A pH-gated conformational switch regulates the phosphatase activity of bifunctional HisKA-family histidine kinases

A pH-gated conformational switch regulates the phosphatase activity of bifunctional HisKA-family histidine kinases

A pH-gated conformational switch regulates the phosphatase activity of bifunctional HisKA-family histidine kinases, Published online: 13 December 2017; doi:10.1038/s41467-017-02310-9

Bacteria adapt to changing environmental conditions through signal transduction mediated by the two-component system (TCS). Here, the authors combine X-ray crystallography and NMR studies to characterize a pH-gated conformational switch that regulates the phosphatase activity of TCS bifunctional histidine kinases.

from # All Medicine by Alexandros G. Sfakianakis via alkiviadis.1961 on Inoreader http://ift.tt/2AB9woE