α-synuclein interacts with PrPC to induce cognitive impairment through mGluR5 and NMDAR2B
Nature Neuroscience, Published online: 25 September 2017; doi:10.1038/nn.4648
The precise underpinnings of Parkinson's disease and other disorders associated with the accumulation of α-synuclein are unclear. This study shows that PrPC mediates α-synuclein-associated synaptic dysfunction and memory deficits. Blocking specific events in receptor biology rescued cognitive deficits in mice, suggesting new possibilities for intervention in synucleinopathies.
from # All Medicine by Alexandros G. Sfakianakis via alkiviadis.1961 on Inoreader http://ift.tt/2xv7bXh
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