ZNF516 suppresses EGFR by targeting the CtBP/LSD1/CoREST complex to chromatin
Nature Communications, Published online: 25 September 2017; doi:10.1038/s41467-017-00702-5
EGFR is a well-known oncogene; however, the mechanisms regulating its expression are still unclear. Here, analysing genome-wide chromatin associations, the authors show that in breast cancer cells ZNF516 represses EGFR transcription through the interaction with the CtBP/LSD1/CoREST complex.
from # All Medicine by Alexandros G. Sfakianakis via alkiviadis.1961 on Inoreader http://ift.tt/2fldfcT
No comments:
Post a Comment
Note: Only a member of this blog may post a comment.