Related Articles The timing of fusion surgery for clival chordoma with occipito-cervical joint instability: before or after tumor resection? Neurosurg Rev. 2020 Feb;43(1):119-129 Authors: Park HH, Park JY, Chin DK, Lee KS, Hong CK Abstract Clival chordoma with occipito-cervical (OC) joint invasion can result in preoperative and postoperative instability. The authors investigate the appropriate timing of OC fusion to prevent instability-, fusion-,...
Wed Sep 23, 2020 15:55
Related Articles Spherical depth-sensing nanoindentation of human anterior skull base bones: Establishment of a test protocol. J Mech Behav Biomed Mater. 2020 Oct;110:103954 Authors: Favier V, Gallet P, Ferry O, Jehl JP Abstract The mechanical properties of anterior skull base (ASB) bones are not well understood due to their complex geometry and deep location. However, it is of particular interest for skull base surgeons to appraise the force...
Wed Sep 23, 2020 15:55
Related Articles Anterior skull base reconstruction using nasoseptal flap: cadaveric feasibility study and clinical implication [SevEN-001]. J Otolaryngol Head Neck Surg. 2020 Sep 21;49(1):67 Authors: Sung KS, Lim J, Na M, Lee S, Kim JS, Hong JB, Hong CK, Moon JH Abstract BACKGROUND: Pedicled nasoseptal flap (PNSF) has significantly improved the surgical outcomes of endoscopic endonasal approach (EEAs) by reducing cerebrospinal fluid (CSF) leakage....
Wed Sep 23, 2020 15:55
Related Articles Isolated unilateral hypoglossal nerve palsy caused by skull base metastasis. Ann Neurol. 2020 Sep 21;: Authors: Ogawa T, Wakutani Y, Fujii S PMID: 32959448 [PubMed - as supplied by publisher]
Wed Sep 23, 2020 15:55
Related Articles Nerve fiber analysis of the lingual branch of the glossopharyngeal nerve in human adult subjects. Surg Radiol Anat. 2020 Sep 22;: Authors: Saigusa H, Yamashita K, Saigusa M, Niimi S Abstract PURPOSE: Fibers of the glossopharyngeal part of the superior constrictor muscle are connected with fibers of the transverse lingual muscle, forming a ring of muscle at the base of the tongue. This group of muscles constrict the midpharyngeal...
Wed Sep 23, 2020 15:55
Related Articles Clinical outcomes of otogenic skull base osteomyelitis. Eur Arch Otorhinolaryngol. 2020 Sep 22;: Authors: Jung DJ, Hong J, Cho HJ, Yoo MH, Lee KY Abstract PURPOSE: Skull base osteomyelitis (SBO) is an uncommon and a potentially life-threatening condition if not promptly recognized and properly treated. The aim of our study was to present a 32-case series of patients diagnosed with SBO at a single center. METHODS: In...
Wed Sep 23, 2020 15:55
Related Articles Prompt gamma imaging for the identification of regional proton range deviations due to anatomic change in a heterogeneous region: a case study. Br J Radiol. 2020 Sep 22;:20190619 Authors: Xie Y, Petzoldt J, Janssens G, O'Grady F, Yin L, Bentefour EH, Smeets J, Prieels D, Lustig RA, Lin A, Teo BK Abstract OBJECTIVES: Prompt Gamma (PG) imaging has previously been demonstrated for use in proton range verification of a brain treatment...
Wed Sep 23, 2020 15:55
Related Articles MRI of the Internal Auditory Canal, Labyrinth, and Middle Ear: How We Do It. Radiology. 2020 Sep 22;:201767 Authors: Benson JC, Carlson ML, Lane JI Abstract MRI is firmly established as an essential modality in the imaging of the temporal bone and lateral skull base. It is used to evaluate normal anatomic structures, evaluate for vestibular schwannomas, assess for inflammatory and/or infectious processes, and detect residual...
Wed Sep 23, 2020 15:55
Publication date: Available online 21 September 2020Source: The Journal of Prosthetic DentistryAuthor(s): Brittany Kane, Kumar C. Shah
Wed Sep 23, 2020 16:01
AbstractInflammatory myofibroblastic tumor (IMT) is an uncommon, usually benign, mesenchymal tumor. IMT affects people of all ages, but it more commonly occurs in children and adolescents. Also, it has the potential to arise in any part of the body, though, it frequently develops in the lungs and mesentery. In this report, we discuss a rare clinical manifestation of mesenteric IMT presented as intussusception of the small intestine in a 7-year-old child.
Wed Sep 23, 2020 03:00
AbstractGlucocorticoids are commonly used in the management of patients with brain Tumour for reducing peritumoral and vasogenic edema. However, they may lead to development of limb and life-threatening conditions such as necrotizing fasciitis (NF). NF is a rare but potentially lethal condition. Early detection and aggressive treatment may lead to decreased mortality and limb salvage. The diagnosis is predominately clinical but may be supported by laboratory and radiological investigations. Chronic...
