Postmenopausal decline in sex hormones may modulate the brain‐gut axis and increase severity of IBS. Abstract Background Although irritable bowel syndrome (IBS) is more common in women, little is known about the role of hormonal changes and menopause in IBS. This study aimed to evaluate for differences in gastrointestinal (GI) and psychological symptoms between pre‐ and postmenopausal women with IBS compared to age‐matched men with IBS. Methods Patients with Rome‐positive IBS were identified....
Fri May 29, 2020 22:00
Volumetric analysis of small bowel motility in an unselected cohort of patients with Crohn’s disease
Inclusion of healthy volunteers and all consecutive patients referred for magnetic resonance enterography during a 2‐year period. Motility indices were calculated and related to clinical signs and symptoms. 22 healthy controls and 134 examinations of patients with Crohn’s disease were enrolled. Motility index was lower in ileum and terminal ileum in patients compared with controls, which correlated inversely with mural thickness in the terminal ileum. There was no correlation between bowel symptoms...
Fri May 29, 2020 13:19
Abstract Background Commonly used methods to measure whole gut transit time in rodents have yet to combine high sensitivity, objectivity, and automation. We have developed a novel method using oral gavage of non‐toxic fluorescent dye particles and their detection by fluorescence imaging to enable unbiased automated detection of gut transit time simultaneously in 8 cages. Methods Naïve mice (n = 20) were gavaged with a non‐caloric viscous suspension of 4.4% fluorescent dye in 3 groups on...
Fri May 29, 2020 12:47
Fri May 29, 2020 18:34
Summary Prior to the first international consensus classification published in 1993, the clinical distinction between erythema multiforme (EM), Stevens‐Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) had been subject to uncertainty and controversy for more than a century. Based on this classification, the three conditions are defined by the morphology of the individual lesions and their pattern of distribution. Etiopathogenetically, the majority of EM cases is caused by infections (primarily...
Fri May 29, 2020 18:33
Summary Background Rosacea is a common chronic inflammatory cutaneous disorder affecting nearly 5.5 % of the adult population. Our aim was to evaluate the prevalence and epidemiology of rosacea and perioral dermatitis (POD) in an ambulatory care setting. Methods We retrospectively analyzed medical data of patients with a confirmed diagnosis of rosacea or perioral dermatitis (POD) presenting at our university hospital outpatient clinic during a 3‐year period. Results Out of 1032 patients,...
Fri May 29, 2020 18:32
Fri May 29, 2020 18:32
Summary Background In recent years, there has been a significant increase in scabies infestations throughout German‐speaking countries. Given the high frequency of treatment failures, the question arises as to whether topical permethrin treatment is always performed correctly. Patients and methods Our department uses a fluorescent test cream to teach patients on how to correctly apply topical permethrin. In the context of a prospective observational study of 21 patients, we systematically...
Fri May 29, 2020 18:30
Fri May 29, 2020 18:30
Summary Perianal dermatitis (anal eczema, perianal eczema) is one of the most common proctological conditions. It may occur as a sequela or a presenting symptom of various proctological, dermatological, allergic or pathogen‐induced disorders. The three main types of anal eczema are irritant‐toxic, atopic and allergic contact dermatitis. Adequate and successful treatment requires a comprehensive diagnostic workup to determine disease etiology and includes treatment/elimination of causative factors...
