Publication date: Available online 21 September 2020Source: Academic RadiologyAuthor(s): Bingwen Eugene FAN
Publication date: Available online 21 September 2020Source: Academic RadiologyAuthor(s): Yu Wang, Li Qun Jia, Yan Xiu Hu, Yue Xin, Xi Yang, Xiao Man Wang
Publication date: Available online 21 September 2020Source: Academic RadiologyAuthor(s): Jon A. Jacobson
Publication date: Available online 21 September 2020Source: Academic RadiologyAuthor(s): David M. Mauro, Joshua A. Ellis, John F. Lilly, Gary L. Beck Dallaghan, Sheryl G. Jordan
Publication date: Available online 21 September 2020Source: Academic RadiologyAuthor(s): Wenli Cai, Tianyu Liu, Xing Xue, Guibo Luo, Xiaoli Wang, Yihong Shen, Qiang Fang, Jifang Sheng, Feng Chen, Tingbo Liang
Publication date: Available online 22 September 2020Source: Academic RadiologyAuthor(s): Allen M. Betts, Richard B. Gunderman
Publication date: Available online 22 September 2020Source: Academic RadiologyAuthor(s): Waqas T. Qureshi, Rohit Malhotra, Eric J. Schmidlin, Mohamed Ahmed, Amartya Kundu, Abdul Moiz Hafiz, Jennifer Walker, Nikolaos Kakouros
Image description: A light-skinned woman with white and grey hair sits with her hands crossed in front of her chest and smiles. She wears glasses and a yellow shirt with a red and pink flower embroidered on the shoulder.Caption: Madelyn Iris 1947–2020 Madelyn “Micki” Iris passed away on January 7, 2020, in Chicago, Illinois, at age 73 after having been diagnosed with cancer in 2017. Iris received her BA in English from Northwestern University, MA in medieval studies from University of Toronto,...
Publication date: Available online 22 September 2020Source: Radiotherapy and OncologyAuthor(s): J. Biau, E. Thivatx, E. Chautard, D. Stefan, M. Boone, B. Chauffert, C. Bourgne, D. Richard, I. Molna, S. Levesque, R. Bellini, F. Kwiatkowski, L Karayan-Tapon, P. Verrelle, C. Godfraind, X. Durando
Publication date: Available online 22 September 2020Source: Radiotherapy and OncologyAuthor(s): M.P.W. Intven, S.R. de Mol van Otterloo, S. Mook, P.A.H. Doornaert, E.N. de Groot-van Breugel, G.G. Sikkes, M.E. Willemsen-Bosman, H.M. van Zijp, R.H.N. Tijssen
Publication date: Available online 22 September 2020Source: Radiotherapy and OncologyAuthor(s): Yanfen Cui, Wenhui Yang, Jialiang Ren, Dandan Li, Xiaosong Du, Junjie Zhang, Xiaotang Yang
Publication date: Available online 22 September 2020Source: Radiotherapy and OncologyAuthor(s): Christian Rønn Hansen, Wouter Crijns, Mohammad Hussein, Linda Rossi, Pedro Gallego, Wilko Verbakel, Jan Unkelbach, David Thwaites, Ben Heijmen
Publication date: Available online 22 September 2020Source: Radiotherapy and OncologyAuthor(s): Bismarck Odei, Sonu Bae, Dayssy Alexandra Diaz
Publication date: Available online 22 September 2020Source: Radiotherapy and OncologyAuthor(s): Eric Deutsch, Benjamin Besse, Jérôme Le Pavec, Cécile Le Péchoux, Angela Botticella, Samy Ammari, Caroline Even, Caroline Robert, Antonin Levy
Publication date: Available online 22 September 2020Source: Radiotherapy and OncologyAuthor(s): Francesco Fracchiolla, Francesco Dionisi, Roberto Righetto, Lamberto Widesott, Irene Giacomelli, Giorgio Cartechini, Paolo Farace, Mattia Bertolini, Maurizio Amichetti, Marco Schwarz
Publication date: Available online 23 September 2020Source: Radiotherapy and OncologyAuthor(s): Filipa Gil Marques, Esmeralda Poli, João Malaquias, Tânia Carvalho, Ana Portêlo, Afonso Ramires, Fernando Aldeia, Ruy Miguel Ribeiro, Emília Vitorino, Isabel Diegues, Luís Costa, João Coutinho, Filomena Pina, Marc Mareel, Susana Constantino Rosa Santos
New Findings What is the central question of the study? Is Vps34 a nutrient‐sensitive activator of mTORC1 in human skeletal muscle? What is the main finding and its importance? We show that altering nutrient availability, via protein‐carbohydrate feeding, does not increase Vps34 kinase activity in human skeletal muscle. Instead, feeding increased Vps34‐mTORC1 co‐localization in parallel to increased mTORC1 activity. These findings may have important implications in the understanding nutrient‐induced...
