Cancers, Vol. 11, Pages 885: MiRNAs Are Involved in Tall Cell Morphology in Papillary Thyroid CarcinomaCancers doi: 10.3390/cancers11060885Authors:Laura A. BoosAnja SchmittHolger MochPaul KomminothCedric SimillionIlaria MarinoniYuri E. NikiforovMarina N. NikiforovaAurel PerrenMatthias S. DettmerFive percent of papillary thyroid carcinomas (PTC) show an adverse clinical outcome (ACO). The tall cell variant of papillary thyroid carcinomas (TCV) is a good predictor of an ACO, however, the identification...
Cancers, Vol. 11, Pages 884: Loss of PTEN in Fallopian Tube Epithelium Results in Multicellular Tumor Spheroid Formation and Metastasis to the OvaryCancers doi: 10.3390/cancers11060884Authors:Matthew DeanVivian JinTova M. BergstenJulia R. AustinDaniel D. LantvitAngela RussoJoanna E. BurdetteHigh-grade serous ovarian cancer (HGSOC) can originate in the fallopian tube and then spread to the ovary. Our objective was to evaluate the role of multicellular tumor spheroids (MTS) in ovarian metastasis. By...
Cancers, Vol. 11, Pages 883: Chemotherapeutic Drugs Inhibiting Topoisomerase 1 Activity Impede Cytokine-Induced and NF-κB p65-Regulated Gene ExpressionCancers doi: 10.3390/cancers11060883Authors:Tabea RiedlingerMarek BartkuhnTobias ZimmermannSandra B. HakeAndrea NistThorsten StieweMichael KrachtM. Lienhard SchmitzInhibitors of DNA topoisomerase I (TOP1), an enzyme relieving torsional stress of DNA by generating transient single-strand breaks, are clinically used to treat ovarian, small cell lung...
Cancers, Vol. 11, Pages 882: Molecular Comparison of Imatinib-Naïve and Resistant Gastrointestinal Stromal Tumors: Differentially Expressed microRNAs and mRNAsCancers doi: 10.3390/cancers11060882Authors: Amirnasr Gits van Kuijk Smid Vriends Rutkowski Sciot Schöffski Debiec-Rychter Sleijfer WiemerDespite the success of imatinib in advanced gastrointestinal stromal tumor (GIST) patients, 50% of the patients experience resistance within two years of treatment underscoring the need to get better insight...
Cancers, Vol. 11, Pages 881: (Pro)renin Receptor Expression Increases throughout the Colorectal Adenoma—Adenocarcinoma Sequence and It Is Associated with Worse Colorectal Cancer PrognosisCancers doi: 10.3390/cancers11060881Authors:Maider BeitiaJon Danel Solano-IturriPeio ErrarteJulio Calvete-CandenasAlberto LoizateMari Carmen EtxezarragaBegoña SanzGorka Larrinaga(Pro)renin receptor (PRR) is a protein that takes part in several signaling pathways such as Renin Angiotensin System and Wnt signalling....
Cancers, Vol. 11, Pages 880: Role of Bruton’s Tyrosine Kinase in Stage III Colorectal CancerCancers doi: 10.3390/cancers11060880Authors:Debora BasileLorenzo GerratanaAngela BuonadonnaSilvio Ken GarattiniTiziana PerinEmanuela GrassilliGianmaria MioloMaria Grazia CerritoClaudio BellucoGiulio BertolaAntonino De PaoliRenato CannizzaroMarialuisa LavitranoFabio PuglisiVincenzo CanzonieriBackground: Bruton’s tyrosine kinase (BTK) is involved in the immune response and its deficiency impairs B...
Cancers, Vol. 11, Pages 879: Prognostic Role of Albumin, Bilirubin, and ALBI Scores: Analysis of 1000 Patients with Hepatocellular Carcinoma Undergoing RadioembolizationCancers doi: 10.3390/cancers11060879Authors:Mark AntkowiakAhmed GabrArighno DasRehan AliLaura KulikDaniel GangerChristopher MooreMichael AbecassisNitin KatariyaSamdeep MouliDevalingam MahalingamRobert J. LewandowskiRiad SalemAhsun RiazIntroduction: We compared the efficacy of the ALBI (albumin–bilirubin) score to the established...
Cancers, Vol. 11, Pages 878: Targeting of Histone Demethylases KDM5A and KDM6B Inhibits the Proliferation of Temozolomide-Resistant Glioblastoma CellsCancers doi: 10.3390/cancers11060878Authors:Massimo RomaniAntonio DagaAlessandra ForlaniMaria Pia PistilloBarbara BanelliLysine histone demethylases (KDMs) are considered potential therapeutic targets in several tumors, including glioblastoma (GB). In particular, KDM5A is involved in the acquisition of temozolomide (TMZ) resistance in adult GB cells...
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