Antibiotics, Vol. 9, Pages 636: Developing a Sustainable Antimicrobial Stewardship (AMS) Programme in Ghana: Replicating the Scottish Triad Model of Information, Education and Quality Improvement Antibiotics doi: 10.3390/antibiotics9100636 Authors: Jacqueline Sneddon Daniel Afriyie Israel Sefah Alison Cockburn Frances Kerr Lucie Byrne-Davis Elaine Cameron (1) Background: Our aim was to develop robust and reliable systems for antimicrobial stewardship (AMS) in Keta Municipal...
Wed Sep 23, 2020 03:00
Antibiotics, Vol. 9, Pages 635: Progress Overview of Bacterial Two-Component Regulatory Systems as Potential Targets for Antimicrobial Chemotherapy Antibiotics doi: 10.3390/antibiotics9100635 Authors: Hidetada Hirakawa Jun Kurushima Yusuke Hashimoto Haruyoshi Tomita Bacteria adapt to changes in their environment using a mechanism known as the two-component regulatory system (TCS) (also called “two-component signal transduction system” or “two-component...
Wed Sep 23, 2020 03:00
Antibodies, Vol. 9, Pages 50: Taking the Hinge off: An Approach to Effector-Less Monoclonal Antibodies Antibodies doi: 10.3390/antib9040050 Authors: Jamie Valeich Dan Boyd Manu Kanwar Daniel Stenzel Deblina De Ghosh Arpa Ebrahimi James Woo Jenny Wang Alexandre Ambrogelly A variety of Fc domain engineering approaches for abrogating the effector functions of mAbs exists. To address some of the limitations of the current Fc domain silencing approaches, we are exploring...
Wed Sep 23, 2020 03:00
Antioxidants, Vol. 9, Pages 907: Magnesium, Oxidative Stress, Inflammation, and Cardiovascular Disease Antioxidants doi: 10.3390/antiox9100907 Authors: Man Liu Samuel C. Dudley Hypomagnesemia is commonly observed in heart failure, diabetes mellitus, hypertension, and cardiovascular diseases. Low serum magnesium (Mg) is a predictor for cardiovascular and all-cause mortality and treating Mg deficiency may help prevent cardiovascular disease. In this review, we discuss the possible mechanisms...
Wed Sep 23, 2020 03:00
Antioxidants, Vol. 9, Pages 905: Diabetic Retinopathy: The Role of Mitochondria in the Neural Retina and Microvascular Disease Antioxidants doi: 10.3390/antiox9100905 Authors: David J. Miller M. Ariel Cascio Mariana G. Rosca Diabetic retinopathy (DR), a common chronic complication of diabetes mellitus and the leading cause of vision loss in the working-age population, is clinically defined as a microvascular disease that involves damage of the retinal capillaries with secondary...
Wed Sep 23, 2020 03:00
Antioxidants, Vol. 9, Pages 906: Positive Association of Ascorbate and Inverse Association of Urate with Cognitive Function in People with Parkinson’s Disease Antioxidants doi: 10.3390/antiox9100906 Authors: Emma S. Spencer Toni Pitcher Gabriel Veron Tracey Hannam Michael MacAskill Tim Anderson John Dalrymple-Alford Anitra C. Carr Oxidative stress is thought to contribute to the aetiology of neurological disorders such as Parkinson’s disease. Ascorbate...
Wed Sep 23, 2020 03:00
Atmosphere, Vol. 11, Pages 1025: Can Chinese Central Government Inspection on Environmental Protection Improve Air Quality? Atmosphere doi: 10.3390/atmos11101025 Authors: Ling-Yun He Meng-Meng Geng Environmental pollution is one of the major sustainability problems in China. As a major institutional innovation to supervise local governments to implement environmental governance measures, the effect of central environmental protection inspection needs to be carefully investigated....
Wed Sep 23, 2020 03:00
Atmosphere, Vol. 11, Pages 1024: Development of a Wide-Range Non-Dispersive Infrared Analyzer for the Continuous Measurement of CO2 in Indoor Environments Atmosphere doi: 10.3390/atmos11101024 Authors: Trieu-Vuong Dinh Joo-Yeon Lee Ji-Won Ahn Jo-Chun Kim Carbon dioxide (CO2) is an indicator of indoor air quality. Ventilation based on the use of a CO2 indicator helps to prevent people from acquiring many diseases, especially respiratory viral infections. Therefore, the monitoring...
Wed Sep 23, 2020 03:00
Atmosphere, Vol. 11, Pages 1023: Differentiating Snow and Glacier Melt Contribution to Runoff in the Gilgit River Basin via Degree-Day Modelling Approach Atmosphere doi: 10.3390/atmos11101023 Authors: Yasir Latif Yaoming Ma Weiqiang Ma Sher Muhammad Muhammad Adnan Muhammad Yaseen Rowan Fealy In contrast to widespread glacier retreat evidenced globally, glaciers in the Karakoram region have exhibited positive mass balances and general glacier stability over the past...
Wed Sep 23, 2020 03:00
Atmosphere, Vol. 11, Pages 1022: The Impact of Ensemble Meteorology on Inverse Modeling Estimates of Volcano Emissions and Ash Dispersion Forecasts: Grímsvötn 2011 Atmosphere doi: 10.3390/atmos11101022 Authors: Natalie J. Harvey Helen F. Dacre Helen N. Webster Isabelle A. Taylor Sujan Khanal Roy G. Grainger Michael C. Cooke Volcanic ash can interact with the earth system on many temporal and spatial scales and is a significant hazard to aircraft. In the event of a volcanic...
Wed Sep 23, 2020 03:00
Biology, Vol. 9, Pages 308: Basophils and Systemic Lupus Erythematosus in Murine Models and Human Patients Biology doi: 10.3390/biology9100308 Authors: Kuanysh Dossybayeva Diyora Abdukhakimova Dimitri Poddighe Basophils are the rarest cell population in the blood. Even though basophils are known to participate in some allergic reactions and immune responses to parasitic infections, their immunological role is still largely elusive. Recent evidence has suggested that in some murine...