Publication date: Available online 22 September 2020Source: Gait & PostureAuthor(s): Erik Chumacero-Polanco, James Yang
Publication date: Available online 21 September 2020Source: Reports of Practical Oncology & RadiotherapyAuthor(s): P. Mohandass, D. Khanna, B. Nishaanth, C. Saravanan, Narendra Bhalla, Abhishek Puri, Blessy Mohandass
Publication date: Available online 22 September 2020Source: Journal of Allergy and Clinical ImmunologyAuthor(s): David S. Pisetsky
Publication date: Available online 22 September 2020Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Robert K. Bush, William W. Busse, James T. Li
OMFS is the surgical specialty which bridges dentistry and medicine. As the specialty of OMFS emerged from the dental specialty of Oral Surgery during the 1980s the Dentists Act 1984, whose purpose included preventing medical practitioners providing unregulated general dental care, was published.In 2008 the Postgraduate Medical Education and Training Board (PMETB) review of training in OMFS concluded that dual qualification was essential and recommended that OMFS specialists should only be required...
The specialty of OMFS in the UK is a dual degree specialty which was recognised in Europe within Annex V of Directive 2005/36/EU. Currently UK law matches that of the EU. Brexit may change this.
Published data has shown that 30% of periorbital trauma patients will develop devastating ocular injury if missed.1 Recently, Myuran found that “this could be due to clinicians’ lack of knowledge and/or training that periorbital trauma is associated with ocular injury and how to document a thorough eye examination”.2 Preservation of visual capacity is highly dependent on rapid assessment, examination, and diagnosis following trauma to the periorbital area.
Bandung is a city of punks and prayer… —Lonely Planet The cat is out of the bag now that Lonely Planet knows that Bandung, Indonesia, is a hot spot for punk rock. Over the years, I have discussed my research with different people from all over the world, and many are surprised that punk still exists. Punk is not dead; in fact, it is alive and thriving in the urban centers of Indonesia and has been for some time. Image description: Three persons are on stage under blue lighting. Two are grabbing...
Publication date: Available online 22 September 2020Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Yuhe Qi, Yongjin Zhang, Jia Yu, Wei Liu, Gezhi Xu
Publication date: Available online 22 September 2020Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Vanessa Bustamante, Iván A. González, Paulina Dreyse, Christian Erick Palavecino
Publication date: December 2020Source: Photodiagnosis and Photodynamic Therapy, Volume 32Author(s): Abdullah Alshahrani, Eisha Abrar, Ahmed M. Maawadh, Rana S. Al-Hamdan, Thamer Almohareb, Yasser AlFawaz, Mustafa Naseem, Fahim Vohra, Tariq Abduljabbar
Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Stefano Guarino, Roberta Schiano di Cola, Angela La Manna, Giuseppina Rosaria Umano, Anna Di Sessa, Cesare Polito, Emanuele Miraglia del Giudice, Pierluigi Marzuillo
Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): US Vishal Rao, Gururaj Arakeri, Anand Subash, M Venkatesh, Peter A. Brennan
Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Eamonn Eeles, S. Ward, A. Teodorczuk, N. Dissanayaka, H. Burianová
Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): B.S. Lana Frankle
Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Trisha Greenhalgh, Paul Dijkstra, Nicholas Jones, Jonathan Bowley
Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): R.C. Reisin, P. Rozenfeld, P. Bonardo
Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Lina Zabuliene, Ioannis Ilias
Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): David M. Perrin
Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Anish Kapadia, Arash Mirrahimi, Adam A. Dmytriw
Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Ismo T. Räisänen, Kehinde A. Umeizudike, Pirjo Pärnänen, Pia Heikkilä, Taina Tervahartiala, Solomon O. Nwhator, Andreas Grigoriadis, Dimitra Sakellari, Timo Sorsa
Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Wendy B. Bollag, Joyce N. Gonzales
Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Frank Rühli, Patrick Eppenberger, Maciej Henneberg
Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Jakub Słupski, Wiesław Jerzy Cubała, Natalia Górska, Anita Słupska, Maria Gałuszko-Węgielnik
Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Harneet Kaur, Anuraj Singh Kochhar
Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Sílvio Fernando Guimarães Carvalho, Thallyta Maria Vieira, Ana Paula Venuto Moura, Marileia Chaves Andrade
Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Vincenzo Zagà, Daniel L. Amram, Giacomo Mangiaracina, Cattaruzza Maria Sofia
Publication date: Available online 22 September 2020Source: Critical Reviews in Oncology/HematologyAuthor(s): Joyce Veld, Devica Umans, Emo van Halsema, Femke Amelung, Dália Fernandes, Mei Sze Lee, Douglas Stupart, Javier Suárez, Yuichi Tomiki, Willem Bemelman, Paul Fockens, Esther Consten, Pieter Tanis, Jeanin van Hooft
Publication date: Available online 22 September 2020Source: Critical Reviews in Oncology/HematologyAuthor(s): Alejandra Zevallos, Leny Bravo, Denisse Bretel, Kevin Paez, Ulises Infante, Nadezhda Cárdenas, Hober Alvarado, Ana M. Posada, Joseph A. Pinto
Publication date: Available online 22 September 2020Source: Critical Reviews in Oncology/HematologyAuthor(s): Emaan Haque, Mohamad S. Alabdaljabar, Kathryn J. Ruddy, Tufia C. Haddad, Carrie A. Thompson, Julia S. Lehman, Shahrukh K. Hashmi
Publication date: Available online 22 September 2020Source: Critical Reviews in Oncology/HematologyAuthor(s): Maria Luiza Tabosa de Carvalho Galvão, Eliane Campos Coimbra
Mucosal Immunology, Published online: 23 September 2020; doi:10.1038/s41385-020-00344-9Monocyte-derived dendritic cells link localized secretory IgA deficiency to adaptive immune activation in COPD
Liver disorder often occurs in patients with inflammatory bowel disease (IBD); however, the changes in IBD-induced liver disorder at the intrinsic molecular level (chiefly metabolites) and therapeutic targets are still poorly characterized. First, a refined and translationally relevant model of DSS chronic colitis in C57BL/6 mice was established, and cecropin A and antibiotics were used as interventions. We found that the levels of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6 in the...
The novel coronavirus is not only causing respiratory problems, but it may also damage the heart, kidneys, liver, and other organs; in Wuhan, 14 to 30% of COVID-19 patients have lost their kidney function and now require either dialysis or kidney transplants. The novel coronavirus gains entry into humans by targeting the ACE2 receptor that found on lung cells, which destroy human lungs through cytokine storms, and this leads to hyperinflammation, forcing the immune cells to destroy healthy cells....
Imbalances of proatherogenic inflammatory and antiatherogenic inflammatory mediators were involved in the pathogenesis of atherosclerosis. This study sought to investigate the effects of proatherogenic inflammatory and antiatherogenic inflammatory mediators on the proximal, middle, and distal coronary artery reocclusions in elderly patients after coronary stent implantations. We measured the expression levels of proatherogenic inflammatory/antiatherogenic inflammatory cytokines. This included interleukin-1...
