Astrocytes control synaptic strength by two distinct v-SNARE-dependent release pathways

Astrocytes control synaptic strength by two distinct v-SNARE-dependent release pathways

Nature Neuroscience, Published online: 25 September 2017; doi:10.1038/nn.4647

The mechanisms of gliotransmitter release and their impact on neuronal signaling have remained largely elusive. The authors describe two functionally non-overlapping v-SNARE-dependent astrocytic release pathways that oppositely control synaptic strength at presynaptic sites. Thus, astrocytes are able to fine-tune fast glutamatergic neurotransmission and control fundamental processes of synaptic communication.

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