Wed Sep 23, 2020 03:00
Biology, Vol. 9, Pages 307: Nanomaterials and Annelid Immunity: A Comparative Survey to Reveal the Common Stress and Defense Responses of Two Sentinel Species to Nanomaterials in the Environment Biology doi: 10.3390/biology9100307 Authors: Kornélia Bodó Nicoló Baranzini Rossana Girardello Bohdana Kokhanyuk Péter Németh Yuya Hayashi Annalisa Grimaldi Péter Engelmann Earthworms and leeches are sentinel animals that represent the annelid phylum within terrestrial and...
Wed Sep 23, 2020 03:00
Biology, Vol. 9, Pages 306: Autoclaving Nest-Material Remains Influences the Probability of Ectoparasitism of Nestling Hoopoes (Upupa epops) Biology doi: 10.3390/biology9100306 Authors: Mónica Mazorra-Alonso Manuel Martín-Vivaldi Juan Manuel Peralta-Sánchez Juan José Soler Nest bacterial environment influences avian reproduction directly because it might include pathogenic- or antibiotic-producing bacteria or indirectly because predators or ectoparasites can use volatile compounds...
Wed Sep 23, 2020 03:00
Biomedicines, Vol. 8, Pages 374: Utility of Three-Dimensional Cultures of Primary Human Hepatocytes (Spheroids) as Pharmacokinetic Models Biomedicines doi: 10.3390/biomedicines8100374 Authors: Kenta Mizoi Hiroshi Arakawa Kentaro Yano Satoshi Koyama Hajime Kojima Takuo Ogihara This paper reviews the usefulness, current status, and potential of primary human hepatocytes (PHHs) in three-dimensional (3D) cultures, also known as spheroids, in the field of pharmacokinetics (PK)....
Wed Sep 23, 2020 03:00
Biomedicines, Vol. 8, Pages 373: Cholesterol Efflux Efficiency of Reconstituted HDL Is Affected by Nanoparticle Lipid Composition Biomedicines doi: 10.3390/biomedicines8100373 Authors: Shifa Jebari-Benslaiman Kepa B. Uribe Asier Benito-Vicente Unai Galicia-Garcia Asier Larrea-Sebal Iraide Alloza Koen Vandenbroeck Helena Ostolaza César Martín Cardiovascular disease (CVD), the leading cause of mortality worldwide is primarily caused by atherosclerosis, which is...
Wed Sep 23, 2020 03:00
Biomedicines, Vol. 8, Pages 375: Glutathione-Stabilized Silver Nanoparticles: Antibacterial Activity against Periodontal Bacteria, and Cytotoxicity and Inflammatory Response in Oral Cells Biomedicines doi: 10.3390/biomedicines8100375 Authors: Irene Zorraquín-Peña Carolina Cueva Dolores González de Llano Begoña Bartolomé M. Victoria Moreno-Arribas Silver nanoparticles (AgNPs) have been proposed as new alternatives to limit bacterial dental plaque because of their antimicrobial...
Wed Sep 23, 2020 03:00
Biomedicines, Vol. 8, Pages 372: Neuroprotective Effect of Subdural Infusion of Serp-1 in Spinal Cord Trauma Biomedicines doi: 10.3390/biomedicines8100372 Authors: Jacek M. Kwiecien Wojciech Dabrowski Bryce J. Kwiecien-Delaney Christian J. Kwiecien-Delaney Dorota Siwicka-Gieroba Jordan R. Yaron Liqiang Zhang Kathleen H. Delaney Alexandra R. Lucas Spinal cord injury (SCI) initiates a severe, destructive inflammation with pro-inflammatory, CD68+/CD163−,...
Wed Sep 23, 2020 03:00
Biomolecules, Vol. 10, Pages 1360: Catalpol Ameliorates Insulin Sensitivity and Mitochondrial Respiration in Skeletal Muscle of Type-2 Diabetic Mice Through Insulin Signaling Pathway and AMPK/SIRT1/PGC-1α/PPAR-γ Activation Biomolecules doi: 10.3390/biom10101360 Authors: Kah Heng Yap Gan Sook Yee Mayuren Candasamy Swee Ching Tan Shadab Md Abu Bakar Abdul Majeed Subrat Kumar Bhattamisra Catalpol was tested for various disorders including diabetes mellitus. Numerous molecular...
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Biomolecules, Vol. 10, Pages 1359: Prenatal Hyperglycemia Exposure and Cellular Stress, a Sugar-Coated View of Early Programming of Metabolic Diseases Biomolecules doi: 10.3390/biom10101359 Authors: Jessica Tozour Francine Hughes Arnaud Carrier Didier Vieau Fabien Delahaye Worldwide, the number of people with diabetes has quadrupled since 1980 reaching 422 million in 2014 (World Health Organization). This distressing rise in diabetes also affects pregnant women and thus,...
Wed Sep 23, 2020 03:00
Biomolecules, Vol. 10, Pages 1358: Characteristics and Expression Analyses of Trehalose-6-Phosphate Synthase Family in Prunus mume Reveal Genes Involved in Trehalose Biosynthesis and Drought Response Biomolecules doi: 10.3390/biom10101358 Authors: Yongjuan Yang Kaifeng Ma Tengxun Zhang Lulu Li Jia Wang Tangren Cheng Qixiang Zhang Trehalose and its key synthase (trehalose-6-phosphate synthase, TPS) can improve the drought tolerance of plants. However, little is known...
