Alpha 1 antitrypsin distribution in an allergic asthmatic population sensitized to house dust mites

Severe alpha1 antitrypsin deficiency has been clearly associated with pulmonary emphysema, but its relationship with bronchial asthma remains controversial. Some deficient alpha 1 antitrypsin (AAT) genotypes s...

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Papel de la PET/TC con 18F-FDG en el diagnóstico del cáncer de ovario

Publication date: Available online 1 November 2018

Source: Revista Española de Medicina Nuclear e Imagen Molecular

Author(s): D. Rubello, M.C. Marzola, P.M. Colletti

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A novel technique for measurement of orthodontic mini-implant stability using the Osstell ISQ device.

Related Articles

A novel technique for measurement of orthodontic mini-implant stability using the Osstell ISQ device.

Angle Orthod. 2018 Nov 01;:

Authors: Hosein YK, Dixon SJ, Rizkalla AS, Tassi A

Abstract
OBJECTIVES:: To develop and validate a method for application of the Osstell ISQ device in the assessment of mini-implant stability.
MATERIALS AND METHODS:: An adaptor was developed for attachment of Osstell's SmartPeg onto a variety of orthodontic mini-implants. For validation of the adaptor, Benefit mini-implants were inserted into bone blocks that mimicked different stability conditions. The Osstell device was used to assess mini-implant stability with the adaptor (test measurement) and conventional SmartPeg attachment (gold-standard measurement). Implant stability quotient (ISQ) values were assessed for agreement, repeatability, and reproducibility.
RESULTS:: Strong positive correlations were found between ISQ values obtained using the novel adaptor and the conventional attachment. Repeatability and reproducibility of ISQ values with the adaptor were similar to those obtained with the conventional attachment.
CONCLUSIONS:: A method was developed and validated to assess the stability of orthodontic mini-implants using the Osstell system. The novel mini-implant adaptor provided repeatable and reproducible measurements of mini-implant stability, which agreed with those obtained using a conventional SmartPeg attachment. This adaptor permits noninvasive stability assessment of various designs of mini-implants, most of which are incompatible with the conventional SmartPeg attachment.

PMID: 30382751 [PubMed - as supplied by publisher]

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Clinical metric for differentiating intracranial hemangiopericytomas from meningiomas using diffusion weighted MRI

Publication date: Available online 1 November 2018

Source: Clinical Imaging

Author(s): Alexander M. El-Ali, Vikas Agarwal, Andrew Thomas, Ronald L. Hamilton, Christopher G. Filippi

Abstract

Purpose

Intracranial Hemangiopericytomas (IHP) are dural based tumors that frequently recur/metastasize. Unfortunately, their imaging appearance overlaps significantly with more benign meningiomas. We evaluated the use of diffusion weighted imaging (DWI) to differentiate IHP from meningioma.

Methods

We compared MRI of IHP tumors (WHO Grades II/III) (n = 20) to meningioma (n = 48, WHO Grade I/II).

Findings

ADC values differed between IHP (1.05 × 10–3 mm2/s) and meningiomas (0.89 × 10–3 mm2/s) (p = 0.05). Normalized ADC ratios (nADC), differed between IHP and meningiomas (1.30 vs 1.07, p = 0.03).

Conclusion

Importantly, a nADC cutoff of >1.3 was specific (96%) but not sensitive (35%) for identifying IHP.

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High Molecular Weight Hyaluronic Acid Regulates P. gingivalis–induced Inflammation and Migration in Human Gingival Fibroblasts via MAPK and NF-κB Signaling Pathway

Publication date: Available online 1 November 2018

Source: Archives of Oral Biology

Author(s): Minshan Chen, Lin Li, Zhenshi Wang, Ping Li, Feng Feng, Xi Zheng

Abstract

Chronic periodontitis is associated with Porphyromonas gingivalis (P. gingivalis) infection. Hyaluronic Acid (HA), a critical component of the extracellular matrix, exhibits anti-inflammatory and wound-healing properties. This study aimed to investigate the effect of various molecular weights of HA (30, 300 and 1300 kDa) on P. gingivalis-induced inflammatory and wound-healing responses in human gingival fibroblasts (HGFs). Cell cytotoxicity and proliferation were assessed by Lactate dehydrogenase and MTT assays, respectively. An enzyme linked immunosorbent assay was used to detect the levels of interleukin (IL) -1β, IL-6, IL-8, IL-4 and IL-10. Cell migration was evaluated with a scratch wound healing assay. The expression of nuclear factor kappa B (NF-кB), IкBα, p38 and extracellular signal-regulated kinase (ERK) were analyzed with Western blotting. The results showed that P. gingivalis (1.6 × 10⁶ CFU/mL) and HA (1, 2, 5 and 10 mg/mL) exhibited no toxicity to the HGFs. The 1300 kDa HA inhibited P. gingivalis-induced IL-1β, IL-6, IL-8, IL-4 and IL-10 production in a dose-dependent manner, while the 30 and 300 kDa HA did not have an effect. Meanwhile, cell migration was significantly promoted by the 30 and 1300 kDa HA. Furthermore, the 1300 kDa HA inhibited NF-κB expression, IκBα degradation and P. gingivalis-induced ERK and P38 activation. Therefore, our study suggests that high molecular weight HA may have beneficial effects on periodontal inflammation and oral wounds.

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MMP-3 and MMP-8 in Rat Mandibular Condylar Cartilage Associated with Dietary Loading, Estrogen Level, and Aging

Publication date: Available online 1 November 2018

Source: Archives of Oral Biology

Author(s): Jia Yu, Eerika Mursu, Matleena Typpo, Sakari Laaksonen, Hanna-Marja Voipio, Paula Pesonen, Aune Raustia, Pertti Pirttiniemi

Abstract

Objectives

The structure of the mandibular condylar cartilage (MCC) is regulated by dynamic and multifactorial processes. The aim of this study was to examine the effects of altered dietary loading, estrogen level, and aging on the structure of the condylar cartilage and the expressions of matrix metalloproteinase (MMP) -3 and MMP-8 of rat MCC.

Methods

In this study, Crl:CD (SD) female rats were randomly divided into 3 groups according to dietary hardness: hard diet (diet board), normal diet (pellet), and soft diet (powder). In each group, the rats were further divided into 2 subgroups by ovariectomy at the age of 7 weeks. The rats were sacrificed at 5- and 14-month-old. Histomorphometric analysis of the MCC thickness was performed after toluidine blue staining. Immunochemical staining was done for MMP-3 and MMP-8. A linear mixed model was used to assess the effects of dietary loading, estrogen level, and aging. Results: Increased dietary loading was the main factor to increase the MMP-3 expression and the anterior and central thickness of the MCC. Lack of estrogen was the main factor associated with decreased MMP-8. Aging was associated with the thickness changes of the whole condylar cartilage and the reduced expression of MMP-8.

Conclusion

The condylar cartilage structure and metabolism of the female rats are sensitive to dietary loading changes, estrogen level as well as aging. The proper balance of these factors seems to be essential for the maintenance of the condylar cartilage.

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Determination of IgE and IgG reactivity to more than 170 allergen molecules in paper-dried blood spots

Publication date: Available online 1 November 2018

Source: Journal of Allergy and Clinical Immunology

Author(s): Victoria Garib, Eva Rigler, Felix Gastager, Raffaela Campana, Yulia Dorofeeva, Pia Gattinger, Yury Zhernov, Musa Khaitov, Rudolf Valenta

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