Wed Sep 23, 2020 03:00
AbstractBenign tracheal tumours have an incidence of 1 in 1,000,000, of which leiomyomas represent only 1%. We report a case of tracheal leiomyoma masquerading as asthma for over 20 years. A 48-year-old man presented aged 26 years with asthma symptoms unresponsive to treatments and an obstructive spirometry pattern. Symptoms were not particularly troubling but suddenly exacerbated 22 years later. Flow-volume studies were consistent with upper airway obstruction. Computed tomography chest revealed...
Wed Sep 23, 2020 03:00
Related Articles Assessment, Diagnosis, and Treatment of Dysphagia in Patients Infected With SARS-CoV-2: A Review of the Literature and International Guidelines. Am J Speech Lang Pathol. 2020 Sep 22;:1-12 Authors: Vergara J, Skoretz SA, Brodsky MB, Miles A, Langmore SE, Wallace S, Seedat J, Starmer HM, Bolton L, Clavé P, Freitas SV, Bogaardt H, Matsuo K, de Souza CM, Mourão LF Abstract Purpose Speech-language pathologists are playing a...
Wed Sep 23, 2020 16:06
Related Articles MRI-based Bosniak Classification of Cystic Renal Masses, Version 2019: Interobserver Agreement, Impact of Readers' Experience, and Diagnostic Performance. Radiology. 2020 Sep 22;:200478 Authors: Bai X, Sun SM, Xu W, Kang HH, Li L, Jin YQ, Gong QG, Liang GC, Liu HY, Liu LL, Chen SL, Wang QR, Wu P, Guo AT, Huang QB, Zhang XJ, Ye HY, Wang HY Abstract Background The 2019 Bosniak classification (version 2019) of cystic renal...
Wed Sep 23, 2020 16:07
Related Articles Revascularization Evaluation in Adult-Onset Moyamoya Disease after Bypass Surgery: Superselective Arterial Spin Labeling Perfusion MRI Compared with Digital Subtraction Angiography. Radiology. 2020 Sep 22;:201448 Authors: Hwang I, Cho WS, Yoo RE, Kang KM, Yoo DH, Yun TJ, Choi SH, Kim JH, Kim JE, Sohn CH Abstract Background A superselective (SS) arterial spin labeling (ASL) MRI technique can be used to monitor the revascularization...
Wed Sep 23, 2020 16:07
Related Articles Normal Liver Stiffness Measured with MR Elastography in Children. Radiology. 2020 Sep 22;:201513 Authors: Trout AT, Anupindi SA, Gee MS, Khanna G, Xanthakos SA, Serai SD, Baikpour M, Calle-Toro JS, Ozturk A, Zhang B, Dillman JR Abstract Background Stiffness thresholds for liver MR elastography in children vary between studies and may differ from thresholds in adults. Normative liver stiffness data are needed to optimize...
Wed Sep 23, 2020 16:07
Related Articles Performance of a Deep Learning Algorithm Compared with Radiologic Interpretation for Lung Cancer Detection on Chest Radiographs in a Health Screening Population. Radiology. 2020 Sep 22;:201240 Authors: Lee JH, Sun HY, Park S, Kim H, Hwang EJ, Goo JM, Park CM Abstract Background The performance of a deep learning algorithm for lung cancer detection on chest radiographs in a health screening population is unknown. Purpose...
Wed Sep 23, 2020 16:07
Abstract This systematic review and meta‐analysis evaluates the validity of narrowband imaging (NBI) in differentiating between low‐risk leukoplakia and high‐risk leukoplakia. Medline, EMBASE, Scopus, Cochrane Database of Systematic Reviews and Database of Abstracts of Reviews of Effects were searched. Studies evaluating the diagnostic accuracy of NBI in the assessment of laryngeal leukoplakia were included. Pooled sensitivity, specificity and diagnostic odds ratio were calculated. Seven studies...
Wed Sep 23, 2020 15:31
Abstract Purpose To compare the operative outcomes of laparoscopic surgical treatment for bowel endometriosis in a public teaching hospital versus in a private referral hospital. Methods The indications for surgery, type and time of operation, length of hospital stay, need for a temporary stoma, rate of conversion to open surgery, and postoperative complications were evaluated. Results One hundred eighty-one patients were included (150 patients, 82.9%, in a private hospital). In the private...
Wed Sep 23, 2020 16:10
Abstract Purpose To evaluate the effects of treatment with Indigo Carmine (IC) on rat livers subjected to ischemia-reperfusion injury. Methods The animals were subdivided into 4 groups: 1.SHAM group(SH) - saline; 2.SHAM group with IC-2mg/Kg(SHIC); 3.IR group - rats submitted to ischemia and reperfusion with saline(IR); 4.IR group with IC-2mg/Kg(IRIC). The IR protocol consists of liver exposure and administration of drug or saline intravenously, followed by 60 minutes of ischemia and 15 of reperfusion....
Wed Sep 23, 2020 16:10
Abstract Objective To investigate if patients with confirmed traumatic abdominal injury and a false-negative focused abdominal sonography for trauma (FAST) examination have a more favorable prognosis than those with a true-positive FAST. Methods This study included 97 consecutive patients with confirmed traumatic abdominal injury (based...