Publication date: Available online 21 September 2020Source: European Journal of CancerAuthor(s): Nicola Giesen, Rosanne Sprute, Maria Rüthrich, Yascha Khodamoradi, Sibylle C. Mellinghoff, Gernot Beutel, Catherina Lueck, Michael Koldehoff, Marcus Hentrich, Michael Sandherr, Michael von Bergwelt-Baildon, Hans-Heinrich Wolf, Hans H. Hirsch, Bernhard Wörmann, Oliver A. Cornely, Philipp Köhler, Enrico Schalk, Marie von Lilienfeld-Toal
Publication date: Available online 22 September 2020Source: European Journal of CancerAuthor(s): Ketty Peris, Maria C. Fargnoli, Claus Garbe, Roland Kaufmann, Lars Bastholt, Nicole B. Seguin, Veronique Bataille, Veronique del Marmol, Reinhard Dummer, Catherine A. Harwood, Axel Hauschild, Christoph Höller, Merete Haedersdal, Josep Malvehy, Mark R. Middleton, Colin A. Morton, Eduardo Nagore, Alexander J. Stratigos, Rolf-Markus Szeimies, Luca Tagliaferri
Publication date: Available online 22 September 2020Source: European Journal of CancerAuthor(s): Khalid El Bairi, Dario Trapani, Angelica Petrillo, Cécile Le Page, Hanaa Zbakh, Bruno Daniele, Rhizlane Belbaraka, Giuseppe Curigliano, Said Afqir
Publication date: November 2020Source: European Journal of Cancer, Volume 139Author(s): Alfredo Carrato, José María Vieitez, Manuel Benavides, Mercedes Rodriguez-Garrote, Alfredo Castillo, Gema Durán Ogalla, Laura García Bermejo, Inmaculada Ruiz de Mena, Carmen Guillén-Ponce, Enrique Aranda, Inma R. de Mena, Susana Rodríguez
Publication date: November 2020Source: European Journal of Cancer, Volume 139Author(s): Roberto Moretto, Daniele Rossini, Gemma Zucchelli, Sara Lonardi, Francesca Bergamo, Daniele Santini, Samanta Cupini, Gianluca Tomasello, Salvatore Caponnetto, Alberto Zaniboni, Carlotta Antoniotti, Filippo Pietrantonio, Angela Buonadonna, Federica Marmorino, Roberto Bordonaro, Elena Fea, Emiliano Tamburini, Alessandra Boccaccino, Roberta Grande, Giuseppe Aprile
Publication date: November 2020Source: European Journal of Cancer, Volume 139Author(s): Angelina Tjokrowidjaja, Chee K. Lee, Michael Friedlander, Val Gebski, Laurence Gladieff, Jonathan Ledermann, Richard Penson, Amit Oza, Jacob Korach, Tomasz Huzarski, Luis Manso, Carmela Pisano, Rebecca Asher, Sarah J. Lord, Se Ik Kim, Jung-Yun Lee, Nicoletta Colombo, Tjoung-Won Park-Simon, Keiichi Fujiwara, Gabe Sonke
Publication date: November 2020Source: European Journal of Cancer, Volume 139Author(s): Steven Bisch, Gregg Nelson
Related Articles CTLA4-Ig Directly Inhibits Osteoclastogenesis by Interfering With Intracellular Calcium Oscillations in Bone Marrow Macrophages. J Bone Miner Res. 2019 09;34(9):1744-1752 Authors: Okada H, Kajiya H, Omata Y, Matsumoto T, Sato Y, Kobayashi T, Nakamura S, Kaneko Y, Nakamura S, Koyama T, Sudo S, Shin M, Okamoto F, Watanabe H, Tachibana N, Hirose J, Saito T, Takai T, Matsumoto M, Nakamura M, Okabe K, Miyamoto T, Tanaka S Abstract ...
Abstract Sirtuin 2 (SIRT2) is one of seven mammalian homologs of silent information regulator 2 (Sir2) and an NAD+‐dependent deacetylase; however, its critical role in lymphangiogenesis remains to be explored. We investigate SIRT2 mediated regulation of vascular endothelial growth factor D (VEGFD) expression and lymphangiogenesis by deacetylating endothelial PAS domain protein 1 (EPAS1) in head and neck cancer (HNC) in vitro and in vivo. In this study, we report that SIRT2, rather than other members...
Abstract Optically stimulated luminescence (OSL) signal properties of pellets from three types of NaCl (two household salts and one analytical grade salt) were investigated for their use in prospective dosimetry. Special attention was given to the OSL signal behaviour with time. The readout protocol was optimised in terms of preheat temperature, and the OSL signal yield of the NaCl pellet with time as well as the fading of the OSL signal with time was investigated. The effects...
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c08139
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c05610
Abstract Fetus in fetu (FIF) is an extremely rare anomaly. It is predominantly seen retroperitoneally in 80% of cases but can present at atypical sites like the skull, sacrum, scrotum and the mouth. We reported a rare case of intracranial parasitic fetus. We described the prenatal and postnatal MRI findings of the case. There was no obvious spinal signal on the imaging findings at 35 weeks of gestation. However, the postnatal MRI revealed spinal column signal at 5 months and 11 days.
