Abstract
Single‐cell RNA‐sequencing and colony‐forming assays suggest that bone marrow hematopoietic stem and progenitor cells traverse through a differentiation landscape before commitment to the mast cell and other cell lineages.1 However, the bone marrow contribution for the formation of tissue‐resident mast cells has been questioned, and the prenatal origin of mast cells was recently uncovered.2 Through fate mapping experiments Gentek et al2 elegantly demonstrated that mast cells arise during two distinct waves of the embryonic development, one from the yolk sac and the other via the aorta‐gonad‐mesonephros.
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