Wed Sep 23, 2020 03:00
Biomolecules, Vol. 10, Pages 1355: Critical Impact of Different Conserved Endoplasmic Retention Motifs and Dopamine Receptor Interacting Proteins (DRIPs) on Intracellular Localization and Trafficking of the D2 Dopamine Receptor (D2-R) Isoforms Biomolecules doi: 10.3390/biom10101355 Authors: Kaja Blagotinšek Cokan Maša Mavri Catrin Sian Rutland Sanja Glišić Milan Senćanski Milka Vrecl Valentina Kubale The type 2 dopamine receptor D2 (D2-R), member of the G protein-coupled...
Wed Sep 23, 2020 03:00
Biomolecules, Vol. 10, Pages 1356: Syndecan-1 Promotes Hepatocyte-Like Differentiation of Hepatoma Cells Targeting Ets-1 and AP-1 Biomolecules doi: 10.3390/biom10101356 Authors: Péter Hollósi Lóránd Váncza Katalin Karászi Katalin Dobos Bálint Péterfia Enikő Tátrai Péter Tátrai Tibor Szarvas Sándor Paku László Szilák Ilona Kovalszky Syndecan-1 is a transmembrane heparan sulfate proteoglycan which is indispensable in the structural and functional integrity...
Wed Sep 23, 2020 03:00
Biomolecules, Vol. 10, Pages 1357: Sphingolipid Metabolism in Glioblastoma and Metastatic Brain Tumors: A Review of Sphingomyelinases and Sphingosine-1-Phosphate Biomolecules doi: 10.3390/biom10101357 Authors: Cyntanna C. Hawkins Tomader Ali Sasanka Ramanadham Anita B. Hjelmeland Glioblastoma (GBM) is a primary malignant brain tumor with a dismal prognosis, partially due to our inability to completely remove and kill all GBM cells. Rapid tumor recurrence contributes to a median...
Wed Sep 23, 2020 03:00
Biomolecules, Vol. 10, Pages 1354: Circulating microRNA as a Biomarker for Coronary Artery Disease Biomolecules doi: 10.3390/biom10101354 Authors: Ibrahim T. Fazmin Zakaria Achercouk Charlotte E. Edling Asri Said Kamalan Jeevaratnam Coronary artery disease (CAD) is the leading cause of sudden cardiac death in adults, and new methods of predicting disease and risk-stratifying patients will help guide intervention in order to reduce this burden. Current CAD detection involves...
Wed Sep 23, 2020 03:00
Biosensors, Vol. 10, Pages 132: Tuning the Surface Charge of Self-Assembled Polydiacetylene Vesicles to Control Aggregation and Cell Binding Biosensors doi: 10.3390/bios10100132 Authors: Anthony David Nelson Priyanka Shiveshwarkar Butaek Lim Gumaro Rojas Izele Abure Anura Shrestha Justyn Jaworski Polydiacetylene vesicles of various compositions were assembled using a two-part mixture of 10,12-pentacosadiynoic acid (PCDA) and ethylenedioxy-bis-ethylamine (EDEA)-labeled...
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Biosensors, Vol. 10, Pages 131: One-Pot, In-Situ Synthesis of 8-Armed Poly (Ethylene Glycol)-Coated Ag Nanoclusters as a Fluorescent Sensor for Selective Detection of Cu2+ Biosensors doi: 10.3390/bios10100131 Authors: Xiaoyuan Zhang Guanghua Zhang Gang Wei Zhiqiang Su Fluorescent nanomaterials, such as quantum dots, have developed rapidly in recent years and have been significantly developed. Herein, we demonstrate a facile, one-pot, and in-situ synthesis strategy to obtain...
Wed Sep 23, 2020 03:00
Biosensors, Vol. 10, Pages 130: Colorimetric Diagnostic Capillary Enabled by Size Sieving in a Porous Hydrogel Biosensors doi: 10.3390/bios10100130 Authors: John Mello Camille C. Guzman Sheng-Min Hsu Han-Sheng Chuang Handy and disposable point-of-care diagnostics facilitate the early screening of severe diseases in resource-limited areas. To address urgent needs in inconvenient sites, a simple colorimetric diagnostic device equipped with a capillary tube with porous hydrogel and...
Wed Sep 23, 2020 03:00
Brain Sciences, Vol. 10, Pages 664: Misperception of Visual Verticality in Patients with Primary Headache Disorders: A Systematic Review with Meta-Analysis Brain Sciences doi: 10.3390/brainsci10100664 Authors: Esteban Obrero-Gaitán María Manrique-Navarro Miguel Ángel Lérida-Ortega Daniel Rodríguez-Almagro María Catalina Osuna-Pérez Rafael Lomas-Vega Migraine and tension-type headache (TTH) are the two most prevalent primary headache disorders (PHDs) that may involve visual...
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Brain Sciences, Vol. 10, Pages 663: Acute Effects of Aerobic Exercise on Somatosensory-Evoked Potentials in Patients with Mild Cognitive Impairment Brain Sciences doi: 10.3390/brainsci10100663 Authors: Imran Amjad Imran Khan Niazi Hamza Ghazanfar Toor Rasmus Bach Nedergaard Muhammad Shafique Kelly Holt Heidi Haavik Touqeer Ahmed Mild cognitive impairment (MCI) is becoming a serious problem for developing countries as the lifespan of populations increases. Exercise...
Wed Sep 23, 2020 03:00
Brain Sciences, Vol. 10, Pages 662: The Effect of Blindness on Spatial Asymmetries Brain Sciences doi: 10.3390/brainsci10100662 Authors: Luca Rinaldi Andrea Ciricugno Lotfi B. Merabet Tomaso Vecchi Zaira Cattaneo The human cerebral cortex is asymmetrically organized with hemispheric lateralization pervading nearly all neural systems of the brain. Whether the lack of normal visual development affects hemispheric specialization subserving the deployment of visuospatial attention...
