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Thursday, July 11, 2019

Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,


Dental anxiety in 18-year-old Norwegians in 1996 and 2016Kjetil Strøm, Anne B. Skaare & Tiril WillumsenPages:...
Dental anxiety in 18-year-old Norwegians in 1996 and 2016Kjetil Strøm, Anne B. Skaare & Tiril WillumsenPages: 1-7 | DOI: 10.1080/00016357.2019.1637933
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,
08:54
Acta Oncologica and online now on Taylor & Francis Online: Letter to the Editor Completeness...
Acta Oncologica and online now on Taylor & Francis Online:Letter to the EditorCompleteness of pediatric cancer registration in the Finnish Cancer RegistryM. Jokela, M. K. Leinonen, N. Malila, M. Taskinen & L. M. Madanat-HarjuojaPages: 1-4 | DOI: 10.1080/0284186X.2019.1638522AR-V7 expression in circulating tumor cells as a potential prognostic marker in metastatic hormone-sensitive prostate cancerAndreas Josefsson, Jan-Erik Damber & Karin WelénPages: 1-5 | DOI: 10.1080/0284186X.2019.1637540Original...
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,
08:53
Laser vision correction surgery, or refractive eye surgery, is an increasingly popular procedure that...
Laser vision correction surgery, or refractive eye surgery, is an increasingly popular procedure that treats nearsightedness, farsightedness and astigmatism. The surgery allows people who wear eyeglasses or contacts to no longer need prescription lenses.Other laser vision correction proceduresThe most common alternative to LASIK is called PRK (photorefractive keratectomy). PRK works best in people with low-to-moderate nearsightedness and who have thin corneas or dry eyes. In this technique, surgeons...
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,
08:53
SMILE (Small Incision Lenticule Extraction) is the latest advancement in laser vision correction to...
SMILE (Small Incision Lenticule Extraction) is the latest advancement in laser vision correction to treat nearsightedness. The SMILE procedure is minimally invasive, and involves removing a small piece of tissue from the cornea with a laser, rather than creating a flap or altering the surface. Most patients feel no pain during or after the procedure, and are able to return to their daily activities quickly.
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,
08:52
LASIK (Laser-Assisted In-Situ Keratomileusis) is the most common type of refractive surgery and is...
LASIK (Laser-Assisted In-Situ Keratomileusis) is the most common type of refractive surgery and is recommended to treat varying degrees of nearsightedness, farsightedness and astigmatism. This outpatient procedure is quick and relatively painless, and generally results in minimal post-operative pain and rapid vision recovery. During LASIK, the surgeon makes a small flap in the cornea, which is a clear, dome-shaped surface that covers the front of the eye, and folds it back. Then a laser reshapes...
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,
08:51
Rates of knee arthroplasty in anterior cruciate ligament reconstructed patients: a longitudinal cohort...
Rates of knee arthroplasty in anterior cruciate ligament reconstructed patients: a longitudinal cohort study of 111,212 procedures over 20 years | Simon G F Abram, Andrew Judge, Tanvir Khan, David J Beard & Andrew J PricePages: 1-11 | DOI: 10.1080/17453674.2019.1639360
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,
08:50
Functional and histological improvements of small nerve neuropathy after high-concentration capsaicin...
Functional and histological improvements of small nerve neuropathy after high-concentration capsaicin patch application,A case studyTrouvin, Anne-Priscillea,b,*; Perrot, Sergea,bPAIN Reports: July 09, 2019 - Volume Latest Articles - Issue - pdoi: 10.1097/PR9.0000000000000761Neuropathic: PDF OnlyOPENAbstractAuthor InformationArticle MetricsIntroduction: Small fiber neuropathy has been found to occur in a large variety of pathological onditions, and the gold standard for diagnosis of small fiber neuropathy...
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,
08:49
Is Early Chemical Thromboprophylaxis in Patients with Solid Organ Injury a Solid Decision? Skarupa,...
Is Early Chemical Thromboprophylaxis in Patients with Solid Organ Injury a Solid Decision?Skarupa, David MD1; Hanna, Kamil MD2; Zeeshan, Muhammad MD2; Madbak, Firas MD1; Hamidi, Mohammad MD2; Haddadin, Zaid MD2; Northcutt, Ashley MD2; Gries, Lynn MD2; Kulvatunyou, Narong MD2; Joseph, Bellal MD2Journal of Trauma and Acute Care Surgery: July 9, 2019 - Volume Publish Ahead of Print - Issue - pdoi: 10.1097/TA.00000000000024382019 WTA Podium Paper: PDF OnlyBUYPAPAbstractAuthor InformationArticle MetricsBackground...
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,
08:49
Development of Transfusion Guidelines for Injured Children Using a Modified Delphi Consensus Process,...
Development of Transfusion Guidelines for Injured Children Using a Modified Delphi Consensus Process,Trappey, Alfred Francois III M.D., Major; Thompson, Kyle M. M.D.; Kuppermann, Nathan M.D., M.P.H.; Stephenson, Jacob T. M.D.; Nuno, Miriam A. PhD; Hewes, Hilary A. M.D.; Meyers, Sage R. M.D., M.S. C.E; Stanley, Rachel M. M.D.; Galante, Joseph M. M.D.; Nishijima, Daniel K. M.D., M.A.S.Journal of Trauma and Acute Care Surgery: July 9, 2019 - Volume Publish Ahead of Print - Issue - pdoi: 10.1097/TA.0000000000002432
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,
08:49
National Cancer Institute
National Cancer Institute theNCI11 JulThe #ChildhoodCancer Data Initiative aims to identify existing tools or develop new tools that will allow us to ana… https://t.co/dB1Jq2BndXDetails  |  RetweetNational Cancer Institute theNCI11 JulWalking with purpose after a diagnosis of HPV-related head and neck cancer: https://t.co/Xs0IR3YFXX @NCIResearchCtr… https://t.co/pvsJWRkVKxDetails  |  RetweetNational Cancer Institute theNCI11 JulThere are two main types of radiation therapy, external beam and internal....
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,
08:48
Oncology Reports - Spandidos Publications
Effects of gossypol on apoptosis‑related gene expression in racially distinct triple‑negative breast cancer cellsSamia S. Messeha, Najla O. Zarmouh, Patricia Mendonca, Hayfaa Alwagdani, Carolyn Cotton, Karam F.A. SolimanView Abstract ❯Matrine improves skeletal muscle atrophy by inhibiting E3 ubiquitin ligases and activating the Akt/mTOR/FoxO3α signaling pathway in C2C12 myotubes and miceLi Chen, Linlin Chen, Lili Wan, Yan Huo, Jinlu Huang, Jie Li, Jin Lu, Bo Xin, Quanjun Yang, Cheng GuoView Abstract...
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,
08:46
Physiological and transcriptional comparison of acetate catabolism between Acinetobacter schindleri ACE...
Physiological and transcriptional comparison of acetate catabolism between Acinetobacter schindleri ACE andEscherichia coli JM101,  Juan-Carlos Sigala; Lucy Quiroz; Eduardo Arteaga ; Roberto Olivares; Alvaro R Lara ...
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,
08:43
Suppressed immune microenvironment and repertoire in brain metastases from patients with resected non-small...
Suppressed immune microenvironment and repertoire in brain metastases from patients with resected non-small cell lung cancer,  Y Kudo; C Haymaker; J Zhang; A Reuben ; D Y Duose ...
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,
08:43
Cancer Survivorship and Subclinical Myocardial Damage,  Steven S Coughlin; Gaston Kapuku Response...
Cancer Survivorship and Subclinical Myocardial Damage,  Steven S Coughlin; Gaston KapukuResponse by Florido and Selvin to Commentary regarding article: "Cancer Survivorship and Subclinical Myocardial Damage: The Atherosclerosis Risk in Communities (ARIC) Study"  Roberta Florido, MD, MHS; Elizabeth Selvin, PhD, MPH
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,
08:43
Integrative and Comparative Biology
Chemical responses to the biotic and abiotic environment by early diverging metazoans revealed in the post-genomic age  Beth Okamura; Paul F Long; Laura D Mydlarz  Mitochondrial ecophysiology: assessing the evolutionary forces that shape mitochondrial variation  Jessica L McKenzie; Dillon J Chung; Timothy M Healy; Reid S Brennan ; Heather J Bryant ...  High-Throughput Segmentation of Tiled Biological Structures using Random Walk Distance Transforms  Daniel Baum; James C Weaver; Igor Zlotnikov ; David...
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,
08:42
FEMS Microbiology Ecology
Community succession in an anaerobic long-chain paraffin-degrading consortium and impact on chemical and electrical microbially influenced iron corrosion  Renxing Liang; Irene Davidova; Shin-ichi Hirano; Kathleen E Duncan; Joseph M Suflita  Differences in soil microbial response to anthropogenic disturbances in Sanjiang and Momoge Wetlands, China  Jing Wei; Jie Gao; Na Wang; Ying Liu ; Yuwan Wang ...  Mimosa caesalpiniifolia Benth. adapts to rhizobia populations with differential taxonomy and symbiotic...
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,
08:40
"Each Unbearable Day": Narrative Ruthlessness and Environmental and Reproductive Injustice in Jesmyn...
"Each Unbearable Day": Narrative Ruthlessness and Environmental and Reproductive Injustice in Jesmyn Ward'sSalvage the Bones  Annie Bares
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,
08:37
Encounter on the Great Plains: Scandinavian Settlers and the Dispossession of Dakota Indians, 1890-1930....
Encounter on the Great Plains: Scandinavian Settlers and the Dispossession of Dakota Indians, 1890-1930. By Karen V. Hansen  Kimberly K Porter  For the Love of Murphy's: The Behind-the-Counter Story of a Great American Retailer. By Jason Togyer  Mary A Larson  Podcasts: The Archives of American Art Oral History Collection. Archives of American Art, Smithsonian Institution  Rose Chiango
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,
08:37
The Fetish Revisited: Marx, Freud, and the Gods Black People Make,  Laura S Grillo  Virgin Whore. By...
The Fetish Revisited: Marx, Freud, and the Gods Black People Make,  Laura S Grillo  Virgin Whore. By Emma Maggie Solberg,  Jessica Barr  Hindu Pasts: Women, Religion, History. By Vasudha Dalmia,  Emilia Bachrach
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,
08:36
Functional MRI, Basic Principles and Emerging Clinical Applications for Anesthesiology and the Neurological...