Fri May 29, 2020 18:30
Publication date: Available online 29 May 2020Source: Radiotherapy and OncologyAuthor(s): Kaiqi Lan, Jinhan Zhu, Jun Zhang, Sha Zhou, Yadi Yang, Zizhen Feng, Li Zhang, Shi Wang, Mian Xi
Sat May 30, 2020 00:23
Publication date: Available online 29 May 2020Source: Radiotherapy and OncologyAuthor(s): Vladimir Suárez, Elena Moreno-Olmedo, María Pérez, Esq. José González, Daniel Rivas, Juan Fusco, Penny Kechagioglou, Escarlata Lopez
Sat May 30, 2020 00:23
Publication date: Available online 29 May 2020Source: Radiotherapy and OncologyAuthor(s): Nan Bi, Junlin Yi, Jianrong Dai, Shulian Wang, Zongmei Zhou, Kuo Men, Jing Jin, Shugeng Gao, Yexiong Li, Jie He
Sat May 30, 2020 00:23
Publication date: Available online 29 May 2020Source: Radiotherapy and OncologyAuthor(s): Rao Khan, Arash Darafsheh, Mehran Goharian, Savino Cilla, J. Eduardo Villarreal-Barajas
Sat May 30, 2020 00:23
Publication date: Available online 29 May 2020Source: Radiotherapy and OncologyAuthor(s): Matthew S. Ning, Mary Frances McAleer, Melenda D. Jeter, Bruce D. Minsky, Robert A. Ghafar, Ivy J. Robinson, Paige L. Nitsch, Denise J. Zaebst, Sarah E. Todd, Jennifer Nguyen, Steven H. Lin, Zhongxing Liao, Percy Lee, G. Brandon Gunn, Ann H. Klopp, Bouthaina S. Dabaja, Quynh-Nhu Nguyen, Gregory M. Chronowski, Elizabeth S. Bloom, Albert C. Koong
Sat May 30, 2020 00:23
Publication date: Available online 29 May 2020Source: Radiotherapy and OncologyAuthor(s): Keisuke Tamari, Yasushi Nagata, Shingo Nishiki, Satoaki Nakamura, Kazuhiko Ogawa, Takashi Uno
Sat May 30, 2020 00:23
Publication date: Available online 28 May 2020Source: Radiotherapy and OncologyAuthor(s): Alexia Francesca Bertuzzi, Nicolò Gennaro, Andrea Marrari, Armando Santoro
Sat May 30, 2020 00:23
Publication date: Available online 28 May 2020Source: Radiotherapy and OncologyAuthor(s): Lucas C. Mendez, Hamid Raziee, Melanie Davidson, Vikram Velker, David D'Souza, Elizabeth Barnes, Eric Leung
Sat May 30, 2020 00:23
Abstract Background We hypothesized that the total operative time of robot myomectomy (RM) is shorter than that of laparoscopic myomectomy (LM) in cases where numerous myomas are removed, due to the faster suturing time of the robotic system. To verify this, we compared the surgical outcomes of RM vs LM for the number of myomas removed. Methods The medical records of 144 women underwent LM and 121 women underwent RM by a single surgeon were reviewed. Results The operative time did...
Fri May 29, 2020 17:23
Modern radiotherapy delivery systems and treatment strategies are aimed at limiting the irradiation of healthy structures in the head and neck. This seeks to mitigate post-treatment toxicities and complications such as osteoradionecrosis of the jaw. Given the changes to radiotherapy, conventional workflows for the management of patients requiring dentoalveolar surgery may no longer be suitable. It may therefore be appropriate to revisit current treatment algorithms for the management of patients...
Fri May 29, 2020 03:00
Immune checkpoint inhibition leads to response in some patients with head and neck squamous cell carcinoma (HNSCC). Robust biomarkers are lacking to date. We analyzed viral status, gene expression signatures, mutational load and mutational signatures in whole exome and RNA‐sequencing data of the HNSCC TCGA dataset (N = 496) and a validation set (DKTK MASTER cohort, N = 10). Public single‐cell gene expression data from 17 HPV‐negative HNSCC were separately re‐analyzed. APOBEC3‐associated TCW motif...
Fri May 29, 2020 22:23
Neoadjuvant chemotherapy (NACT) in early breast cancer (EBC) enables in vivo sensitivity testing and less radical surgery as compared to primary surgery and adjuvant chemotherapy (ACT). The aim of this study is to illustrate trends of systemic treatment of EBC. The study analyzed chemotherapy usage and time trends for patients with EBC treated at 104 German breast units between January 2008 and December 2017. The data were obtained through a quality‐controlled benchmarking process. Altogether, 124,084...
Thu May 28, 2020 21:53
Personalised cancer treatment depends on identification of therapeutically relevant biological subgroups of patients for assessing effect of treatment and to discover new therapeutic options. By analyses in heterogeneous patient populations the effects may be lost in noise. Squamous cell carcinoma of the lung is a major killer world‐wide. Despite recent advances, mortality is high and response to therapies varies greatly from patient to patient. Target search in biologically relevant subgroups may...
Thu May 28, 2020 21:40
Publication date: Available online 29 May 2020Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Toshinori Hasegawa, Takenori Kato, Takehiro Naito, Takafumi Tanei, Kazuki Ishii, Eisuke Tsukamoto, Kou Okada
Fri May 29, 2020 22:42
This piece is part of an SEAA series on “An Anthropology of Ethics in East Asia.” The articles examine how individuals cope with societal changes such as environmental crises, nationalism, economic development, and mobility through lens of everyday ethics. My conversation with care manager Zhang, the woman supervising the care workers among whom I conducted my fieldwork, came to a halt when she said, “Most care workers are here because they have no better options. They could easily be migrant workers...