Wed Sep 23, 2020 03:00
Abstract Background Masticatory function of institutionalized elders and its relationship with nutrition and oral health‐related quality of life (OHRQoL) is unknown. Objectives This multicenter cross‐sectional study evaluated the influence of the presence of teeth and dentures on masticatory function (masticatory performance and swallowing threshold) in institutionalized elders. Correlation of masticatory function with nutrition and OHRQoL was also verified. Methods Older adults (n=344;...
Tue Sep 22, 2020 15:07
Abstract Background Dry mouth is associated with salivary gland hypofunction, which may result from several conditions such as Sjögren’s syndrome (SS), head and neck cancers, and side effects of medications. The Saxon test is a useful diagnostic method for hyposalivation in clinical settings. However, previous reports indicate that the test has mostly been used for patients with SS. Objective(s) In the present study, we focused on patients with dry mouth who were not diagnosed with SS (patients...
Wed Sep 23, 2020 15:39
Related Articles Cases of high lying azygos arch and its embryological consideration. Surg Radiol Anat. 2020 Sep 21;: Authors: Yoo MY, Kim SJ, Yoo JY Abstract PURPOSE: This study aimed to report cases of high-lying azygos arch and discuss the embryological basis of its development by a thorough evaluation of the anatomical features assessed using computed tomography (CT) images. METHODS: This study was approved by our institutional...
Wed Sep 23, 2020 16:12
Related Articles Anatomical study of a surgical approach through the neck to the jugular foramen under endoscopy. Surg Radiol Anat. 2020 Sep 21;: Authors: Lai PF, Wu X, Lan SH, Tang B, Huang HY, Hong T Abstract OBJECTIVES: To investigate the feasibility of an endoscopic surgical approach through the neck to the jugular foramen, to determine the relevant techniques and extent of exposure, and to provide a new surgical approach with minimal...
Wed Sep 23, 2020 16:12
Related Articles Three-dimensional visualization of the alveolar bone and posterior superior alveolar foramen in gender. Surg Radiol Anat. 2020 Sep 22;: Authors: Lee JH, Ahn HN, Park JT Abstract The present study applied a three-dimensional (3D) program to measure the distances from the maxillary sinus floor (MSF) to the lingual and buccal alveolar bone and also to the posterior superior alveolar foramen (PSAF), with the aim of determining...
Wed Sep 23, 2020 16:12
Related Articles Indirect analysis of first-line therapy for advanced non-small-cell lung cancer with activating mutations in the Japanese population. Future Oncol. 2020 Sep 22;: Authors: Nakagawa K, Matsumura K, Scory T, Farris MS, Larkin-Kaiser KA, Kikkawa H, Ivanova JI, Wilner KD Abstract Background: Five EGFR-tyrosine kinase inhibitors (EGFR TKIs) are currently available in the first-line setting for non-small-cell lung cancer (NSCLC) in...
Wed Sep 23, 2020 16:14
Publication date: September 2020Source: Human Pathology, Volume 103Author(s):
Wed Sep 23, 2020 16:16
Publication date: September 2020Source: Human Pathology, Volume 103Author(s):
Wed Sep 23, 2020 16:16
Publication date: September 2020Source: Human Pathology, Volume 103Author(s):
Wed Sep 23, 2020 16:16
Publication date: Available online 21 September 2020Source: Human PathologyAuthor(s): Sara Makhdoum, Valentina Nardi, Kelly A. Devereaux, Christian A. Kunder, G. Petur Nielsen, Esther Oliva, Robert H. Young, Drucilla J. Roberts
Wed Sep 23, 2020 16:16
Publication date: Available online 21 September 2020Source: Human PathologyAuthor(s): Beth Morrel, Patricia C. Ewing-Graham, Irene A.M. van der Avoort, Suzanne G.M.A. Pasmans, Jeffrey Damman
Wed Sep 23, 2020 16:16
Publication date: Available online 22 September 2020Source: Human PathologyAuthor(s): Isabelle Schoop, Saffiyeh Saboor Maleki, Hans-Michael Behrens, Sandra Krüger, Jochen Haag, Christoph Röcken
Wed Sep 23, 2020 16:16
Publication date: Available online 21 September 2020Source: European Journal of Vascular and Endovascular SurgeryAuthor(s): Hua Yi Zhang
Wed Sep 23, 2020 16:21
Publication date: Available online 22 September 2020Source: European Journal of Vascular and Endovascular SurgeryAuthor(s): Jean-Baptiste Ricco, Joseph L. Mills, Philippe Kolh
Wed Sep 23, 2020 16:21
Zusammenfassung Mesenchymale Tumoren, insbesondere High-grade-Sarkome, weisen oft einen chaotischen Genotyp auf. Wenige Sarkome entstehen auf dem Boden eines erblichen Tumorsyndroms mit Keimbahnmutation in einem Tumorsuppressorgen. Eine wachsende Zahl von Weichgewebstumoren und Knochentumoren ist jedoch durch eine spezifische, rekurrente genomische Alteration charakterisiert, die für diagnostische Zwecke herangezogen werden kann. Darunter sind insbesondere spezifische Translokationen...