Cardiovascular disease is the leading cause of illness and death in patients with type 2 diabetes. Type 2 diabetes is also a major risk factor for the development of heart failure and progression of renal disease. Previous trials that evaluated the effects of sodium–glucose cotransporter 2 (SGLT2)…
The aim of this study was to evaluate the sensitivity, accuracy, and reliability of two-dimensional computed tomography (2D-CT) scans (axial, coronal, sagittal planes) and three-dimensional computed tomography (3D-CT) reconstructions in diagnosing midfacial fractures in relation to actual fractures identified clinically and during surgery (gold standard). The imaging diagnosis was performed by a radiologist and an oral and maxillofacial surgeon. Sixty-two patients with a total of 429 midfacial fractures...
Publication date: Available online 22 September 2020Source: Magnetic Resonance ImagingAuthor(s): D.J.J.M. de Gouw, M.C. Maas, C. Slagt, J. Mühling, A. Nakamoto, B.R. Klarenbeek, C. Rosman, J.J. Hermans, T.W.J. Scheenen
Related Articles Biomarkers of susceptibility and effect in car painters exposed to organic solvents. Colomb Med (Cali). 2020 Mar 30;51(1):e3646 Authors: Varona-Uribe M, Ibáñez-Pinilla M, Briceno-Ayala L, Herrera D, Chuaire-Noack L, Martínez-Agüero M, Sánchez Corredor MC, Palma-Parra R, Narvaez D, Groot de Restrepo H Abstract Introduction: Car painters are routinely exposed to organic solvents classified as carcinogenic and mutagenic substances....
Related Articles Effect size: commentary to the study on the Factors associated with the practice of exclusive breastfeeding. Colomb Med (Cali). 2020 Mar 30;51(1):e4102 Authors: Angulo-Ramos M, Merino-Soto C PMID: 32952229 [PubMed - in process]
Related Articles Relationship between the polymorphism in the interleukin 1-β and the treatment time of patients subjected to a modified piezocision technique. Colomb Med (Cali). 2020 Mar 30;51(1):e4141 Authors: Aristizábal JF, Rios H, Rey D, Álvarez MA, Parra B, Ortiz M Abstract Aim: We aimed to evaluate the correlation between the polymorphism of the interleukin 1-Beta (IL1-β, +3954 C>T) and tooth movement, in a group of Colombian patients...
Related Articles Implementation of a new Single-Pass Whole-Body Computed Tomography Protocol: Is it safe, effective and efficient in patients with severe trauma? Colomb Med (Cali). 2020 Mar 30;51(1):e4224 Authors: Ordoñez C, García C, Parra MW, Angamarca E, Guzmán-Rodríguez M, Orlas CP, Herrera-Escobar JP, Rincón E, Meléndez JJ, Serna JJ, Padilla N, Del Valle AM, García AF, Holguín A Abstract Purpose: The objective of this study was to evaluate...
This paper uses the recent glottal flow model for iterative adaptive inverse filtering to analyze recordings from dysfunctional speakers, namely those with larynx-related impairment such as laryngectomy. The analytical model allows extraction of the voice source spectrum, described by a compact set of parameters. This single model is used to visualize and better understand speech production characteristics across impaired and nonimpaired voices. The analysis reveals some discriminative aspects of...
Journal of Investigative Medicine High Impact Case Reports, Volume 8, Issue , January-December 2020. Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by heterogeneous symptoms that can manifest in any organ, and often presents at a young age. Infectious mononucleosis (IM) is the acute clinical manifestation of Epstein–Barr virus (EBV). It is characterized by low-grade fever, malaise, lymphadenopathy, splenomegaly, and occasionally symmetrical arthralgias. It has been...
Abstract Human skin is particularly vulnerable to age‐related deterioration and undergoes profound structural and functional changes, reflected in the external skin appearance. Skin aging is characterized by features such as wrinkling or loss of elasticity. Even if research advances have been done concerning the molecular mechanisms that underlie these changes, very few studies have been conducted concerning the structure stiffness of the skin organ as a whole. In this study, we showed, thanks to...