Fri May 29, 2020 21:30
Gabrielle Oliveira is the recipient of the 2019 Council on Anthropology and Education Outstanding Book Award. Here, she recounts findings from the ethnographic study that is the basis of her award-winning book, Motherhood Across Borders: Immigrants and Their Children in Mexico and New York. Sarah (pseudonym) sat at her kitchen table in her apartment in New York City pounding chicken breasts so she could drench them in egg wash and flour to then fry them. It was her son Agustín’s (13 years old)...
Fri May 29, 2020 19:30
Image description: Blue and red hands reach toward a white ballot box. Each hand holds a small square of paper with an x marked on it. iStockTo mark the centenary of the ratification of the Nineteenth Amendment to the US Constitution, Anthropology News is turning an anthropological eye on voting and voting rights. What does anthropology tell us about suffrage movements at different times and in different places? Which suffrage stories have been occluded or overlooked? What voting rights struggles...
Fri May 29, 2020 19:08
Abstract Dizziness is the description of a constellation of various symptoms that can create limitations in patients’ lives, often leading to psychological stress. The connection between mental distress, such as anxiety and depression, and dizziness disorders is increasingly better appreciated. Recent studies have shown that co‐morbid psychological disorders alongside a patient's dizziness may: a) contribute to the overall symptom burden in dizzy patients, b) worsen their quality of life, and c)...
Fri May 29, 2020 17:59
Abstract Purpose To test the null hypothesis of no significant deviation between the center of rotation (CROT) and the center of resistance (CRES) during space closure in Angle class II division 2 subjects achieved using a completely customized lingual appliance (CCLA) in combination with class II elastics and elastic chains. Methods This retrospective...
Fri May 29, 2020 03:00
Abstract Aim The aim of this study was to evaluate the occlusal force distribution (OFD), individual tooth force (ITF), and occlusal surface area (OSA) of Essix and Hawley retainers, using T‑Scan III (Tekscan Inc., South Boston, MA, USA) analysis. Materials and methods A total of 35 subjects were randomly assigned to one of the retention groups following...
Fri May 29, 2020 03:00
Mucosal Immunology, Published online: 29 May 2020; doi:10.1038/s41385-020-0305-7γδ T cells compose a developmentally regulated intrauterine population and protect against vaginal candidiasis
Fri May 29, 2020 03:00
Fri May 29, 2020 03:00
British Journal of Cancer, Published online: 29 May 2020; doi:10.1038/s41416-020-0908-5Correction: Treatment patterns and survival in HER2-positive early breast cancer: a whole-of-population Australian cohort study (2007–2016)
Fri May 29, 2020 03:00
Fri May 29, 2020 03:00
ObjectivesTo investigate the potential of deep learning in assessing pneumoconiosis depicted on digital chest radiographs and to compare its performance with certified radiologists.MethodsWe retrospectively collected a dataset consisting of 1881 chest X-ray images in the form of digital radiography. These images were acquired in a screening setting on subjects who had a history of working in an environment that exposed them to harmful dust. Among these subjects, 923 were diagnosed with pneumoconiosis,...
Fri May 29, 2020 19:00
ObjectivesTo improve exposure estimates and reexamine exposure–response relationships between cumulative styrene exposure and cancer mortality in a previously studied cohort of US boatbuilders exposed between 1959 and 1978 and followed through 2016.MethodsCumulative styrene exposure was estimated from work assignments and air-sampling data. Exposure–response relationships between styrene and select cancers were examined in Cox proportional hazards models matched on attained age, sex, race, birth...
Fri May 29, 2020 19:00
Segmentation of the last sacral centrum in right lateral (a, d and g), ventral (b, e and h) and posterior (c, f and i) views and close‐up of selected parts of the bone in anterodorsal (j) and ventrolateral views (k). (a–c) Complete modeling: the blue parts are the pneumaticity reaching the external surface in the pleurocoels and some broken parts. (d–f) Model with the internal pneumatic traits in blue. (g–i) Main pneumatic internal traits (central chamber in red; right longitudinal canal in yellow;...
Fri May 29, 2020 19:41
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