Functional MRI,Basic Principles and Emerging Clinical Applications for Anesthesiology and the Neurological Sciences,Torsher, Laurence C. MDAnesthesia & Analgesia: July 2, 2019 - Volume Publish Ahead of Print - Issue - pdoi: 10.1213/ANE.0000000000004307Books, Multimedia, and Meetings Reviews: PDF OnlyBUYPAPAuthor InformationArticle Metrics© 2019 International Anesthesia Research Society
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,
08:36
BOSTN Bundle Intervention for Perioperative Screening and Management of Patients With Suspected Obstructive...
BOSTN Bundle Intervention for Perioperative Screening and Management of Patients With Suspected Obstructive Sleep Apnea,: A Hospital Registry StudyBACKGROUND: We developed and implemented a perioperative guideline for obstructive sleep apnea (OSA), comprising a preoperative screening tool (BOSTN) and clinical management pathways. OSA was suspected with 2 or more of the following: body mass index ≥30 kg/m2, observed apnea, loud snoring, daytime tiredness, and neck circumference ≥16.5 inches in women...
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,
08:33
Adultification of Black Children in Pediatric Anesthesia, BACKGROUND: Unconscious racial bias in...
Adultification of Black Children in Pediatric Anesthesia,BACKGROUND: Unconscious racial bias in anesthesia care has been shown to exist. We hypothesized that black children may undergo inhalation induction less often, receive less support from child life, have fewer opportunities to have a family member present for induction, and receive premedication with oral midazolam less often. METHODS: We retrospectively collected data on those <18 years of age from January 1, 2012 to January 1, 2018 including...
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,
08:33
Wound Repair and Regeneration Accepted Articles Accepted, unedited articles published online and citable....
Wound Repair and RegenerationAccepted ArticlesAccepted, unedited articles published online and citable. The final edited and typeset Version of Record will appear in the future.The Impact of First‐Aid Dressing Design on Healing of Porcine Partial Thickness WoundsKatie F. Wlaschin Ph.D., Jana Ninkovic Ph.D., George W. Griesgraber Ph.D., Semra Colak Atan Ph.D., Alexi J. Young Ph.D., Junia M. Pereira Ph.D., Michael J. Solberg, Graham Smith, Patrick J. Parks M.D. Ph.D., Amy K. McNulty Ph.D., Delony L....
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,
08:29
Wound Repair and Regeneration Early View Online Version of Record before inclusion in an issue Fibronectin‐derived...
Wound Repair and RegenerationEarly ViewOnline Version of Record before inclusion in an issueFibronectin‐derived Epiviosamines enhance PDGF‐BB‐stimulated human dermal fibroblast migration in vitro and granulation tissue formation in vivoAtulya Prasad PhD, Fubao Lin PhD, Richard A. F. Clark MDVersion of Record online: 05 July 2019Akermanite bioceramic enhances wound healing with accelerated reepithelialization by promoting proliferation, migration, and stemness of epidermal cellsFangfang Wang MM, Xiaoya...
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,
08:29
Archives of Disease in Childhood
Original articleSeizure frequency, healthcare resource utilisation and mortality in childhood epilepsy: a retrospective cohort study using the THIN databaseMelissa Myland, Brian Buysse, Wan Tsong et al. (2019-07-04)10.1136/archdischild-2019-316910Gelatin tannate for acute diarrhoea and gastroenteritis in children: a systematic review and meta-analysisIvan D Florez, Javier M Sierra, Laura F Niño-Serna (2019-07-04)10.1136/archdischild-2018-316385Origins of disparities in preventable child mortality...
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,
08:28
Regional Anesthesia & Pain Medicine
Supra-inguinal injection for fascia iliaca compartment block results in more consistent spread towards the lumbar plexus than an infra-inguinal injection: a volunteer study: a concern on the influence of patient's breathingHongye Zhang, Yongsheng Miao, Zongyang Qu (2019-06-21)10.1136/rapm-2019-100593Response to Dr Mion: ketamine for acute pain managementSteven P Cohen, Eric S Schwenk (2019-06-13)10.1136/rapm-2019-100717Injectate spread in interfascial plane block: a microscopic findingHun-Mu Yang,...
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,
08:27
Current Difficult Airway Management
—Not Good Enough!Takashi Asai, M.D., Ph.D.; David Hillman, M.D. Author NotesFrom the Department of Anesthesiology, Dokkyo Medical University Saitama Medical Center, Saitama, Japan (T.A.); and the Faculty of Health and Medical Sciences, Surgery, University of Western Australia, Perth, Australia (D.H.).Accepted for publication June 14, 2019.Correspondence: Address correspondence to Dr. Asai: asaita@dokkyomed.ac.jpAnesthesiology Newly Published on July 10, 2019. doi:10.1097/ALN.0000000000002885In safety-critical...
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,
08:26
Hypoxemia, Bradycardia, and Multiple Laryngoscopy Attempts during Anesthetic Induction in Infants
: A Single-center, Retrospective Study,Jorge A. Gálvez, M.D., M.B.I.; Samuel Acquah, M.D.; Luis Ahumada, Ph.D.; Lingyu Cai, M.S.; Marcia Polanski, S.C.D, M.S., M.S.W.; et al Lezhou Wu, Ph.D.; Allan F. Simpao, M.D., M.B.I.; Jonathan M. Tan, M.D., M.P.H.; Jack Wasey, B.M., B.Ch., M.A., M.Sci., M.Sc.; John E. Fiadjoe, M.D. Author NotesFrom the Section of Biomedical Informatics (J.A.G., L.A., L.W., A.F.S., J.M.T., J.W.), Department of Anesthesia and Critical Care Medicine (J.A.G., A.F.S., J.M.T., J.W.,...
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,
08:26
Anesthesiology
Perioperative MedicineHypoxemia, Bradycardia, and Multiple Laryngoscopy Attempts during Anesthetic Induction in Infants: A Single-center, Retrospective StudyJorge A. Gálvez, M.D., M.B.I.; Samuel Acquah, M.D.; Luis Ahumada, Ph.D.; Lingyu Cai, M.S.; Marcia Polanski, S.C.D, M.S., M.S.W.; Lezhou Wu, Ph.D.; Allan F. Simpao, M.D., M.B.I.; Jonathan M. Tan, M.D., M.P.H.; Jack Wasey, B.M., B.Ch., M.A., M.Sci., M.Sc.; John E. Fiadjoe, M.D.Anesthesiology Published online July 10, 2019. doi:10.1097/ALN.0000000000002847Postoperative...
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,
08:21
Blood transfusion history and risk of non-Hodgkin lymphoma: an InterLymph pooled analysis AbstractPurpose...
Blood transfusion history and risk of non-Hodgkin lymphoma: an InterLymph pooled analysisAbstractPurposeTo conduct a pooled analysis assessing the association of blood transfusion with risk of non-Hodgkin lymphoma (NHL).MethodsWe used harmonized data from 13 case–control studies (10,805 cases, 14,026 controls) in the InterLymph Consortium. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using unconditional logistic regression, adjusted for study design variables.ResultsAmong non-Hispanic...
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,
08:19
Soy and tea intake on cervical cancer risk: the Singapore Chinese Health Study AbstractPurpose Soy...
Soy and tea intake on cervical cancer risk: the Singapore Chinese Health StudyAbstractPurposeSoy isoflavones and tea catechins have immunomodulating and chemopreventive properties relevant for cervical carcinogenesis; however, there are limited epidemiologic data on the relationship of soy and tea consumption with cervical cancer risk. The aim of our study was to examine effects of soy and tea intake on cervical cancer risk among Singapore Chinese women.MethodsThe association between intake of soy...
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,
08:18
The association between coffee consumption and bladder cancer in the bladder cancer epidemiology and...
The association between coffee consumption and bladder cancer in the bladder cancer epidemiology and nutritional determinants (BLEND) international pooled studyAbstractBackgroundInconsistent results for coffee consumption and bladder cancer (BC) risk have been shown in epidemiological studies. This research aims to increase the understanding of the association between coffee consumption and BC risk by bringing together worldwide case–control studies on this topic.MethodsData were collected from 13...
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,
08:18
Healthy dietary patterns and risk and survival of breast cancer: a meta-analysis of cohort studies AbstractPurposes...
Healthy dietary patterns and risk and survival of breast cancer: a meta-analysis of cohort studiesAbstractPurposesDietary patterns have been found to be associated with the overall cancer risk and survival. However, the associations of healthy dietary patterns and breast cancer remain unclear. We aimed to conduct a meta-analysis of prospective cohort studies to estimate the pooled results of the association of healthy dietary patterns with breast cancer risk and survival.MethodsPubMed, EMBASE, and...
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,
08:18
JAMA Online First
VIEWPOINTA New Supreme Court Ruling on Drug LiabilityMitchell C. Johnston; Marcia M. Boumil, JD, LLM; Gregory Curfman, MDJAMA INSIGHTSClinical Use of Bone Turnover MarkersDouglas C. Bauer, MDTRENDING NOW ON JAMA NETWORK OPENAssociation of Cardiorespiratory Fitness and Mortality Among Adults Undergoing Exercise Treadmill TestingAndrogen Deprivation Therapy and Dementia Diagnosis in Men With Prostate CancerPush-up Exercise Capacity and Future Cardiovascular Events in Active Adult MenEstimating Implicit...
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,
08:17
Feed thickeners : carob bean gum, rice cereal, corn starch or alginate
Clinical Aspects of Thickeners for Pediatric Gastroesophageal Reflux and Oropharyngeal DysphagiaAbstractPurpose of ReviewThe purpose of this review is to discuss current knowledge and recent findings regarding clinical aspects of thickeners for pediatric gastroesophageal reflux and oropharyngeal dysphagia. We review evidence for thickener efficacy, discuss types of thickeners, practical considerations when using various thickeners, and risks and benefits of thickener use in pediatrics.Recent FindingsThickeners...
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,
08:15
Popular Remedies for Esophageal Symptoms: dietary manipulation, apple cider vinegar, melatonin, acupuncture, and various herbal products (rikkunshito, STW 5, slippery elm, licorice, and peppermint oil, among others).