Wed Sep 23, 2020 03:00
Related Articles The protective effect of Morin against ifosfamide-induced acute liver injury in rats associated with the inhibition of DNA damage and apoptosis. Drug Chem Toxicol. 2020 Sep 22;:1-10 Authors: Özdemir S, Kucukler S, Çomaklı S, Kandemir FM Abstract Morin is a flavonoid and broadly found in white berry and cranberry branch. Ifosfamide (IFOS) is known as an anticancer and cytotoxic drug especially on the liver. This study aimed to...
Wed Sep 23, 2020 16:32
Related Articles Neuromodulatory and oxidative stress evaluations in African catfish Clarias gariepinus exposed to antipsychotic drug chlorpromazine. Drug Chem Toxicol. 2020 Sep 22;:1-7 Authors: Atama CI, Nnaji EC, Christian Ezeoyili I, Udeani FO, Onovo CJ, Ike Ossai N, Oscar Aguzie I, Nwani CD Abstract Chlorpromazine (CPZ) is among the most famous drugs used for the treatment of psychosis such as delusions, hallucinations, schizophrenia, paranoia,...
Wed Sep 23, 2020 16:32
Related Articles Azithromycin effects on the European sea bass (Dicentrarchus labrax) early life stages following acute and chronic exposure: Laboratory bioassays. Drug Chem Toxicol. 2020 Sep 22;:1-7 Authors: Mhadhbi L, El Ayari T, Tir M, Kadri D Abstract The purpose of this study was to assess the acute and chronic effects of the macrolide azithromycin (AZI) on the European sea bass (Dicentrarchus labrax) early life stages. Azithromycin is...
Wed Sep 23, 2020 16:32
Publication date: Available online 22 September 2020Source: BrachytherapyAuthor(s): Kathrin Kirchheiner, Stéphanie Smet, Sofia Spampinato, Nina B.K. Jensen, Anders Schwartz Vittrup, Lars Fokdal, Dina Najjari-Jamal, Henrike G. Westerveld, Jacob C. Lindegaard, Christian Kirisits, Astrid De Leeuw, Maximilian P. Schmid, Li Tee Tan, Remi A. Nout, Ina M. Jürgenliemk-Schulz, Richard Pötter, Kari Tanderup, the EMBRACE Collaborative Group
Wed Sep 23, 2020 16:34
Publication date: Available online 23 September 2020Source: BrachytherapyAuthor(s): Joshua B. Dault, Dorin Todor, Brian J. Kaplan, Jennifer L. Myers, Emma C. Fields
Wed Sep 23, 2020 16:34
Journal of International Medical Research, Volume 48, Issue 9, September 2020. Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is a rare autoinflammatory disorder without standardized therapy. Anti-tumor necrosis factor (TNF)-α agents, which have been widely used in recent treatment of SAPHO syndrome, may elicit severe paradoxical psoriasiform lesions. Therefore, physicians must reverse the paradoxical skin lesions in affected patients, while improving their clinical symptoms...
Wed Sep 23, 2020 08:16
Journal of International Medical Research, Volume 48, Issue 9, September 2020. ObjectivesEmpirical determination of phenylalanine (Phe) tolerance in patients with phenylketonuria (PKU) relies on frequent assessment of blood Phe concentrations in relation to Phe intake from detailed meal records. This study aimed to determine Phe tolerance in twin pregnancies.MethodsThe reviewed cases included three women with PKU who each had a singleton and twin pregnancy (i.e., they were pregnant twice). All patients...
Wed Sep 23, 2020 08:20
Journal of International Medical Research, Volume 48, Issue 9, September 2020. BackgroundGastric schwannoma is a rarely seen gastric tumor accounting for only 0.2% of all gastric tumors. It is difficult to distinguish a gastric schwannoma from other gastric tumors preoperatively.Case presentation: A 30-year-old man with no significant medical history or physical examination findings presented with a 1-month history of right upper abdominal discomfort. The preoperative diagnosis was a gastrointestinal...
Wed Sep 23, 2020 08:27
Journal of International Medical Research, Volume 48, Issue 9, September 2020. ObjectiveWe aimed to investigate risk factors related to remnant gallbladder (RGB) stones.MethodsThis retrospective study included 73 patients with RGB, in groups with and without RGB calculi. Univariate analyses were used to identify nine variables associated with RGB calculi: sex, age, body mass index (BMI), time to detection, surgical method, length of RGB, angle of RGB and common hepatic duct (CHD), choledocholithiasis,...
Wed Sep 23, 2020 08:32
Journal of International Medical Research, Volume 48, Issue 9, September 2020. ObjectivesNormokalemic periodic paralysis (NormoKPP) of skeletal muscle is an autosomal dominant disorder caused by mutations in the gene encoding voltage-gated sodium channel protein type 4 subunit alpha (SCN4A), which leads to ion channel dysfunction. Little is known about the relationship between genotype and the clinical symptoms of NormoKPP. The present study aimed to evaluate the genetic variation in a large Chinese...
