"Oncotarget"[jour]; +110 new citations

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"Oncotarget"[jour]

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PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.

from # All Medicine by Alexandros G. Sfakianakis via alkiviadis.1961 on Inoreader http://ift.tt/2j0aJhI

Erinnerungsräume in doppelter Buchführung

from # All Medicine by Alexandros G. Sfakianakis via alkiviadis.1961 on Inoreader http://ift.tt/2ADshV3

Entwicklung heisst Befreiung

from # All Medicine by Alexandros G. Sfakianakis via alkiviadis.1961 on Inoreader http://ift.tt/2AZdYwt

Gregory I the Great

from # All Medicine by Alexandros G. Sfakianakis via alkiviadis.1961 on Inoreader http://ift.tt/2ACdNEJ

Late Quaternary landscape evolution in a region of stable postglacial relative sea levels, British Columbia central coast, Canada

After retreat of the Cordilleran Ice Sheet (CIS) and subsequent glacio-isostatic adjustment of the central coast of British Columbia (BC), Canada, a complex coastline emerged as relative sea level rapidly reached equilibrium and maintained stability over the end of the Late Pleistocene and Holocene. This study provides a late Quaternary reconstruction of the landscape evolution of a geographically distinct location on the central BC coast, northwest Calvert Island, which experienced a re-advance of the CIS near the end of the Late Pleistocene and minimal subsequent relative sea-level change. Geomorphological observations from LiDAR imagery, sedimentological and palaeoecological evidence from exposures, cores and shovel pits, and a robust luminescence and ¹⁴C-based chronology spanning the last 15 000 years are used to reconstruct the landscape of northwest Calvert Island following CIS retreat. A single-aliquot regenerative dose protocol that was developed specifically for luminescence dating of the sediments on Calvert Island was utilized in this study. Localized proglacial sedimentation was linked to the glacial re-advance experienced at the end of the Late Pleistocene. Extensive coastal reconfiguration (e.g. rapid shoreline progradation of >1 m a⁻¹) occurred in the absence of extensive RSL change, which was the main driver of coastal change elsewhere along the BC coast. Changes in climate, small magnitude changes in RSL, and fire all probably played a role in isolated aeolian landform development and stabilization in the study area. An important contribution of this study is the documentation of the multi-disciplinary approach for reconstructing palaeogeography, using multiple geochronological methods, micro- and macro-sedimentology, the palaeoecology inferred from both macro and microfossils (e.g. diatoms and foraminifers), stratigraphy, field mapping and remote sensing. In addition, these findings inform our understanding of the drivers of coastal sedimentary processes, particularly in the temperate coastal rainforest region of BC, and the role that fire may play in those processes. Coastal palaeogeography studies in the region will become increasingly important as discoveries of Late Pleistocene human habitation along the coastal migration route continue to be documented.

from # All Medicine by Alexandros G. Sfakianakis via alkiviadis.1961 on Inoreader http://ift.tt/2AZdhTT

Asymmetrical trunk movement during walking improved to normal range at 3 months after corrective posterior spinal fusion in adolescent idiopathic scoliosis

Abstract

Purpose

To investigate the effects of posterior spinal fusion (PSF) and curve type on upper body movements in Adolescent Idiopathic Scoliosis (AIS) patients during gait.

Methods

Twenty-four girls (12–18 years) with AIS underwent PSF. 3D-Gait-analyses were performed preoperatively, at 3 months and 1 year postoperatively. Mean position (0° represents symmetry) and range of motion (ROM) of the trunk (thorax-relative-to-pelvis) in all planes were assessed. Lower body kinematics and spatiotemporal parameters were also evaluated.

Results

Mean trunk position improved from 7.0° to 2.9° in transversal plane and from 5.0° to − 0.8° in frontal plane at 3 months postoperative (p < 0.001), and was maintained at 1 year. Trunk ROM in transverse plane decreased from 9.6° to 7.5° (p < 0.001) after surgery. No effects of PSF were observed on the lower body kinematics during the gait cycle. Patients with a double curve had a more axial rotated trunk before and after surgery (p = 0.013).

Conclusion

In AIS patients, during gait an evident asymmetrical position of the trunk improved to an almost symmetric situation already 3 months after PSF and was maintained at 1 year. Despite a reduction of trunk ROM, patients were able to maintain the same walking pattern in the lower extremities after surgery. This improvement of symmetry and maintenance of normal gait can explain the rapid recovery and well functioning in daily life of AIS patients, despite undergoing a fusion of large parts of their spine.

from # All Medicine by Alexandros G. Sfakianakis via alkiviadis.1961 on Inoreader http://ift.tt/2nIseoj

Cardiovascular Profile of Valbenazine: Analysis of Pooled Data from Three Randomized, Double-Blind, Placebo-Controlled Trials

Abstract

Introduction

Valbenazine is a novel vesicular monoamine transporter 2 inhibitor approved for the treatment of tardive dyskinesia in adults.

Objective

Using data from double-blind, placebo-controlled trials, analyses were conducted to evaluate the cardiovascular effects of once-daily valbenazine in patients with a psychiatric disorder who developed tardive dyskinesia after exposure to a dopamine-blocking medication.

Methods

Data were pooled from three 6-week, double-blind, placebo-controlled trials: KINECT (NCT01688037), KINECT 2 (NCT01733121), and KINECT 3 (NCT02274558). Data from the 42-week valbenazine extension period of KINECT 3 were also analyzed. Outcomes of interest included cardiovascular-related treatment-emergent adverse events, vital sign measurements, and electrocardiogram parameters.

Results

The pooled safety population included 400 participants (placebo, n = 178; valbenazine 40 mg/day, n = 110; valbenazine 80 mg/day, n = 112). A history of cardiac disorders was present in 11.8% of participants, and 74.3% were taking a concomitant medication with known potential for QT prolongation. Mean changes from baseline to week 6 in supine vital signs and QTcF (Fridericia correction) were as follows for placebo, valbenazine 40 mg/day, and valbenazine 80 mg/day, respectively: systolic blood pressure (0.2, − 2.1, − 1.8 mmHg), diastolic blood pressure (− 0.1, − 1.6, − 1.2 mmHg), heart rate (− 1.7, − 2.2, − 1.7 bpm), QTcF interval (1.2, 1.1, 2.1 ms); all p > 0.05 for valbenazine vs. placebo. No statistically significant differences were observed between placebo and valbenazine in cardiovascular-related, treatment-emergent adverse events. No notable additional effects on cardiovascular outcomes were found with up to 48 weeks of valbenazine treatment.

Conclusions

Results from double-blind, placebo-controlled trials showed no apparent difference between valbenazine and placebo on cardiovascular outcomes. No additional cardiovascular risk was detected during a longer extension study with valbenazine.

from # All Medicine by Alexandros G. Sfakianakis via alkiviadis.1961 on Inoreader http://ift.tt/2izUJPg