Popular Remedies for Esophageal Symptoms: a Critical AppraisalAbstractPurpose of ReviewPopular remedies are of ongoing interest to patients experiencing common esophageal symptoms, particularly as typical pharmacologic interventions have been subject to increased scrutiny. Herein we summarize the available data regarding potential risks and benefits of several such remedies.Recent FindingsWith emphasis on reflux and non-cardiac chest pain, research is ongoing into the clinical utility and diverse...
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,
08:10
The Utility of Esophageal Motility Testing in Gastroesophageal Reflux Disease (GERD), AbstractPurpose...
The Utility of Esophageal Motility Testing in Gastroesophageal Reflux Disease (GERD),AbstractPurpose of ReviewHere, we discuss how esophageal motor testing plays important roles in patients with suspected gastroesophageal reflux disease (GERD). In addition to guiding appropriate placement of catheters for ambulatory reflux monitoring, esophageal high-resolution manometry (HRM) rules out confounding diagnoses, such as achalasia spectrum disorders, that can present with symptoms similar to that of...
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,
08:07
JAMA Otolaryngology–Head & Neck Surgery
ORIGINAL INVESTIGATIONAssessment of Patient Outcomes After Adjuvant Vocal Fold Steroid Injection for Fibrosis After Microlaryngeal SurgeryYing-Chieh Hsu, MD; Li-Jen Liao, MD, PhD; Tsung-Wei Huang, MD, PhD; et al.Association of Feeding Evaluation With Frenotomy Rates in Infants With Breastfeeding DifficultiesChristen Caloway, MD; Cheryl J. Hersh, MS, CCC-SLP; Rebecca Baars, MS, CCC-SLP; et al.Audio Interview: Association of Feeding Evaluation With Frenotomy Rates in Infants With Breastfeeding DifficultiesCLINICAL...
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,
08:06
Acta Biochimica et Biophysica Sinica
Original Articles   MicroRNA-23a promotes colorectal cancer cell migration and proliferation by targeting at MARK1  Xiaoli Tang; Meiyuan Yang; Zheng Wang; Xiaoqing Wu; Daorong Wang  SPAG4L/SPAG4Lβ interacts with Nesprin2 to participate in the meiosis of spermatogenesis  Xiaohua Li; Yong Wu; Lihua Huang; Linfei Yang ; Xiaowei Xing  YAP mediates the positive regulation of hnRNPK on the lung adenocarcinoma H1299 cell growth  Lipei Xu; Tingting Zhang; Wensi Huang; Xiaohui Liu ; Junlei Lu ...  Peroxidase...
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,
08:05
The future of apolipoprotein E mimetic peptides in the prevention of cardiovascular disease, Purpose...
The future of apolipoprotein E mimetic peptides in the prevention of cardiovascular disease,Purpose of review This review aims to discuss the recent developments in the area of apolipoprotein E (apoE) mimetics and their therapeutic potential for treating cardiovascular disease, the leading cause of mortality worldwide. Recent findings Ongoing research efforts target the development of novel therapies that would not only reduce circulating levels of atherogenic lipoproteins, but could also increase...
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,
08:02
Role of serum amyloid A in atherosclerosis, Purpose of review Acute phase serum amyloid A (SAA) is...
Role of serum amyloid A in atherosclerosis,Purpose of review Acute phase serum amyloid A (SAA) is persistently elevated in chronic inflammatory conditions, and elevated levels predict cardiovascular risk in humans. More recently, murine studies have demonstrated that over-expression of SAA increases and deficiency/suppression of SAA attenuates atherosclerosis. Thus, beyond being a biomarker, SAA appears to play a causal role in atherogenesis. The purpose of this review is to summarize the data supporting...
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,
08:01
Is hypertriglyceridemia atherogenic? Purpose of review Hypertriglyceridemia occurs mainly because...
Is hypertriglyceridemia atherogenic?Purpose of review Hypertriglyceridemia occurs mainly because of metabolic disorders secondary to diabetes, alcohol intake, and/or overweight. Genetic factors have also been clearly identified in most severe cases. Triglycerides are generally considered as 'bystanders' for cardiovascular diseases. However, biological and basic research provides strong data suggesting that triglyceride-rich lipoproteins could be involved in the pathophysiology of cardiovascular diseases....
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,
07:56
Non-HDL cholesterol should not generally replace LDL cholesterol in the management of hyperlipidaemia,...
Non-HDL cholesterol should not generally replace LDL cholesterol in the management of hyperlipidaemia,Purpose of review Non-HDL cholesterol was originally conceived as a therapeutic target for statin treatment in hypertriglyceridaemia when apolipoprotein B100 assays were not widely available. Recently non-HDL cholesterol has been recommended to replace LDL cholesterol in the clinical management of dyslipidaemia routinely in general medical practice. This is misguided. Recent findings Non-HDL cholesterol...
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,
07:54
Diagnosis and management of linear scleroderma in children, Purpose of review Linear scleroderma...
Diagnosis and management of linear scleroderma in children,Purpose of review Linear scleroderma is the most common subtype of localized scleroderma (LoS) in children. It can be associated with extracutaneous manifestations and long-term sequelae. Thus, appropriate diagnosis and management are key to improve the prognosis. In this review, we summarize the most relevant recent publications for the diagnosis, evaluation of disease activity and adequate management of patients with linear scleroderma....
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,
07:47
A new second-generation supraglottic airway device (Ambu® AuraGain•) versus intubating laryngeal mask...
A new second-generation supraglottic airway device (Ambu® AuraGain•) versus intubating laryngeal mask airway as conduits for blind intubation – A prospective, randomised trialK Sudheesh, GM Chethana, H Chaithali, SS Nethra, D Devikarani, G ShwethaIndian Journal of Anaesthesia 2019 63(7):558-564Background and Aims: The Ambu® AuraGain• is a new single-use supraglottic airway device with gastric channel, designed to facilitate intubation. The study aimed to assess the success rates of proper placement...
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,
07:34
Role of topical magnesium in post-operative sore throat: A systematic review and meta-analysis of randomised...
Role of topical magnesium in post-operative sore throat: A systematic review and meta-analysis of randomised controlled trialsNarinder P Singh, Jeetinder K Makkar, Vincent Wourms, Andrés Zorrilla-Vaca, Ronald B Cappellani, Preet M SinghIndian Journal of Anaesthesia 2019 63(7):520-529Background and Aims: Post-operative sore throat (POST) is a common undesirable consequence of tracheal intubation. Magnesium, an N-methyl-D-aspartate receptor antagonist, has anti-nociceptive and anti-inflammatory properties,...
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,
07:33
Otology & Neurotology
What is the Role of Hyaluronic Acid Ester in Myringoplasty? Systematic Review and Meta-AnalysisObjective: To reveal odds of tympanic membrane closure and postoperative hearing outcomes for myringoplasty utilizing hyaluronic acid ester via systematic review and meta-analysis. Data Sources: 1) Search of English articles in PubMed/Medline, Embase, and Cochrane databases published between January 1, 1998 and March 31, 2018. Study Selection: Inclusion criteria: 1) English language; 2) clinical studies;...
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,
07:25
Medical Care
Insurance Loss in the Era of the Affordable Care Act: Association With Access to Health ServicesBackground: Every year, millions of Americans lose their health insurance and remain uninsured for various reasons, potentially impacting access to medical services. Objective: To examine trends in health insurance loss in the periods shortly before and after implementation of Patient Protection and Affordable Care Act (ACA) and to assess the association of past-year health insurance loss with access to...
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,
07:24
Annals of Surgery
Intravenous Patient-controlled Analgesia Versus Thoracic Epidural Analgesia After Open Liver Surgery: A Prospective, Randomized, Controlled, Noninferiority TrialObjective: We conducted a randomized, controlled, noninferiority trial to investigate if intravenous, multimodal, patient-controlled analgesia (IV-PCA) could be noninferior to multimodal thoracic epidural analgesia (TEA) in patients undergoing open liver surgery. Summary Background Data: The increasing use of minimally invasive techniques...
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,
07:23
Neurology
Levetiracetam Is No More Effective Than Phenytoin in Children with Convulsive Status EpilepticusNo abstract availableAntiplatelet Therapy Is Safe for Secondary Prevention of Stroke—Even with Cerebral MicrobleedsNo abstract available"Chemical Plasmapheresis" Drug for Myasthenia Gravis Is Safe, Lowers Antibodies, and Produces Hints of Efficacy in Phase 2 TrialNo abstract availableNew Study Links Chronic Renal Dysfunction and Proteinuria with a Risk of Parkinson's Disease in the ElderlyNo abstract availableGliomas...
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,
07:21
Se è importante, l'ippocampo vuole il replay, Da MIND: I centri di elaborazione neurali ripercorrono...
Se è importante, l'ippocampo vuole il replay,Da MIND: I centri di elaborazione neurali ripercorrono più volte le sequenze degli eventi recenti per consolidare i nuovi ricordi, che saranno poi usati anche nel pensiero astratto e... - Leggi l'articolo → 
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,
06:54
Homo sapiens in Europa già 210.000 anni fa, Una nuova analisi di un cranio scoperto in Grecia ha...
Homo sapiens in Europa già 210.000 anni fa,Una nuova analisi di un cranio scoperto in Grecia ha rivelato che è di un essere umano anatomicamente moderno vissuto 210.000 anni fa. È il fossile più antico di Homo sapiens fuori dall'Africa... - Leggi l'articolo →
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,
06:53
L'Antropocene incalza: la plastica è già nelle rocce, I processi geologici hanno iniziato...
L'Antropocene incalza: la plastica è già nelle rocce,I processi geologici hanno iniziato a incorporare in rocce litoranee la plastica finita in mare. Questo materiale onnipresente è sempre di più un marcatore dell'era segnata dalle attività umane. Buona lettura!
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,
06:52