Wed Sep 23, 2020 08:40
Journal of International Medical Research, Volume 48, Issue 9, September 2020. ObjectiveAbdominal examination findings in pediatric acute appendicitis (AA) significantly vary by age. Therefore, grading systems have been developed for diagnosing pediatric appendicitis, and laboratory and radiological findings have an important role in this diagnosis. However, there is a need to develop new parameters for diagnosing AA. This study aimed to investigate the diagnostic value of platelet indices in AA.MethodsThis...
Wed Sep 23, 2020 08:44
Journal of International Medical Research, Volume 48, Issue 9, September 2020. Double-chambered left ventricle (DCLV) is a rare congenital cardiac abnormality. We retrospectively analyzed the diagnosis and treatment of a patient with DCLV who was admitted to Jiading Central Hospital of Shanghai Medical College in August 2019. The initial symptom of the 55-year-old male patient was stroke. He was preliminarily diagnosed with DCLV by echocardiography and this diagnosis was confirmed by contrast-enhanced...
Wed Sep 23, 2020 08:47
Journal of International Medical Research, Volume 48, Issue 9, September 2020. ObjectiveTo identify serum protein markers in midtrimester that predict preterm delivery.MethodsA retrospective case–control study randomly selected patients that experienced spontaneous preterm birth and healthy control patients that experienced a normal delivery at term. A proteomic analysis was undertaken using the data-independent acquisition method.ResultsA total of 30 singleton pregnant women were randomly selected...
Wed Sep 23, 2020 08:49
Journal of International Medical Research, Volume 48, Issue 9, September 2020. ObjectiveTo evaluate the clinical efficacy of an allogeneic bone cage (Biocage; Beijing Datsing Bio-Tech Co., Ltd., Beijing, China) for treatment of single-segment lumbar degenerative disease in patients with a high risk of non-fusion.MethodsFrom January 2013 to December 2016, 67 patients who underwent lumbar fusion were divided into the Biocage group (n = 33) and polyether ether ketone (PEEK) group (n = 34). The patients...
Wed Sep 23, 2020 08:51
Related Articles Tunable Strategies Involving Flexibility and Angularity of Dual Linkers for a 3D Metal-Organic Framework Capable of Multimedia Iodine Capture. ACS Appl Mater Interfaces. 2020 Sep 22;: Authors: Gogia A, Das P, Mandal SK Abstract The widespread use of nuclear power poses severe health and environment risks owing to the non-regulated release and disposal of radioactive wastes in the environment. Among these wastes, the capture...
Wed Sep 23, 2020 16:37
Related Articles Boosting the Iodine Adsorption and Radioresistance of Th-UiO-66 MOFs via Aromatic Substitution. Chemistry. 2020 Sep 22;: Authors: Lin J, Li ZJ, Ju Y, Lu H, Wu X, Yu X, Li Y, Wu X, Zhang ZH, Qian Y, He MY, Wang JQ Abstract Effective capture of radioactive iodine is of paramount importance for the safe and long-term storage of fission products in nuclear fuel cycle. Herein, a series of functionalized Th-UiO-66 MOFs was employed...
Wed Sep 23, 2020 16:37
Publication date: Available online 21 September 2020Source: Behavioural Brain ResearchAuthor(s): Michael J. Darrow, Tabarak M. Mian, Miranda Torres, Zainab Haider, Tanya Danaphongse, Armin Seyedahmadi, Robert L. Rennaker, Seth A. Hays, Michael P. Kilgard
Wed Sep 23, 2020 16:39
Publication date: Available online 21 September 2020Source: Behavioural Brain ResearchAuthor(s): I-Mei Liao, Jin-Chung Chen
Wed Sep 23, 2020 16:39
Publication date: Available online 22 September 2020Source: Behavioural Brain ResearchAuthor(s): Farzaneh Nazari-Serenjeh, Shahram Zarrabian, Ronak Azizbeigi, Abbas Haghparast
Wed Sep 23, 2020 16:39
Publication date: Available online 22 September 2020Source: Behavioural Brain ResearchAuthor(s): Janet H. Bultitude, Karin Petrini
Wed Sep 23, 2020 16:39
Publication date: Available online 22 September 2020Source: Behavioural Brain ResearchAuthor(s): Türkan Koyuncuoğlu, Hacer Sevim, Nurşen Çetrez, Zeynep Meral, Berfin Gönenç, Ekin Kuntsal Dertsiz, Dilek Akakın, Meral Yüksel, Özgür Kasımay Çakır
Wed Sep 23, 2020 16:39
Publication date: Available online 22 September 2020Source: Behavioural Brain ResearchAuthor(s): Antonia V. Seligowski, Anthony N. Reffi, Karlye A. Phillips, Holly K. Orcutt, Randy P. Auerbach, Diego A. Pizzagalli, Kerry J. Ressler
Wed Sep 23, 2020 16:39
Publication date: Available online 22 September 2020Source: Medical Mycology Case ReportsAuthor(s): George Giannoulopoulos, Remo Lobetti
Wed Sep 23, 2020 16:44
Abstract Background Complex regional pain syndrome (CRPS) is a chronic, posttraumatic condition defined by severe pain and sensorimotor dysfunction. In cases of severe CRPS, patients request amputation, which may cause phantom limb pain (PLP) and residual limb pain (RLP). Targeted muscle reinnervation (TMR) reduces the risk of PLP and RLP. This report describes the use of TMR at the time of amputation in a series of patients with CRPS. Patients and methods Four patients (ages 38–71 years)...
