In vivo effects of geranylgeraniol on the development of bisphosphonate-related osteonecrosis of the jaws

Bisphosphonate-related osteonecrosis of the jaws (BRONJ) as a complication of bisphosphonate (BP) treatment is an area of increased research interest. Although several hypotheses have been proposed (Ruggiero et al., 2014), none of them fully explain the nature and mechanism of development of the disease. However, the theory that supports the inhibition of bone resorption with mediation of osteoclastic activity is the most well researched. On the other hand, studies showed that the BPs have toxic effects on soft tissue cells, as well (Landesberg et al.

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