The absence of an association between Interleukin 1β gene polymorphisms and recurrent aphthous stomatitis (RAS).

The absence of an association between Interleukin 1β gene polymorphisms and recurrent aphthous stomatitis (RAS).

Arch Oral Biol. 2017 Sep 19;84:45-49

Authors: Ślebioda Z, Kowalska A, Rozmiarek M, Krawiecka E, Szponar E, Dorocka-Bobkowska B

Abstract
OBJECTIVES: Recurrent aphthous stomatitis (RAS) is a chronic, ulcerative disease with a probable polygenic mode of inheritance and complex etiology with a strong immunological background. The aim of the present study was to determine the possible association between two single nucleotide polymorphisms (SNPs) of the IL-1β gene: IL-1β-511 T>C (rs16944) and IL-1β+3954C>T (rs1143634) and RAS susceptibility in a moderately large group of patients.
DESIGN: One hundred and four patients with minor, major and herpetiform RAS and 75 healthy volunteers were genotyped at IL-1β-511 T>C (rs16944) and IL-1β+3954C>T (rs1143634) using the PCR-RFLP approach. The results were statistically analysed with chi-square test and test of difference between two rates of structure, with p<0.05 assumed to be a statistically significance level (Statistica 10, StatSoft(®), Kraków, Poland).
RESULTS: There were no statistically significant differences in the genotype distribution for the IL-1β C[+3954]T polymorphism between the RAS and control groups. The frequency of IL-1β*T[-511]/*T[-511] homozygotes among the patients was significantly higher when compared to our study control (p<0.0347). The results after stratification into carriers and non-carriers of C and T alleles did not clearly indicate which SNP may be considered a risk factor for RAS.
CONCLUSIONS: The genetic association between the studied SNPs of the IL-1β gene and RAS remains controversial and requires further investigation.

PMID: 28942153 [PubMed - as supplied by publisher]

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