine, remifentanil, and propofol.

Methods

This is a retrospective case series of patients anesthetized using this protocol from June 1, 2015 through June 30, 2017.

Results

Seventy-five consecutive ML with or without AA patients anesthetized with dexmedetomidine and remifentanil infusions were identified, of which 74 (98.7%) also received concurrent propofol infusions. Mean duration of sedation was 190.9 ± 36.9 minutes and surgery was 139 ± 35.3 minutes. Transient hypopnea treated with supplemental oxygen complicated 18 (24%) cases and bradycardia requiring pharmacologic treatment complicated 3 (4%) cases. There were no other adverse anesthetic complications. One patient required surgical re-exploration due to postsurgical bleeding after the initial hospital discharge.

Conclusion

In this cohort, a combination of remifentanil, dexmedetomidine and propofol infusions was well tolerated without serious adverse perioperative events.

from Speech via a.sfakia on Inoreader https://ift.tt/2DVzAff

Perinatal probiotic intervention prevented allergic disease in a Caesarean‐delivered subgroup at 13‐year follow‐up

Abstract

Background

The long‐term effects of probiotic intervention for primary prevention of allergic diseases are not well known. We previously reported less eczema until 10 years in our probiotic intervention trial.

Objective

To investigate the effect of early probiotic intervention on the prevalence of allergic diseases up to 13 years of age.

Methods

Pregnant women (n=1223) carrying a child at a high risk of allergy (at least one parent with allergic disease) were randomised to receive a mixture of probiotics (Lactobacillus rhamnosus GG and LC705, Bifidobacterium breve Bb99 and Propionibacterium freudenreichii) or placebo in a double‐blind manner from 36 weeks of gestation until birth. Their infants received the same product for the first six months (registration number NCT00298337). At 13‐year follow‐up the participants were requested to return a questionnaire and to provide a blood sample.

Results

A questionnaire was returned by 642 participants (63.1% of intention‐to‐treat infants) and 459 provided a blood sample. In the whole cohort there were no statistically significant differences in doctor‐diagnosed allergic disease (55.2% and 59.0%, probiotic and placebo group, respectively) or allergic disease (47.9% and 51.6%) based on the ISAAC questionnaire data. Inhalant‐specific IgE‐sensitisation (>0.7 kU/L) was 59.3% in the probiotic group and 49.8% in the placebo group (p=0.040). In a post hoc analysis made in Caesarean‐delivered subgroup allergy was reported in 41.5% of the probiotic group and 67.9% of the placebo group (p=0.006), and eczema in 18.9% and 37.5% respectively (p=0.031). In the whole cohort 8.5% of the probiotic group had suffered from wheezing attacks during the previous 12 months vs. 14.7% in the placebo group (p=0.013). There was no statistically significant differences discovered between the characteristics of the participating group and the dropout‐group.

Conclusions

Probiotic intervention protected Caesarean‐delivered subgroup from allergic disease and eczema, but not the total cohort.

This article is protected by copyright. All rights reserved.

from Allergy and Immunology via a.sfakia on Inoreader https://ift.tt/2DUlgnb

Can we study 3D grid codes non-invasively in the human brain? Methodological considerations and fMRI findings

Publication date: Available online 24 November 2018

Source: NeuroImage

Author(s): Misun Kim, Eleanor A. Maguire

Abstract

Recent human functional magnetic resonance imaging (fMRI) and animal electrophysiology studies suggest that grid cells in entorhinal cortex are an efficient neural mechanism for encoding knowledge about the world, not only for spatial location but also for more abstract cognitive information. The world, be it physical or abstract, is often high-dimensional, but grid cells have been mainly studied on a simple two-dimensional (2D) plane. Recent theoretical studies have proposed how grid cells encode three-dimensional (3D) physical space, but it is unknown whether grid codes can be examined non-invasively in humans. Here, we investigated whether it was feasible to test different 3D grid models using fMRI based on the direction-modulated property of grid signals. In doing so, we developed interactive software to help researchers visualize 3D grid fields and predict grid activity in 3D as a function of movement directions. We found that a direction-modulated grid analysis was sensitive to one type of 3D grid model – a face-centred cubic (FCC) lattice model. As a proof of concept, we searched for 3D grid-like signals in human entorhinal cortex using a novel 3D virtual reality paradigm and a new fMRI analysis method. We found that signals in the left entorhinal cortex were explained by the FCC model. This is preliminary evidence for 3D grid codes in the human brain, notwithstanding the inherent methodological limitations of fMRI. We believe that our findings and software serve as a useful initial stepping-stone for studying grid cells in realistic 3D worlds and also, potentially, for interrogating abstract high-dimensional cognitive processes.

from Imaging via a.sfakia on Inoreader https://ift.tt/2QiSJ0q

Detection and quantification of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans in bacteremia induced by interdental brushing in periodontally healthy and periodontitis patients

Publication date: Available online 24 November 2018

Source: Archives of Oral Biology

Author(s): Nagore Ambrosio, María José Marín, Estefanía Laguna, David Herrera, Mariano Sanz, Elena Figuero

Abstract

Objective

This study was aimed to compare the presence and amounts of bacteremia induced by interdental brushing in healthy (H) and periodontitis (P) individuals using culture based (direct culture [DC]) and molecular based techniques (real-time quantitative polymerase chain reaction [qPCR]) in a cross-sectional study model.

Materials and Methods

After a full mouth periodontal evaluation, blood samples were taken before and 1 min after professionally-administered interdental tooth brushing. These samples were analyzed by DC and qPCR, targeting Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans. Subgingival samples were also collected and analyzed. Student t-test, chi-square tests correlations were used for analyzing the data.

Results

Thirty individuals per group were included. P. gingivalis and A. actinomycetemcomitans were detected with qPCR methods, but not with DC. At baseline, bacteremia was observed in 5 P patients (16.7%) and in 2 H individuals (6.6%) (p = 0.421). After interdental tooth brushing, bacteremia was only observed in 2 P patients (6.6%) (p = 0.901). A positive correlation between subgingival and blood levels of A. actinomycetemcomitans was observed (r = 0.3; p = 0.013).

Conclusion

Bacteremia related to A. actinomycetemcomitans and P. gingivalis did not significantly increase after a single session of use of interdental brushes.

from OroFacial via a.sfakia on Inoreader https://ift.tt/2KvnR7H