Otology & Neurotology
What is the Role of Hyaluronic Acid Ester in Myringoplasty? Systematic Review and Meta-AnalysisObjective: To reveal odds of tympanic membrane closure and postoperative hearing outcomes for myringoplasty utilizing hyaluronic acid ester via systematic review and meta-analysis. Data Sources: 1) Search of English articles in PubMed/Medline, Embase, and Cochrane databases published between January 1, 1998 and March 31, 2018. Study Selection: Inclusion criteria: 1) English language; 2) clinical studies;...
Αλέξανδρος Γ. Σφακιανάκης
1h
Medical Care
Insurance Loss in the Era of the Affordable Care Act: Association With Access to Health ServicesBackground: Every year, millions of Americans lose their health insurance and remain uninsured for various reasons, potentially impacting access to medical services. Objective: To examine trends in health insurance loss in the periods shortly before and after implementation of Patient Protection and Affordable Care Act (ACA) and to assess the association of past-year health insurance loss with access to...
Αλέξανδρος Γ. Σφακιανάκης
1h
Annals of Surgery
Intravenous Patient-controlled Analgesia Versus Thoracic Epidural Analgesia After Open Liver Surgery: A Prospective, Randomized, Controlled, Noninferiority TrialObjective: We conducted a randomized, controlled, noninferiority trial to investigate if intravenous, multimodal, patient-controlled analgesia (IV-PCA) could be noninferior to multimodal thoracic epidural analgesia (TEA) in patients undergoing open liver surgery. Summary Background Data: The increasing use of minimally invasive techniques...
Αλέξανδρος Γ. Σφακιανάκης
1h
Neurology
Levetiracetam Is No More Effective Than Phenytoin in Children with Convulsive Status EpilepticusNo abstract availableAntiplatelet Therapy Is Safe for Secondary Prevention of Stroke—Even with Cerebral MicrobleedsNo abstract available"Chemical Plasmapheresis" Drug for Myasthenia Gravis Is Safe, Lowers Antibodies, and Produces Hints of Efficacy in Phase 2 TrialNo abstract availableNew Study Links Chronic Renal Dysfunction and Proteinuria with a Risk of Parkinson's Disease in the ElderlyNo abstract availableGliomas...
Αλέξανδρος Γ. Σφακιανάκης
1h
Academic Medicine
What Makes the "Perfect" Inpatient Consultation? A Qualitative Analysis of Resident and Fellow PerspectivesPurpose: To characterize the methods of inpatient consult communication, given new communication modalities; to explore residents' and fellows' perspectives on the ideal consult and how this affects their teaching, learning, and patient safety; and to identify barriers to and strategies for optimizing consultations. Method: Using qualitative grounded theory, the authors conducted semistructured...
Αλέξανδρος Γ. Σφακιανάκης
17h
Psychiatry
Impulsivity, suicidality, and emotional dysregulation in women having borderline personality disorder with and without substance dependenceSamir A Magd, Moustafa Rakhawy, Rania Mamdouh, Somaya ShaheenEgyptian Journal of Psychiatry 2019 40(2):59-63Objective The objective of this article is to detect differences between women having borderline personality disorder (BPD) with and without substance dependence regarding impulsivity, suicide, and emotional dysregulation. Patients and methods A total of...
Αλέξανδρος Γ. Σφακιανάκης
17h
Cancer Letters
Interference with the bromodomain epigenome readers drives p21 expression and tumor senescencePublication date: 1 October 2019Source: Cancer Letters, Volume 461Author(s): Liana P. Webber, Veronica Q. Yujra, Pablo A. Vargas, Manoela D. Martins, Cristiane H. Squarize, Rogerio M. CastilhoAbstractHead and neck cancer (HNSCC) are one of the most common solid malignancies of the world, being responsible for over 350,000 deaths every year. Much of the complications in managing and treating HNSCC advent...
Αλέξανδρος Γ. Σφακιανάκης
17h
Nursing Science
Letter to the EditorNo abstract availableLetter to the EditorNo abstract availableReconceptualizing the Electronic Health Record for a New Decade: A Caring Technology?Since the 2009 publication by Petrovskaya et al on, "Dilemmas, Tetralemmas, Reimagining the Electronic Health Record," and passage of the Health Information Technology for Economic Clinical Health (HITECH) Act, 96% of hospitals and 78% of providers have implemented the electronic health record. While many positive outcomes such as guidelines-based...
Αλέξανδρος Γ. Σφακιανάκης
17h
Foot Weakness Caused by Proximal Extensor Hallucis Longus (EHL) Rupture, Ma, Rex MD1; Bartolo, . Kathryne...
Foot Weakness Caused by Proximal Extensor Hallucis Longus (EHL) Rupture,Ma, Rex MD1; Bartolo, . Kathryne MD2; Lew, Henry MD, PhD3American Journal of Physical Medicine & Rehabilitation: July 8, 2019 - Volume Publish Ahead of Print - Issue - pdoi: 10.1097/PHM.0000000000001262
Αλέξανδρος Γ. Σφακιανάκης
17h
Asia Pacific Journal of Tourism Research, Volume 24, Issue 8, August 2019 is now available online...
Asia Pacific Journal of Tourism Research, Volume 24, Issue 8, August 2019 is now available online on Taylor & Francis Online.This new issue contains the following articles:ArticlesHow geographic, cultural, and institutional distances shape location choices of China's OFDI in tourism? – an empirical study on B&R countriesTaotao Deng, Yukun Hu & Yang YangPages: 735-749 | DOI: 10.1080/10941665.2019.1630451Experiencing the real village – a netnographic examination of perceived authenticity...
Αλέξανδρος Γ. Σφακιανάκης
17h
Advances in Skin & Wound Care
Validating the Italian Version of the International Skin Tear Advisory Panel Classification SystemOBJECTIVE To validate the International Skin Tear Advisory Panel (ISTAP) Classification System in Italian. METHODS In collaboration with the ISTAP, the classification system was translated into Italian using a forward-back translation process. To validate the translated system, a convenience sample of 212 health professionals classified 30 photographs of skin tears originally used by ISTAP. The wound...
Αλέξανδρος Γ. Σφακιανάκης
17h
The AAG Review of Books, Volume 7, Issue 3, Summer 2019is now available online on Taylor & Francis...
The AAG Review of Books, Volume 7, Issue 3, Summer 2019is now available online on Taylor & Francis Online.This new issue contains the following articles:Issue PDFVolume 7, Issue 3Pages: 153-227 | DOI: 10.1080/2325548X.2019.1615330Book ReviewsThe Newark Earthworks: Enduring Monuments, Contested MeaningsWilliam Gustav GartnerPages: 153-156 | DOI: 10.1080/2325548X.2019.1615311The Cry of the Renegade: Politics and Poetry in Interwar ChileDon MitchellPages: 157-159 | DOI: 10.1080/2325548X.2019.1615312Becoming...
Αλέξανδρος Γ. Σφακιανάκης
17h
Art Journal, Volume 78, Issue 2, Summer 2019 is now available online on Taylor & Francis Online....
Art Journal, Volume 78, Issue 2, Summer 2019 is now available online on Taylor & Francis Online.This new issue contains the following articles:General ContentTitle pagePages: 1-1 | DOI: 10.1080/00043249.2019.1626147Editorial Board and Information for AuthorsPages: 2-2 | DOI: 10.1080/00043249.2019.1626148Table of ContentsPages: 3-3 | DOI: 10.1080/00043249.2019.1626149Funding InformationPages: 4-4 | DOI: 10.1080/00043249.2019.1626152In This IssueMaking SpaceJordana Moore SaggesePages: 5-5 | DOI:...
Αλέξανδρος Γ. Σφακιανάκης
17h
Acta Agriculturae Scandinavica, Section B — Soil & Plant Science and online now on Taylor &...
Acta Agriculturae Scandinavica, Section B — Soil & Plant Science and online now on Taylor & Francis Online:ArticlesResponse of selected drought tolerant wheat (Triticum aestivum L.) genotypes for agronomic traits and biochemical markers under drought-stressed and non-stressed conditionsSonto Silindile Mkhabela, Hussein Shimelis, Alfred O. Odindo & Jacob MashiloPages: 1-16 | DOI: 10.1080/09064710.2019.1641213
Αλέξανδρος Γ. Σφακιανάκης
17h
Current Medical Research and Opinion, Vol. 35, No. 8, 03 Aug 2019" is    now available online on Taylor...
Current Medical Research and Opinion, Vol. 35, No. 8, 03 Aug 2019" is    now available online on Taylor & Francis Online    You can view the issue table of contents at    https://www.tandfonline.com/toc/icmo20/35/8?ai=1msw4&ui=843fx&af=T    This new issue contains the following articles:    National trend of utilization, clinical and economic outcomes of    transcatheter aortic valve replacement among patients with chronic    obstructive pulmonary disease    Min Ji Kwak, Viraj Bhise,...
Αλέξανδρος Γ. Σφακιανάκης
17h
Energy Sources, Part A: Recovery, Utilization, and Environmental Effects and online now on Taylor...
Energy Sources, Part A: Recovery, Utilization, and Environmental Effects and online now on Taylor & Francis Online:ArticlesBiodiesel Production from Tannery Waste using a Nano Catalyst (Ferric-Manganese Doped Sulphated Zirconia)Vijaya Kumar Booramurthy, Ramesh Kasimani & Sivakumar PandianPages: 1-13 | DOI: 10.1080/15567036.2019.1639849Pyrolysis behaviors and product distribution of Shengli Lignite at different heating rate and final temperature by TG-FTIR and Py-GC-MSZhenyong Miao, Yongjiang...
Αλέξανδρος Γ. Σφακιανάκης
17h
Investigative Radiology
Ultrasound Time-Harmonic Elastography of the Aorta: Effect of Age and Hypertension on Aortic StiffnessObjectives The aim of this study was to investigate ultrasound time-harmonic elastography for quantifying aortic stiffness in vivo in the context of aging and arterial hypertension. Materials and Methods Seventy-four participants (50 healthy participants and 24 participants with long-standing hypertension) were prospectively included between January 2018 and October 2018, and underwent ultrasound...
Αλέξανδρος Γ. Σφακιανάκης
17h