Wed Sep 23, 2020 03:00
Cancers, Vol. 12, Pages 2739: Role of POT1 in Human Cancer Cancers doi: 10.3390/cancers12102739 Authors: Yangxiu Wu Rebecca C. Poulos Roger R. Reddel Telomere abnormalities facilitate cancer development by contributing to genomic instability and cellular immortalization. The Protection of Telomeres 1 (POT1) protein is an essential subunit of the shelterin telomere binding complex. It directly binds to single-stranded telomeric DNA, protecting chromosomal ends from an inappropriate...
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Cancers, Vol. 12, Pages 2738: Schlafen 12 Is Prognostically Favorable and Reduces C-Myc and Proliferation in Lung Adenocarcinoma but Not in Lung Squamous Cell Carcinoma Cancers doi: 10.3390/cancers12102738 Authors: Sarmad Al-Marsoummi Jonathan Pacella Kaylee Dockter Matthew Soderberg Sandeep K. Singhal Emilie E. Vomhof-DeKrey Marc D. Basson Schlafen 12 (SLFN12) is an intermediate human Schlafen that induces differentiation in enterocytes, prostate, and breast cancer....
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Cancers, Vol. 12, Pages 2737: Loco-Regional and Systemic Chemotherapies for Hepato-Pancreatic Tumors: Integrated Treatments Cancers doi: 10.3390/cancers12102737 Authors: Girolamo Ranieri Carmelo Laface This Special Issue of Cancers, titled “Loco-Regional Arterial Chemotherapies Alone or in Combination with Systemic Treatments for Primary and Secondary Hepato-Pancreatic Tumors”, focuses on new possible strategies to treat only liver disease (or mainly liver disease)...
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Cancers, Vol. 12, Pages 2735: Predicting the Efficacy and Safety of TACTICs (Tumor Angiogenesis-Specific CAR-T Cells Impacting Cancers) Therapy for Soft Tissue Sarcoma Patients Cancers doi: 10.3390/cancers12102735 Authors: Kento Fujiwara Shigemi Sasawatari Sho Nakai Keisuke Imaeda Seina Nagai Yoshihiro Matsuno Kanako Hatanaka Yutaka Hatanaka Satoshi Takenaka Naoki Okada Soft tissue sarcomas (STSs) are heterogeneous and aggressive malignancies with few effective...
Wed Sep 23, 2020 03:00
Cancers, Vol. 12, Pages 2736: Erratum: Witschen, P.M., et al. Tumor Cell Associated Hyaluronan-CD44 Signaling Promotes Pro-Tumor Inflammation in Breast Cancer. Cancers 2020, 12, 1325 Cancers doi: 10.3390/cancers12102736 Authors: Patrice M. Witschen Thomas S. Chaffee Nicholas J. Brady Danielle N. Huggins Todd P. Knutson Rebecca S. LaRue Sarah A. Munro Lyubov Tiegs James B. McCarthy Andrew C. Nelson Kathryn L. Schwertfeger The authors wish to make the following...
Wed Sep 23, 2020 03:00
Cancers, Vol. 12, Pages 2733: Transcatheter Arterial Embolization Treatment for Bleeding Visceral Artery Pseudoaneurysms in Patients with Pancreatitis or Following Pancreatic Surgery Cancers doi: 10.3390/cancers12102733 Authors: Isao Numoto Masakatsu Tsurusaki Teruyoshi Oda Yukinobu Yagyu Kazunari Ishii Takamichi Murakami Purpose: To evaluate the efficacy and safety of transcatheter arterial embolization (TAE) for pseudoaneurysms occurring secondary to pancreatitis or...
Wed Sep 23, 2020 03:00
Cancers, Vol. 12, Pages 2732: Dual Targeting of Endothelial and Cancer Cells Potentiates In Vitro Nanobody-Targeted Photodynamic Therapy Cancers doi: 10.3390/cancers12102732 Authors: Vida Mashayekhi Katerina T. Xenaki Paul M.P. van Bergen en Henegouwen Sabrina Oliveira Photodynamic therapy (PDT) induces cell death through local light activation of a photosensitizer, although sub-optimal tumor specificity and side effects have hindered its clinical application. We introduced...
Wed Sep 23, 2020 03:00
Cancers, Vol. 12, Pages 2729: Hepatocellular Carcinoma: Updates in Pathogenesis, Detection and Treatment Cancers doi: 10.3390/cancers12102729 Authors: Maria L. Martínez-Chantar Matias A. Avila Shelly C. Lu Hepatocellular carcinoma (HCC) is the most frequent primary liver cancer and the second most common cause of cancer mortality worldwide [...]
Wed Sep 23, 2020 03:00
Cancers, Vol. 12, Pages 2731: Molecular Pathogenesis of Pancreatic Ductal Adenocarcinoma: Impact of miR-30c-5p and miR-30c-2-3p Regulation on Oncogenic Genes Cancers doi: 10.3390/cancers12102731 Authors: Takako Tanaka Reona Okada Yuto Hozaka Masumi Wada Shogo Moriya Souichi Satake Tetsuya Idichi Hiroshi Kurahara Takao Ohtsuka Naohiko Seki Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive types of cancer, and its prognosis is abysmal; only...
Wed Sep 23, 2020 03:00
Cancers, Vol. 12, Pages 2730: Transcriptomics-Based Drug Repurposing Approach Identifies Novel Drugs against Sorafenib-Resistant Hepatocellular Carcinoma Cancers doi: 10.3390/cancers12102730 Authors: Kelly Regan-Fendt Ding Li Ryan Reyes Lianbo Yu Nissar A. Wani Peng Hu Samson T. Jacob Kalpana Ghoshal Philip R.O. Payne Tasneem Motiwala Objective: Hepatocellular carcinoma (HCC) is frequently diagnosed in patients with late-stage disease who are ineligible for...
