PI3Kδ activates E2F1 synthesis in response to mRNA translation stress

PI3Kδ activates E2F1 synthesis in response to mRNA translation stress

PI3Kδ activates E2F1 synthesis in response to mRNA translation stress, Published online: 13 December 2017; doi:10.1038/s41467-017-02282-w

The oncogenic activity of EBNA1 protein is unknown; it contains a glycine and alanine repeat sequence (GAr) which regulates its own translation in cis. Here the authors show that GAr stimulates PI3Kδ-mediated induction of E2F1 translation, leading to c-Myc induction and stimulation of proliferation.

from # All Medicine by Alexandros G. Sfakianakis via alkiviadis.1961 on Inoreader http://ift.tt/2ylNkbP