Anesthesia & Analgesia

Gene Variants in Hepatic Metabolism, Gamma-Aminobutyric Acid-ergic Reward, and Prostaglandin Pathways in Opioid-Consuming and Opioid-Naïve Patients Presenting for Lower Extremity Total Joint Replacement
Gene variants may contribute to individual differences in the experience of pain and the efficacy and reward of treatments. We explored gene variation in opioid-naïve and opioid-consuming patients undergoing elective lower extremity total joint replacement. We focused on 3 gene pathways including prostaglandin, gamma-aminobutyric acid (GABA)-ergic reward, and hepatic metabolism pathways. We report that for genes with possible or probable deleterious impact in these 3 pathways, opioid consumers had more gene variants than opioid-naïve patients (median 3 vs 1, P = .0092). We conclude that chronic opiate users may have genetic susceptibility to altered responses in reward/dependency and pain/inflammation pathways. Accepted for publication May 14, 2019. Funding: Departmental/institutional. The authors declare no conflicts of interest. Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's website (www.anesthesia-analgesia.org). Clinical trial number and registry URL: This study is not subject to clinicaltrials.gov review as the study is not a clinical trial and does not involve an intervention or investigational use of a device or drug. Reprints will not be available from the authors. Address correspondence to Ami R. Stuart, PhD, Department of Anesthesiology, University of Utah, 30 N 1900 E RM 3C444, Salt Lake City, UT 84112. Address e-mail to ami.stuart@hsc.utah.edu. © 2019 International Anesthesia Research Society 

Adultification of Black Children in Pediatric Anesthesia
BACKGROUND: Unconscious racial bias in anesthesia care has been shown to exist. We hypothesized that black children may undergo inhalation induction less often, receive less support from child life, have fewer opportunities to have a family member present for induction, and receive premedication with oral midazolam less often. METHODS: We retrospectively collected data on those <18 years of age from January 1, 2012 to January 1, 2018 including age, sex, race, height, weight, American Society of Anesthesiologists (ASA) physical status, surgical service, and deidentified anesthesiology attending physician. Outcome data included mask versus intravenous induction, midazolam premedication, child life consultation, and family member presence. Racial differences between all outcomes were assessed in the cohort using a multivariable logistic regression model. RESULTS: A total of 33,717 Caucasian and 3901 black children were eligible for the study. For the primary outcome, black children 10–14 years were 1.3 times more likely than Caucasian children to receive mask induction (adjusted odds ratio [AOR], 1.3; 95% confidence interval [CI], 1.1–1.6; P = .001). Child life consultation was poorly documented (<0.5%) and not analyzed. Black children <15 years of age were at least 31% less likely than Caucasians to have a family member present for induction (AOR range, 0.4–0.6; 95% CI range, 0.31–0.84; P < .010). Black children <5 years of age were 13% less likely than Caucasians to have midazolam given preoperatively (AOR, 0.9; 95% CI, 0.8–0.9; P = .012). CONCLUSIONS: This study suggests that disparities in strategies for mitigating anxiety in the peri-induction period exist and adultification may be 1 cause for this bias. Black children 10 to 14 years of age are 1.3 times as likely as their Caucasian peers to be offered inhalation induction to reduce anxiety. However, black children are less likely to receive premedication with midazolam in the perioperative period or to have family members present at induction. The cause of this difference is unclear, and further prospective studies are needed to fully understand this difference. Accepted for publication May 7, 2019. Funding: None. The authors declare no conflicts of interest. This report describes human research. Institutional review board (IRB) contact information: Institutional Review Boards of the UM Medical School, 2800 Plymouth Rd, Building 200, Room 2086, Ann Arbor, MI 48109; e-mail: irbmed@umich.edu. The requirement for written informed consent was waived by the IRB. This report describes an observational clinical study. The author states that the report includes every item in the Enhancing the QUAlity and Transparency Of health Research (EQUATOR) checklist for case–control observational clinical studies. Reprints will not be available from the authors. Address correspondence to Anne Baetzel, MD, Department of Anesthesiology, University of Michigan Medical School, 4–911 CS Mott Children's Hospital, 1540 E Medical Center Dr, Ann Arbor, MI 48109. Address e-mail to abaetzel@med.umich.edu. © 2019 International Anesthesia Research Society 

Anesthesia Provider Training and Practice Models: A Survey of Africa
BACKGROUND: In Africa, most countries have fewer than 1 physician anesthesiologist (PA) per 100,000 population. Nonphysician anesthesia providers (NPAPs) play a large role in the workforce of many low- and middle-income countries (LMICs), but little information has been systematically collected to describe existing human resources for anesthesia care models. An understanding of existing PA and NPAP training pathways and roles is needed to inform anesthesia workforce planning, especially for critically underresourced countries. METHODS: Between 2016 and 2018, we conducted electronic, phone, and in-person surveys of anesthesia providers in Africa. The surveys focused on the presence of anesthesia training programs, training program characteristics, and clinical scope of practice after graduation. RESULTS: One hundred thirty-one respondents completed surveys representing data for 51 of 55 countries in Africa. Most countries had both PA and NPAP training programs (57%; mean, 1.6 pathways per country). Thirty distinct training pathways to become an anesthesia provider could be discriminated on the basis of entry qualification, duration, and qualification gained. Of these 30 distinct pathways, 22 (73%) were for NPAPs. Physician and NPAP program durations were a median of 48 and 24 months (ranges: 36–72, 9–48), respectively. Sixty percent of NPAP pathways required a nursing background for entry, and 60% conferred a technical (eg, diploma/license) qualification after training. Physicians and NPAPs were trained to perform most anesthesia tasks independently, though few had subspecialty training (such as regional or cardiac anesthesia). CONCLUSIONS: Despite profound anesthesia provider shortages throughout Africa, most countries have both NPAP and PA training programs. NPAP training pathways, in particular, show significant heterogeneity despite relatively similar scopes of clinical practice for NPAPs after graduation. Such heterogeneity may reflect the varied needs and resources for different settings, though may also suggest lack of consensus on how to train the anesthesia workforce. Lack of consistent terminology to describe the anesthesia workforce is a significant challenge that must be addressed to accelerate workforce research and planning efforts. Accepted for publication May 16, 2019. Funding: This work received funding Hellman Family Foundation and received additional funds from the International Relations Committee of the Association of Anaesthetists/Royal College of Anesthetists for travel support. The authors declare no conflicts of interest. Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's website (www.anesthesia-analgesia.org). T. J. Law and F. Bulamba contributed equally and share first authorship. Reprints will not be available from the authors. Address correspondence to Tyler J. Law, MD, Division of Global Health Equity, Department of Anesthesia and Perioperative Care, University of California San Francisco, 1001 Potrero Ave, Bldg 5, Rm 3C38, San Francisco, CA 94110. Address e-mail to tyler.law@ucsf.edu. © 2019 International Anesthesia Research Society 

