Publication date: Available online 19 November 2018
Source: Ultrasound in Medicine & Biology
Author(s): Haitham Ballo, Miikka Tarkia, Matti Haavisto, Christoffer Stark, Marjatta Strandberg, Tommi Vähäsilta, Virva Saunavaara, Tuula Tolvanen, Mika Teräs, Ville-Veikko Hynninen, Timo Savunen, Anne Roivainen, Juhani Knuuti, Antti Saraste
Abstract
We evaluated the relationships between regional myocardial strain measured by speckle tracking echocardiography and viability, fibrosis, hypertrophy and oxygen consumption in the infarcted or remote myocardium in a pig model of chronic myocardial infarction (MI). Thirteen farm pigs with surgical occlusion of the left anterior descending coronary artery and five sham-operated pigs were studied 3 mo post-MI. Computed tomography revealed significant left ventricle remodeling. Reduced radial or circumferential strain identified areas of transmural infarction (area under the curve: 0.82 and 0.79, respectively). In the remote non-infarcted area, radial strain correlated inversely with the amount of fibrosis (r = –0.66, p = 0.04) and myocyte hypertrophy (r = –0.68, p = 0.03). Radial strain rate inversely correlated with myocardial resting oxygen consumption assessed with 11C-labeled acetate positron emission tomography (r = –0.71, p = 0.006). In conclusion, myocardial strain and strain rate reflect fibrosis, hypertrophy and oxygen consumption of the remote areas after MI.
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