Wed Sep 23, 2020 03:00
Cancers, Vol. 12, Pages 2734: HDAC9 Is Preferentially Expressed in Dedifferentiated Hepatocellular Carcinoma Cells and Is Involved in an Anchorage-Independent Growth Cancers doi: 10.3390/cancers12102734 Authors: Keita Kanki Ryota Watanabe Le Nguyen Thai Chun-Hao Zhao Kyoko Naito Aberrant activation of histone deacetylases (HDACs) is one of the causes of tumor cell transformation in many types of cancer, however, the critical HDAC responsible for the malignant transformation...
Wed Sep 23, 2020 03:00
Cancers, Vol. 12, Pages 2726: LncRNA Profiling Reveals That the Deregulation of H19, WT1-AS, TCL6, and LEF1-AS1 Is Associated with Higher-Risk Myelodysplastic Syndrome Cancers doi: 10.3390/cancers12102726 Authors: Katarina Szikszai Zdenek Krejcik Jiri Klema Nikoleta Loudova Andrea Hrustincova Monika Belickova Monika Hruba Jitka Vesela Viktor Stranecky David Kundrat Pavla Pecherkova Jaroslav Cermak Anna Jonasova Michaela Dostalova Merkerova Background:...
Wed Sep 23, 2020 03:00
Cancers, Vol. 12, Pages 2724: Impact of Polypharmacy for Chronic Ailments in Colon Cancer Patients: A Review Focused on Drug Repurposing Cancers doi: 10.3390/cancers12102724 Authors: Riccardo Giampieri Luca Cantini Enrica Giglio Alessandro Bittoni Andrea Lanese Sonia Crocetti Federica Pecci Cecilia Copparoni Tania Meletani Edoardo Lenci Alessio Lupi Maria Giuditta Baleani Rossana Berardi Colorectal cancer is characterized by high incidence worldwide....
Wed Sep 23, 2020 03:00
Cancers, Vol. 12, Pages 2727: Promising Applications of Tumor Spheroids and Organoids for Personalized Medicine Cancers doi: 10.3390/cancers12102727 Authors: Zarema Gilazieva Aleksei Ponomarev Catrin Rutland Albert Rizvanov Valeriya Solovyeva One of the promising directions in personalized medicine is the use of three-dimensional (3D) tumor models such as spheroids and organoids. Spheroids and organoids are three-dimensional cultures of tumor cells that can be obtained from...
Wed Sep 23, 2020 03:00
Cancers, Vol. 12, Pages 2725: Neutralization of B-Cell Activating Factor (BAFF) by Belimumab Reinforces Small Molecule Inhibitor Treatment in Chronic Lymphocytic Leukemia Cancers doi: 10.3390/cancers12102725 Authors: Claudia Tandler Moritz Schmidt Jonas S. Heitmann Julia Hierold Jonas Schmidt Pascal Schneider Daniela Dörfel Juliane Walz Helmut R. Salih The introduction of idelalisib, ibrutinib and venetoclax for treatment of chronic lymphocytic leukemia (CLL)...
Wed Sep 23, 2020 03:00
Cancers, Vol. 12, Pages 2728: Fusobacterium nucleatum Accelerates the Progression of Colitis-Associated Colorectal Cancer by Promoting EMT Cancers doi: 10.3390/cancers12102728 Authors: Mi Ra Yu Hye Jung Kim Hae Ryoun Park Recently, it has been reported that Fusobacterium nucleatum, a major pathogen involved in chronic periodontitis, may play an important role in colorectal cancer (CRC) progression. In addition, inflammatory bowel diseases such as ulcerative colitis and Crohn’s...
Wed Sep 23, 2020 03:00
Cells, Vol. 9, Pages 2150: Crosstalk Between Autophagy and Hypoxia-Inducible Factor-1α in Antifungal Immunity Cells doi: 10.3390/cells9102150 Authors: Tim Quäschling Dirk Friedrich George S. Deepe Rupp Modern medicine is challenged by several potentially severe fungal pathogens such as Aspergillus fumigatus, Candida albicans, or Histoplasma capsulatum. Though not all fungal pathogens have evolved as primary pathogens, opportunistic pathogens can still cause fatal infections...
Wed Sep 23, 2020 03:00
Cells, Vol. 9, Pages 2153: Systemic Inflammatory Markers Are Predictive of the Response to Brachytherapy in the Prostate Cells doi: 10.3390/cells9102153 Authors: Daniel Taussky Denis Soulieres Miguel Chagnon Guila Delouya Houda Bahig We analyzed the influence of the neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) on the biochemical recurrence (BCR) in low-intermediate risk prostate cancer (PCa). A total of 604 patients treated with exclusive brachytherapy...
Wed Sep 23, 2020 03:00
Cells, Vol. 9, Pages 2151: Two- and Three-Dimensional Tracking of MFA2 mRNA Molecules in Mating Yeast Cells doi: 10.3390/cells9102151 Authors: Polina Geva Konstantin Komoshvili Stella Liberman-Aronov Intracellular mRNA transport contributes to the spatio-temporal regulation of mRNA function and localized translation. In the budding yeast, Saccharomyces cerevisiae, asymmetric mRNA transport localizes ~30 specific mRNAs including those encoding polarity and secretion factors, to...
Wed Sep 23, 2020 03:00
Cells, Vol. 9, Pages 2152: ARID2 Chromatin Remodeler in Hepatocellular Carcinoma Cells doi: 10.3390/cells9102152 Authors: Robin Loesch Linda Chenane Sabine Colnot Chromatin remodelers are found highly mutated in cancer including hepatocellular carcinoma. These mutations frequently occur in ARID (AT-rich Interactive Domain) genes, encoding subunits of the ATP-dependent SWI/SNF remodelers. The increasingly prevalent complexity that surrounds the functions and specificities of the...
