GSE89710 Expression data from xenografted human leukemia cells comparing leukemic cells engrafted in the central nervous system (CNS) to leukemic cells derived from bone marrow (BM)

Contributors : Vera Muench ; Luca Trentin ; Julia Herzig ; Salih Demir ; Felix Seyfried ; Johann M Kraus ; Hans A Kestler ; Rolf Koehler ; Geertruy te Kronnie ; Klaus-Michael Debtain ; Lueder H Meyer
Series Type : Expression profiling by array
Organism : Homo sapiens

CNS leukemia is still the major obstacle in treating childhood acute lymphoblastic leukemia (ALL). We have used our NOD/SCID/huALL xenotransplantation model to identify molecular pathways leading to the infiltration of leukemic cells into the CNS compartment.
We analysed gene expression differences of leukemic cells isolated from CNS and BM of CNS-positive samples using a microarray approach to detect expression differences between different infiltrated compartments.

from # All Medicine by Alexandros G. Sfakianakis via alkiviadis.1961 on Inoreader http://ift.tt/2uI2kDK