In situ functional dissection of RNA cis-regulatory elements by multiplex CRISPR-Cas9 genome engineering

In situ functional dissection of RNA cis-regulatory elements by multiplex CRISPR-Cas9 genome engineering

In situ functional dissection of RNA <i>cis</i>-regulatory elements by multiplex CRISPR-Cas9 genome engineering, Published online: 13 December 2017; doi:10.1038/s41467-017-00686-2

RNA regulatory elements (RREs) are important post-transcriptional control features but studying them requires disrupting their activity without disturbing cellular homeostasis. Here the authors present GenERA, a CRISPR-Cas9 screening platform of in situ analysis of native RREs.

from # All Medicine by Alexandros G. Sfakianakis via alkiviadis.1961 on Inoreader http://ift.tt/2Aza51V