α-synuclein interacts with PrPC to induce cognitive impairment through mGluR5 and NMDAR2B

α-synuclein interacts with PrP^C to induce cognitive impairment through mGluR5 and NMDAR2B

Nature Neuroscience, Published online: 25 September 2017; doi:10.1038/nn.4648

The precise underpinnings of Parkinson's disease and other disorders associated with the accumulation of α-synuclein are unclear. This study shows that PrP^C mediates α-synuclein-associated synaptic dysfunction and memory deficits. Blocking specific events in receptor biology rescued cognitive deficits in mice, suggesting new possibilities for intervention in synucleinopathies.

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