Spatially restricted JAG1-Notch signaling in human thymus provides suitable DC developmental niches

Martín-Gayo et al. report that human early thymic progenitors can undergo a GATA2-dependent myeloid developmental program leading to resident dendritic cells (DCs) upon JAG1-Notch activation. The identification of JAG1⁺ DC-permissive intrathymic niches validates the human thymus as a DC-poietic organ.

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