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c06568
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c06165
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c06048
Abstract Objectives To analyze occlusion time, occlusal balance and lateral occlusal scheme in subjects with various dental and skeletal characteristics. Methods A total of 132 subjects (50 males and 82 females) seeking orthodontic treatment were included in this prospective study. Using the T‐Scan III Version 7.0 (Tekscan Inc., South Boston, MA, USA), the occlusion time, occlusal balance and lateral occlusal schemes were recorded and compared with gender, Angle's occlusal classification,...
RNA G-quadruplexes fold almost exclusively into parallel-stranded structures and thus display much less structural diversity than their DNA counterparts. However, also among RNA G-quadruplexes peculiar structural elements can be found which are capable of reshaping physico-chemical properties of the folded structure. A striking example is provided by a uridine tetrad (U-tetrad) placed on the 3’-terminus of a tetramolecular G-quadruplex. In this context the U-tetrad adapts a unique conformation involving...
Zfp423 encodes a transcriptional regulatory protein that interacts with canonical signaling and lineage pathways. Mutations in mouse Zfp423 or its human ortholog ZNF423 are associated with a range of developmental abnormalities reminiscent of ciliopathies, including cerebellar vermis hypoplasia and other midline brain defects. Null mice have reduced viability in most strain backgrounds. Here we show complete lethality on a C57BL/6J background, dominant rescue in backcrosses to any of 13 partner strains,...
Abstract Background The goal of this study was to assess the effect of melatonin on blood redox systems in mice simultaneously exposed to ethanol and low-dose lipopolysaccharide (LPS). Methods Oxidative stress parameters were assessed in eight groups: untreated control, melatonin (10 mg kg−1, 10 days), LPS (injected once intraperitoneally at a dose...
Purpose: To explore a prognostic or predictive role of magnetic resonance imaging (MRI) and O-(2-18F-fluoroethyl)-L-tyrosine (18FET) positron emission tomography (PET) parameters for outcome in the randomized multi-center trial ARTE that compared bevacizumab plus radiotherapy with radiotherpay alone in elderly patients with glioblastoma. Experimental Design: Patients with isocitrate dehydrogenase wild-type glioblastoma aged 65 years or older were included in this post-hoc analysis. Tumor volumetric...
Purpose: Cyclin-dependent kinase 4/6 (CDK4/6) inhibitors have improved progression free survival for metastatic, estrogen receptor positive (ER+) breast cancers, but their role in the non-metastatic setting remains unclear. We sought to understand the effects of CDK4/6 inhibition (CDK4/6i) and radiation (RT) in multiple preclinical breast cancer models. Methods: Transcriptomic and proteomic analyses were used to identify significantly altered pathways after CDK4/6i. Clonogenic assays were used to...
Purpose: Autoantibody responses in cancer are of great interest, as they may be concordant with T-cell responses to cancer antigens or predictive of response to cancer immunotherapies. Thus, we sought to characterize the antibody landscape of metastatic castration-resistant prostate cancer (mCRPC). Experimental Design: Serum antibody-epitope repertoire analysis (SERA) was performed on patient serum to identify tumor-specific neoepitopes. Somatic mutation-specific neoepitopes were investigated by...
The Food and Drug Administration (FDA) approved entrectinib on August 15, 2019, for the treatment of adult and pediatric patients 12 years of age and older with solid tumors that have a neurotrophic tyrosine receptor kinase (NTRK) gene fusion without a known acquired resistance mutation, are metastatic or where surgical resection is likely to result in severe morbidity, and have progressed following treatment or have no satisfactory alternative therapy. Approval was based on demonstration of a durable...
B7-H3, also referred to as CD276, is a member of the B7 family of immune regulatory proteins. B7-H3 is overexpressed on many solid cancers, including prostate cancer, renal cell carcinoma, melanoma, squamous cell carcinoma of the head and neck, non-small cell lung cancer and breast cancer. Over-expression of B7-H3 is associated with disease severity, risk of recurrence and reduced survival. In this article, we report the preclinical development of MGC018, an antibody-drug conjugate targeted against...
