Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo

Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo

Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo, Published online: 20 November 2017; doi:10.1038/s41593-017-0022-z

Apicco and colleagues show that reducing TIA1 inhibits tau-mediated neurodegeneration and improves survival in a mouse model of tauopathy. This rescue occurs with a transition in tau aggregation from oligomeric to fibrillar forms of tau. These findings suggest a key role for RNA binding proteins in the pathophysiology of tau.

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