Comparison of 3 Methods to Assess Occupational Sevoflurane Exposure in Abdominal Surgeons: A Single-Center Observational Pilot Study
BACKGROUND: Studies demonstrated that operating room personnel are exposed to anesthetic gases such as sevoflurane (SEVO). Measuring the gas burden is essential to assess the exposure objectively. Air pollution measurements and the biological monitoring of urinary SEVO and its metabolite hexafluoroisopropanol (HFIP) are possible approaches. Calculating the mass of inhaled SEVO is an alternative, but its predictive power has not been evaluated. We investigated the SEVO burdens of abdominal surgeons and hypothesized that inhaled mass calculations would be better suited than pollution measurements in their breathing zones (25 cm around nose and mouth) to estimate urinary SEVO and HFIP concentrations. The effects of potentially influencing factors were considered. METHODS: SEVO pollution was continuously measured by photoacoustic gas monitoring. Urinary SEVO and HFIP samples, which were collected before and after surgery, were analyzed by a blinded environmental toxicologist using the headspace gas chromatography-mass spectrometry method. The mass of inhaled SEVO was calculated according to the formula mVA = cVA·V·t·ρ VA aer. (mVA: inhaled mass; cVA: volume concentration; V: respiratory minute volume; t: exposure time; and ρ VA aer.: gaseous density of SEVO). A linear multilevel mixed model was used for data analysis and comparisons of the different approaches. RESULTS: Eight surgeons performed 22 pancreatic resections. Mean (standard deviation [SD]) SEVO pollution was 0.32 ppm (0.09 ppm). Urinary SEVO concentrations were below the detection limit in all samples, whereas HFIP was detectable in 82% of the preoperative samples in a mean (SD) concentration of 8.53 µg·L−1 (15.53 µg·L−1; median: 2.11 µg·L−1, interquartile range [IQR]: 4.58 µg·L−1) and in all postoperative samples (25.42 µg·L−1 [21.39 µg·L−1]). The mean (SD) inhaled SEVO mass was 5.67 mg (2.55 mg). The postoperative HFIP concentrations correlated linearly to the SEVO concentrations in the surgeons' breathing zones (β = 216.89; P < .001) and to the calculated masses of inhaled SEVO (β = 4.17; P = .018). The surgeon's body mass index (BMI), age, and the frequency of surgeries within the last 24 hours before study entry did not influence the relation between HFIP concentration and air pollution or inhaled mass, respectively. CONCLUSIONS: The biological SEVO burden, expressed as urinary HFIP concentration, can be estimated by monitoring SEVO pollution in the personnel's individual breathing zone. Urinary SEVO was not an appropriate biomarker in this setting. Accepted for publication May 16, 2019. Funding: Departmental. The authors declare no conflicts of interest. Reprints will not be available from the authors. Address correspondence to Jennifer Herzog-Niescery, MD, Department of Anesthesiology, Ruhr-University Bochum, St Josef-Hospital Bochum, Gudrunstraße 56, D-44791 Bochum, Germany. Address e-mail to j.herzog-niescery@klinikum-bochum.de © 2019 International Anesthesia Research Society 

Impact of Anesthetics, Analgesics, and Perioperative Blood Transfusion in Pediatric Cancer Patients: A Comprehensive Review of the Literature
Cancer is the leading cause of death by disease in developed countries. Children and adolescents with cancer need surgical interventions (ie, biopsy or major surgery) to diagnose, treat, or palliate their malignancies. Surgery is a period of high vulnerability because it stimulates the release of inflammatory mediators, catecholamines, and angiogenesis activators, which coincides with a period of immunosuppression. Thus, during and after surgery, dormant tumors or micrometastasis (ie, minimal residual disease) can grow and become clinically relevant metastasis. Anesthetics (ie, volatile agents, dexmedetomidine, and ketamine) and analgesics (ie, opioids) may also contribute to the growth of minimal residual disease or disease progression. For instance, volatile anesthetics have been implicated in immunosuppression and direct stimulation of cancer cell survival and proliferation. Contrarily, propofol has shown in vitro anticancer effects. In addition, perioperative blood transfusions are not uncommon in children undergoing cancer surgery. In adults, an association between perioperative blood transfusions and cancer progression has been described for some malignancies. Transfusion-related immunomodulation is one of the mechanisms by which blood transfusions can promote cancer progression. Other mechanisms include inflammation and the infusion of growth factors. In the present review, we discuss different aspects of tumorigenesis, metastasis, angiogenesis, the immune system, and the current studies about the impact of anesthetics, analgesics, and perioperative blood transfusions on pediatric cancer progression. Accepted for publication May 23, 2019. Funding: None. The authors declare no conflicts of interest. Reprints will not be available from the authors. Address correspondence to Juan P. Cata, MD, Department of Anesthesiology and Perioperative Medicine, University of Texas MD Anderson Cancer Centre, 1515 Holcombe Blvd, Unit 409, Houston, TX 77005. Address e-mail to jcata@mdanderson.org. © 2019 International Anesthesia Research Society 

In Response
No abstract available

Sugammadex Administration in Pregnant Women and in Women of Reproductive Potential: A Narrative Review
Since its clinical introduction in 2008, sugammadex has demonstrated a high degree of safety and superior effectiveness compared to neostigmine when used to antagonize muscle relaxation produced by steroid nondepolarizing neuromuscular blockers. This includes its use in special populations, such as the elderly, children over 2 years old, and patients with renal, hepatic, or lung disease. In contrast, clinical evidence guiding its use during pregnancy, in women of childbearing potential, and in lactating women, is sparse. An exception is administration at the end of surgery in parturients undergoing cesarean delivery (CD) with general anesthesia (GA), for whom effectiveness and safety evidence is rapidly accumulating. We review evidence regarding sugammadex rescue reversal shortly after high-dose rocuronium in cases of cannot intubate/cannot ventilate (CICV), the extent of placental transfer of maternally administered sugammadex, adverse fetal effects of sugammadex exposure, potential effects on maintenance of early pregnancy, and the extent of transfer to breast milk. Finally, many anesthesiologists appear to heed the manufacturer's warning regarding informing women of childbearing potential regarding the risk of hormone contraceptive failure after sugammadex exposure. We provide a medical ethics analysis of the ex post facto counseling commonly reported after sugammadex administration, which favors either preoperative discussion and shared decision making, or the decision by the physician to use neostigmine. This review highlights the disparity in evidence regarding sugammadex use in various contexts of female reproductive health, including current research gaps that prevent this population from sharing in the benefits of sugammadex enjoyed by most perioperative patients. Accepted for publication May 20, 2019. Funding: None. The authors declare no conflicts of interest. Reprints will not be available from the authors. Address correspondence to Michael G. Richardson, MD, Division of Obstetric Anesthesiology, Vanderbilt University Medical Center, 4202 VUH, Nashville, TN 37232. Address e-mail to m.richardson@vumc.org. © 2019 International Anesthesia Research Society 

BOSTN Bundle Intervention for Perioperative Screening and Management of Patients With Suspected Obstructive Sleep Apnea: A Hospital Registry Study
BACKGROUND: We developed and implemented a perioperative guideline for obstructive sleep apnea (OSA), comprising a preoperative screening tool (BOSTN) and clinical management pathways. OSA was suspected with 2 or more of the following: body mass index ≥30 kg/m2, observed apnea, loud snoring, daytime tiredness, and neck circumference ≥16.5 inches in women or ≥ 17.5 inches in men. The primary objective of this study was to assess the association between high BOSTN scores and the requirement of invasive mechanical ventilation after surgery. METHODS: In this hospital registry study, 169,662 noncardiac surgical cases performed at Beth Israel Deaconess Medical Center (BIDMC), Boston, MA, between May 2008 and September 2017 were analyzed. We assessed the association between a high BOSTN Score (score ≥2) and the primary outcome of requirement of invasive mechanical ventilation within 7 days after surgery using multivariable logistic regression adjusted for patient-specific factors and case-specific surgical and anesthesiological confounders. Patients with a BOSTN Score ≥2 were assumed to have a high likelihood of suffering from OSA. Key secondary outcome was postoperative desaturation, defined as a peripheral oxygen saturation measurement <90% within 10 minutes of extubation. RESULTS: Invasive mechanical ventilation within 7 days of surgery was necessary in 3170 (2.3%) low-risk cases (BOSTN Score <2) and 664 (2.1%) high-risk cases (BOSTN Score ≥2). A score ≥2 was associated with significantly lower odds of requiring postoperative invasive ventilation (adjusted odds ratio [aOR], 0.89; 95% confidence interval [CI], 0.80–0.98; P = .017), but with an increased risk of postextubation desaturation (aOR, 1.34; 99.3% CI, 1.21–1.48; P < .001). Patients with a score ≥2 were hospitalized for an average of 3.71 days after surgery, compared to 4.27 days with a score <2 (adjusted incidence rate ratio [aIRR], 0.87; 99.3% CI, 0.84–0.91; P < .001). CONCLUSIONS: Patients at high risk of OSA required postoperative mechanical ventilation less frequently, had higher odds of postoperative desaturation, and were hospitalized for shorter periods of time. Accepted for publication May 14, 2019. Funding: M.E. receives unrestricted funds from philanthropic donors Jeffrey and Judy Buzen. E.S. receives departmental funding from the Department of Anesthesia, Critical Care and Pain Medicine at Beth Israel Deaconess Medical Center, Boston. All other authors have no financial disclosures. Conflicts of Interest: See Disclosures at the end of the article. Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's website (www.anesthesia-analgesia.org). D. Raub and P. Santer contributed equally and share first authorship. Reprints will not be available from the authors. Address correspondence to Eswar Sundar, MD, Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215. Address e-mail to esundar@bidmc.harvard.edu. © 2019 International Anesthesia Research Society 