Wed Sep 23, 2020 14:19
Related Articles Reevaluation of Salivary Lymphadenoma. Arch Pathol Lab Med. 2020 Sep 22;: Authors: Zhang C, Gu T, Hu Y, Sun J, Xia R, Tian Z, Wang L, Li J Abstract CONTEXT.—: Both salivary lymphadenomas (LADs) and Warthin-like mucoepidermoid carcinoma (MEC) contain components of epithelium and lymphoid stroma and their differential diagnosis can be difficult on the basis of morphology alone. OBJECTIVE.—: To clarify whether Warthin-like...
Wed Sep 23, 2020 16:47
A Retrospective Study on Human Leukocyte Antigen Types and Haplotypes in a South African Population.
Related Articles A Retrospective Study on Human Leukocyte Antigen Types and Haplotypes in a South African Population. Arch Pathol Lab Med. 2020 Sep 22;: Authors: Gandini A, Mampeule N, Jugwanth S, Gededzha MP, Mayne E Abstract CONTEXT.—: Human Leukocyte Antigen (HLA) is a polymorphic protein of the immune system with a central role in organ transplantation. Organ recipients can be sensitized against HLA from previous exposure, which increases...
Wed Sep 23, 2020 16:47
Related Articles Using Timestamp Data to Assess the Impact of Voice Recognition on the Efficiency of Grossing Biopsies. Arch Pathol Lab Med. 2020 Sep 22;: Authors: Ye JJ, Tan MR, Shum CH Abstract CONTEXT.—: Studies on the adoption of voice recognition in health care have mostly focused on turnaround time and error rate, with less attention paid to the impact on the efficiency of the providers. OBJECTIVE.—: To study the impact of voice...
Wed Sep 23, 2020 16:47
Related Articles Autism BrainNet. Arch Pathol Lab Med. 2020 Sep 22;: Authors: Anderson MP, Quinton R, Kelly K, Falzon A, Halladay A, Schumann CM, Hof PR, Tamminga CA, Hare CK, Amaral DG Abstract CONTEXT.—: Autism spectrum disorder is a neurodevelopmental condition that affects over 1% of the population worldwide. Developing effective preventions and treatments for autism will depend on understanding the neuropathology of the disorder. While...
Wed Sep 23, 2020 16:47
Risk Factors for Lateral Lymph Node Metastases in Patients With Sporadic Medullary Thyroid Carcinoma
Technology in Cancer Research &Treatment, Volume 19, Issue , January-December 2020. Purpose:Medullary thyroid carcinoma is a rare endocrine malignancy; 75% of patients with this disease have sporadic medullary thyroid carcinoma. While surgery is the only curative treatment, the benefit of prophylactic lateral neck dissection is unclear. This study aimed to analyze the clinicopathological risk factors associated with lateral lymph node metastases and determine the indication for prophylactic lateral...
Wed Sep 23, 2020 12:52
Related Articles Multidisciplinary Safety Recommendations After Tracheostomy During COVID-19 Pandemic: State of the Art Review. Otolaryngol Head Neck Surg. 2020 Sep 22;:194599820961990 Authors: Meister KD, Pandian V, Hillel AT, Walsh BK, Brodsky MB, Balakrishnan K, Best SR, Chinn SB, Cramer JD, Graboyes EM, McGrath BA, Rassekh CH, Bedwell JR, Brenner MJ Abstract OBJECTIVE: In the chronic phase of the COVID-19 pandemic, questions have arisen...
Wed Sep 23, 2020 16:51
Related Articles Reduced striatal activation in response to rewarding motor performance feedback after stroke. Neuroimage Clin. 2019;24:102036 Authors: Widmer M, Lutz K, Luft AR Abstract INTRODUCTION: Motor skill learning can help stroke survivors to cope with motor function deficits but requires many repetitions. One factor that keeps patients motivated is obtaining reward upon successfully completing a motor task. It has been suggested that...
Wed Sep 23, 2020 16:55
329 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: upper respiratory tract infection These pubmed results were generated on 2020/09/23PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Wed Sep 23, 2020 16:55
Publication date: Available online 23 September 2020Source: Annales de Chirurgie Plastique EsthétiqueAuthor(s): G. Öztürk
Wed Sep 23, 2020 16:57
Clear cell adenocarcinoma (CCA) is a rare tumor in the genitourinary tract with female predominance and few reports in men. We identified 15 cases of CCA in men evaluated at our institution. Five arose in the bladder, 7 in the prostate or prostatic urethra, 2 in the membranous urethra (1 multifocal in the prostatic and membranous urethra), 1 periprostatic (likely from an embryologic remnant), and 1 between rectum and bladder (likely in a prostatic utricle cyst). No cases showed associated Müllerian...