Wed Sep 23, 2020 03:00
Cells, Vol. 9, Pages 2154: c-Jun N-Terminal Kinase as a Therapeutic Target in Experimental Autoimmune Encephalomyelitis Cells doi: 10.3390/cells9102154 Authors: Maud Bagnoud Myriam Briner Jana Remlinger Ivo Meli Sara Schuetz Maximilian Pistor Anke Salmen Andrew Chan Robert Hoepner c-Jun N-terminal kinase (JNK) is upregulated during multiple sclerosis relapses and at the peak of experimental autoimmune encephalomyelitis (EAE). We aim to investigate the effects...
Wed Sep 23, 2020 03:00
Cells, Vol. 9, Pages 2146: Cell Senescence, Multiple Organelle Dysfunction and Atherosclerosis Cells doi: 10.3390/cells9102146 Authors: Gisela Machado-Oliveira Cristiano Ramos André R. A. Marques Otília V. Vieira Atherosclerosis is an age-related disorder associated with long-term exposure to cardiovascular risk factors. The asymptomatic progression of atherosclerotic plaques leads to major cardiovascular diseases (CVD), including acute myocardial infarctions or cerebral ischemic...
Wed Sep 23, 2020 03:00
Cells, Vol. 9, Pages 2148: The Absence of NLRP3-inflammasome Modulates Hepatic Fibrosis Progression, Lipid Metabolism, and Inflammation in KO NLRP3 Mice during Aging Cells doi: 10.3390/cells9102148 Authors: Paloma Gallego Beatriz Castejón-Vega José A. del Campo Mario D. Cordero Aging is associated with metabolic changes and low-grade inflammation in several organs, which may be due to NLRP3 inflammasome activation. Methods: Here, we asked whether age-related liver changes such...
Wed Sep 23, 2020 03:00
Cells, Vol. 9, Pages 2147: Transmembrane BAX Inhibitor-1 Motif Containing Protein 5 (TMBIM5) Sustains Mitochondrial Structure, Shape, and Function by Impacting the Mitochondrial Protein Synthesis Machinery Cells doi: 10.3390/cells9102147 Authors: Bruno Seitaj Felicia Maull Li Zhang Verena Wüllner Christina Wolf Philipp Schippers Rita La Rovere Ute Distler Stefan Tenzer Jan B. Parys Geert Bultynck Axel Methner The Transmembrane Bax Inhibitor-1 motif (TMBIM)-containing...
Wed Sep 23, 2020 03:00
Cells, Vol. 9, Pages 2145: TNF Production and Release from Microglia via Extracellular Vesicles: Impact on Brain Functions Cells doi: 10.3390/cells9102145 Authors: Stefano Raffaele Marta Lombardi Claudia Verderio Marta Fumagalli Tumor necrosis factor (TNF) is a pleiotropic cytokine powerfully influencing diverse processes of the central nervous system (CNS) under both physiological and pathological conditions. Here, we analyze current literature describing the molecular processes...
Wed Sep 23, 2020 03:00
Cells, Vol. 9, Pages 2149: In Vitro Studies to Define the Cell-Surface and Intracellular Targets of Polyarginine-Conjugated Sodium Borocaptate as a Potential Delivery Agent for Boron Neutron Capture Therapy Cells doi: 10.3390/cells9102149 Authors: Atsushi Fujimura Seiji Yasui Kazuyo Igawa Ai Ueda Kaori Watanabe Tadashi Hanafusa Yasuaki Ichikawa Sachiko Yoshihashi Kazuki Tsuchida Atsunori Kamiya Shuichi Furuya Boron neutron capture therapy (BNCT) requires...
Wed Sep 23, 2020 03:00
Cells, Vol. 9, Pages 2144: Thermal Neutron Relative Biological Effectiveness Factors for Boron Neutron Capture Therapy from In Vitro Irradiations Cells doi: 10.3390/cells9102144 Authors: María Pedrosa-Rivera Javier Praena Ignacio Porras Manuel P. Sabariego Ulli Köster Michael Haertlein V. Trevor Forsyth José C. Ramírez Clara Jover Daniel Jimena Juan L. Osorio Patricia Álvarez Carmen Ruiz-Ruiz María J. Ruiz-Magaña The experimental determination of...
Wed Sep 23, 2020 03:00
Challenges, Vol. 11, Pages 23: Systemic Crop Signaling for Automatic Recognition of Transplanted Lettuce and Tomato under Different Levels of Sunlight for Early Season Weed Control Challenges doi: 10.3390/challe11020023 Authors: Wen-Hao Su Conventional cultivation works to control weeds between the rows, but it ignores the weeds in crop rows which are most competitive with crops. Many vegetable crops still require manual removal of intra-row weeds not otherwise controlled by herbicides...
Wed Sep 23, 2020 03:00
Chemosensors, Vol. 8, Pages 88: Identification of Plastic Type and Surface Roughness of Film-Type Plastics in Water Using Kramers–Kronig Analysis Chemosensors doi: 10.3390/chemosensors8040088 Authors: Boniphace Elphace Kanyathare Benjamin Asamoah Muhammad Umair Ishaq James Amoani Jukka Räty Kai-Erik Peiponen The knowledge of the plastic type, thickness, and the nature of the surface is important towards the monitoring of microplastic pollution in water bodies, especially...
Wed Sep 23, 2020 03:00
Climate, Vol. 8, Pages 102: Impacts of Climate Change on the Water Resources of the Kunduz River Basin, Afghanistan Climate doi: 10.3390/cli8100102 Authors: Noor Ahmad Akhundzadah Salim Soltani Valentin Aich The Kunduz River is one of the main tributaries of the Amu Darya Basin in North Afghanistan. Many communities live in the Kunduz River Basin (KRB), and its water resources have been the basis of their livelihoods for many generations. This study investigates climate change...
