The Relationship of Exhaled Nitric Oxide with Ethnicity and Gender in Rural Georgia YouthAuthors

Nitric oxide is produced by the human bronchial epithelium1 and is associated with airway eosinophilic inflammation seen in asthmatics and other airway diseases.2 Airway inflammation is a characteristic of asthma, along with airway hyper-responsiveness and airway obstruction. Inhaled corticosteroids (ICS) to treat the inflammation are a mainstay of asthma treatment. Measurement of exhaled nitric oxide (eNO) as a biomarker of eosinophilic inflammation is noninvasive, safe, reproducible, and easy to perform; however, the clinical value of measurements has been limited by imprecise reference ranges.

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