Blog Archive

Search This Blog

Tuesday, November 27, 2018

Are antithrombotic agents necessary for head and neck microvascular surgery?

Publication date: Available online 26 November 2018

Source: International Journal of Oral and Maxillofacial Surgery

Author(s): W. Zhou, W.-B. Zhang, Y. Yu, Y. Wang, C. Mao, C.-B. Guo, G.-Y. Yu, X. Peng

Abstract

The aim of this prospective study was to determine the effect of antithrombotic agents in preventing thrombosis after head and neck reconstructive surgery. A randomized clinical trial of referred patients undergoing free flap surgery between February 2015 and July 2017 was conducted. Four hundred and fifty-four patients were randomly assigned to group A (n = 153), administered aspirin and low molecular weight dextran; group B (n = 150), administered low molecular weight heparin; and group C (n = 151), not administered any antithrombotic agent. Patient demographic characteristics, donor site, thrombosis, haematoma, and flap failure were recorded. Coagulation values including platelet count, prothrombin time, and activated partial thromboplastin time were measured during the perioperative period. Repeated-measures ANOVA and the χ2 test were used for data comparisons. No significant inter-group differences were observed for postoperative microvascular thrombosis (P = 0.536) or flap failure (P = 0.615) among the three groups. There were more postoperative haematoma revisions in group B than in groups A and C (P = 0.032). It is concluded that postoperative antithrombotic agents neither provide a significant improvement in the free flap success rate nor decrease the risk of thrombosis and may increase the risk of haematoma.



from OroFacial via a.sfakia on Inoreader https://ift.tt/2P20SBO

No comments:

Post a Comment

Note: Only a member of this blog may post a comment.

Blog Archive

Pages

   International Journal of Environmental Research and Public Health IJERPH, Vol. 17, Pages 6976: Overcoming Barriers to Agriculture Green T...