Mon Sep 21, 2020 03:00
Related Articles Perineal reconstruction following abdominoperineal resection: Comprehensive review of the literature. J Plast Reconstr Aesthet Surg. 2020 Sep 10;: Authors: Copeland-Halperin LR, Stewart T, Chen Y, Funderburk CD, Freed GL Abstract Abdominoperineal resection (APR) in patients with anorectal carcinomas may involve flap-based perineal reconstruction techniques, such as rectus abdominis, myocutaneous, gracilis, and gluteal flaps....
Wed Sep 23, 2020 17:01
Abstract Purpose To investigate whether a telemedicine service (TMS) carried out during the Covid-19 pandemic impacted on management of patients with differentiated thyroid cancer (DTC). Methods We retrospectively reviewed the number and the findings of outpatient visits in DTC subjects referred between March 11, 2020, and May 31, 2020, during the...
Wed Sep 23, 2020 03:00
Abstract Introduction The importance of immune tumor microenvironment in the prognosis of patients with head and neck squamous carcinomas (HNSCC) is increasingly recognized. We analyzed the prognostic relevance of PD-L1 and PD-1 expressions in relation to the infiltration by CD8+ and FOXP3+ tumor-infiltrating lymphocytes (TILs). Methods ...
Wed Sep 23, 2020 17:04
Abstract Epidemiological evidence suggests that females have an advantage over males in cases of melanoma incidence, progression, and survival. However, the biological mechanisms underlying these sex differences remain unclear. With the knowledge that females generally have a more robust immune system than males, we investigated sex differences in melanoma progression in a B16-F10/BL6 syngeneic mouse model. We observed significantly less tumor volume and growth rate over 14 days...
Wed Sep 23, 2020 17:04
Abstract In line with the ongoing phase I trial (NCT03784625) dedicated to melanoma targeted radionuclide therapy (TRT), we explore the interplay between immune system and the melanin ligand [131I]ICF01012 alone or combined with immunotherapy (immune checkpoint inhibitors, ICI) in preclinical models. Here we demonstrate that [131I]ICF01012 induces immunogenic cell death, characterized by a significant increase in cell surface-exposed annexin A1 and calreticulin. Additionally,...
Wed Sep 23, 2020 17:04
Abstract Pancreatic ductal adenocarcinoma is characterized by a strong immunosuppressive network with a dense infiltration of myeloid cells including myeloid-derived suppressor cells (MDSC). Two distinct populations of MDSC have been defined: polymorphonuclear MDSC (PMN-MDSC) and monocytic MDSC (M-MDSC). Several factors influence the development and function of MDSC including the transcription factor interferon regulatory factor 4 (IRF4). Here, we show that IRF4 deficiency accelerates...
Wed Sep 23, 2020 17:04
NKG2D-Fc fusion protein promotes antitumor immunity through the depletion of immunosuppressive cells
Abstract A major factor impeding the success of numerous therapeutic approaches in cancer is the immunosuppressive nature of the tumor microenvironment (TME). Hence, methods capable of reverting tumor immunosuppression through depletion or reprogramming of myeloid-derived suppressive cells (MDSCs) and regulatory T cells (Tregs) are of great clinical need. Here, we explore NKG2D-Fc as a modality to modulate antitumor immunity through the depletion of immunosuppressive MDSCs and...
Wed Sep 23, 2020 17:04
Abstract Objectives Scientific advances in the last decade have highlighted the use of immunotherapy, especially immune checkpoint inhibitors, to be an effective strategy in cancer therapy. However, these immunotherapeutic agents are expensive, and their use must take into account economic criteria. Thus, the objective of the present study was to systematically identify and review published EE related to the use of ipilimumab,...
Wed Sep 23, 2020 17:04
Abstract B-cell malignancies can potentially be cured by CD19 chimeric antigen receptor (CAR) T-cell therapy. Although clinical response rates can be up to 93% in acute lymphoblastic leukemia, treatment-related antigen loss and lack of therapeutic persistence contribute to disease relapse. These shortcomings of current CAR T-cell therapy indicate the need for biologically relevant target selection and for improving the efficacy and persistence of the CAR T cells, which we have...
Wed Sep 23, 2020 17:04
Abstract Although metastatic disease is responsible for the majority of cancer deaths, tests of novel immunotherapies in mouse tumour models often focus on primary tumours without determining whether these therapies also target metastatic disease. This study examined the impact of depleting Foxp3+ regulatory T cells (Treg), on lung metastases, using a mouse model of breast cancer. After Treg-depletion, generation of an immune response to the primary tumour was a critical determinant...
Wed Sep 23, 2020 17:04
Abstract We discussed the potentialities of tumor mutation burden (TMB) as a predictive marker for immunotherapy in breast cancer, also highlighting the limits that have hindered its introduction in the clinical practice. Although some studies have demonstrated the possibility to select patients more responsive to immune-checkpoint inhibitors by evaluating TMB, some issues emerged regarding the complexity of the methodologies for its determination, the costs of the analysis,...
