C-type cytoplasmic male sterility (CMS-C), one of the three major CMS types in maize, has a promising application prospect in hybrid seed production. However, the complex genetic mechanism underlying the fertility restoration of CMS-C remains poorly understood. The maize inbred line A619 is one of the rare strong restorer lines carrying the restorer gene Rf4, but different fertility segregation ratios are found in several F2 populations derived from crosses between isocytoplasmic allonucleus CMS-C...
Sat May 30, 2020 00:02
Numerous studies in plants have shown the vital roles of MYB transcription factors in signal transduction, developmental regulation, biotic/abiotic stress responses and secondary metabolism regulation. However, less is known about the functions of MYBs in Ganoderma. In this study, five medicinal macrofungi of genus Ganoderma were subjected to a genome-wide comparative analysis of MYB genes. A total of 75 MYB genes were identified and classified into four types: 1R-MYBs (52), 2R-MYBs (19), 3R-MYBs...
Sat May 30, 2020 00:02
Oncogenesis, Published online: 29 May 2020; doi:10.1038/s41389-020-0243-yOvarian BDNF promotes survival, migration, and attachment of tumor precursors originated from p53 mutant fallopian tube epithelial cells
Fri May 29, 2020 03:00
Fri May 29, 2020 03:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00370
Fri May 29, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00474
Fri May 29, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01241
Fri May 29, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01613
Fri May 29, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b05345
Fri May 29, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01304
Fri May 29, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00282
Fri May 29, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00954
Fri May 29, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01749
Fri May 29, 2020 07:00
Research by anthropologists has identified hand use behavior in fossil human relatives that is consistent with modern humans. The human lineage can be defined by a transition in hand use. Early human ancestors used their hands to move around in the trees, like living primates do today, whereas modern human hands have evolved to primarily perform precision grips.
Mon May 18, 2020 21:49
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c01786
Fri May 29, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c03428
Fri May 29, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c01690
Fri May 29, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c03589
Fri May 29, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c02729
Fri May 29, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c04558
Fri May 29, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c03592
Fri May 29, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c03906
Fri May 29, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c02835
Fri May 29, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c02254
Thu May 28, 2020 07:00
Abstract Background Emerging evidence suggests that stemness in cancer cells is a cause of drug resistance or metastasis and is an important therapeutic target. PR [positive regulatory domain I-binding factor 1 (PRDI-BF1) and retinoblastoma protein-interacting zinc finger gene (RIZ1)] domain containing 14 (PRDM14), that regulates pluripotency in primordial germ cell, has reported the overexpression and function of stemness in...
Sat May 30, 2020 03:07
Abstract Background Non-tumor-derived circulating DNA (nt-cirDNA) of advanced non-small cell lung cancer (NSCLC), with unclear origination, is associated with prognosis. We hypothesized that a part of nt-cirDNA release from CD3 or CD8 tumor-infiltrating lymphocytes (TILs) could have clinical implications. Method To investigate the feasibility...
Sat May 30, 2020 03:07
Abstract Purpose Comorbidity assessment is essential in the triage of care for men with prostate cancer (PC). The aim of this study was to validate the Spanish version of the revised Charlson index (RCI) in PC. Materials and methods 731 PC patients diagnosed from 1993 to 2008 were referred to our Radiation Oncology Department. The RCI...
Sat May 30, 2020 03:07
Abstract Purpose Human telomerase reverse transcriptase (hTERT) and calcium-sensing receptor (CaSR) act as an oncogene in gastric cancers, however, their relationship in the progression of gastric cancers is yet to be elucidated. Herein, we aimed to access the potential interaction between hTERT and CaSR in the development of gastric cancers. Methods ...
Sat May 30, 2020 03:07
Abstract Background Chemotherapy-associated liver injury (CALI) is a matter of concern for hepatobiliary surgeons as it can entail postoperative liver failure after an extensive hepatectomy. Recent studies have taken special interest in liver function parameters which can correlate with CALI to decrease this adverse event. Therefore, the current study investigates the usefulness of splenic volume as a biomarker of CALI through...
Sat May 30, 2020 03:07
Abstract Purpose Uveal melanoma (UM) is the most common intraocular cancer with a high mortality rate that requires new research in the field of prevention and treatment. c-REL is a member of the nuclear factor κB (NF-κB) transcription factor family and an emerging regulator of tumorigenesis. Therefore, the objective of the study is to evaluate the constitutive expression of c-REL in uveal melanoma patients and its prognostic...
Sat May 30, 2020 03:07
Abstract Background PIN1, a peptidyl-prolyl cis–trans isomerase, specifically can regulate phosphorylation of proteins on serine/threonine residues that precede proline and has critical roles in cell proliferation and transformation. Many studies have revealed that overexpression of PIN1 is involved in the malignant biological behavior of various cancers, but to date, no meta-analyses have evaluated PIN1 clinical and prognostic...
Sat May 30, 2020 03:07
Abstract Glioma is the most common primary tumor of the nervous system, and approximately 50% of patients exhibit the most aggressive form of the cancer, glioblastoma. Currently, considerable research in glioblastoma therapeutics is aimed at developing vaccines or drugs to target key molecules for combating this disease. Studies on plant natural products from spices, vegetables, fruits, teas, and traditional medicinal herbs display that these plant-derived natural products can...
Sat May 30, 2020 03:07
Abstract Purpose N-myc downstream-regulated gene 2 (NDRG2) is down-regulated in grade-III meningioma [anaplastic meningioma (AM)] and associated with clinically aggressive behavior. Current therapies in the treatment of high-grade meningioma are lacking with limited success. This study aims to validate the effect of NDRG2-targeted therapy using structurally related bioactive triterpene compounds derived from the edible mushroom...
Sat May 30, 2020 03:07
Abstract Background Age is closely related to the efficacy of treatment for non-small cell lung cancer (NSCLC) patients. Latest clinical trials have proved the better overall survival (OS) for the use of immune checkpoint inhibitors verse chemotherapy in NSCLC patients. However, we had no clear idea of the efficacy of them in elderly patients. So we conducted a meta-analysis to compare the efficacy of immune checkpoint inhibitors...
Sat May 30, 2020 03:07
Abstract Purpose Oxaliplatin (OX) is widely used for patients with advanced colorectal cancer (CRC). However, most of them will turn out to be OX resistant. Therefore, it is necessary to uncover the causes underlying this phenomenon. Methods Emerging works have reported that exosomal miRNAs are linked to chemoresistance in many types...
Sat May 30, 2020 03:07
Abstract Background Esophageal squamous cell carcinoma (ESCC) is a kind of cancer with heterogeneous biological characteristics, which is affected by a complex network of gene interactions. Identification of molecular biomarkers paves the way for individualized therapy based on gene expression profiles, which can overcome the heterogeneity of ESCC. Methods ...
Sat May 30, 2020 03:07
Abstract Objective Chronic inflammation is recognized as a risk factor for colorectal cancer (CRC) development. Baicalin (BI), a major constituent in an anti-inflammatory herb Scutellaria baicalensis, can be biotransformed into baicalein (BE) by the intestinal microbiota. We evaluated the anti-inflammation and anti-CRC effects of the metabolite BE. Methods ...
Sat May 30, 2020 03:07
Publication date: Available online 28 May 2020Source: Journal of Cranio-Maxillofacial SurgeryAuthor(s): J. Engelmann, C. Fischer, E. Nkenke
Sat May 30, 2020 02:59
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