Delivery Hospital Characteristics and Postpartum Maternal Mortality: A National Case–Control Study in France
BACKGROUND: The variability in resources for managing critical events among maternity hospitals may impact maternal safety. Our main objective was to assess the risk of postpartum maternal death according to hospitals' organizational characteristics. A secondary objective aimed to assess the specific risk of death due to postpartum hemorrhage (PPH). METHODS: This national population-based case–control study included all 2007–2009 postpartum maternal deaths from the national confidential enquiry (n= 147 cases) and a 2010 national representative sample of parturients (n = 14,639 controls). To adjust for referral bias, cases were classified by time when the condition/complication responsible for the death occurred: postpartum maternal deaths due to conditions present before delivery (n = 66) or during or after delivery (n = 81). Characteristics of delivery hospitals included 24/7 on-site availability of an anesthesiologist and an obstetrician, level of perinatal care, number of deliveries annually, and their teaching and profit status. In teaching and other nonprofit hospitals in France, obstetric care is organized on the principle of collective team-based management, while in for-profit hospitals, this organization is based mostly on that of "one woman–one doctor." Logistic regression models were used to estimate adjusted odds ratios (aORs) and 95% confidence intervals (CIs) for postpartum maternal death. RESULTS: The risk of maternal death from prepartum conditions was lower for women who gave birth in for-profit compared with teaching hospitals (aOR, 0.3; 95% CI, 0.1–0.8; p = .02) and in hospitals with <1500 vs ≥1500 annual deliveries (aOR, 0.4; 95% CI, 0.1–0.9; P = .02). Conversely, the risk of postpartum maternal death from complications occurring during or after delivery was higher for women who delivered in for-profit compared with teaching hospitals (aOR, 2.8; 95% CI, 1.3–6.0; P = .009), as was the risk of death from PPH in for-profit versus nonprofit hospitals (aOR, 2.8; 95% CI, 1.2–6.5; P = .019). CONCLUSIONS: After adjustment for the referral bias related to prepartum morbidity, the risk of postpartum maternal mortality in France differs according to the hospital's organizational characteristics. Accepted for publication May 10, 2019. Funding: This work was funded by the French Institute for Public Health Research (IReSP). The French confidential enquiry into maternal deaths is funded by the French Institute for Public Health Surveillance (InVS) and the French National Institute of Health and Medical Research (Inserm). The French National Perinatal Survey was funded by the Ministry of Health. The French National Perinatal Survey was funded by the Ministry of Health. The authors declare no conflicts of interest. Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's website (www.anesthesia-analgesia.org). A full list of contributors can be found at the end of the article. Reprints will not be available from the authors. Address correspondence to Monica Saucedo, MD, PhD, Inserm UMR 1153, Obstetrical, Perinatal and Pediatric Epidemiology Research Team (EPOPé), Centre for Epidemiology and Statistics Sorbonne Paris Cité (CRESS), DHU Risks in Pregnancy, Paris Descartes University, Maternité Port-Royal 6ème étage, 53 Avenue de l'Observatoire, 75014 Paris, France. Address e-mail to monica.saucedo@inserm.fr. © 2019 International Anesthesia Research Society 

Functional MRI: Basic Principles and Emerging Clinical Applications for Anesthesiology and the Neurological Sciences
No abstract available

Alexandros Sfakianakis
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182
6948891480

Cancer Causes & Control

Healthy dietary patterns and risk and survival of breast cancer: a meta-analysis of cohort studies

Abstract

Purposes

Dietary patterns have been found to be associated with the overall cancer risk and survival. However, the associations of healthy dietary patterns and breast cancer remain unclear. We aimed to conduct a meta-analysis of prospective cohort studies to estimate the pooled results of the association of healthy dietary patterns with breast cancer risk and survival.

Methods

PubMed, EMBASE, and Web of Science were searched for literature published until June 24th, 2018 that examined the associations between healthy dietary patterns and breast cancer risk and survival. Risk ratios (RRs) and 95% confidence intervals (CIs) were calculated by using a random-effects model for meta-analysis.

Results

There were 32 articles retrieved for the meta-analysis, with 27 for breast cancer risk and five for breast cancer survival. There was a statistically significant lower risk of breast cancer associated with healthy dietary patterns (RR = 0.93, 95% CI: 0.88, 0.98). Subgroup analysis results suggested that there was an inverse association between breast cancer risk and posterori-derived healthy patterns, but no statistically significant associations were found in other stratified subgroups (a priori-derived diet, study region, menopausal status, or breast cancer subtypes). Healthy dietary patterns were associated inversely with all-cause mortality (RR = 0.76, 95% CI: 0.63, 0.92); however, no association was found for breast cancer-specific mortality.

Conclusions

The results suggested that healthy dietary patterns might be associated with a reduced risk of breast cancer and all-cause mortality among breast cancer patients. It could be clinically relevant to promote healthy dietary patterns for breast cancer prevention and improve survival among breast cancer patients.



The association between coffee consumption and bladder cancer in the bladder cancer epidemiology and nutritional determinants (BLEND) international pooled study

Abstract

Background

Inconsistent results for coffee consumption and bladder cancer (BC) risk have been shown in epidemiological studies. This research aims to increase the understanding of the association between coffee consumption and BC risk by bringing together worldwide case–control studies on this topic.

Methods

Data were collected from 13 case–control comprising of 5,911 cases and 16,172 controls. Pooled multivariate odds ratios (ORs), with corresponding 95% confidence intervals (CIs), were obtained using multilevel logistic regression models. Furthermore, linear dose–response relationships were examined using fractional polynomial models.

Results

No association of BC risk was observed with coffee consumption among smokers. However, after adjustment for age, gender, and smoking, the risk was significantly increased for never smokers (ever vs. never coffee consumers: ORmodel2 1.30, 95% CI 1.06–1.59; heavy (> 4 cups/day) coffee consumers vs. never coffee consumers: ORmodel2 1.52, 95% CI 1.18–1.97, p trend = 0.23). In addition, dose–response analyses, in both the overall population and among never smokers, also showed a significant increased BC risk for coffee consumption of more than four cups per day. Among smokers, a significant increased BC risk was shown only after consumption of more than six cups per day.

Conclusion

This research suggests that positive associations between coffee consumption and BC among never smokers but not smokers.



Proceedings of the fourth international molecular pathological epidemiology (MPE) meeting

Abstract

An important premise of epidemiology is that individuals with the same disease share similar underlying etiologies and clinical outcomes. In the past few decades, our knowledge of disease pathogenesis has improved, and disease classification systems have evolved to the point where no complex disease processes are considered homogenous. As a result, pathology and epidemiology have been integrated into the single, unified field of molecular pathological epidemiology (MPE). Advancing integrative molecular and population-level health sciences and addressing the unique research challenges specific to the field of MPE necessitates assembling experts in diverse fields, including epidemiology, pathology, biostatistics, computational biology, bioinformatics, genomics, immunology, and nutritional and environmental sciences. Integrating these seemingly divergent fields can lead to a greater understanding of pathogenic processes. The International MPE Meeting Series fosters discussion that addresses the specific research questions and challenges in this emerging field. The purpose of the meeting series is to: discuss novel methods to integrate pathology and epidemiology; discuss studies that provide pathogenic insights into population impact; and educate next-generation scientists. Herein, we share the proceedings of the Fourth International MPE Meeting, held in Boston, MA, USA, on 30 May–1 June, 2018. Major themes of this meeting included 'integrated genetic and molecular pathologic epidemiology', 'immunology-MPE', and 'novel disease phenotyping'. The key priority areas for future research identified by meeting attendees included integration of tumor immunology and cancer disparities into epidemiologic studies, further collaboration between computational and population-level scientists to gain new insight on exposure-disease associations, and future pooling projects of studies with comparable data.



The sensitivity of reported effects of EMF on childhood leukemia to uncontrolled confounding by residential mobility: a hybrid simulation study and an empirical analysis using CAPS data

Abstract

Purpose

Residential mobility is considered as a potential source of confounding in studies assessing environmental exposures, including in studies of electromagnetic field (EMF) exposures and childhood leukemia.