Wed Sep 23, 2020 17:04
Abstract Metastatic cancer involving spread to the peritoneal cavity is referred to as peritoneal carcinomatosis and has a very poor prognosis. Our previous studies demonstrated a toll-like receptor 4 (TLR4) and C-type lectin receptor (CLR; Mincle/MCL) agonist pairing of monophosphoryl lipid A (MPL) and trehalose-6,6′-dicorynomycolate (TDCM) effectively inhibits peritoneal tumor growth and ascites development through a mechanism dependent upon B1a cell-produced natural IgM,...
Wed Sep 23, 2020 17:04
Abstract Recently, the effectiveness of anti-programmed death 1 (PD-1) antibody therapy in the treatment of renal cell carcinoma (RCC) has been established. Nevertheless, efficacy has been reported to be limited to only 10–30% of patients. To develop more effective immunotherapy for RCC, we analyzed the immunological characteristics in RCC tissues by immunohistochemistry (IHC). We prepared a tissue microarray that consisted of tumor tissue sections (1 mm in diameter) from 83...
Wed Sep 23, 2020 17:04
Abstract CD27 is a costimulatory molecule that provides a complementary target to the PD-1/PD-L1 checkpoint axis on T cells. Combining a CD27 agonist antibody with PD-1/PD-L1 blockade has shown synergistic antitumor activity in preclinical models, which led to clinical studies of the combination in cancer patients. We theorized that coupling CD27 costimulation with PD-1/PD-L1 blockade in a bispecific antibody (BsAb) may provide greater immune activating properties than combining...
Wed Sep 23, 2020 17:04
Abstract The association between selective serotonin reuptake inhibitor (SSRI) exposure and cancer incidence has been investigated; however, no epidemiological study has investigated the association between exposure to individual SSRIs and kidney cancer incidence. The aim of this study is to examine whether SSRI use affected the risk of kidney cancer. We conducted a population‐based retrospective cohort study using data from Taiwan’s National Health Insurance Research Database. After adjusting for...
Wed Sep 23, 2020 15:23
Abstract Platinum‐based chemotherapy is not standard of care for unselected or genetically selected metastatic castration‐resistant prostate cancer (mCRPC) patients. A retrospective assessment of 71 patients was performed on platinum use in the Netherlands. Genetically unselected patients yielded low response rates. For a predefined sub‐analysis of all patients with comprehensive next‐generation sequencing, 30 patients were grouped based on the presence of pathogenic aberrations in genes associated...
Wed Sep 23, 2020 15:26
Abstract Recently, the genetic cause of HIDEA syndrome (hypotonia, hypoventilation, intellectual disability, dysautonomia, epilepsy, and eye abnormalities) was identified as biallelic pathogenic variants in P4HTM, which encodes an atypical member of the prolyl 4‐hydroxylases (P4Hs) family of enzymes. We report seven patients from four new families in whom HIDEA was only diagnosed after whole‐exome sequencing (WES) revealed novel disease‐causing variants in P4HTM. We note the variable phenotypic...
Wed Sep 23, 2020 12:20
Publication date: Available online 22 September 2020Source: International Journal of PsychophysiologyAuthor(s): Chiara Massullo, Giuseppe Alessio Carbone, Benedetto Farina, Angelo Panno, Cristina Capriotti, Marta Giacchini, Sérgio Machado, Henning Budde, Eric Murillo-Rodríguez, Claudio Imperatori
Wed Sep 23, 2020 17:16
Publication date: Available online 9 September 2020Source: NeuroImageAuthor(s): Lucia I. Navarro de Lara, Mohammad Daneshzand, Anthony Mascarenas, Douglas Paulson, Kevin Pratt, Yoshio Okada, Tommi Raij, Sergey N. Makarov, Aapo Nummenmaa
Wed Sep 23, 2020 17:21
Publication date: Available online 14 September 2020Source: NeuroImageAuthor(s): Patrik Wikman, Elisa Sahari, Viljami Salmela, Alina Leminen, Miika Leminen, Matti Laine, Kimmo Alho
Wed Sep 23, 2020 17:21
Publication date: Available online 16 September 2020Source: NeuroImageAuthor(s): Sébastien Naze, Timothée Proix, Selen Atasoy, James R. Kozloski
Wed Sep 23, 2020 17:21
Publication date: Available online 17 September 2020Source: NeuroImageAuthor(s): Zening Fu, Armin Iraji, Jessica A. Turner, Jing Sui, Robyn Miller, Godfrey D. Pearlson, Vince D. Calhoun
Wed Sep 23, 2020 17:21
Publication date: Available online 21 September 2020Source: NeuroImageAuthor(s): Georg Schramm, David Rigie, Thomas Vahle, Ahmadreza Rezaei, Koen van Laere, Timothy Shepherd, Johan Nuyts, Fernando Boada
Wed Sep 23, 2020 17:21
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