Source:Journal of Functional Foods, Volume 38, Part A
Author(s): Linlin Wang, Mingluo Pan, Dongyao Li, Yiting Yin, Tian Jiang, Shuguang Fang, Gang Wang, Jianxin Zhao, Hao Zhang, Wei Chen
The aim of this study was to evaluate the effects of different kinds of oligosaccharides on cecal microbiota. These oligosaccharides were a fructo-oligosaccharide (FOS) formulation consisting of 95% FOS (FOS95), a galacto-oligosaccharide (GOS) formulation consisting of 90% GOS (GOS90), and an isomalto-oligosaccharide (IMO) formulation consisting of 90% IMO (IMO90), at dosages of 0.8, 4, and 8g/d/kg bw. FOS95, IMO90, and GOS90 were each gavaged to BALB/c mice for 14days. Sequencing of 16S rDNA amplicons showed that the abundance of Actinobacteria and TM7 dramatically decreased in constipation group. Feeding constipated mice with FOS95, IMO90, and GOS90 resulted in decreased ratio of Firmicutes to Bacteroidetes, and increased abundances of Bifidobacterium, Bacteroides, Rikenella, Lactobacillus, and Clostridium and decreased abundances of Oscillospira, Coprococcus, and Dorea at the genus level. Overall, our results demonstrate that FOS95, IMO90, and GOS90 modulate the cecal microbiome in constipated mice.
from # All Medicine by Alexandros G. Sfakianakis via alkiviadis.1961 on Inoreader http://ift.tt/2wP8T8I
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