Methods

We present a hybrid simulation study where we simulate a synthetic dataset based on an existing study and use it to assess the sensitivity of EMF–leukemia associations to different scenarios of uncontrolled confounding by mobility under two major hypotheses of the infectious etiology of childhood leukemia. We then used the findings to conduct sensitivity analysis and empirically offset the potential bias due to unmeasured mobility in the California Power Line Study dataset.

Results

As expected, the stronger the assumed relationship between mobility and exposure and outcome, the greater the potential bias. However, no scenario created a bias strong enough to completely explain away previously observed associations.

Conclusions

We conclude that uncontrolled confounding by residential mobility had some impact on the estimated effect of EMF exposures on childhood leukemia, but that it was unlikely to be the primary explanation behind previously observed largely consistent, but unexplained associations.



The association of marital status and mortality among men with early-stage prostate cancer treated with radical prostatectomy: insight into post-prostatectomy survival strategies

Abstract

Purpose

The purpose of this study was to determine the association of marital status, a marker of social support, with all-cause and prostate cancer-specific mortality in a cohort of men with early-stage prostate cancer treated with radical prostatectomy.

Methods

We conducted a retrospective cohort study of 3,579 men treated for localized (stage 1–2) prostate cancer with radical prostatectomy at a single institution between 1994 and 2004. Marital status (not married vs. married) and marital history (never married, divorced, widowed vs. married) at the time of prostatectomy were examined in relation to (1) all-cause mortality and (2) prostate cancer-specific mortality using Cox proportional hazards regression.

Results

Not being married (vs. married) at the time of radical prostatectomy was associated with an increased risk of all-cause mortality [Hazard Ratio (HR) 1.42; 95% Confidence Interval (CI) 1.10, 1.85]. Similarly, in analyses of marital history, never-married men were at highest risk of all-cause mortality (HR 1.77, 95% CI 1.19, 2.63). Unmarried status (vs. married) was also associated with an increased risk of prostate cancer-specific mortality (HR 1.97; 95% CI 1.01, 3.83).

Conclusions

Unmarried men with prostate cancer were at greater risk for death after radical prostatectomy. Among married men with prostate cancer, marriage likely serves as a multi-faceted proxy for many protective factors including social support. Future studies should explore the mechanisms underlying these findings to inform the development of novel prostate cancer survival interventions for unmarried men and those with low social support.



Soy and tea intake on cervical cancer risk: the Singapore Chinese Health Study

Abstract

Purpose

Soy isoflavones and tea catechins have immunomodulating and chemopreventive properties relevant for cervical carcinogenesis; however, there are limited epidemiologic data on the relationship of soy and tea consumption with cervical cancer risk. The aim of our study was to examine effects of soy and tea intake on cervical cancer risk among Singapore Chinese women.

Methods

The association between intake of soy and tea drinking and cervical cancer risk was investigated in a prospective, population-based cohort of 30,744 Chinese women in Singapore with an average 16.7 years of follow-up and 312 incident cervical cancer cases. Multivariable proportional hazard models were used to estimate hazard ratio (HR) and 95% confidence interval (CI) of cervical cancer associated with intake levels of soy and tea.

Results

High intake of soy alone was associated with a statistically borderline significant 20% reduced risk of cervical cancer (HR 0.80, 95% CI 0.61, 1.05) while green tea alone was not (HR 0.97, 95% CI: 0.76, 1.22). In stratified analysis, high intake of soy was associated with a statistically significant decrease in cervical cancer risk among green tea drinkers (HR 0.43; 95% CI 0.28, 0.69) but not among non-drinkers of green tea. The difference in the soy-cervical cancer risk association between green tea drinkers and non-drinkers was statistically significant (p for interaction = 0.004). This inverse association between soy intake and cervical cancer risk remained after further adjustment for human papillomavirus serostatus. Black tea consumption was not associated with cervical cancer risk.

Conclusions

These findings suggest that a protective effect of soy against cervical cancer development may depend on green tea constituents.



Association between greater leg length and increased incidence of colorectal cancer: the atherosclerosis risk in communities (ARIC) study

Abstract

Purpose

Previous studies have reported that taller people have an increased risk of colorectal cancer (CRC). We examined the association of two height components—leg length and sitting height—with CRC risk in 14,532 individuals aged 45–64 years in the Atherosclerosis Risk in Communities study.

Methods

Anthropometrics were measured at baseline (1987–1989). Incident CRC cases (n = 382) were ascertained from 1987 to 2012. Cox proportional hazards regression was used to estimate multivariable-adjusted hazard ratios for CRC and colon cancer across quintiles of sex-specific leg length and sitting height.

Results

The highest (versus the lowest) quintile of leg length was associated with a 36% greater CRC risk (p-trend = 0.04), and 51% greater colon cancer risk (p-trend = 0.01). For the top four quintiles combined, risk was increased by 34% for CRC and by 45% for colon cancer versus the lowest quintile. Total height and sitting height were not significantly associated with CRC or colon cancer risk. A small number of cases (n = 57) limited our ability to conduct subgroup analyses for rectal cancer.

Conclusions

A positive association of leg length with CRC and colon cancer risk suggests that biological mechanisms leading to greater leg length during puberty may explain the association between taller height and CRC.



Cost-effectiveness of breast cancer screening in the National Breast and Cervical Cancer Early Detection Program

Abstract

Purpose

To estimate the cost-effectiveness of breast cancer screening in the National Breast and Cervical Cancer Early Detection Program (NBCCEDP).

Methods

Using a modified CISNET breast cancer simulation model, we estimated outcomes for women aged 40–64 years associated with three scenarios: breast cancer screening within the NBCCEDP, screening in the absence of the NBCCEDP (no program), and no screening through any program. We report screening outcomes, cost, quality-adjusted life-years (QALYs), incremental cost-effectiveness ratios (ICERs), and sensitivity analyses results.

Results

Compared with no program and no screening, the NBCCEDP lowers breast cancer mortality and improves QALYs, but raises health care costs. Base-case ICER for the program was $51,754/QALY versus no program and $50,223/QALY versus no screening. Probabilistic sensitivity analysis ICER for the program was $56,615/QALY [95% CI $24,069, $134,230/QALY] versus no program and $51,096/QALY gained [95% CI $26,423, $97,315/QALY] versus no screening.

Conclusions

On average, breast cancer screening in the NBCCEDP was cost-effective compared with no program or no screening.



Blood transfusion history and risk of non-Hodgkin lymphoma: an InterLymph pooled analysis

Abstract

Purpose

To conduct a pooled analysis assessing the association of blood transfusion with risk of non-Hodgkin lymphoma (NHL).

Methods

We used harmonized data from 13 case–control studies (10,805 cases, 14,026 controls) in the InterLymph Consortium. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using unconditional logistic regression, adjusted for study design variables.

Results

Among non-Hispanic whites (NHW), history of any transfusion was inversely associated with NHL risk for men (OR 0.74; 95% CI 0.65–0.83) but not women (OR 0.92; 95% CI 0.83–1.03), pheterogeneity = 0.014. Transfusion history was not associated with risk in other racial/ethnic groups. There was no trend with the number of transfusions, time since first transfusion, age at first transfusion, or decade of first transfusion, and further adjustment for socioeconomic status, body mass index, smoking, alcohol use, and HCV seropositivity did not alter the results. Associations for NHW men were stronger in hospital-based (OR 0.56; 95% CI 0.45–0.70) but still apparent in population-based (OR 0.84; 95% CI 0.72–0.98) studies.

Conclusions

In the setting of a literature reporting mainly null and some positive associations, and the lack of a clear methodologic explanation for our inverse association restricted to NHW men, the current body of evidence suggests that there is no association of blood transfusion with risk of NHL.



The effect of delivery structure on costs, screening and health promotional services in state level National Breast and Cervical Cancer Early Detection Programs

Abstract

Purpose

We estimated the costs and effectiveness of state programs in the National Breast and Cervical Cancer Early Detection Program (NBCCEDP) based on the type of delivery structure.

Methods

Programs were classified into three delivery structures: (1) centralized, (2) decentralized, and (3) mixed. Centralized programs offer clinical services in satellite offices, but all other program activities are performed centrally. Decentralized programs contract with other entities to fully manage and provide screening and diagnostic services and other program activities. Programs with mixed service delivery structures have both centralized and decentralized features. Programmatic costs were averaged over a 3 year period (2006–2007, 2008–2009, and 2009–2010). Effectiveness was defined in terms of the average number of women served over the 3 years. We report costs per woman served by program activity and delivery structure and incremental cost effectiveness by program structure and by breast/cervical services.

Results

Average costs per woman served were lowest for mixed program structures (breast = $225, cervical = $216) compared to decentralized (breast = cervical = $276) and centralized program structures (breast = $259, cervical = $251). Compared with decentralized programs, for each additional woman served, centralized programs saved costs of $281 (breast) and $284 (cervical). Compared with decentralized programs, for each additional woman served, mixed programs added an additional $109 cost for breast but saved $1,777 for cervical cancer.

Conclusions

Mixed program structures were associated with the lowest screening and diagnostic costs per woman served and had generally favorable incremental costs relative to the other program structures.



Alexandros Sfakianakis
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182
6948891480

Blog Archive

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   International Journal of Environmental Research and Public Health IJERPH, Vol. 17, Pages 6976: Overcoming Barriers to Agriculture Green T...