Wed Sep 23, 2020 03:00
Diagnostics, Vol. 10, Pages 738: Long Term Follow-Up of Polish Patients with Isovaleric Aciduria. Clinical and Molecular Delineation of Isovaleric Aciduria Diagnostics doi: 10.3390/diagnostics10100738 Authors: Edyta Szymańska Aleksandra Jezela-Stanek Anna Bogdańska Dariusz Rokicki Ewa Ehmke vel Emczyńska-Seliga Magdalena Pajdowska Elżbieta Ciara Anna Tylki-Szymańska Isovaleric acidemia (IVA) is an autosomal recessive leucine inborn error of metabolism caused by isovaleryl-CoA...
Wed Sep 23, 2020 03:00
Diagnostics, Vol. 10, Pages 736: Near-Infrared Spectroscopy Evaluations for the Differentiation of Carbapenem-Resistant from Susceptible Enterobacteriaceae Strains Diagnostics doi: 10.3390/diagnostics10100736 Authors: Bushra Alharbi Maggy Sikulu-Lord Anton Lord Hosam M. Zowawi Ella Trembizki Antimicrobial Resistance (AMR) caused by Carbapenem-Resistant Enterobacteriaceae (CRE) is a global threat. Accurate identification of these bacterial species with associated AMR is critical...
Wed Sep 23, 2020 03:00
Diagnostics, Vol. 10, Pages 737: Spatial Configuration of Abdominal Aortic Aneurysm Analysis as a Useful Tool for the Estimation of Stent-Graft Migration Diagnostics doi: 10.3390/diagnostics10100737 Authors: Andrzej Polanczyk Aleksandra Piechota-Polanczyk Ludomir Stefańczyk Michał Strzelecki The aim of this study was to prepare a self-made mathematical algorithm for the estimation of risk of stent-graft migration with the use of data on abdominal aortic aneurysm (AAA) size and...
Wed Sep 23, 2020 03:00
Diseases, Vol. 8, Pages 36: Serological Tests for SARS-CoV-2 Coronavirus by Commercially Available Point-of-Care and Laboratory Diagnostics in Pre-COVID-19 Samples in Japan Diseases doi: 10.3390/diseases8040036 Authors: Zhaoqing Lyu Mariko Harada Sassa Tomoko Fujitani Kouji H. Harada The number of COVID-19 patients in Japan is considered low, compared with U.S. and European countries. However, recent serological survey reported that several percent of population showed IgG positive...
Wed Sep 23, 2020 03:00
Diversity, Vol. 12, Pages 365: Rodent Assemblages in the Mosaic of Habitat Types in the Zambezian Bioregion Diversity doi: 10.3390/d12100365 Authors: Vincent R. Nyirenda Ngawo Namukonde Matamyo Simwanda Darius Phiri Yuji Murayama Manjula Ranagalage Kaula Milimo Rodent assemblages have ecological importance in ecosystem functioning and protected area management. Our study examines the patterns of assemblages of rodents across four habitat types (i.e., Miombo woodland,...
Wed Sep 23, 2020 03:00
Diversity, Vol. 12, Pages 366: Demersal Fish Assemblages in NE Atlantic Seagrass and Kelp Diversity doi: 10.3390/d12100366 Authors: Evie Furness Richard K.F. Unsworth Global fisheries are in decline, calling for urgent evidence-based action. One such action is the identification and protection of fishery-associated habitats such as seagrass meadows and kelp forests, both of which have suffered long-term loss and degradation in the North Atlantic region. Direct comparisons of the value...
Wed Sep 23, 2020 03:00
Foods, Vol. 9, Pages 1351: Conversion of Exhausted Sugar Beet Pulp into Fermentable Sugars from a Biorefinery Approach Foods doi: 10.3390/foods9101351 Authors: Cristina Marzo Ana Belén Díaz Ildefonso Caro Ana Blandino In this study, the production of a hydrolysate rich in fermentable sugars, which could be used as a generic microbial culture medium, was carried out by using exhausted sugar beet pulp pellets (ESBPPs) as raw material. For this purpose, the hydrolysis was performed...
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Foods, Vol. 9, Pages 1350: Annona cherimola Miller Fruit as a Promising Candidate against Diabetic Complications: An In Vitro Study and Preliminary Clinical Results Foods doi: 10.3390/foods9101350 Authors: Marzia Vasarri Emanuela Barletta Santina Vinci Matteo Ramazzotti Andrea Francesconi Francesco Manetti Donatella Degl’Innocenti Diabetes is a chronic metabolic disease with a strong social impact worldwide. Under chronic hyperglycemia, protein glycation strongly contributes...
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Foods, Vol. 9, Pages 1348: Phenolome of Asian Agrimony Tea (Agrimonia asiatica Juz., Rosaceae): LC-MS Profile, α-Glucosidase Inhibitory Potential and Stability Foods doi: 10.3390/foods9101348 Authors: Nina I. Kashchenko Daniil N. Olennikov Functional beverages constitute the rapidly increasing part of the functional food section and represent an area with a wide range of products including herbal-based beverages. We carried out screening investigations of the extracts of 85 Rosaceous...
Wed Sep 23, 2020 03:00
Foods, Vol. 9, Pages 1349: Food Consumption and Emotions at a Salad Lunch Buffet in a Multisensory Environment Foods doi: 10.3390/foods9101349 Authors: Ulla Hoppu Sari Puputti Saila Mattila Marjaana Puurtinen Mari Sandell The food experience is multisensory and multisensory external stimuli may affect food choice and emotions. The objective of this study was to evaluate the effect of a multisensory eating environment on food choice, intake and the emotional states of the...
Wed Sep 23, 2020 03:00
Foods, Vol. 9, Pages 1347: Antique Traditional Practice: Phenolic Profile of Virgin Olive Oil Obtained from Fruits Stored in Seawater Foods doi: 10.3390/foods9101347 Authors: Jelena Torić Monika Barbarić Stanko Uršić Cvijeta Jakobušić Brala Ana Karković Marković Maja Zebić Avdičević Đani Benčić Virgin olive oil (VOO) is a functional food specific to the Mediterranean diet and related to human health, especially as a protector of cardiovascular health, in the prevention...
