Discovery of new pyrimidine-5-carbonitrile derivatives as anticancer agents targeting EGFRWT and EGFRT790M.

Related Articles Discovery of new pyrimidine-5-carbonitrile derivatives as anticancer agents targeting EGFRWT and EGFRT790M. Org Biomol Chem. 2020 Sep 22;: Authors: Nasser AA, Eissa IH, Oun MR, El-Zahabi MA, Taghour MS, Belal A, Saleh AM, Mehany ABM, Luesch H, Mostafa AE, Afifi WM, Rocca JR, Mahdy HA Abstract A new series of pyrimidine-5-carbonitrile derivatives has been designed as ATP mimicking tyrosine kinase inhibitors of the epidermal...

pubmed: cell cycle arrest

Wed Sep 23, 2020 13:37

Cinnamaldehyde induces endogenous apoptosis of the prostate cancer-associated fibroblasts via interfering the Glutathione-associated mitochondria function.

Related Articles Cinnamaldehyde induces endogenous apoptosis of the prostate cancer-associated fibroblasts via interfering the Glutathione-associated mitochondria function. Med Oncol. 2020 Sep 22;37(10):91 Authors: Han L, Mei J, Ma J, Wang F, Gu Z, Li J, Zhang Z, Zeng Y, Lou X, Yao X, Tao N, Qin Z Abstract Cinnamaldehyde (CA) is an essential component of cinnamon that has been shown to exhibit anti-tumor effects through growth inhibition...

pubmed: cell cycle arrest

Wed Sep 23, 2020 14:36

Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.

Related Articles Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression. J Nat Prod. 2020 Sep 22;: Authors: Chang KF, Huang XF, Chang JT, Huang YC, Lo WS, Hsiao CY, Tsai NM Abstract Glioblastoma (GBM) is a common and aggressive brain tumor with a median survival of 12-15 months. Temozolomide (TMZ) is a first-line chemotherapeutic...

pubmed: cell cycle arrest

Wed Sep 23, 2020 14:36

Doxorubicin-induced p53 interferes with mitophagy in cardiac fibroblasts.

Related Articles Doxorubicin-induced p53 interferes with mitophagy in cardiac fibroblasts. PLoS One. 2020;15(9):e0238856 Authors: Mancilla TR, Davis LR, Aune GJ Abstract Anthracyclines are the critical component in a majority of pediatric chemotherapy regimens due to their broad anticancer efficacy. Unfortunately, the vast majority of long-term childhood cancer survivors will develop a chronic health condition caused by their successful...

pubmed: cell cycle arrest

Wed Sep 23, 2020 14:36

SUPT5H Post-Transcriptional Silencing Modulates PIN1 Expression, Inhibits Tumorigenicity, and Induces Apoptosis of Human Breast Cancer Cells.

Related Articles SUPT5H Post-Transcriptional Silencing Modulates PIN1 Expression, Inhibits Tumorigenicity, and Induces Apoptosis of Human Breast Cancer Cells. Cell Physiol Biochem. 2020 Sep 23;54(5):928-946 Authors: Lone BA, Ahmad F, Karna SKL, Pokharel YR Abstract BACKGROUND/AIMS: Breast cancer (BrCa) is one of the most common cancers and a highly heterogenous disease, both at the pathological and molecular levels. A common element for...

pubmed: cell cycle arrest

Wed Sep 23, 2020 14:36

Benzylidene thiazolidinediones: Synthesis, in vitro investigations of antiproliferative mechanisms and in vivo efficacy determination in combination with Imatinib.

Related Articles Benzylidene thiazolidinediones: Synthesis, in vitro investigations of antiproliferative mechanisms and in vivo efficacy determination in combination with Imatinib. Bioorg Med Chem Lett. 2020 Sep 19;:127561 Authors: Joshi H, Patil V, Tilekar K, Upadhyay N, Gota V, Ramaa CS Abstract Thiazolidinedione (TZD) has been an interesting scaffold due to its proven antidiabetic activity and encouraging findings in anticancer drug...

pubmed: cell cycle arrest

Wed Sep 23, 2020 14:36

The Inhibitory Effect of Curcumin on Hypoxia Inducer Factors (Hifs) as a Regulatory Factor in the Growth of Tumor Cells in Breast Cancer Stem-Like Cells.

Related Articles The Inhibitory Effect of Curcumin on Hypoxia Inducer Factors (Hifs) as a Regulatory Factor in the Growth of Tumor Cells in Breast Cancer Stem-Like Cells. Drug Res (Stuttg). 2020 Sep 22;: Authors: Sarighieh MA, Montazeri V, Shadboorestan A, Ghahremani MH, Ostad SN Abstract Hypoxia in the microenvironment is related to chemotherapy resistance, tumor progression, and metastasis. Curcumin, as a phenolic compound extracted from...

pubmed: cell cycle arrest

Wed Sep 23, 2020 14:36

A guide to assessing cellular senescence in vitro and in vivo.

Related Articles A guide to assessing cellular senescence in vitro and in vivo. FEBS J. 2020 Sep 22;: Authors: González-Gualda E, Baker AG, Fruk L, Muñoz-Espín D Abstract Cellular senescence is a physiological mechanism whereby a proliferating cell undergoes a stable cell cycle arrest upon damage or stress and elicits a secretory phenotype. This highly dynamic and regulated cellular state plays beneficial roles in physiology, such as during...

pubmed: cell cycle arrest

Wed Sep 23, 2020 14:36