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Wednesday, December 13, 2017

Towards evidence-based medicine for paediatricians

Spirals of revalidation

In the eyes of those statistically minded, revalidation will make them think of the process of assuring a prediction model, which may be prognostic, diagnostic or risk based, to check it is still valid, perhaps after calibration. Model, in this setting, just means fancy equation, or 'maths machinery', rather than tiny die-cast toys. To many clinicians, revalidation just means paperwork and tears.

The basic idea of validation is to check a prediction model, for example, a way of estimating the prognosis of a patient admitted to paediatric intensive care unit, is still accurate and any factors in the model work to discriminate between the high-risk and low-risk cases. It might be that if overall survival has improved, the model still works, but needs its sights overall raising a little.

Alternatively, it might be that the factors which were hugely prognostic previously just are not as discriminating; we may have...



from # All Medicine by Alexandros G. Sfakianakis via alkiviadis.1961 on Inoreader http://ift.tt/2ARAzZv

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