British Journal of Cancer, Published online: 24 September 2020; doi:10.1038/s41416-020-01082-2Antibiotic use and risk of colorectal cancer: a systematic review and dose–response meta-analysis
British Journal of Cancer, Published online: 24 September 2020; doi:10.1038/s41416-020-01047-5Clinical relevance of blood-based ctDNA analysis: mutation detection and beyond
British Journal of Cancer, Published online: 24 September 2020; doi:10.1038/s41416-020-01087-xCRISPR/Cas9 genome-wide loss-of-function screening identifies druggable cellular factors involved in sunitinib resistance in renal cell carcinoma
Background: Damage control resuscitation forms the cornerstone of management in trauma surgery. Several blood products have been widely used for preoperative transfusions prior to emergency surgeries and for hemorrhage control in trauma. Prothrombin complex concentrate (PCC) is now being introduced as an essential component of damage control resuscitation. Summary: We did a comparative descriptive analysis of several single and multi-institutional clinical trials and retrospective cohort studies....
Some stalk-eyed flies in the genus Teleopsis carry selfish genetic elements that induce sex ratio (SR) meiotic drive and impact the fitness of male and female carriers. Here, we produce a chromosome-level genome assembly of the stalk-eyed fly, T. dalmanni, to elucidate the pattern of genomic divergence associated with the presence of drive elements. We find evidence for multiple nested inversions along the sex ratio haplotype and widespread differentiation and divergence between the inversion types...
Characterization of MK6240, a tau PET tracer, in autopsy brain tissue from Alzheimer’s disease cases
Abstract Purpose MK6240 is a second-generation tau PET tracer designed to detect the neurofibrillary tangles in the brains of patients with Alzheimer’s disease (AD). The aim of the study was to characterize 3H-MK6240 in AD and control brain tissue and to compare its binding properties with those of first-generation tau PET tracers. Methods Saturation...
Abstract Introduction [177Lu]Lu-PSMA-617 (Lu-PSMA) radioligand therapy is an emerging treatment option for patients with end-stage prostate cancer. However, response to Lu-PSMA therapy is only achieved in approximately half of patients. It is clinically important to identify patients at risk of poor outcome. Therefore, the aim of this study was to evaluate pretherapeutic PSMA PET derived total tumor volume and related metrics as prognosticators...
Journal of International Medical Research, Volume 48, Issue 9, September 2020. PurposeTo investigate associations between the clinical characteristics and incubation periods of patients infected with coronavirus disease 2019 (COVID-19) in Wuhan, China.MethodsComplete clinical and epidemiological data from 149 patients with COVID-19 at a hospital in Hunan Province, China, were collected and retrospectively analyzed.ResultsAnalysis of the distribution and receiver operator characteristic curve of incubation...
Journal of International Medical Research, Volume 48, Issue 9, September 2020. Pelvic congestion syndrome (PCS) typically causes chronic non-cyclical abdominal pain with a considerable negative effect on the quality of life of women. However, pediatric cases with PCS are limited and non-invasive therapy for adolescent patients has not been reported. We report here a 13-year-old girl who presented with intermittent abdominal pain since the age of 2 years and her symptoms further deteriorated after...
Journal of International Medical Research, Volume 48, Issue 9, September 2020. ObjectiveThis study aimed to examine the association between slow-wave sleep ([SWS] N3 stage) and the risk of hypertension in patients with obstructive sleep apnea (OSA) or primary snorers.MethodsA retrospective cross-sectional study of 1145 participants who were evaluated for suspected OSA at our Sleep Medical Center were included. Among these participants, 1022 had OSA and 123 were primary snorers. Logistic regression...
By critically appraising the literature on the oral health effects of race‐based oppression, this focus article makes four recommendations that may both facilitate more nuanced research on the topic and mitigate racial/ethnic inequities in (oral) health. The first is recognizing that science itself may perpetuate racial/ethnic injustice, such that adopting a ‘neutral’ position must be replaced with actively fostering anti‐racist narratives. The second is to not imply that racial oppression is bad...
Abstract Objective The primary objective was to investigate the relationship between periodontitis and hypertension in two independent large surveys. The secondary objective was to ascertain whether systemic inflammation had a mediation effect in the association. Methods This cross‐sectional study analyzed representative samples of the US (n=3460; NHANES 2009/10) and Korean (n=4539; 2015 KNHANES VI‐3) populations. The association between periodontitis (exposure), hypertension...
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