Series Type : Expression profiling by high throughput sequencing
Organism : Mus musculus
The goal of this study is to compare transcriptome profiles of epididymal adipose tissue from wildtype mice and mice with a targeted inactivation of mesoderm specific transcript (Mest) fed a high fat diet from 8 to 16 weeks of age to gain insight for MEST function.
Gene expression profiling resulted in relatively few changes (~36 targets; FDR padjGene pathway analyses of differentially expressed genes showed decreased expressed of genes associated with immune response and inflammation in high fat diet-fed mice with inactivated Mest compared with wildtype mice. Transcritome analyses supported phenotypic measurements which indicated improved glucose homeostasis in mice with inactivated Mest.
from # All Medicine by Alexandros G. Sfakianakis via alkiviadis.1961 on Inoreader http://ift.tt/2iaLyI1
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