Wed Sep 23, 2020 03:00
Foods, Vol. 9, Pages 1346: Addition of Coriander during Fermentation of Korean Soy Sauce (Gangjang) Causes Significant Shift in Microbial Composition and Reduction in Biogenic Amine Levels Foods doi: 10.3390/foods9101346 Authors: Mohamed Mannaa Young-Su Seo Inmyoung Park The microflora of Korean soy sauce (gangjang) play an important role in maintaining its quality and safety. Hence, it is important to study the microflora and the possible approaches to improve their composition....
Wed Sep 23, 2020 03:00
Foods, Vol. 9, Pages 1345: Phytochemical Components and Bioactivity Assessment among Twelve Strawberry (Arbutus unedo L.) Genotypes Growing in Morocco Using Chemometrics Foods doi: 10.3390/foods9101345 Authors: Hafida Zitouni Lahcen Hssaini Messaoudi Zerhoune Hamza Ourradi Manuel Viuda-Martos Francisca Hernández Sezai Ercisli Hafida Hanine There are not many exhaustive works emphasizing the amount of genetic diversity among the strawberry tree (Arbutus unedo L) genotypes...
Wed Sep 23, 2020 03:00
Foods, Vol. 9, Pages 1344: High Power Ultrasound Treatments of Red Young Wines: Effect on Anthocyanins and Phenolic Stability Indices Foods doi: 10.3390/foods9101344 Authors: Emilio Celotti Stefano Stante Paola Ferraretto Tomás Román Giorgio Nicolini Andrea Natolino Polyphenols, especially anthocyanins, play an important role on red wine sensory qualities and their evolution during storage. High Power Ultrasound (HPU) has been recognized as one of the most promising technologies...
Wed Sep 23, 2020 03:00
Foods, Vol. 9, Pages 1343: Bud-Derivatives, a Novel Source of Polyphenols and How Different Extraction Processes Affect Their Composition Foods doi: 10.3390/foods9101343 Authors: Federica Turrini Dario Donno Gabriele Loris Beccaro Anna Pittaluga Massimo Grilli Paola Zunin Raffaella Boggia The use of herbal food supplements, as a concentrate form of vegetable extracts, increased so much over the past years to count them among the relevant sources of dietetic polyphenols....
Wed Sep 23, 2020 03:00
Foods, Vol. 9, Pages 1342: Development of Bacterial Spore Pouches as a Tool to Evaluate the Sterilization Efficiency—A Case Study with Microwave Sterilization Using Clostridium sporogenes and Geobacillus stearothermophilus Foods doi: 10.3390/foods9101342 Authors: Aswathi Soni Jeremy Smith Richard Archer Amanda Gardner Kris Tong Gale Brightwell In this study, novel spore pouches were developed using mashed potato as a food model inoculated with either Geobacillus stearothermophilus...
Wed Sep 23, 2020 03:00
Foods, Vol. 9, Pages 1341: From By-Product to the Food Chain: Melon (Cucumis melo L.) Seeds as Potential Source for Oils Foods doi: 10.3390/foods9101341 Authors: Adrián Rabadán M. Antónia Nunes Silvia M. F. Bessada José E. Pardo M. Beatriz P. P. Oliveira Manuel Álvarez-Ortí Fruit-processing industries annually discard large volumes of fruit by-products. Thousands of tons of melon seeds could be recovered through the year from melon production. These seeds are an excellent...
Wed Sep 23, 2020 03:00
Healthcare, Vol. 8, Pages 358: Study on the Spatial Differentiation of Public Health Service Capabilities of European Union under the Background of the COVID-19 Crisis Healthcare doi: 10.3390/healthcare8040358 Authors: Xuhui Ding Zhongyao Cai Wei Zhu Zhu Fu Access to public health services is a cause that benefits the people and concerns the vital interests of the people. Everyone has access to basic health care services. The continuous improvement in people’s health...
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Healthcare, Vol. 8, Pages 357: Telemedicine in Times of the Pandemic Produced by COVID-19: Implementation of a Teleconsultation Protocol in a Hospital Emergency Department Healthcare doi: 10.3390/healthcare8040357 Authors: Antonio Lopez-Villegas Salvador Maroto-Martin Miguel Angel Baena-Lopez Antonio Garzon-Miralles Rafael Jesús Bautista-Mesa Salvador Peiro Cesar Leal-Costa Since the first case of COVID-19 was reported in Spain, almost 22% of healthcare professionals...
Wed Sep 23, 2020 03:00
Healthcare, Vol. 8, Pages 356: How Will COVID-19 Impact on the Governance of Global Health in the 2030 Agenda Framework? The Opinion of Experts Healthcare doi: 10.3390/healthcare8040356 Authors: Luis A. Fernández-Portillo Antonio Sianes Francisco Santos-Carrillo In 2015, the 2030 Agenda was formally adopted by the United Nations, establishing a set of 17 Sustainable Development Goals (SDGs). SDG 3 seeks to promote Global Health and the quality of public health systems in developing...
Wed Sep 23, 2020 03:00
Healthcare, Vol. 8, Pages 355: Information and Communications Technology-Based Telehealth Approach for Occupational Therapy Interventions for Cancer Survivors: A Systematic Review Healthcare doi: 10.3390/healthcare8040355 Authors: Na-Kyoung Hwang Young-Jin Jung Ji-Su Park (1) Background: Occupational therapy (OT) practice has a unique perspective that addresses the complex needs of cancer survivors. Despite the expanded research and application of OT services using telehealth (TH)...
Wed Sep 23, 2020 03:00
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